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Acylated iridoid glycosides with hyaluronidase inhibitory activity from the rhizomes of Picrorhiza kurroa Royle ex Benth.

Morikawa T, Nakanishi Y, Inoue N, Manse Y, Matsuura H, Hamasaki S, Yoshikawa M, Muraoka O, Ninomiya K.

Phytochemistry. 2019 Oct 31;169:112185. doi: 10.1016/j.phytochem.2019.112185. [Epub ahead of print]


K-line (-) in the neck-flexed position affects surgical outcomes in patients with ossification of the posterior longitudinal ligament after muscle-preserving selective laminectomy.

Nori S, Aoyama R, Ninomiya K, Suzuki S, Anazawa U, Shiraishi T.

J Orthop Sci. 2019 Oct 28. pii: S0949-2658(19)30322-7. doi: 10.1016/j.jos.2019.10.002. [Epub ahead of print]


Patients' preferences and perceptions of lung cancer treatment decision making: results from Okayama lung cancer study group trial 1406.

Makimoto G, Hotta K, Oze I, Ninomiya K, Nakanishi M, Hara N, Kano H, Watanabe H, Hata Y, Nishii K, Nakasuka T, Itano J, Ninomiya T, Kubo T, Ohashi K, Ichihara E, Minami D, Sato A, Tabata M, Maeda Y, Kiura K.

Acta Oncol. 2019 Oct 25:1-5. doi: 10.1080/0284186X.2019.1679880. [Epub ahead of print] No abstract available.


Evaluation and Suppression of Retrogradation of Gelatinized Rice Starch.

Yamaguchi Y, Okawa Y, Ninomiya K, Kumagai H, Kumagai H.

J Nutr Sci Vitaminol (Tokyo). 2019;65(Supplement):S134-S138. doi: 10.3177/jnsv.65.S134.


EGFR-TKI acquired resistance in lung cancers harboring EGFR mutations in immunocompetent C57BL/6J mice.

Higo H, Ohashi K, Makimoto G, Nishii K, Kudo K, Kayatani H, Watanabe H, Kano H, Ninomiya K, Hotta K, Maeda Y, Kiura K.

Lung Cancer. 2019 Oct;136:86-93. doi: 10.1016/j.lungcan.2019.08.019. Epub 2019 Aug 20.


Predictive factors of mortality of patients with fragility hip fractures at 1 year after discharge: A multicenter, retrospective study in the northern Kyushu district of Japan.

Kimura A, Matsumoto Y, Wakata Y, Oyamada A, Ohishi M, Fujiwara T, Ikuta K, Tsuchiya K, Tayama N, Tomari S, Miyahara H, Mae T, Hara T, Saito T, Arizono T, Kaji K, Mawatari T, Fujiwara M, Sakimura R, Shin K, Ninomiya K, Nakaie K, Antoku Y, Tokunaga S, Nakashima N, Iwamoto Y, Nakashima Y.

J Orthop Surg (Hong Kong). 2019 Sep-Dec;27(3):2309499019866965. doi: 10.1177/2309499019866965.


Polygenic risk scores in schizophrenia with clinically significant copy number variants.

Taniguchi S, Ninomiya K, Kushima I, Saito T, Shimasaki A, Sakusabe T, Momozawa Y, Kubo M, Kamatani Y, Ozaki N, Ikeda M, Iwata N.

Psychiatry Clin Neurosci. 2019 Aug 28. doi: 10.1111/pcn.12926. [Epub ahead of print]


Evaluation of fatty pancreas by proton density fat fraction using 3-T magnetic resonance imaging and its association with pancreatic cancer.

Fukui H, Hori M, Fukuda Y, Onishi H, Nakamoto A, Ota T, Ogawa K, Ninomiya K, Tatsumi M, Osuga K, Yamada D, Eguchi H, Miyoshi E, Tomiyama N.

Eur J Radiol. 2019 Sep;118:25-31. doi: 10.1016/j.ejrad.2019.06.024. Epub 2019 Jun 28.


The Dural Tube Continues to Expand after Muscle-Preserving Cervical Laminectomy.

Aoyama R, Shiraishi T, Yamane J, Ninomiya K, Kitamura K, Nori S, Suzuki S.

Spine Surg Relat Res. 2018 Aug 25;3(2):136-140. doi: 10.22603/ssrr.2018-0034. eCollection 2019 Apr 27.


First determination of Pu isotopes (239Pu, 240Pu and 241Pu) in radioactive particles derived from Fukushima Daiichi Nuclear Power Plant accident.

Igarashi J, Zheng J, Zhang Z, Ninomiya K, Satou Y, Fukuda M, Ni Y, Aono T, Shinohara A.

Sci Rep. 2019 Aug 14;9(1):11807. doi: 10.1038/s41598-019-48210-4.


Rapid Acquisition of Alectinib Resistance in ALK-Positive Lung Cancer With High Tumor Mutation Burden.

Makimoto G, Ohashi K, Tomida S, Nishii K, Matsubara T, Kayatani H, Higo H, Ninomiya K, Sato A, Watanabe H, Kano H, Ninomiya T, Kubo T, Rai K, Ichihara E, Hotta K, Tabata M, Toyooka S, Takata M, Maeda Y, Kiura K.

J Thorac Oncol. 2019 Nov;14(11):2009-2018. doi: 10.1016/j.jtho.2019.07.017. Epub 2019 Jul 30.


Impact of abdominal fat distribution, visceral fat, and subcutaneous fat on coronary plaque scores assessed by 320-row computed tomography coronary angiography.

Tanaka T, Kishi S, Ninomiya K, Tomii D, Koseki K, Sato Y, Okuno T, Sato K, Koike H, Yahagi K, Komiyama K, Aoki J, Tanabe K.

Atherosclerosis. 2019 Aug;287:155-161. doi: 10.1016/j.atherosclerosis.2019.06.910. Epub 2019 Jun 24.


Suvorexant for insomnia in patients with psychiatric disorder: A 1-week, open-label study.

Kishi T, Sakuma K, Okuya M, Ninomiya K, Oya K, Kubo M, Matsui Y, Nomura I, Okuyama Y, Matsunaga S, Iwata N.

Neuropsychopharmacol Rep. 2019 Sep;39(3):252-255. doi: 10.1002/npr2.12069. Epub 2019 Jul 8.


Use of Unsintered Hydroxyapatite and Poly-L-lactic Acid Composite Sheets for Management of Orbital Wall Fracture.

Tsumiyama S, Umeda G, Ninomiya K, Miyawaki T.

J Craniofac Surg. 2019 Oct;30(7):2001-2003. doi: 10.1097/SCS.0000000000005734.


A Review of Biologically Active Natural Products from a Desert Plant Cistanche tubulosa.

Morikawa T, Xie H, Pan Y, Ninomiya K, Yuan D, Jia X, Yoshikawa M, Nakamura S, Matsuda H, Muraoka O.

Chem Pharm Bull (Tokyo). 2019;67(7):675-689. doi: 10.1248/cpb.c19-00008. Review.


Two distinct nuclear stress bodies containing different sets of RNA-binding proteins are formed with HSATIII architectural noncoding RNAs upon thermal stress exposure.

Aly MK, Ninomiya K, Adachi S, Natsume T, Hirose T.

Biochem Biophys Res Commun. 2019 Aug 20;516(2):419-423. doi: 10.1016/j.bbrc.2019.06.061. Epub 2019 Jun 18.


Programmed cell death-ligand 1 expression and efficacy of cisplatin-based chemotherapy in lung cancer: A sub-analysis of data from the two Okayama Lung Cancer Study Group prospective feasibility studies.

Nishii K, Hotta K, Ninomiya K, Kato Y, Ichihara E, Ohashi K, Ninomiya T, Kubo T, Rai K, Tabata M, Maeda Y, Kiura K.

Respir Investig. 2019 Sep;57(5):460-465. doi: 10.1016/j.resinv.2019.04.004. Epub 2019 Jun 8.


Re-administration of osimertinib in osimertinib-acquired resistant non-small-cell lung cancer.

Ichihara E, Hotta K, Ninomiya K, Kubo T, Ohashi K, Rai K, Tanaka H, Tabata M, Maeda Y, Kiura K.

Lung Cancer. 2019 Jun;132:54-58. doi: 10.1016/j.lungcan.2019.02.021. Epub 2019 Apr 6.


The effect and safety of immune checkpoint inhibitor rechallenge in non-small cell lung cancer.

Watanabe H, Kubo T, Ninomiya K, Kudo K, Minami D, Murakami E, Ochi N, Ninomiya T, Harada D, Yasugi M, Ichihara E, Ohashi K, Fujiwara K, Hotta K, Tabata M, Maeda Y, Kiura K.

Jpn J Clin Oncol. 2019 Aug 1;49(8):762-765. doi: 10.1093/jjco/hyz066.


A Prospective Cohort Study to Define the Clinical Features and Outcome of Lung Cancers Harboring HER2 Aberration in Japan (HER2-CS STUDY).

Ninomiya K, Hata T, Yoshioka H, Ohashi K, Bessho A, Hosokawa S, Ishikawa N, Yamasaki M, Shibayama T, Aoe K, Kozuki T, Harita S, Ueda Y, Murakami T, Fujimoto N, Yanai H, Toyooka S, Takata M, Hotta K, Kiura K; HER2-CS Network.

Chest. 2019 Aug;156(2):357-366. doi: 10.1016/j.chest.2019.01.011. Epub 2019 May 6.


The Japanese Lung Cancer Society Guideline for non-small cell lung cancer, stage IV.

Akamatsu H, Ninomiya K, Kenmotsu H, Morise M, Daga H, Goto Y, Kozuki T, Miura S, Sasaki T, Tamiya A, Teraoka S, Tsubata Y, Yoshioka H, Hattori Y, Imamura CK, Katsuya Y, Matsui R, Minegishi Y, Mizugaki H, Nosaki K, Okuma Y, Sakamoto S, Sone T, Tanaka K, Umemura S, Yamanaka T, Amano S, Hasegawa K, Morita S, Nakajima K, Maemondo M, Seto T, Yamamoto N.

Int J Clin Oncol. 2019 Jul;24(7):731-770. doi: 10.1007/s10147-019-01431-z. Epub 2019 May 2.


Activity of 90Sr in Fallout Particles Collected in the Difficult-to-Return Zone around the Fukushima Daiichi Nuclear Power Plant.

Zhang Z, Igarashi J, Satou Y, Ninomiya K, Sueki K, Shinohara A.

Environ Sci Technol. 2019 May 21;53(10):5868-5876. doi: 10.1021/acs.est.8b06769. Epub 2019 May 8.


Salacia chinensis stem extract and its thiosugar sulfonium constituent, neokotalanol, improves HbA1c levels in ob/ob mice.

Kobayashi M, Akaki J, Yamaguchi Y, Yamasaki H, Ninomiya K, Pongpiriyadacha Y, Yoshikawa M, Muraoka O, Morikawa T.

J Nat Med. 2019 Jun;73(3):584-588. doi: 10.1007/s11418-019-01311-w. Epub 2019 Apr 26.


Effect of exercise therapy combined with branched-chain amino acid supplementation on muscle strengthening in persons with osteoarthritis.

Ikeda T, Jinno T, Masuda T, Aizawa J, Ninomiya K, Suzuki K, Hirakawa K.

Hong Kong Physiother J. 2018 Jun;38(1):23-31. doi: 10.1142/S1013702518500038. Epub 2018 Mar 27.


Evaluation of objective nutritional indexes as predictors of one-year outcomes after transcatheter aortic valve implantation.

Okuno T, Koseki K, Nakanishi T, Sato K, Ninomiya K, Tomii D, Tanaka T, Sato Y, Horiuchi Y, Koike H, Yahagi K, Komiyama K, Tanaka J, Aoki J, Yokozuka M, Miura S, Tanabe K.

J Cardiol. 2019 Jul;74(1):34-39. doi: 10.1016/j.jjcc.2019.02.017. Epub 2019 Mar 28.


Recent treatment strategy for advanced squamous cell carcinoma of the lung in Japan.

Senoo S, Ninomiya K, Hotta K, Kiura K.

Int J Clin Oncol. 2019 May;24(5):461-467. doi: 10.1007/s10147-019-01424-y. Epub 2019 Mar 7. Review.


Fungal spore involvement in the resuspension of radiocaesium in summer.

Igarashi Y, Kita K, Maki T, Kinase T, Hayashi N, Hosaka K, Adachi K, Kajino M, Ishizuka M, Sekiyama TT, Zaizen Y, Takenaka C, Ninomiya K, Okochi H, Sorimachi A.

Sci Rep. 2019 Feb 13;9(1):1954. doi: 10.1038/s41598-018-37698-x.


Patients 10 years after total hip arthroplasty have the deficits in functional performance, physical activity, and high fall rate compared to healthy adults.

Ninomiya K, Hirakawa K, Ikeda T, Nakura N, Suzuki K.

Phys Ther Res. 2018 Oct 20;21(2):53-58. doi: 10.1298/ptr.E9941. eCollection 2018.


Immunoglobulin G4-Related Coronary Periarteritis With Multiple Intracoronary Images.

Koseki K, Yahagi K, Okuno T, Kikushima H, Saito A, Ninomiya K, Tomii D, Nakanishi T, Tanaka T, Sato Y, Sato K, Komiyama K, Aoki J, Tanabe K.

JACC Cardiovasc Interv. 2019 Apr 8;12(7):e59-e61. doi: 10.1016/j.jcin.2018.11.018. Epub 2019 Jan 16. No abstract available.


Lignin as a Functional Green Coating on Carbon Fiber Surface to Improve Interfacial Adhesion in Carbon Fiber Reinforced Polymers.

Szabó L, Imanishi S, Tetsuo F, Hirose D, Ueda H, Tsukegi T, Ninomiya K, Takahashi K.

Materials (Basel). 2019 Jan 6;12(1). pii: E159. doi: 10.3390/ma12010159.


ST-Segment Elevation Myocardial Infarction Related to Variable Calcified Lesions in Saphenous Vein Graft 33 Years After Coronary Artery Bypass Grafting.

Tanaka T, Yahagi K, Ninomiya K, Tomii D, Nakanishi T, Koseki K, Okuno T, Sato Y, Sato K, Komiyama K, Aoki J, Tanabe K.

JACC Cardiovasc Interv. 2018 Nov 26;11(22):e181-e183. doi: 10.1016/j.jcin.2018.08.011. Epub 2018 Nov 1. No abstract available.


Potentials of radiomics for cancer diagnosis and treatment in comparison with computer-aided diagnosis.

Arimura H, Soufi M, Ninomiya K, Kamezawa H, Yamada M.

Radiol Phys Technol. 2018 Dec;11(4):365-374. doi: 10.1007/s12194-018-0486-x. Epub 2018 Oct 29. Review.


Upper cervical lordosis compensates lower cervical kyphosis to maintain whole cervical lordosis after selective laminectomy.

Nori S, Shiraishi T, Aoyama R, Ninomiya K, Yamane J, Kitamura K, Ueda S.

J Clin Neurosci. 2018 Dec;58:64-69. doi: 10.1016/j.jocn.2018.10.049. Epub 2018 Oct 16.


Suppressive Effect of the α-Amylase Inhibitor Albumin from Buckwheat (Fagopyrum esculentum Moench) on Postprandial Hyperglycaemia.

Ninomiya K, Ina S, Hamada A, Yamaguchi Y, Akao M, Shinmachi F, Kumagai H, Kumagai H.

Nutrients. 2018 Oct 15;10(10). pii: E1503. doi: 10.3390/nu10101503.


Collagen Synthesis-Promoting Effects of Andiroba Oil and its Limonoid Constituents in Normal Human Dermal Fibroblasts.

Morikawa T, Nagatomo A, Kitazawa K, Muraoka O, Kikuchi T, Yamada T, Tanaka R, Ninomiya K.

J Oleo Sci. 2018;67(10):1271-1277. doi: 10.5650/jos.ess18143.


Prognostic Impact of Computed Tomography-Derived Abdominal Fat Area on Transcatheter Aortic Valve Implantation.

Okuno T, Koseki K, Nakanishi T, Ninomiya K, Tomii D, Tanaka T, Sato Y, Osanai A, Sato K, Koike H, Yahagi K, Kishi S, Komiyama K, Aoki J, Yokozuka M, Miura S, Tanabe K.

Circ J. 2018 Nov 24;82(12):3082-3089. doi: 10.1253/circj.CJ-18-0709. Epub 2018 Oct 5.


A phase II trial of EGFR-TKI readministration with afatinib in advanced non-small-cell lung cancer harboring a sensitive non-T790M EGFR mutation: Okayama Lung Cancer Study Group trial 1403.

Oda N, Hotta K, Ninomiya K, Minami D, Ichihara E, Murakami T, Yokoyama T, Ichikawa H, Chikamori K, Takigawa N, Ochi N, Harita S, Maeda Y, Kiura K.

Cancer Chemother Pharmacol. 2018 Dec;82(6):1031-1038. doi: 10.1007/s00280-018-3694-5. Epub 2018 Oct 1.


Feasibility of anatomical feature points for the estimation of prostate locations in the Bayesian delineation frameworks for prostate cancer radiotherapy.

Ninomiya K, Arimura H, Sasahara M, Kai Y, Hirose TA, Ohga S.

Radiol Phys Technol. 2018 Dec;11(4):434-444. doi: 10.1007/s12194-018-0481-2. Epub 2018 Sep 28.


Interphase Engineering of a Cellulose-Based Carbon Fiber Reinforced Composite by Applying Click Chemistry.

Szabó L, Imanishi S, Kawashima N, Hoshino R, Hirose D, Tsukegi T, Ninomiya K, Takahashi K.

ChemistryOpen. 2018 Sep 24;7(9):720-729. doi: 10.1002/open.201800180. eCollection 2018 Sep.


Radiomics with artificial intelligence for precision medicine in radiation therapy.

Arimura H, Soufi M, Kamezawa H, Ninomiya K, Yamada M.

J Radiat Res. 2019 Jan 1;60(1):150-157. doi: 10.1093/jrr/rry077. Review.


Pembrolizumab for the first-line treatment of non-small cell lung cancer.

Ninomiya K, Hotta K.

Expert Opin Biol Ther. 2018 Oct;18(10):1015-1021. doi: 10.1080/14712598.2018.1522300. Epub 2018 Sep 19. Review.


Nuclear Magnetic Field in Solids Detected with Negative-Muon Spin Rotation and Relaxation.

Sugiyama J, Umegaki I, Nozaki H, Higemoto W, Hamada K, Takeshita S, Koda A, Shimomura K, Ninomiya K, Kubo MK.

Phys Rev Lett. 2018 Aug 24;121(8):087202. doi: 10.1103/PhysRevLett.121.087202.


Comparison of privacy consciousness between Japanese and Taiwanese.

Tabata N, Sato H, Ninomiya K, Yamamoto C.

Psych J. 2018 Dec;7(4):268-269. doi: 10.1002/pchj.229. Epub 2018 Sep 3.


Significance of re-biopsy of histological tumor samples in advanced non-small-cell lung cancer in clinical practice.

Hotta K, Ninomiya K, Ichihara E, Kiura K.

Int J Clin Oncol. 2019 Jan;24(1):41-45. doi: 10.1007/s10147-018-1344-x. Epub 2018 Aug 29. Review.


An Autopsy Case of Injuries Caused by Automobile Dragging for a Distance of 3.4 km Without Thoracoabdominal Organ Injuries.

Fukasawa M, Ninomiya K, Kawakami Y, Fuke C, Ihama Y, Miyazaki T.

Am J Forensic Med Pathol. 2018 Dec;39(4):348-350. doi: 10.1097/PAF.0000000000000423.


Atmospheric Activity Concentration of 90Sr and 137Cs after the Fukushima Daiichi Nuclear Accident.

Zhang Z, Ninomiya K, Yamaguchi Y, Kita K, Tsuruta H, Igarashi Y, Shinohara A.

Environ Sci Technol. 2018 Sep 4;52(17):9917-9925. doi: 10.1021/acs.est.8b01697. Epub 2018 Aug 21.


Combined effect of cabozantinib and gefitinib in crizotinib-resistant lung tumors harboring ROS1 fusions.

Kato Y, Ninomiya K, Ohashi K, Tomida S, Makimoto G, Watanabe H, Kudo K, Matsumoto S, Umemura S, Goto K, Ichihara E, Ninomiya T, Kubo T, Sato A, Hotta K, Tabata M, Toyooka S, Maeda Y, Kiura K.

Cancer Sci. 2018 Oct;109(10):3149-3158. doi: 10.1111/cas.13752. Epub 2018 Sep 11.


Osimertinib Depletes EGFR T790M in the Spinal Fluid of Patients with Carcinomatous Meningitis of Lung Adenocarcinoma Harboring De Novo EGFR T790M.

Senoo S, Ohashi K, Nishii K, Hara N, Kano H, Ninomiya K, Maeda Y, Kiura K.

J Thorac Oncol. 2018 Aug;13(8):e140-e142. doi: 10.1016/j.jtho.2018.03.016. No abstract available.


Clinical significance of repeat rebiopsy in detecting the EGFR T790M secondary mutation in patients with non-small cell lung cancer.

Ichihara E, Hotta K, Kubo T, Higashionna T, Ninomiya K, Ohashi K, Tabata M, Maeda Y, Kiura K.

Oncotarget. 2018 Jun 29;9(50):29525-29531. doi: 10.18632/oncotarget.25705. eCollection 2018 Jun 29.

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