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139 results

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Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury.
Kayagaki N, Stowe IB, Alegre K, Deshpande I, Wu S, Lin Z, Kornfeld OS, Lee BL, Zhang J, Liu J, Suto E, Lee WP, Schneider K, Lin W, Seshasayee D, Bhangale T, Chalouni C, Johnson MC, Joshi P, Mossemann J, Zhao S, Ali D, Goldenberg NM, Sayed BA, Steinberg BE, Newton K, Webster JD, Kelly RL, Dixit VM. Kayagaki N, et al. Nature. 2023 Jun;618(7967):1072-1077. doi: 10.1038/s41586-023-06191-5. Epub 2023 May 17. Nature. 2023. PMID: 37196676 Free PMC article.
Here we describe an anti-NINJ1 monoclonal antibody that specifically targets mouse NINJ1 and blocks oligomerization of NINJ1, preventing PMR. Electron microscopy studies showed that this antibody prevents NINJ1 from forming oligomeric filaments. In mic …
Here we describe an anti-NINJ1 monoclonal antibody that specifically targets mouse NINJ1 and blocks oligomerization of NINJ …
NINJ1 mediates plasma membrane rupture during lytic cell death.
Kayagaki N, Kornfeld OS, Lee BL, Stowe IB, O'Rourke K, Li Q, Sandoval W, Yan D, Kang J, Xu M, Zhang J, Lee WP, McKenzie BS, Ulas G, Payandeh J, Roose-Girma M, Modrusan Z, Reja R, Sagolla M, Webster JD, Cho V, Andrews TD, Morris LX, Miosge LA, Goodnow CC, Bertram EM, Dixit VM. Kayagaki N, et al. Nature. 2021 Mar;591(7848):131-136. doi: 10.1038/s41586-021-03218-7. Epub 2021 Jan 20. Nature. 2021. PMID: 33472215
Mechanistically, NINJ1 used an evolutionarily conserved extracellular domain for oligomerization and subsequent PMR. The discovery of NINJ1 as a mediator of PMR overturns the long-held idea that cell death-related PMR is a passive event....
Mechanistically, NINJ1 used an evolutionarily conserved extracellular domain for oligomerization and subsequent PMR. The discovery of …
Structural basis of NINJ1-mediated plasma membrane rupture in cell death.
Degen M, Santos JC, Pluhackova K, Cebrero G, Ramos S, Jankevicius G, Hartenian E, Guillerm U, Mari SA, Kohl B, Müller DJ, Schanda P, Maier T, Perez C, Sieben C, Broz P, Hiller S. Degen M, et al. Nature. 2023 Jun;618(7967):1065-1071. doi: 10.1038/s41586-023-05991-z. Epub 2023 May 17. Nature. 2023. PMID: 37198476 Free PMC article.
Plasma membrane rupture was long thought to be driven by osmotic pressure, but it has recently been shown to be in many cases an active process, mediated by the protein ninjurin-1(8) (NINJ1). Here we resolve the structure of NINJ1 and the mechanism by which it ruptu …
Plasma membrane rupture was long thought to be driven by osmotic pressure, but it has recently been shown to be in many cases an active proc …
NINJ1 Regulates Platelet Activation and PANoptosis in Septic Disseminated Intravascular Coagulation.
Zhou X, Yu X, Wan C, Li F, Wang Y, Zhang K, Feng L, Wen A, Deng J, Li S, Xin G, Huang W. Zhou X, et al. Int J Mol Sci. 2023 Feb 19;24(4):4168. doi: 10.3390/ijms24044168. Int J Mol Sci. 2023. PMID: 36835580 Free PMC article.
The aim of this study was to evaluate the expression of NINJ1 in human and murine platelets and elucidate the role of NINJ1 in platelets and septic DIC. In this study, NINJ1 blocking peptide (NINJ1(26-37)) was used to verify the effect of NINJ1 …
The aim of this study was to evaluate the expression of NINJ1 in human and murine platelets and elucidate the role of NINJ1 in …
Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death.
Borges JP, Sætra RSR, Volchuk A, Bugge M, Devant P, Sporsheim B, Kilburn BR, Evavold CL, Kagan JC, Goldenberg NM, Flo TH, Steinberg BE. Borges JP, et al. Elife. 2022 Dec 5;11:e78609. doi: 10.7554/eLife.78609. Elife. 2022. PMID: 36468682 Free PMC article.
NINJ1 is thought to cluster within the plasma membrane to cause cell rupture. We demonstrate that the execution of pyroptotic cell rupture is similar for human and mouse NINJ1 and that NINJ1 knockout functionally and morphologically phenocopies glycine cytopr …
NINJ1 is thought to cluster within the plasma membrane to cause cell rupture. We demonstrate that the execution of pyroptotic cell ru …
The Ninj1/Dusp1 Axis Contributes to Liver Ischemia Reperfusion Injury by Regulating Macrophage Activation and Neutrophil Infiltration.
Hu Y, Zhan F, Wang Y, Wang D, Lu H, Wu C, Xia Y, Meng L, Zhang F, Wang X, Zhou S. Hu Y, et al. Cell Mol Gastroenterol Hepatol. 2023;15(5):1071-1084. doi: 10.1016/j.jcmgh.2023.01.008. Epub 2023 Jan 31. Cell Mol Gastroenterol Hepatol. 2023. PMID: 36731792 Free PMC article.
METHODS: Myeloid Ninj1-deficient mice were generated by bone marrow chimeric models using Ninj1 knockout mice and wild-type mice. ...Liver injury and hepatic inflammation were investigated. In vitro, primary Kupffer cells (KCs) isolated from Ninj1 knockout an …
METHODS: Myeloid Ninj1-deficient mice were generated by bone marrow chimeric models using Ninj1 knockout mice and wild-type mi …
NINJ1 is activated by cell swelling to regulate plasma membrane permeabilization during regulated necrosis.
Dondelinger Y, Priem D, Huyghe J, Delanghe T, Vandenabeele P, Bertrand MJM. Dondelinger Y, et al. Cell Death Dis. 2023 Nov 18;14(11):755. doi: 10.1038/s41419-023-06284-z. Cell Death Dis. 2023. PMID: 37980412 Free PMC article.
During ferroptosis, NINJ1 acts downstream of lipid peroxidation, which suggested a role for reactive oxygen species (ROS) in NINJ1 activation. Reactive oxygen species were however neither sufficient nor required to trigger NINJ1-dependent PMP. Instead, we fou …
During ferroptosis, NINJ1 acts downstream of lipid peroxidation, which suggested a role for reactive oxygen species (ROS) in NINJ1 …
Inhibiting NINJ1-dependent plasma membrane rupture protects against inflammasome-induced blood coagulation and inflammation.
Cui J, Li H, Zhang G, Zhang Y, Yang L, Sim MMS, Wood JP, Wei Y, Li Z, Wu C. Cui J, et al. bioRxiv [Preprint]. 2023 Aug 30:2023.08.30.555561. doi: 10.1101/2023.08.30.555561. bioRxiv. 2023. PMID: 37693519 Free PMC article. Preprint.
Plasma membrane rupture (PMR) in pyroptosis was recently reported to be actively mediated by the transmembrane protein Ninjurin-1 (NINJ1). Here we show that NINJ1 promotes procoagulant MV release during pyroptosis. ...Our findings suggest a crucial role for NINJ1 …
Plasma membrane rupture (PMR) in pyroptosis was recently reported to be actively mediated by the transmembrane protein Ninjurin-1 (NINJ1 …
NINJ1 mediates inflammatory cell death, PANoptosis, and lethality during infection conditions and heat stress.
Han JH, Karki R, Malireddi RKS, Mall R, Sarkar R, Sharma BR, Klein J, Berns H, Pisharath H, Pruett-Miller SM, Bae SJ, Kanneganti TD. Han JH, et al. Nat Commun. 2024 Feb 26;15(1):1739. doi: 10.1038/s41467-024-45466-x. Nat Commun. 2024. PMID: 38409108 Free PMC article.
Caspase-7 also contributes to PANoptosis in this context. Furthermore, NINJ1 is an important executioner of this cell death to release inflammatory molecules, independent of other pore-forming executioner proteins, gasdermin D, gasdermin E, and MLKL. In an in vivo HS model …
Caspase-7 also contributes to PANoptosis in this context. Furthermore, NINJ1 is an important executioner of this cell death to releas …
139 results