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Items: 1 to 50 of 109

1.

Assessment of sigma-1 receptor occupancy in mice with non-radiolabelled FTC-146 as a tracer.

Bhyrapuneni G, Thentu JB, Mohammed AR, Aleti RR, Padala NP, Ajjala DR, Nirogi R.

J Recept Signal Transduct Res. 2018 Jun 18:1-9. doi: 10.1080/10799893.2018.1478855. [Epub ahead of print]

PMID:
29912606
2.

SUVN-502, a novel, potent, pure, and orally active 5-HT6 receptor antagonist: pharmacological, behavioral, and neurochemical characterization.

Nirogi R, Abraham R, Benade V, Medapati RB, Jayarajan P, Bhyrapuneni G, Muddana N, Mekala VR, Subramanian R, Shinde A, Kambhampati R, Jasti V.

Behav Pharmacol. 2018 May 29. doi: 10.1097/FBP.0000000000000414. [Epub ahead of print]

PMID:
29847336
3.

Synthesis, Structure-Activity Relationships, and Preclinical Evaluation of Heteroaromatic Amides and 1,3,4-Oxadiazole Derivatives as 5-HT4 Receptor Partial Agonists.

Nirogi R, Mohammed AR, Shinde AK, Gagginapally SR, Kancharla DM, Middekadi VR, Bogaraju N, Ravella SR, Singh P, Birangal SR, Subramanian R, Palacharla RC, Benade V, Muddana N, Jayarajan P.

J Med Chem. 2018 Jun 14;61(11):4993-5008. doi: 10.1021/acs.jmedchem.8b00457. Epub 2018 May 31.

PMID:
29763304
4.

Methoxsalen as an in vitro phenotyping tool in comparison with 1-aminobenzotriazole.

Palacharla RC, Molgara P, Panthangi HR, Boggavarapu RK, Manoharan AK, Ponnamaneni RK, Ajjala DR, Nirogi R.

Xenobiotica. 2018 Feb 15:1-8. doi: 10.1080/00498254.2018.1434913. [Epub ahead of print]

PMID:
29382249
5.

Safety, Tolerability and Pharmacokinetics of the Serotonin 5-HT6 Receptor Antagonist, SUVN-502, in Healthy Young Adults and Elderly Subjects.

Nirogi R, Mudigonda K, Bhyrapuneni G, Muddana NR, Goyal VK, Pandey SK, Palacharla RC.

Clin Drug Investig. 2018 May;38(5):401-415. doi: 10.1007/s40261-018-0618-4.

PMID:
29380267
6.

Simultaneous monitoring of electroencephalographic characteristics in animals subjected to behavioral tests: a preclinical investigation.

Nirogi R, Daripelli S, Benade V, Tirumalasetty C, Bhyrapuneni G, Jayarajan P.

Behav Pharmacol. 2017 Dec;28(8):661-669. doi: 10.1097/FBP.0000000000000364.

PMID:
29099402
7.

Assessment of toxicity and tolerability of a combination vehicle; 5% Pharmasolve, 45% Propylene glycol and 50% Polyethylene glycol 400 in rats following repeated intravenous administration.

Pandey SK, Goyal VK, Nalge P, Are P, Vincent S, Nirogi R.

Regul Toxicol Pharmacol. 2017 Dec;91:103-108. doi: 10.1016/j.yrtph.2017.10.016. Epub 2017 Oct 21.

PMID:
29066335
8.

Quantitative in vitro phenotyping and prediction of drug interaction potential of CYP2B6 substrates as victims.

Palacharla RC, Nirogi R, Uthukam V, Manoharan A, Ponnamaneni RK, Kalaikadhiban I.

Xenobiotica. 2018 Jul;48(7):663-675. doi: 10.1080/00498254.2017.1354267. Epub 2017 Jul 28.

PMID:
28737446
9.

Development and validation of sensitive LC-MS/MS method for the quantification of SUVN-502 and its metabolite and its application for first in human pharmacokinetic study.

Nirogi R, Ajjala DR, Aleti R, Rayapati L, Pantangi HR, Boggavarapu RK, Padala NSP.

J Pharm Biomed Anal. 2017 Oct 25;145:423-430. doi: 10.1016/j.jpba.2017.04.005. Epub 2017 Apr 14.

PMID:
28734271
10.

Mechanistic evaluation of tapentadol in reducing the pain perception using in-vivo brain and spinal cord microdialysis in rats.

Benade V, Nirogi R, Bhyrapuneni G, Daripelli S, Ayyanki G, Irappanavar S, Ponnamaneni R, Manoharan A.

Eur J Pharmacol. 2017 Aug 15;809:224-230. doi: 10.1016/j.ejphar.2017.04.013. Epub 2017 Apr 12.

PMID:
28412373
11.

Incurred sample reanalysis of fingolimod and fingolimod phosphate in blood: stability evaluation and application to a rat pharmacokinetic study.

Nirogi R, Padala NP, Ajjala DR, Boggavarapu RK, Kunduru P.

Bioanalysis. 2017 Apr;9(7):565-577. doi: 10.4155/bio-2016-0308. Epub 2017 Mar 16.

PMID:
28300418
12.

Discovery and Development of 1-[(2-Bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole Dimesylate Monohydrate (SUVN-502): A Novel, Potent, Selective and Orally Active Serotonin 6 (5-HT6) Receptor Antagonist for Potential Treatment of Alzheimer's Disease.

Nirogi R, Shinde A, Kambhampati RS, Mohammed AR, Saraf SK, Badange RK, Bandyala TR, Bhatta V, Bojja K, Reballi V, Subramanian R, Benade V, Palacharla RC, Bhyrapuneni G, Jayarajan P, Goyal V, Jasti V.

J Med Chem. 2017 Mar 9;60(5):1843-1859. doi: 10.1021/acs.jmedchem.6b01662. Epub 2017 Feb 17.

PMID:
28212021
13.

Inhibition of cytochrome P450 enzymes by saturated and unsaturated fatty acids in human liver microsomes, characterization of enzyme kinetics in the presence of bovine serum albumin (0.1 and 1.0% w/v) and in vitro - in vivo extrapolation of hepatic clearance.

Palacharla RC, Uthukam V, Manoharan A, Ponnamaneni RK, Padala NP, Boggavarapu RK, Bhyrapuneni G, Ajjala DR, Nirogi R.

Eur J Pharm Sci. 2017 Apr 1;101:80-89. doi: 10.1016/j.ejps.2017.01.027. Epub 2017 Feb 4.

PMID:
28179134
14.

Simultaneous in-vivo receptor occupancy assays for serotonin 1A, 2A, and dopamine 2 receptors with the use of non-radiolabelled tracers: Proposed method in screening antipsychotics.

Thentu JB, Nirogi R, Bhyrapuneni G, Ajjala DR, Aleti RR, Palacharla RC.

J Pharmacol Toxicol Methods. 2017 May - Jun;85:22-28. doi: 10.1016/j.vascn.2017.01.001. Epub 2017 Jan 4.

PMID:
28063918
15.

Synthesis and biological evaluation of novel N1-phenylsulphonyl indole derivatives as potent and selective 5-HT6R ligands for the treatment of cognitive disorders.

Nirogi RV, Bandyala TR, Gangadasari PR, Khagga M.

J Enzyme Inhib Med Chem. 2016;31(sup1):1-15. Epub 2016 Nov 3.

PMID:
27806648
16.

Skin sample preparation by collagenase digestion for diclofenac quantification using LC-MS/MS after topical application.

Nirogi R, Padala NS, Boggavarapu RK, Kalaikadhiban I, Ajjala DR, Bhyrapuneni G, Muddana NR.

Bioanalysis. 2016 Jun;8(12):1251-63. doi: 10.4155/bio-2016-0031. Epub 2016 May 26.

PMID:
27226048
17.

Benzamide derivatives and their constrained analogs as histamine H3 receptor antagonists.

Nirogi R, Shinde A, Tiriveedhi V, Kota L, Saraf SK, Badange RK, Mohammed AR, Subramanian R, Muddana N, Bhyrapuneni G, Abraham R.

Eur J Med Chem. 2016 Jan 27;108:655-662. doi: 10.1016/j.ejmech.2015.12.005. Epub 2015 Dec 10.

PMID:
26731168
18.

Evaluation of clinical chemistry analytes from a single mouse using diluted plasma: effective way to reduce the number of animals in toxicity studies.

Goyal VK, Pandey SK, Kakade S, Nirogi R.

Lab Anim. 2016 Oct;50(5):354-61. doi: 10.1177/0023677215620969. Epub 2015 Dec 6.

PMID:
26643282
19.

5-HT6 receptor antagonist attenuates the memory deficits associated with neuropathic pain and improves the efficacy of gabapentinoids.

Jayarajan P, Nirogi R, Shinde A, Goura V, Babu VA, Yathavakilla S, Bhyrapuneni G.

Pharmacol Rep. 2015 Oct;67(5):934-42. doi: 10.1016/j.pharep.2015.03.013. Epub 2015 Apr 8.

PMID:
26398388
20.

Synthesis and SAR of Imidazo[1,5-a]pyridine derivatives as 5-HT4 receptor partial agonists for the treatment of cognitive disorders associated with Alzheimer's disease.

Nirogi R, Mohammed AR, Shinde AK, Bogaraju N, Gagginapalli SR, Ravella SR, Kota L, Bhyrapuneni G, Muddana NR, Benade V, Palacharla RC, Jayarajan P, Subramanian R, Goyal VK.

Eur J Med Chem. 2015 Oct 20;103:289-301. doi: 10.1016/j.ejmech.2015.08.051. Epub 2015 Sep 1.

PMID:
26363507
21.

Determining the effect of storage conditions on prothrombin time, activated partial thromboplastin time and fibrinogen concentration in rat plasma samples.

Goyal VK, Kakade S, Pandey SK, Gothi AK, Nirogi R.

Lab Anim. 2015 Oct;49(4):311-8. doi: 10.1177/0023677215597137. Epub 2015 Jul 23.

PMID:
26206586
22.

Chronic treatment with a selective 5-HT6 receptor antagonist alters the behavioral and neurochemical effects of ethanol in young adult rats.

Jayarajan P, Nirogi R, Shinde A, Benade V, Muddana NR.

Behav Pharmacol. 2016 Apr;27(2-3 Spec Issue):225-35. doi: 10.1097/FBP.0000000000000141.

PMID:
25932717
23.

Evaluation of metabolism dependent inhibition of CYP2B6 mediated bupropion hydroxylation in human liver microsomes by monoamine oxidase inhibitors and prediction of potential as perpetrators of drug interaction.

Nirogi R, Palacharla RC, Mohammed AR, Manoharan A, Ponnamaneni RK, Bhyrapuneni G.

Chem Biol Interact. 2015 Mar 25;230:9-20. doi: 10.1016/j.cbi.2015.01.028. Epub 2015 Feb 3.

PMID:
25656918
24.

Low-dose prazosin in combination with 5-HT6 antagonist PRX-07034 has antipsychotic effects.

Abraham R, Nirogi R, Shinde A, Irupannanavar S.

Can J Physiol Pharmacol. 2015 Jan;93(1):13-21. doi: 10.1139/cjpp-2014-0254.

PMID:
25429515
25.

Therapeutic Potential of 5-HT6 Antagonist SB399885 in Traumatic Stress Disorder.

Abraham R, Nirogi R, Shinde A, Benade VS.

Drug Res (Stuttg). 2015 Aug;65(8):442-5. doi: 10.1055/s-0034-1390418. Epub 2014 Oct 13.

PMID:
25310249
26.

Mutagenicity and clastogenicity evaluation of metaphenoxy benzyl chloride by ames and micronucleus assays.

Nirogi R, Goyal VK, Jana S, Pandey SK, Gothi A.

Drug Chem Toxicol. 2015 Apr;38(2):235-40. doi: 10.3109/01480545.2014.947424. Epub 2014 Aug 11.

PMID:
25109298
27.

Chemical inhibitors of CYP450 enzymes in liver microsomes: combining selectivity and unbound fractions to guide selection of appropriate concentration in phenotyping assays.

Nirogi R, Palacharla RC, Uthukam V, Manoharan A, Srikakolapu SR, Kalaikadhiban I, Boggavarapu RK, Ponnamaneni RK, Ajjala DR, Bhyrapuneni G.

Xenobiotica. 2015 Feb;45(2):95-106. doi: 10.3109/00498254.2014.945196. Epub 2014 Jul 29.

PMID:
25070627
28.

Role of glutamate and advantages of combining memantine with a 5HT6 ligand in a model of depression.

Abraham R, Nirogi R, Shinde A.

Pharmacol Rep. 2014 Jun;66(3):394-8. doi: 10.1016/j.pharep.2013.10.007. Epub 2014 Apr 13.

PMID:
24905514
29.

Design, synthesis and pharmacological evaluation of indolylsulfonamide amines as potent and selective 5-HT6 receptor antagonists.

Nirogi RV, Bandyala TR, Reballi V, Konda JB, Daulatabad AV, Khagga M.

J Enzyme Inhib Med Chem. 2015 Feb;30(1):85-97. doi: 10.3109/14756366.2014.889126. Epub 2014 Mar 25.

PMID:
24666297
30.

Identification of a suitable and selective inhibitor towards aldehyde oxidase catalyzed reactions.

Nirogi R, Kandikere V, Palacharla RC, Bhyrapuneni G, Kanamarlapudi VB, Ponnamaneni RK, Manoharan AK.

Xenobiotica. 2014 Mar;44(3):197-204. doi: 10.3109/00498254.2013.819594. Epub 2013 Oct 24.

PMID:
24156774
31.

Effect of olanzapine on scopolamine induced deficits in differential reinforcement of low rate 72s (DRL-72s) schedule in rats: involvement of the serotonergic receptors in restoring the deficits.

Jayarajan P, Nirogi R, Shinde A.

Eur J Pharmacol. 2013 Nov 15;720(1-3):344-54. doi: 10.1016/j.ejphar.2013.10.005. Epub 2013 Oct 14.

PMID:
24135200
32.

LC-MS/MS method for the determination of pitolisant: application to rat pharmacokinetic and brain penetration studies.

Nirogi R, Ajjala DR, Kandikere V, Pantangi HR, Jonnala MR, Bhyrapuneni G, Muddana NR, Vurimindi H.

Biomed Chromatogr. 2013 Nov;27(11):1431-7. doi: 10.1002/bmc.2939. Epub 2013 Jun 13.

PMID:
23760876
33.

LC-MS/MS method for the quantification of almotriptan in dialysates: application to rat brain and blood microdialysis study.

Nirogi R, Ajjala DR, Kandikere V, Aleti R, Pantangi HR, Srikakolapu SR, Benade V, Bhyrapuneni G, Vurimindi H.

J Pharm Biomed Anal. 2013 Jul-Aug;81-82:160-7. doi: 10.1016/j.jpba.2013.04.008. Epub 2013 Apr 16.

PMID:
23666253
34.

α4β2* neuronal nicotinic receptor ligands (agonist, partial agonist and positive allosteric modulators) as therapeutic prospects for pain.

Nirogi R, Goura V, Abraham R, Jayarajan P.

Eur J Pharmacol. 2013 Jul 15;712(1-3):22-9. doi: 10.1016/j.ejphar.2013.04.021. Epub 2013 May 7. Review.

PMID:
23660369
35.

In-vivo rat striatal 5-HT4 receptor occupancy using non-radiolabelled SB207145.

Nirogi R, Kandikere V, Bhyrapuneni G, Saralaya R, Ajjala DR, Aleti RR, Rasheed MA.

J Pharm Pharmacol. 2013 May;65(5):704-12. doi: 10.1111/jphp.12030. Epub 2013 Jan 25.

PMID:
23600388
36.

Aripiprazole in an animal model of chronic alcohol consumption and dopamine D₂ receptor occupancy in rats.

Nirogi R, Kandikere V, Jayarajan P, Bhyrapuneni G, Saralaya R, Muddana N, Abraham R.

Am J Drug Alcohol Abuse. 2013 Mar;39(2):72-9. doi: 10.3109/00952990.2012.730590.

PMID:
23421566
37.

A sensitive and selective quantification of catecholamine neurotransmitters in rat microdialysates by pre-column dansyl chloride derivatization using liquid chromatography-tandem mass spectrometry.

Nirogi R, Komarneni P, Kandikere V, Boggavarapu R, Bhyrapuneni G, Benade V, Gorentla S.

J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Jan 15;913-914:41-7. doi: 10.1016/j.jchromb.2012.09.034. Epub 2012 Sep 27.

PMID:
23270937
38.

LC-MS/MS method for the quantification of aldose reductase inhibitor-epalrestat and application to pharmacokinetic study.

Nirogi R, Kandikere V, Ajjala DR, Bhyrapuneni G, Muddana NR.

J Pharm Biomed Anal. 2013 Feb 23;74:227-34. doi: 10.1016/j.jpba.2012.10.020. Epub 2012 Oct 23.

PMID:
23245255
39.

Design, synthesis and pharmacological evaluation of 4-(piperazin-1-yl methyl)-N₁-arylsulfonyl indole derivatives as 5-HT₆ receptor ligands.

Nirogi RV, Badange R, Kambhampati R, Chindhe A, Deshpande AD, Tiriveedhi V, Kandikere V, Muddana N, Abraham R, Khagga M.

Bioorg Med Chem Lett. 2012 Dec 15;22(24):7431-5. doi: 10.1016/j.bmcl.2012.10.057. Epub 2012 Oct 17.

PMID:
23141912
40.

N,N-Dimethyl-[9-(arylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amines as novel, potent and selective 5-HT₆ receptor antagonists.

Nirogi RV, Konda JB, Kambhampati R, Shinde A, Bandyala TR, Gudla P, Kandukuri KK, Jayarajan P, Kandikere V, Dubey PK.

Bioorg Med Chem Lett. 2012 Nov 15;22(22):6980-5. doi: 10.1016/j.bmcl.2012.06.002. Epub 2012 Aug 30.

PMID:
23036955
41.

Dried blood spot analysis of an iron chelator--deferasirox and its potential application to therapeutic drug monitoring.

Nirogi R, Ajjala DR, Kandikere V, Aleti R, Srikakolapu S, Vurimindi H.

J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Oct 15;907:65-73. doi: 10.1016/j.jchromb.2012.08.036. Epub 2012 Sep 2.

PMID:
23036906
42.

Design, synthesis, and pharmacological evaluation of piperidin-4-yl amino aryl sulfonamides: novel, potent, selective, orally active, and brain penetrant 5-HT₆ receptor antagonists.

Nirogi R, Shinde A, Daulatabad A, Kambhampati R, Gudla P, Shaik M, Gampa M, Balasubramaniam S, Gangadasari P, Reballi V, Badange R, Bojja K, Subramanian R, Bhyrapuneni G, Muddana N, Jayarajan P.

J Med Chem. 2012 Nov 8;55(21):9255-69. doi: 10.1021/jm300955x. Epub 2012 Sep 28.

PMID:
23006002
43.

Approach to reduce the non-specific binding in microdialysis.

Nirogi R, Kandikere V, Bhyrapuneni G, Benade V, Saralaya R, Irappanavar S, Muddana N, Ajjala DR.

J Neurosci Methods. 2012 Aug 15;209(2):379-87. doi: 10.1016/j.jneumeth.2012.06.010. Epub 2012 Jun 23.

PMID:
22732212
44.

Pharmacokinetic profiling of efavirenz-emtricitabine-tenofovir fixed dose combination in pregnant and non-pregnant rats.

Nirogi R, Bhyrapuneni G, Kandikere V, Muddana N, Saralaya R, Komarneni P, Mudigonda K, Mukkanti K.

Biopharm Drug Dispos. 2012 Jul;33(5):265-77. doi: 10.1002/bdd.1794. Epub 2012 Jun 20.

PMID:
22610784
45.

Methyllycaconitine: a non-radiolabeled ligand for mapping α7 neuronal nicotinic acetylcholine receptors - in vivo target localization and biodistribution in rat brain.

Nirogi R, Kandikere V, Bhyrapuneni G, Saralaya R, Muddana N, Komarneni P.

J Pharmacol Toxicol Methods. 2012 Jul;66(1):22-8. doi: 10.1016/j.vascn.2012.05.003. Epub 2012 May 16.

PMID:
22609758
46.

Comparison of manual and automated filaments for evaluation of neuropathic pain behavior in rats.

Nirogi R, Goura V, Shanmuganathan D, Jayarajan P, Abraham R.

J Pharmacol Toxicol Methods. 2012 Jul;66(1):8-13. doi: 10.1016/j.vascn.2012.04.006. Epub 2012 Apr 30.

PMID:
22575456
47.

Rat thalamic α₄β₂ neuronal nicotinic acetylcholine receptor occupancy assay using LC-MS/MS.

Nirogi R, Kandikere V, Bhyrapuneni G, Saralaya R, Muddana N, Ajjala DR.

J Pharmacol Toxicol Methods. 2012 May-Jun;65(3):136-41. doi: 10.1016/j.vascn.2012.04.007. Epub 2012 Apr 21.

PMID:
22546347
48.

In vivo receptor occupancy assay of histamine H₃ receptor antagonist in rats using non-radiolabeled tracer.

Nirogi R, Kandikere V, Bhyrapuneni G, Muddana N, Saralaya R, Ponnamaneni RK, Manoharan AK.

J Pharmacol Toxicol Methods. 2012 May-Jun;65(3):115-21. doi: 10.1016/j.vascn.2012.03.003. Epub 2012 Apr 1.

PMID:
22487318
49.

Difference in the norepinephrine levels of experimental and non-experimental rats with age in the object recognition task.

Nirogi R, Abraham R, Jayarajan P, Medapati RB, Shanmuganathan D, Kandikere V, Irappanavar S, Saralaya R, Benade V, Bhyrapuneni G, Muddana N.

Brain Res. 2012 May 9;1453:40-5. doi: 10.1016/j.brainres.2012.03.013. Epub 2012 Mar 13.

PMID:
22464882
50.

Exploring dried blood spot sampling technique for simultaneous quantification of antiretrovirals: lamivudine, stavudine and nevirapine in a rodent pharmacokinetic study.

Nirogi R, Kandikere V, Komarneni P, Aleti R, Padala N, Kalaikadhiban I, Bhyrapuneni G, Muddana N.

Biomed Chromatogr. 2012 Dec;26(12):1472-81. doi: 10.1002/bmc.2718. Epub 2012 Feb 16.

PMID:
22344535

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