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Items: 1 to 50 of 93

1.

Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response.

Nakamura A, Nambu T, Ebara S, Hasegawa Y, Toyoshima K, Tsuchiya Y, Tomita D, Fujimoto J, Kurasawa O, Takahara C, Ando A, Nishigaki R, Satomi Y, Hata A, Hara T.

Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7776-E7785. doi: 10.1073/pnas.1805523115. Epub 2018 Jul 30.

2.

Contribution of pharmacists with expertise in infectious diseases to appropriate individualized vancomycin dosing.

Nakashima T, Koido K, Baba H, Otsuka R, Okinaka K, Sano T, Nishigaki R, Hashimoto H, Otsuka T, Esaki M, Terakado H.

Pharmazie. 2018 Jul 1;73(7):422-424. doi: 10.1691/ph.2018.8427.

PMID:
30001779
3.

Monosodium glutamate ingestion during the development period reduces aggression mediated by the vagus nerve in a rat model of attention deficit-hyperactivity disorder.

Nishigaki R, Yokoyama Y, Shimizu Y, Marumoto R, Misumi S, Ueda Y, Ishida A, Shibuya Y, Hida H.

Brain Res. 2018 Jul 1;1690:40-50. doi: 10.1016/j.brainres.2018.04.006. Epub 2018 Apr 9.

4.

Disorganization of Oligodendrocyte Development in the Layer II/III of the Sensorimotor Cortex Causes Motor Coordination Dysfunction in a Model of White Matter Injury in Neonatal Rats.

Ueda Y, Misumi S, Suzuki M, Ogawa S, Nishigaki R, Ishida A, Jung CG, Hida H.

Neurochem Res. 2018 Jan;43(1):136-146. doi: 10.1007/s11064-017-2352-3. Epub 2017 Jul 31.

PMID:
28762105
5.

Discovery of Novel and Potent Stearoyl Coenzyme A Desaturase 1 (SCD1) Inhibitors as Anticancer Agents.

Imamura K, Tomita N, Kawakita Y, Ito Y, Ono K, Nii N, Miyazaki T, Yonemori K, Tawada M, Sumi H, Satoh Y, Yamamoto Y, Miyahisa I, Sasaki M, Satomi Y, Hirayama M, Nishigaki R, Maezaki H.

Bioorg Med Chem. 2017 Jul 15;25(14):3768-3779. doi: 10.1016/j.bmc.2017.05.016. Epub 2017 May 11.

PMID:
28571972
6.

In vitro and in vivo antitumor activities of T-3764518, a novel and orally available small molecule stearoyl-CoA desaturase 1 inhibitor.

Nishizawa S, Sumi H, Satoh Y, Yamamoto Y, Kitazawa S, Honda K, Araki H, Kakoi K, Imamura K, Sasaki M, Miyahisa I, Satomi Y, Nishigaki R, Hirayama M, Aoyama K, Maezaki H, Hara T.

Eur J Pharmacol. 2017 Jul 15;807:21-31. doi: 10.1016/j.ejphar.2017.03.064. Epub 2017 Apr 22.

PMID:
28442322
7.

Dysfunction in Motor Coordination in Neonatal White Matter Injury Model Without Apparent Neuron Loss.

Misumi S, Ueda Y, Nishigaki R, Suzuki M, Ishida A, Jung CG, Hida H.

Cell Transplant. 2016;25(7):1381-93. doi: 10.3727/096368915X689893. Epub 2015 Nov 11.

PMID:
26564423
8.

Efficient gene-targeting in rat embryonic stem cells by CRISPR/Cas and generation of human kynurenine aminotransferase II (KAT II) knock-in rat.

Yamamoto S, Ooshima Y, Nakata M, Yano T, Nishimura N, Nishigaki R, Satomi Y, Matsumoto H, Matsumoto Y, Takeyama M.

Transgenic Res. 2015 Dec;24(6):991-1001. doi: 10.1007/s11248-015-9909-1. Epub 2015 Oct 10.

PMID:
26454650
9.

Differentiation of oligodendrocytes from mouse induced pluripotent stem cells without serum.

Misumi S, Nishigaki R, Ueda Y, Watanabe Y, Shimizu Y, Ishida A, Jung C, Hida H.

Transl Stroke Res. 2013 Apr;4(2):149-57. doi: 10.1007/s12975-012-0250-1. Epub 2013 Jan 11.

PMID:
24323274
10.

Proteomic approaches to oxidative protein modifications implicated in the mechanism of aging.

Toda T, Nakamura M, Morisawa H, Hirota M, Nishigaki R, Yoshimi Y.

Geriatr Gerontol Int. 2010 Jul;10 Suppl 1:S25-31. doi: 10.1111/j.1447-0594.2010.00606.x. Review.

PMID:
20590839
11.

Contribution of rat pulmonary metabolism to the elimination of lidocaine, midazolam, and nifedipine.

Aoki M, Okudaira K, Haga M, Nishigaki R, Hayashi M.

Drug Metab Dispos. 2010 Jul;38(7):1183-8. doi: 10.1124/dmd.110.032227. Epub 2010 Apr 6.

PMID:
20371639
12.

Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammation.

Takahashi H, Ogata H, Nishigaki R, Broide DH, Karin M.

Cancer Cell. 2010 Jan 19;17(1):89-97. doi: 10.1016/j.ccr.2009.12.008.

13.

Isolation and identification of a novel aromatic amine mutagen produced by the Maillard reaction.

Nishigaki R, Watanabe T, Kajimoto T, Tada A, Takamura-Enya T, Enomoto S, Nukaya H, Terao Y, Muroyama A, Ozeki M, Node M, Hasei T, Totsuka Y, Wakabayashi K.

Chem Res Toxicol. 2009 Sep;22(9):1588-93. doi: 10.1021/tx900119j.

PMID:
19685856
14.

Simple and sensitive HPLC method for determination of amrubicin and amrubicinol in human plasma: application to a clinical pharmacokinetic study.

Ando R, Makino Y, Tamura T, Yamamoto N, Nishigaki R, Kimura T, Yokote N, Yamamoto H.

Biomed Chromatogr. 2010 Mar;24(3):301-6. doi: 10.1002/bmc.1289.

PMID:
19634123
15.

Carcinogenic risk of heterocyclic amines in combination - assessment with a liver initiation model.

Hirata A, Tsukamoto T, Sakai H, Takasu S, Ban H, Imai T, Totsuka Y, Nishigaki R, Wakabayashi K, Yanai T, Masegi T, Tatematsu M.

Food Chem Toxicol. 2008 Jun;46(6):2003-9. doi: 10.1016/j.fct.2008.01.040. Epub 2008 Feb 2.

PMID:
18331778
16.

Detection of aminophenylnorharman, a possible endogenous mutagenic and carcinogenic compound, in human urine samples.

Nishigaki R, Totsuka Y, Kataoka H, Ushiyama H, Goto S, Akasu T, Watanabe T, Sugimura T, Wakabayashi K.

Cancer Epidemiol Biomarkers Prev. 2007 Jan;16(1):151-6.

17.

Characterization of the hepatic disposition of lanoteplase, a rationally designed variant of tissue plasminogen activator in rodents.

Komoriya K, Kato Y, Hayashi Y, Ohsuye K, Nishigaki R, Sugiyama Y.

Drug Metab Dispos. 2007 Mar;35(3):469-75. Epub 2006 Dec 18.

PMID:
17178768
18.

Structures and biological properties of DNA adducts derived from N-nitroso bile acid conjugates.

Totsuka Y, Nishigaki R, Enomoto S, Takamura-Enya T, Masumura K, Nohmi T, Kawahara N, Sugimura T, Wakabayashi K.

Chem Res Toxicol. 2005 Oct;18(10):1553-62.

PMID:
16533019
19.

Evidence for a role of Collapsin response mediator protein-2 in signaling pathways that regulate the proliferation of non-neuronal cells.

Tahimic CG, Tomimatsu N, Nishigaki R, Fukuhara A, Toda T, Kaibuchi K, Shiota G, Oshimura M, Kurimasa A.

Biochem Biophys Res Commun. 2006 Feb 24;340(4):1244-50. Epub 2006 Jan 5.

PMID:
16414354
20.

Contribution of OATP (organic anion-transporting polypeptide) family transporters to the hepatic uptake of fexofenadine in humans.

Shimizu M, Fuse K, Okudaira K, Nishigaki R, Maeda K, Kusuhara H, Sugiyama Y.

Drug Metab Dispos. 2005 Oct;33(10):1477-81. Epub 2005 Jul 13.

PMID:
16014768
21.

Proteomic identification of differentially-expressed genes in human gastric carcinomas.

Nishigaki R, Osaki M, Hiratsuka M, Toda T, Murakami K, Jeang KT, Ito H, Inoue T, Oshimura M.

Proteomics. 2005 Aug;5(12):3205-13.

PMID:
16003825
22.

[Proteomics and epigenetics learned from Down syndrome model mouse].

Murakami K, Nishigaki R, Kazuki Y, Kadota M, Oshimura M.

Seikagaku. 2004 Oct;76(10):1296-304. Review. Japanese. No abstract available.

PMID:
15580861
23.

Proteomic signatures and aberrations of mouse embryonic stem cells containing a single human chromosome 21 in neuronal differentiation: an in vitro model of Down syndrome.

Kadota M, Nishigaki R, Wang CC, Toda T, Shirayoshi Y, Inoue T, Gojobori T, Ikeo K, Rogers MS, Oshimura M.

Neuroscience. 2004;129(2):325-35.

PMID:
15501590
24.

Identification of cytochrome P-450s involved in the formation of APNH from norharman with aniline.

Nishigaki R, Totsuka Y, Takamura-Enya T, Sugimura T, Wakabayashi K.

Mutat Res. 2004 Aug 8;562(1-2):19-25.

PMID:
15279827
26.

A new mouse model for Down syndrome.

Kazuki Y, Schulz TC, Shinohara T, Kadota M, Nishigaki R, Inoue T, Kimura M, Kai Y, Abe S, Shirayoshi Y, Oshimura M.

J Neural Transm Suppl. 2003;(67):1-20. Review.

PMID:
15068235
27.

Human chromosome 21q22.2-qter carries a gene(s) responsible for downregulation of mlc2a and PEBP in Down syndrome model mice.

Kazuki Y, Kimura M, Nishigaki R, Kai Y, Abe S, Okita C, Shirayoshi Y, Schulz TC, Tomizuka K, Hanaoka K, Inoue T, Oshimura M.

Biochem Biophys Res Commun. 2004 Apr 30;317(2):491-9.

PMID:
15063784
28.

Mutagens formed from beta-carbolines with aromatic amines.

Totsuka Y, Takamura-Enya T, Nishigaki R, Sugimura T, Wakabayashi K.

J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Mar 25;802(1):135-41. Review.

PMID:
15036005
29.

Searching for genes involved in arteriosclerosis: proteomic analysis of cultured human umbilical vein endothelial cells undergoing replicative senescence.

Kamino H, Hiratsuka M, Toda T, Nishigaki R, Osaki M, Ito H, Inoue T, Oshimura M.

Cell Struct Funct. 2003 Dec;28(6):495-503.

30.

Molecular hierarchy in neurons differentiated from mouse ES cells containing a single human chromosome 21.

Wang CC, Kadota M, Nishigaki R, Kazuki Y, Shirayoshi Y, Rogers MS, Gojobori T, Ikeo K, Oshimura M.

Biochem Biophys Res Commun. 2004 Feb 6;314(2):335-50.

PMID:
14733910
31.

Analysis of HPRT and supF mutations caused by pierisin-1, a guanine specific ADP-ribosylating toxin derived from the cabbage butterfly.

Totsuka Y, Kawanishi M, Nishigaki R, Matsukawa K, Yagi T, Takamura-Enya T, Watanabe M, Sugimura T, Wakabayashi K.

Chem Res Toxicol. 2003 Aug;16(8):945-52.

PMID:
12924921
32.
33.

Structure of DNA adduct formed with aminophenylnorharman, being responsible for the comutagenic action of norharman with aniline.

Totsuka Y, Takamura-Enya T, Kawahara N, Nishigaki R, Sugimura T, Wakabayashi K.

Chem Res Toxicol. 2002 Oct;15(10):1288-94.

PMID:
12387627
34.

An extra human chromosome 21 reduces mlc-2a expression in chimeric mice and Down syndrome.

Nishigaki R, Shinohara T, Toda T, Omori A, Ichinose S, Itoh M, Shirayoshi Y, Kurimasa A, Oshimura M.

Biochem Biophys Res Commun. 2002 Jul 5;295(1):112-8.

PMID:
12083776
35.

Chemiluminescence associated with the oxidative metabolism of salicylic acid in rat liver microsomes.

Doi H, Iwasaki H, Masubuchi Y, Nishigaki R, Horie T.

Chem Biol Interact. 2002 May 20;140(2):109-19.

PMID:
12076519
36.
37.

Immunohistochemical localization of mitogen-activated protein kinase (MAPK) family and morphological changes in rat heart after ischemia-reperfusion injury.

Naito Z, Kudo M, Xu G, Nishigaki R, Yokoyama M, Yamada N, Asano G.

Med Electron Microsc. 2000;33(2):74-81.

PMID:
11810462
38.

Ultrastructural changes and immunohistochemical localization of advanced glycation end products in the heart of streptozotocin-treated Mongolian gerbils.

Fujii T, Nishigaki R, Kawahara K, Yamada N, Onda M, Yokoyama M, Naito Z, Asano G, Shimizu-Suganuma M, Shichinohe K.

Med Electron Microsc. 1999 May;32(1):43-49.

PMID:
11810424
39.

Characterization and overproduction of EcoO109I methyltransferase.

Kita K, Tsuda J, Nishigaki R.

Biosci Biotechnol Biochem. 2001 Nov;65(11):2512-8.

40.

Risk factors for development of postoperative hypertension.

Nishigaki R, Ito A, Kamei J, Takahashi T, Fujii E.

Methods Find Exp Clin Pharmacol. 2001 May;23(4):203-7.

PMID:
11676229
41.

Pharmacokinetic study of a gallium-porphyrin photo- and sono-sensitizer, ATX-70, in tumor-bearing mice.

Sasaki K, Yumita N, Nishigaki R, Sakata I, Nakajima S, Umemura SI.

Jpn J Cancer Res. 2001 Sep;92(9):989-95.

42.

Resting ultrasonic tissue characterization and dobutamine stress echocardiography for prediction of functional recovery in chronic left ventricular ischemic dysfunction.

Honma H, Kusama Y, Matsuzaki T, Ohno T, Nishigaki R, Munakata K, Kishida H, Takano T.

Jpn Circ J. 2001 May;65(5):381-8.

43.

Localization of extracellular matrix and mitogen-activated protein kinase (MAPK) in aorta of streptozotocin treated Mongolian gerbils.

Naito Z, Nishigaki R, Kawahara K, Yokoyama M, Yamada N, Asano G, Shimizu-Suganuma M, Shichinohe K.

J Nippon Med Sch. 2001 Feb;68(1):37-44.

44.

Large-scale evaluation of imprinting status in the Prader-Willi syndrome region: an imprinted direct repeat cluster resembling small nucleolar RNA genes.

Meguro M, Mitsuya K, Nomura N, Kohda M, Kashiwagi A, Nishigaki R, Yoshioka H, Nakao M, Oishi M, Oshimura M.

Hum Mol Genet. 2001 Feb 15;10(4):383-94.

PMID:
11157801
45.

Sonodynamically induced antitumor effect of Photofrin II on colon 26 carcinoma.

Yumita N, Nishigaki R, Umemura S.

J Cancer Res Clin Oncol. 2000 Oct;126(10):601-6.

PMID:
11043398
46.

Ultrasonically induced cell damage enhanced by photofrin II: mechanism of sonodynamic activation.

Yumita N, Umemura S, Nishigaki R.

In Vivo. 2000 May-Jun;14(3):425-9.

PMID:
10904876
47.

[DNA damage-induced signal pathway of p53 as a tumor suppressor and the gene mutation in human cancer].

Tsuchida N, Gao C, Tsuchida Y, Nakajima T, Nishigaki R.

Tanpakushitsu Kakusan Koso. 2000 Jul;45(10):1742-51. Review. Japanese. No abstract available.

PMID:
10897687
48.
49.

A detailed linkage map of medaka, Oryzias latipes: comparative genomics and genome evolution.

Naruse K, Fukamachi S, Mitani H, Kondo M, Matsuoka T, Kondo S, Hanamura N, Morita Y, Hasegawa K, Nishigaki R, Shimada A, Wada H, Kusakabe T, Suzuki N, Kinoshita M, Kanamori A, Terado T, Kimura H, Nonaka M, Shima A.

Genetics. 2000 Apr;154(4):1773-84.

50.

Effect of cyclobutane pyrimidine dimers on apoptosis induced by different wavelengths of UV.

Nishigaki R, Mitani H, Tsuchida N, Shima A.

Photochem Photobiol. 1999 Aug;70(2):228-35.

PMID:
10461461

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