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Human CD4+ T cell subsets differ in their abilities to cross endothelial and epithelial brain barriers in vitro.

Nishihara H, Soldati S, Mossu A, Rosito M, Rudolph H, Muller WA, Latorre D, Sallusto F, Sospedra M, Martin R, Ishikawa H, Tenenbaum T, Schroten H, Gosselet F, Engelhardt B.

Fluids Barriers CNS. 2020 Feb 3;17(1):3. doi: 10.1186/s12987-019-0165-2.


Evolution of transposable elements and evolution of eukaryote genomes mediated by transposable elements.

Nishihara H.

Genes Genet Syst. 2019;94(6):231. doi: 10.1266/ggs.94.231. No abstract available.


Japan society of clinical oncology/Japanese society of medical oncology-led clinical recommendations on the diagnosis and use of tropomyosin receptor kinase inhibitors in adult and pediatric patients with neurotrophic receptor tyrosine kinase fusion-positive advanced solid tumors, cooperated by the Japanese society of pediatric hematology/oncology.

Naito Y, Mishima S, Akagi K, Igarashi A, Ikeda M, Okano S, Kato S, Takano T, Tsuchihara K, Terashima K, Nishihara H, Nishiyama H, Hiyama E, Hirasawa A, Hosoi H, Maeda O, Yatabe Y, Okamoto W, Ono S, Kajiyama H, Nagashima F, Hatanaka Y, Miyachi M, Kodera Y, Yoshino T, Taniguchi H.

Int J Clin Oncol. 2020 Jan 24. doi: 10.1007/s10147-019-01610-y. [Epub ahead of print]


Osimertinib Overcomes Alectinib Resistance Caused by Amphiregulin in a Leptomeningeal Carcinomatosis Model of ALK-Rearranged Lung Cancer.

Arai S, Takeuchi S, Fukuda K, Taniguchi H, Nishiyama A, Tanimoto A, Satouchi M, Yamashita K, Ohtsubo K, Nanjo S, Kumagai T, Katayama R, Nishio M, Zheng MM, Wu YL, Nishihara H, Yamamoto T, Nakada M, Yano S.

J Thorac Oncol. 2020 Jan 21. pii: S1556-0864(20)30022-8. doi: 10.1016/j.jtho.2020.01.001. [Epub ahead of print]


Aggressive prostate cancer with somatic loss of the homologous recombination repair gene FANCA: a case report.

Hongo H, Kosaka T, Aimono E, Nishihara H, Oya M.

Diagn Pathol. 2020 Jan 13;15(1):5. doi: 10.1186/s13000-019-0916-z.


Increased programmed death ligand-1 expression in metastatic Merkel cell carcinoma associates with better prognosis.

Nakamura M, Magara T, Nojiri Y, Nishihara H, Kato H, Teramoto Y, Yasuda M, Wada H, Ozawa T, Umemori Y, Ogata D, Kobayashi T, Hata M, Nagase K, Morita A.

J Dermatol Sci. 2020 Feb;97(2):165-167. doi: 10.1016/j.jdermsci.2019.12.012. Epub 2019 Dec 30. No abstract available.


The CENP-B box, a nucleotide motif involved in centromere formation, has multiple origins in New World monkeys.

Thongchum R, Nishihara H, Srikulnath K, Hirai H, Koga A.

Genes Genet Syst. 2020 Jan 30;94(6):301-306. doi: 10.1266/ggs.19-00042. Epub 2019 Dec 7.


Cancer gene profiling explores the possible precision medicine for diffuse-type gastric adenocarcinoma.

Ishikawa M, Hayashi H, Sakamoto N, Tanaka S, Nishihara H.

Med Oncol. 2019 Nov 25;37(1):10. doi: 10.1007/s12032-019-1327-4.


Retrotransposons spread potential cis-regulatory elements during mammary gland evolution.

Nishihara H.

Nucleic Acids Res. 2019 Dec 16;47(22):11551-11562. doi: 10.1093/nar/gkz1003.


A first Japanese case of neuroendocrine prostate cancer accompanied by lung and brain metastasis with somatic and germline BRCA2 mutation.

Kosaka T, Hongo H, Aimono E, Matsumoto K, Hayashida T, Mikami S, Nishihara H, Oya M.

Pathol Int. 2019 Dec;69(12):715-720. doi: 10.1111/pin.12860. Epub 2019 Oct 20.


Photosensing System Using Photosystem I and Gold Nanoparticle on Graphene Field-Effect Transistor.

Nishiori D, Zhu W, Salles R, Miyachi M, Yamanoi Y, Ikuta T, Maehashi K, Tomo T, Nishihara H.

ACS Appl Mater Interfaces. 2019 Nov 13;11(45):42773-42779. doi: 10.1021/acsami.9b14771. Epub 2019 Oct 31.


Evolutionary Gain of Dbx1 Expression Drives Subplate Identity in the Cerebral Cortex.

Arai Y, Cwetsch AW, Coppola E, Cipriani S, Nishihara H, Kanki H, Saillour Y, Freret-Hodara B, Dutriaux A, Okada N, Okano H, Dehay C, Nardelli J, Gressens P, Shimogori T, D'Onofrio G, Pierani A.

Cell Rep. 2019 Oct 15;29(3):645-658.e5. doi: 10.1016/j.celrep.2019.09.007.


Tri- and Tetranuclear Metal-String Complexes with Metallophilic d10 -d10 Interactions.

Olaru M, Kögel JF, Aoki R, Sakamoto R, Nishihara H, Lork E, Mebs S, Vogt M, Beckmann J.

Chemistry. 2020 Jan 2;26(1):275-284. doi: 10.1002/chem.201904106. Epub 2019 Nov 26.


GRP 78 antibodies are associated with clinical phenotype in neuromyelitis optica.

Shimizu F, Takeshita Y, Hamamoto Y, Nishihara H, Sano Y, Honda M, Sato R, Maeda T, Takahashi T, Fujikawa S, Kanda T.

Ann Clin Transl Neurol. 2019 Oct;6(10):2079-2087. doi: 10.1002/acn3.50905. Epub 2019 Sep 30.


Broad Heterochromatic Domains Open in Gonocyte Development Prior to De Novo DNA Methylation.

Yamanaka S, Nishihara H, Toh H, Eijy Nagai LA, Hashimoto K, Park SJ, Shibuya A, Suzuki AM, Tanaka Y, Nakai K, Carninci P, Sasaki H, Siomi H.

Dev Cell. 2019 Oct 7;51(1):21-34.e5. doi: 10.1016/j.devcel.2019.07.023. Epub 2019 Aug 29.


Enhancement of the Photofunction of Phosphorescent Pt(II) Cyclometalated Complexes Driven by Substituents: Solid-State Luminescence and Circularly Polarized Luminescence.

Usuki T, Uchida H, Omoto K, Yamanoi Y, Yamada A, Iwamura M, Nozaki K, Nishihara H.

J Org Chem. 2019 Sep 6;84(17):10749-10756. doi: 10.1021/acs.joc.9b01285. Epub 2019 Aug 15.


Magnetoresistance and Thermal Transformation Arrest in Pd2Mn1.4Sn0.6 Heusler Alloys.

Xu X, Okada H, Chieda Y, Aizawa N, Takase D, Nishihara H, Sakon T, Han K, Ito T, Adachi Y, Kihara T, Kainuma R, Kanomata T.

Materials (Basel). 2019 Jul 19;12(14). pii: E2308. doi: 10.3390/ma12142308.


Japanese Case of Enzalutamide-Resistant Prostate Cancer Harboring a SPOP Mutation With Scattered Allelic Imbalance: Response to Platinum-Based Therapy.

Watanabe K, Kosaka T, Aimono E, Hongo H, Mikami S, Nishihara H, Oya M.

Clin Genitourin Cancer. 2019 Oct;17(5):e897-e902. doi: 10.1016/j.clgc.2019.06.005. Epub 2019 Jun 13. No abstract available.


Japan Society of Clinical Oncology provisional clinical opinion for the diagnosis and use of immunotherapy in patients with deficient DNA mismatch repair tumors, cooperated by Japanese Society of Medical Oncology, First Edition.

Mishima S, Taniguchi H, Akagi K, Baba E, Fujiwara Y, Hirasawa A, Ikeda M, Maeda O, Muro K, Nishihara H, Nishiyama H, Takano T, Tsuchihara K, Yatabe Y, Kodera Y, Yoshino T.

Int J Clin Oncol. 2020 Feb;25(2):217-239. doi: 10.1007/s10147-019-01498-8. Epub 2019 Jul 8.


Establishment of permutation for cancer risk estimation in the urothelium based on genome-wide DNA methylation analysis.

Tsumura K, Arai E, Tian Y, Shibuya A, Nishihara H, Yotani T, Yamada Y, Takahashi Y, Maeshima AM, Fujimoto H, Nakagawa T, Kume H, Homma Y, Yoshida T, Kanai Y.

Carcinogenesis. 2019 Nov 25;40(11):1308-1319. doi: 10.1093/carcin/bgz112.


GRP78 antibodies damage the blood-brain barrier and relate to cerebellar degeneration in Lambert-Eaton myasthenic syndrome.

Shimizu F, Takeshita Y, Sano Y, Hamamoto Y, Shiraishi H, Sato T, Yoshimura S, Maeda T, Fujikawa S, Nishihara H, Kitanosono H, Tsujino A, Motomura M, Kanda T.

Brain. 2019 Aug 1;142(8):2253-2264. doi: 10.1093/brain/awz168.


The Accelerating World of Graphdiynes.

Sakamoto R, Fukui N, Maeda H, Matsuoka R, Toyoda R, Nishihara H.

Adv Mater. 2019 Oct;31(42):e1804211. doi: 10.1002/adma.201804211. Epub 2019 Jun 20. Review.


Interfacial transmetallation synthesis of a platinadithiolene nanosheet as a potential 2D topological insulator.

Pal T, Doi S, Maeda H, Wada K, Tan CM, Fukui N, Sakamoto R, Tsuneyuki S, Sasaki S, Nishihara H.

Chem Sci. 2019 Apr 17;10(20):5218-5225. doi: 10.1039/c9sc01144g. eCollection 2019 May 28.


Force-driven reversible liquid-gas phase transition mediated by elastic nanosponges.

Nomura K, Nishihara H, Yamamoto M, Gabe A, Ito M, Uchimura M, Nishina Y, Tanaka H, Miyahara MT, Kyotani T.

Nat Commun. 2019 Jun 17;10(1):2559. doi: 10.1038/s41467-019-10511-7.


Comprehensive validation of liquid-based cytology specimens for next-generation sequencing in cancer genome analysis.

Akahane T, Yamaguchi T, Kato Y, Yokoyama S, Hamada T, Nishida Y, Higashi M, Nishihara H, Suzuki S, Ueno S, Tanimoto A.

PLoS One. 2019 Jun 14;14(6):e0217724. doi: 10.1371/journal.pone.0217724. eCollection 2019.


Effectiveness of a genetic test panel designed for gynecological cancer: an exploratory study.

Ida K, Miyamoto T, Higuchi S, Takeuchi H, Yamada S, Ono M, Nishihara H, Shiozawa T.

Med Oncol. 2019 May 29;36(7):62. doi: 10.1007/s12032-019-1286-9.


Analysis of DLL3 and ASCL1 in Surgically Resected Small Cell Lung Cancer (HOT1702).

Furuta M, Sakakibara-Konishi J, Kikuchi H, Yokouchi H, Nishihara H, Minemura H, Harada M, Yamazaki S, Akie K, Fujita Y, Takamura K, Kojima T, Harada T, Minami Y, Watanabe N, Oizumi S, Suzuki H, Nishimura M, Dosaka-Akita H, Isobe H; Hokkaido Lung Cancer Clinical Study Group.

Oncologist. 2019 Nov;24(11):e1172-e1179. doi: 10.1634/theoncologist.2018-0676. Epub 2019 May 8.


PECAM-1 Stabilizes Blood-Brain Barrier Integrity and Favors Paracellular T-Cell Diapedesis Across the Blood-Brain Barrier During Neuroinflammation.

Wimmer I, Tietz S, Nishihara H, Deutsch U, Sallusto F, Gosselet F, Lyck R, Muller WA, Lassmann H, Engelhardt B.

Front Immunol. 2019 Apr 5;10:711. doi: 10.3389/fimmu.2019.00711. eCollection 2019.


Blood-brain barrier dysfunction in immuno-mediated neurological diseases.

Shimizu F, Nishihara H, Kanda T.

Immunol Med. 2018 Sep;41(3):120-128. doi: 10.1080/25785826.2018.1531190. Epub 2018 Nov 30.


Practical procedures for the integrated diagnosis of astrocytic and oligodendroglial tumors.

Sonoda Y, Yokoo H, Tanaka S, Kinoshita M, Nakada M, Nishihara H; committee for molecular diagnosis of the Japan Society of Brain Tumor Pathology.

Brain Tumor Pathol. 2019 Apr;36(2):56-62. doi: 10.1007/s10014-019-00337-y. Epub 2019 Mar 7.


Impaired mitochondrial oxidative phosphorylation capacity in epicardial adipose tissue is associated with decreased concentration of adiponectin and severity of coronary atherosclerosis.

Nakajima T, Yokota T, Shingu Y, Yamada A, Iba Y, Ujihira K, Wakasa S, Ooka T, Takada S, Shirakawa R, Katayama T, Furihata T, Fukushima A, Matsuoka R, Nishihara H, Dela F, Nakanishi K, Matsui Y, Kinugawa S.

Sci Rep. 2019 Mar 5;9(1):3535. doi: 10.1038/s41598-019-40419-7.


A Directional Strain Sensor Based on Anisotropic Microhoneycomb Cellulose Nanofiber-Carbon Nanotube Hybrid Aerogels Prepared by Unidirectional Freeze Drying.

Wang C, Pan ZZ, Lv W, Liu B, Wei J, Lv X, Luo Y, Nishihara H, Yang QH.

Small. 2019 Apr;15(14):e1805363. doi: 10.1002/smll.201805363. Epub 2019 Mar 1.


Epithelial-to-Mesenchymal Transition Is a Mechanism of ALK Inhibitor Resistance in Lung Cancer Independent of ALK Mutation Status.

Fukuda K, Takeuchi S, Arai S, Katayama R, Nanjo S, Tanimoto A, Nishiyama A, Nakagawa T, Taniguchi H, Suzuki T, Yamada T, Nishihara H, Ninomiya H, Ishikawa Y, Baba S, Takeuchi K, Horiike A, Yanagitani N, Nishio M, Yano S.

Cancer Res. 2019 Apr 1;79(7):1658-1670. doi: 10.1158/0008-5472.CAN-18-2052. Epub 2019 Feb 8.


Effects of Substituents on the Blue Luminescence of Disilane-Linked Donor‒Acceptor‒Donor Triads.

Usuki T, Omoto K, Shimada M, Yamanoi Y, Kasai H, Nishibori E, Nishihara H.

Molecules. 2019 Jan 31;24(3). pii: E521. doi: 10.3390/molecules24030521.


One-dimensional magnetic chain composed of CuII and polychlorinated dipyridylphenylmethyl radical: temperature-dependent Jahn-Teller distortion correlated to π-conjugation and magnetic properties.

Kimura S, Uchida H, Kusamoto T, Nishihara H.

Dalton Trans. 2019 Jun 7;48(21):7090-7093. doi: 10.1039/c8dt05104f. Epub 2019 Jan 25.


Case of cutaneous myoepithelioma managed with surgical resection without recurrence for 4 years.

Kanemaru H, Honda N, Kubo Y, Nishihara H, Onuma T, Sakai K, Fukushima S, Inoue Y, Honda Y, Ihn H.

J Dermatol. 2019 Jun;46(6):e206-e208. doi: 10.1111/1346-8138.14769. Epub 2019 Jan 23. No abstract available.


A single-stranded coordination copolymer affords heterostructure observation and photoluminescence intensification.

Toyoda R, Sakamoto R, Fukui N, Matsuoka R, Tsuchiya M, Nishihara H.

Sci Adv. 2019 Jan 4;5(1):eaau0637. doi: 10.1126/sciadv.aau0637. eCollection 2019 Jan.


Luminescent Radical-Excimer: Excited-State Dynamics of Luminescent Radicals in Doped Host Crystals.

Kato K, Kimura S, Kusamoto T, Nishihara H, Teki Y.

Angew Chem Int Ed Engl. 2019 Feb 25;58(9):2606-2611. doi: 10.1002/anie.201813479. Epub 2019 Jan 21.


A 0.5-T pure-in-plane-field magnetizing holder for in-situ Lorentz microscopy.

Sugawara A, Shimakura T, Nishihara H, Akashi T, Takahashi Y, Moriya N, Sugaya M.

Ultramicroscopy. 2019 Feb;197:105-111. doi: 10.1016/j.ultramic.2018.11.012. Epub 2018 Nov 22.


A silicon nanomembrane platform for the visualization of immune cell trafficking across the human blood-brain barrier under flow.

Mossu A, Rosito M, Khire T, Li Chung H, Nishihara H, Gruber I, Luke E, Dehouck L, Sallusto F, Gosselet F, McGrath JL, Engelhardt B.

J Cereb Blood Flow Metab. 2019 Mar;39(3):395-410. doi: 10.1177/0271678X18820584. Epub 2018 Dec 19.


Relationship between Ventilator-Associated Events and Timing of Rehabilitation in Subjects with Emergency Tracheal Intubation at Early Mobilization Facility.

Shinoda T, Nishihara H, Shimogai T, Ito T, Takimoto R, Seo R, Kanai M, Izawa KP, Iwata K.

Int J Environ Res Public Health. 2018 Dec 17;15(12). pii: E2892. doi: 10.3390/ijerph15122892.


Targeted next-generation sequencing of cancer-related genes in thyroid carcinoma: A single institution's experience.

Bandoh N, Akahane T, Goto T, Kono M, Ichikawa H, Sawada T, Yamaguchi T, Nakano H, Kawase Y, Kato Y, Kamada H, Harabuchi Y, Shimizu K, Nishihara H.

Oncol Lett. 2018 Dec;16(6):7278-7286. doi: 10.3892/ol.2018.9538. Epub 2018 Oct 2.


Increased IP-10 production by blood-nerve barrier in multifocal acquired demyelinating sensory and motor neuropathy and multifocal motor neuropathy.

Shimizu F, Oishi M, Sawai S, Beppu M, Misawa S, Matsui N, Miyashiro A, Maeda T, Takeshita Y, Nishihara H, Sano Y, Sato R, Kaji R, Kuwabara S, Kanda T.

J Neurol Neurosurg Psychiatry. 2019 Apr;90(4):444-450. doi: 10.1136/jnnp-2018-319270. Epub 2018 Dec 6.


Pancreatic stellate cells derived from human pancreatic cancer demonstrate aberrant SPARC-dependent ECM remodeling in 3D engineered fibrotic tissue of clinically relevant thickness.

Tanaka HY, Kitahara K, Sasaki N, Nakao N, Sato K, Narita H, Shimoda H, Matsusaki M, Nishihara H, Masamune A, Kano MR.

Biomaterials. 2019 Feb;192:355-367. doi: 10.1016/j.biomaterials.2018.11.023. Epub 2018 Nov 17.


Efficiency breakthrough for radical LEDs.

Kusamoto T, Nishihara H.

Nature. 2018 Nov;563(7732):480-481. doi: 10.1038/d41586-018-07394-x. No abstract available.


Performance of a flat-field grating spectrometer for tender x-ray emission spectroscopy.

Imazono T, Ukita R, Nishihara H, Sasai H, Nagano T.

Appl Opt. 2018 Sep 20;57(27):7770-7777. doi: 10.1364/AO.57.007770.


Quantitative detection of IKZF1 deletion by digital PCR in patients with acute lymphoblastic leukemia.

Hashiguchi J, Onozawa M, Okada K, Amano T, Hatanaka KC, Nishihara H, Sato N, Teshima T.

Int J Lab Hematol. 2019 Apr;41(2):e38-e40. doi: 10.1111/ijlh.12945. Epub 2018 Nov 20. No abstract available.


Pathways of Progression From Intraductal Papillary Mucinous Neoplasm to Pancreatic Ductal Adenocarcinoma Based on Molecular Features.

Omori Y, Ono Y, Tanino M, Karasaki H, Yamaguchi H, Furukawa T, Enomoto K, Ueda J, Sumi A, Katayama J, Muraki M, Taniue K, Takahashi K, Ambo Y, Shinohara T, Nishihara H, Sasajima J, Maguchi H, Mizukami Y, Okumura T, Tanaka S.

Gastroenterology. 2019 Feb;156(3):647-661.e2. doi: 10.1053/j.gastro.2018.10.029. Epub 2018 Oct 17.


Glomangiopericytoma of the Nasal Cavity with CTNNB1 p.S37C Mutation: A Case Report and Literature Review.

Kono M, Bandoh N, Matsuoka R, Goto T, Akahane T, Kato Y, Nakano H, Yamaguchi T, Harabuchi Y, Nishihara H.

Head Neck Pathol. 2019 Sep;13(3):298-303. doi: 10.1007/s12105-018-0961-z. Epub 2018 Sep 11. Review.

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