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NLRX1/FUNDC1/NIPSNAP1-2 axis regulates mitophagy and alleviates intestinal ischaemia/reperfusion injury.
Li S, Zhou Y, Gu X, Zhang X, Jia Z. Li S, et al. Cell Prolif. 2021 Mar;54(3):e12986. doi: 10.1111/cpr.12986. Epub 2021 Jan 11. Cell Prolif. 2021. PMID: 33432610 Free PMC article.
MATERIALS AND METHODS: NLRX1 in rats with IR injury or in IEC-6 cells with hypoxia reoxygenation (HR) injury were measured by Western blotting, real-time PCR and immunohistochemistry. The function of NLRX1-FUNDC1-NIPSNAP1/NIPSNAP2 axis in mitochondrial homeostasis and cell …
MATERIALS AND METHODS: NLRX1 in rats with IR injury or in IEC-6 cells with hypoxia reoxygenation (HR) injury were measured by Western blotti …
NIPSNAP1 and NIPSNAP2 Act as "Eat Me" Signals for Mitophagy.
Princely Abudu Y, Pankiv S, Mathai BJ, Håkon Lystad A, Bindesbøll C, Brenne HB, Yoke Wui Ng M, Thiede B, Yamamoto A, Mutugi Nthiga T, Lamark T, Esguerra CV, Johansen T, Simonsen A. Princely Abudu Y, et al. Dev Cell. 2019 May 20;49(4):509-525.e12. doi: 10.1016/j.devcel.2019.03.013. Epub 2019 Apr 11. Dev Cell. 2019. PMID: 30982665 Free article.
Here, we show that the mitochondrial matrix proteins 4-Nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (NIPSNAP1) and NIPSNAP2 accumulate on the mitochondria surface upon mitochondrial depolarization. There, they recruit proteins involved in se …
Here, we show that the mitochondrial matrix proteins 4-Nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (NIPSNAP …
NIPSNAP1 and NIPSNAP2 act as "eat me" signals to allow sustained recruitment of autophagy receptors during mitophagy.
Abudu YP, Pankiv S, Mathai BJ, Lamark T, Johansen T, Simonsen A. Abudu YP, et al. Autophagy. 2019 Oct;15(10):1845-1847. doi: 10.1080/15548627.2019.1637642. Epub 2019 Jul 4. Autophagy. 2019. PMID: 31251109 Free PMC article.
Recently, we identified the mitochondrial matrix proteins, NIPSNAP1 (nipsnap homolog 1) and NIPSNAP2 as 'eat-me' signals for damaged mitochondria. NIPSNAP1 and NIPSNAP2 accumulate on the mitochondrial outer membrane following mitochondrial depolarization, recruiting …
Recently, we identified the mitochondrial matrix proteins, NIPSNAP1 (nipsnap homolog 1) and NIPSNAP2 as 'eat-me' signals for damaged …
Mitophagy Receptors in Tumor Biology.
Xie Y, Liu J, Kang R, Tang D. Xie Y, et al. Front Cell Dev Biol. 2020 Nov 11;8:594203. doi: 10.3389/fcell.2020.594203. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 33262988 Free PMC article. Review.
Many components of mitochondria, including mitochondrial membrane proteins (e.g., PINK1, BNIP3L, BNIP3, FUNDC1, NIPSNAP1, NIPSNAP2, BCL2L13, PHB2, and FKBP8) and lipids (e.g., cardiolipin and ceramides), act as mitophagy receptors in a context-dependent manner. ...
Many components of mitochondria, including mitochondrial membrane proteins (e.g., PINK1, BNIP3L, BNIP3, FUNDC1, NIPSNAP1, NIPSNAP2, B …
NIPSNAP Beacons in Mitophagy.
Mukherjee R, Dikic I. Mukherjee R, et al. Dev Cell. 2019 May 20;49(4):503-505. doi: 10.1016/j.devcel.2019.05.008. Dev Cell. 2019. PMID: 31112696 Free article.
In this issue of Developmental Cell, Princely Abudu et al. (2019) delineate the function of NIPSNAP1 and NIPSNAP2 in recruiting mitophagy receptors to depolarized mitochondria, highlighting their importance in the zebrafish brain....
In this issue of Developmental Cell, Princely Abudu et al. (2019) delineate the function of NIPSNAP1 and NIPSNAP2 in recruiting mitop …
NIPSNAP protein family emerges as a sensor of mitochondrial health.
Fathi E, Yarbro JM, Homayouni R. Fathi E, et al. Bioessays. 2021 Jun;43(6):e2100014. doi: 10.1002/bies.202100014. Epub 2021 Apr 14. Bioessays. 2021. PMID: 33852167 Free PMC article. Review.
Recent evidence demonstrated a direct role for NIPSNAP1 and NIPSNAP2 proteins in regulation of mitophagy, a process that is critical for cellular health and maintenance. ...
Recent evidence demonstrated a direct role for NIPSNAP1 and NIPSNAP2 proteins in regulation of mitophagy, a process that is critical …
Autophagy gene expression in skeletal muscle of older individuals is associated with physical performance, muscle volume and mitochondrial function in the Study of Muscle, Mobility and Aging (SOMMA).
Coen PM, Huo Z, Tranah GJ, Barnes HN, Cawthon PM, Hepple RT, Toledo FGS, Evans DS, Fernández OS, Cuervo AM, Kritchevsky SB, Newman AB, Cummings SR, Esser KA. Coen PM, et al. medRxiv [Preprint]. 2023 Nov 5:2023.11.04.23297979. doi: 10.1101/2023.11.04.23297979. medRxiv. 2023. PMID: 37961308 Free PMC article. Preprint.
In line with this, several mitophagy, fusion and fission related genes (NIPSNAP2, DNM1L, OPA1) were also positively associated with outcomes. ...
In line with this, several mitophagy, fusion and fission related genes (NIPSNAP2, DNM1L, OPA1) were also positively associated with o …
Regulation of CREB signaling through L-type Ca2+ channels by Nipsnap-2.
Brittain JM, Wang Y, Wilson SM, Khanna R. Brittain JM, et al. Channels (Austin). 2012 Mar-Apr;6(2):94-102. doi: 10.4161/chan.19415. Epub 2012 Mar 1. Channels (Austin). 2012. PMID: 22627147
Based upon this finding, we investigated the role of Nipsnap1, and the closely related Nipsnap2, in Ca(2+) channel regulation. Here, we find that overexpression of Nipsnap2 caused a 45% increase in currents though L-type Ca(2+) channels in a neuronal cell line, whil …
Based upon this finding, we investigated the role of Nipsnap1, and the closely related Nipsnap2, in Ca(2+) channel regulation. Here, …
Characterization of the human NIPSNAP1 gene from 22q12: a member of a novel gene family.
Seroussi E, Pan HQ, Kedra D, Roe BA, Dumanski JP. Seroussi E, et al. Gene. 1998 May 28;212(1):13-20. doi: 10.1016/s0378-1119(98)00098-5. Gene. 1998. PMID: 9661659
Thus, the NIPSNAP1 gene is a member of an evolutionarily well conserved, novel gene family with two members in human and mouse that have now been characterized, and one member in C. elegans. The second human gene, NIPSNAP2, is localized in the vicinity of marker D7S499 on …
Thus, the NIPSNAP1 gene is a member of an evolutionarily well conserved, novel gene family with two members in human and mouse that have now …
18 results