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Keeping T-he Killers at Bay via FcγRIIb.

Nimmerjahn F.

Immunity. 2020 Jan 14;52(1):9-11. doi: 10.1016/j.immuni.2019.12.012.


The Immunological Organ Environment Dictates the Molecular and Cellular Pathways of Cytotoxic Antibody Activity.

Gordan S, Albert H, Danzer H, Lux A, Biburger M, Nimmerjahn F.

Cell Rep. 2019 Dec 3;29(10):3033-3046.e4. doi: 10.1016/j.celrep.2019.10.111.


Impact of FcγR variants on the response to alemtuzumab in multiple sclerosis.

Keller CW, Ruck T, McHugh D, Pfeuffer S, Gross CC, Korsukewitz C, Melzer N, Klotz L, Meuth SG, Münz C, Nimmerjahn F, Wiendl H, Lünemann JD.

Ann Clin Transl Neurol. 2019 Dec;6(12):2586-2594. doi: 10.1002/acn3.50935. Epub 2019 Nov 4.


Relevance of Receptor for Advanced Glycation end Products (RAGE) in Murine Antibody-Mediated Autoimmune Diseases.

Eichhorst A, Daniel C, Rzepka R, Sehnert B, Nimmerjahn F, Voll RE, Chevalier N.

Int J Mol Sci. 2019 Jul 1;20(13). pii: E3234. doi: 10.3390/ijms20133234.


Immunomodulation in Primary Immune Thrombocytopenia: A Possible Role of the Fc Fragment of Romiplostim?

Schifferli A, Nimmerjahn F, Kühne T.

Front Immunol. 2019 Jun 4;10:1196. doi: 10.3389/fimmu.2019.01196. eCollection 2019. Review.


Two sequential layers of antibody-mediated control of Legionella pneumophila infection.

Weber SS, Stoycheva D, Nimmerjahn F, Oxenius A.

Eur J Immunol. 2019 Sep;49(9):1415-1420. doi: 10.1002/eji.201948106. Epub 2019 Jun 18.


Editorial: Autoantibodies.

Holmdahl R, Nimmerjahn F, Ludwig RJ.

Front Immunol. 2019 Apr 2;10:484. doi: 10.3389/fimmu.2019.00484. eCollection 2019. No abstract available.


Eosinophils Mediate Basophil-Dependent Allergic Skin Inflammation in Mice.

Eberle JU, Radtke D, Nimmerjahn F, Voehringer D.

J Invest Dermatol. 2019 Sep;139(9):1957-1965.e2. doi: 10.1016/j.jid.2019.03.1129. Epub 2019 Mar 22.


Fra1 Controls Rheumatoid Factor Autoantibody Production by Bone Marrow Plasma Cells and the Development of Autoimmune Bone Loss.

Grötsch B, Lux A, Rombouts Y, Hoffmann AC, Andreev D, Nimmerjahn F, Xiang W, Scherer HU, Schett G, Bozec A.

J Bone Miner Res. 2019 Jul;34(7):1352-1365. doi: 10.1002/jbmr.3705. Epub 2019 Mar 19.


Oral administration of the selective GPR120/FFA4 agonist compound A is not effective in alleviating tissue inflammation in mouse models of prototypical autoimmune diseases.

Wannick M, Bezdek S, Guillen N, Thieme M, Meshrkey F, Mousavi S, Seeling M, Nimmerjahn F, Mócsai A, Zillikens D, Sezin T, Sadik CD.

Pharmacol Res Perspect. 2018 Nov 8;6(6):e00438. doi: 10.1002/prp2.438. eCollection 2018 Dec.


IgG-Independent Co-aggregation of FcεRI and FcγRIIB Results in LYN- and SHIP1-Dependent Tyrosine Phosphorylation of FcγRIIB in Murine Bone Marrow-Derived Mast Cells.

Gast M, Preisinger C, Nimmerjahn F, Huber M.

Front Immunol. 2018 Aug 27;9:1937. doi: 10.3389/fimmu.2018.01937. eCollection 2018.


Dissecting FcγR Regulation through a Multivalent Binding Model.

Robinett RA, Guan N, Lux A, Biburger M, Nimmerjahn F, Meyer AS.

Cell Syst. 2018 Jul 25;7(1):41-48.e5. doi: 10.1016/j.cels.2018.05.018. Epub 2018 Jun 27.


CLEC10A Is a Specific Marker for Human CD1c+ Dendritic Cells and Enhances Their Toll-Like Receptor 7/8-Induced Cytokine Secretion.

Heger L, Balk S, Lühr JJ, Heidkamp GF, Lehmann CHK, Hatscher L, Purbojo A, Hartmann A, Garcia-Martin F, Nishimura SI, Cesnjevar R, Nimmerjahn F, Dudziak D.

Front Immunol. 2018 Apr 27;9:744. doi: 10.3389/fimmu.2018.00744. eCollection 2018.


Estrogen induces St6gal1 expression and increases IgG sialylation in mice and patients with rheumatoid arthritis: a potential explanation for the increased risk of rheumatoid arthritis in postmenopausal women.

Engdahl C, Bondt A, Harre U, Raufer J, Pfeifle R, Camponeschi A, Wuhrer M, Seeling M, Mårtensson IL, Nimmerjahn F, Krönke G, Scherer HU, Forsblad-d'Elia H, Schett G.

Arthritis Res Ther. 2018 May 2;20(1):84. doi: 10.1186/s13075-018-1586-z.


More Rules, Still Exceptions: Understanding Immunomodulatory Antibody Activity In Vivo.

Ipsen-Escobedo A, Nimmerjahn F.

Cancer Cell. 2018 Apr 9;33(4):545-546. doi: 10.1016/j.ccell.2018.03.016.


Specific Inhibition of Complement Activation Significantly Ameliorates Autoimmune Blistering Disease in Mice.

Mihai S, Hirose M, Wang Y, Thurman JM, Holers VM, Morgan BP, Köhl J, Zillikens D, Ludwig RJ, Nimmerjahn F.

Front Immunol. 2018 Mar 16;9:535. doi: 10.3389/fimmu.2018.00535. eCollection 2018.


High-resolution definition of humoral immune response correlates of effective immunity against HIV.

Alter G, Dowell KG, Brown EP, Suscovich TJ, Mikhailova A, Mahan AE, Walker BD, Nimmerjahn F, Bailey-Kellogg C, Ackerman ME.

Mol Syst Biol. 2018 Mar 26;14(3):e7881. doi: 10.15252/msb.20177881.


Detection of Experimental and Clinical Immune Complexes by Measuring SHIP-1 Recruitment to the Inhibitory FcγRIIB.

Stopforth RJ, Oldham RJ, Tutt AL, Duriez P, Chan HTC, Binkowski BF, Zimprich C, Li D, Hargreaves PG, Cong M, Reddy V, Leandro MJ, Cambridge G, Lux A, Nimmerjahn F, Cragg MS.

J Immunol. 2018 Mar 1;200(5):1937-1950. doi: 10.4049/jimmunol.1700832. Epub 2018 Jan 19.


Sweet SIGNs: IgG glycosylation leads the way in IVIG-mediated resolution of inflammation.

Brückner C, Lehmann C, Dudziak D, Nimmerjahn F.

Int Immunol. 2017 Dec 30;29(11):499-509. doi: 10.1093/intimm/dxx053. Review.


Corrigendum: IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions.

Lee CH, Romain G, Yan W, Watanabe M, Charab W, Todorova B, Lee J, Triplett K, Donkor M, Lungu OI, Lux A, Marshall N, Lindorfer MA, Goff OR, Balbino B, Kang TH, Tanno H, Delidakis G, Alford C, Taylor RP, Nimmerjahn F, Varadarajan N, Bruhns P, Zhang YJ, Georgiou G.

Nat Immunol. 2017 Sep 19;18(10):1173. doi: 10.1038/ni1017-1173c. No abstract available.


Differential antibody glycosylation in autoimmunity: sweet biomarker or modulator of disease activity?

Seeling M, Brückner C, Nimmerjahn F.

Nat Rev Rheumatol. 2017 Oct;13(10):621-630. doi: 10.1038/nrrheum.2017.146. Epub 2017 Sep 14. Review.


Human lymphoid organ dendritic cell identity is predominantly dictated by ontogeny, not tissue microenvironment.

Heidkamp GF, Sander J, Lehmann CHK, Heger L, Eissing N, Baranska A, Lühr JJ, Hoffmann A, Reimer KC, Lux A, Söder S, Hartmann A, Zenk J, Ulas T, McGovern N, Alexiou C, Spriewald B, Mackensen A, Schuler G, Schauf B, Forster A, Repp R, Fasching PA, Purbojo A, Cesnjevar R, Ullrich E, Ginhoux F, Schlitzer A, Nimmerjahn F, Schultze JL, Dudziak D.

Sci Immunol. 2016 Dec 16;1(6). pii: eaai7677. doi: 10.1126/sciimmunol.aai7677. Epub 2016 Dec 16.


Tumor location determines tissue-specific recruitment of tumor-associated macrophages and antibody-dependent immunotherapy response.

Lehmann B, Biburger M, Brückner C, Ipsen-Escobedo A, Gordan S, Lehmann C, Voehringer D, Winkler T, Schaft N, Dudziak D, Sirbu H, Weber GF, Nimmerjahn F.

Sci Immunol. 2017 Jan 6;2(7). pii: eaah6413. doi: 10.1126/sciimmunol.aah6413.


IgG subclass and vaccination stimulus determine changes in antigen specific antibody glycosylation in mice.

Kao D, Lux A, Schaffert A, Lang R, Altmann F, Nimmerjahn F.

Eur J Immunol. 2017 Dec;47(12):2070-2079. doi: 10.1002/eji.201747208. Epub 2017 Aug 29.


Mechanisms of Autoantibody-Induced Pathology.

Ludwig RJ, Vanhoorelbeke K, Leypoldt F, Kaya Z, Bieber K, McLachlan SM, Komorowski L, Luo J, Cabral-Marques O, Hammers CM, Lindstrom JM, Lamprecht P, Fischer A, Riemekasten G, Tersteeg C, Sondermann P, Rapoport B, Wandinger KP, Probst C, El Beidaq A, Schmidt E, Verkman A, Manz RA, Nimmerjahn F.

Front Immunol. 2017 May 31;8:603. doi: 10.3389/fimmu.2017.00603. eCollection 2017. Review.


IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions.

Lee CH, Romain G, Yan W, Watanabe M, Charab W, Todorova B, Lee J, Triplett K, Donkor M, Lungu OI, Lux A, Marshall N, Lindorfer MA, Goff OR, Balbino B, Kang TH, Tanno H, Delidakis G, Alford C, Taylor RP, Nimmerjahn F, Varadarajan N, Bruhns P, Zhang YJ, Georgiou G.

Nat Immunol. 2017 Aug;18(8):889-898. doi: 10.1038/ni.3770. Epub 2017 Jun 12. Erratum in: Nat Immunol. 2017 Sep 19;18(10 ):1173.


DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo.

Lehmann CHK, Baranska A, Heidkamp GF, Heger L, Neubert K, Lühr JJ, Hoffmann A, Reimer KC, Brückner C, Beck S, Seeling M, Kießling M, Soulat D, Krug AB, Ravetch JV, Leusen JHW, Nimmerjahn F, Dudziak D.

J Exp Med. 2017 May 1;214(5):1509-1528. doi: 10.1084/jem.20160951. Epub 2017 Apr 7.


Trehalose dimycolate interferes with FcγR-mediated phagosome maturation through Mincle, SHP-1 and FcγRIIB signalling.

Patin EC, Geffken AC, Willcocks S, Leschczyk C, Haas A, Nimmerjahn F, Lang R, Ward TH, Schaible UE.

PLoS One. 2017 Apr 6;12(4):e0174973. doi: 10.1371/journal.pone.0174973. eCollection 2017.


Hierarchical and Redundant Roles of Activating FcγRs in Protection against Influenza Disease by M2e-Specific IgG1 and IgG2a Antibodies.

Van den Hoecke S, Ehrhardt K, Kolpe A, El Bakkouri K, Deng L, Grootaert H, Schoonooghe S, Smet A, Bentahir M, Roose K, Schotsaert M, Schepens B, Callewaert N, Nimmerjahn F, Staeheli P, Hengel H, Saelens X.

J Virol. 2017 Mar 13;91(7). pii: e02500-16. doi: 10.1128/JVI.02500-16. Print 2017 Apr 1.


Enhanced uptake of blood coagulation factor VIII containing immune complexes by antigen presenting cells.

Hartholt RB, Wroblewska A, Herczenik E, Peyron I, Ten Brinke A, Rispens T, Nolte MA, Slot E, Claassens JW, Nimmerjahn F, Verbeek JS, Voorberg J.

J Thromb Haemost. 2017 Feb;15(2):329-340. doi: 10.1111/jth.13570. Epub 2017 Jan 19.


Corrigendum to "Fc-gamma receptors are not involved in cartilage damage during experimental osteoarthritis" [Osteoarthritis Cartilage 23 (2015) 1221-1225].

Stock M, Distler A, Distler J, Beyer C, Ruiz-Heiland G, Ipseiz N, Seeling M, Krönke G, Nimmerjahn F, Schett G.

Osteoarthritis Cartilage. 2017 Jun;25(6):995. doi: 10.1016/j.joca.2016.11.003. Epub 2016 Nov 17. No abstract available.


Elucidating the interplay between IgG-Fc valency and FcγR activation for the design of immune complex inhibitors.

Ortiz DF, Lansing JC, Rutitzky L, Kurtagic E, Prod'homme T, Choudhury A, Washburn N, Bhatnagar N, Beneduce C, Holte K, Prenovitz R, Child M, Killough J, Tyler S, Brown J, Nguyen S, Schwab I, Hains M, Meccariello R, Markowitz L, Wang J, Zouaoui R, Simpson A, Schultes B, Capila I, Ling L, Nimmerjahn F, Manning AM, Bosques CJ.

Sci Transl Med. 2016 Nov 16;8(365):365ra158.


IL-15 enhances the anti-tumor activity of trastuzumab against breast cancer cells but causes fatal side effects in humanized tumor mice (HTM).

Wege AK, Weber F, Kroemer A, Ortmann O, Nimmerjahn F, Brockhoff G.

Oncotarget. 2017 Jan 10;8(2):2731-2744. doi: 10.18632/oncotarget.13159.


Regulation of autoantibody activity by the IL-23-TH17 axis determines the onset of autoimmune disease.

Pfeifle R, Rothe T, Ipseiz N, Scherer HU, Culemann S, Harre U, Ackermann JA, Seefried M, Kleyer A, Uderhardt S, Haugg B, Hueber AJ, Daum P, Heidkamp GF, Ge C, Böhm S, Lux A, Schuh W, Magorivska I, Nandakumar KS, Lönnblom E, Becker C, Dudziak D, Wuhrer M, Rombouts Y, Koeleman CA, Toes R, Winkler TH, Holmdahl R, Herrmann M, Blüml S, Nimmerjahn F, Schett G, Krönke G.

Nat Immunol. 2017 Jan;18(1):104-113. doi: 10.1038/ni.3579. Epub 2016 Nov 7.


Clarifying the Confusion between Cytokine and Fc Receptor "Common Gamma Chain".

Brandsma AM, Hogarth PM, Nimmerjahn F, Leusen JH.

Immunity. 2016 Aug 16;45(2):225-6. doi: 10.1016/j.immuni.2016.07.006. No abstract available.


In vivo enzymatic modulation of IgG antibodies prevents immune complex-dependent skin injury.

Mihai S, Albert H, Ludwig RJ, Iwata H, Björck L, Collin M, Nimmerjahn F.

Exp Dermatol. 2017 Aug;26(8):691-696. doi: 10.1111/exd.13163. Epub 2016 Dec 15.


Immune Monitoring of Trans-endothelial Transport by Kidney-Resident Macrophages.

Stamatiades EG, Tremblay ME, Bohm M, Crozet L, Bisht K, Kao D, Coelho C, Fan X, Yewdell WT, Davidson A, Heeger PS, Diebold S, Nimmerjahn F, Geissmann F.

Cell. 2016 Aug 11;166(4):991-1003. doi: 10.1016/j.cell.2016.06.058. Epub 2016 Jul 28.


Immunomodulation of immunothrombocytopenia.

Nimmerjahn F.

Semin Hematol. 2016 Apr;53 Suppl 1:S10-2. doi: 10.1053/j.seminhematol.2016.04.004. Epub 2016 Apr 6.


Translating Inhibitory Fc Receptor Biology into Novel Therapeutic Approaches.

Nimmerjahn F.

J Clin Immunol. 2016 May;36 Suppl 1:83-7. doi: 10.1007/s10875-016-0249-6. Epub 2016 Mar 8. Review.


A Monosaccharide Residue Is Sufficient to Maintain Mouse and Human IgG Subclass Activity and Directs IgG Effector Functions to Cellular Fc Receptors.

Kao D, Danzer H, Collin M, Groß A, Eichler J, Stambuk J, Lauc G, Lux A, Nimmerjahn F.

Cell Rep. 2015 Dec 22;13(11):2376-2385. doi: 10.1016/j.celrep.2015.11.027. Epub 2015 Dec 6.


Sialylation of anti-histone immunoglobulin G autoantibodies determines their capabilities to participate in the clearance of late apoptotic cells.

Magorivska I, Muñoz LE, Janko C, Dumych T, Rech J, Schett G, Nimmerjahn F, Bilyy R, Herrmann M.

Clin Exp Immunol. 2016 Apr;184(1):110-7. doi: 10.1111/cei.12744. Epub 2016 Jan 27.


bIgG time for large eaters: monocytes and macrophages as effector and target cells of antibody-mediated immune activation and repression.

Gordan S, Biburger M, Nimmerjahn F.

Immunol Rev. 2015 Nov;268(1):52-65. doi: 10.1111/imr.12347. Review.


Pathways Responsible for Human Autoantibody and Therapeutic Intravenous IgG Activity in Humanized Mice.

Schwab I, Lux A, Nimmerjahn F.

Cell Rep. 2015 Oct 20;13(3):610-620. doi: 10.1016/j.celrep.2015.09.013. Epub 2015 Oct 8.


Sialylation of IgG Fc domain impairs complement-dependent cytotoxicity.

Quast I, Keller CW, Maurer MA, Giddens JP, Tackenberg B, Wang LX, Münz C, Nimmerjahn F, Dalakas MC, Lünemann JD.

J Clin Invest. 2015 Nov 2;125(11):4160-70. doi: 10.1172/JCI82695. Epub 2015 Oct 5.


Deregulated Fcγ receptor expression in patients with CIDP.

Quast I, Cueni F, Nimmerjahn F, Tackenberg B, Lünemann JD.

Neurol Neuroimmunol Neuroinflamm. 2015 Aug 20;2(5):e148. doi: 10.1212/NXI.0000000000000148. eCollection 2015 Oct.


Unlocking the bone: Fcγ-receptors and antibody glycosylation are keys to connecting bone homeostasis to humoral immunity.

Seeling M, Nimmerjahn F.

Ann Transl Med. 2015 Jul;3(12):163. doi: 10.3978/j.issn.2305-5839.2015.06.26.


The Pathogenicity of Anti-β2GP1-IgG Autoantibodies Depends on Fc Glycosylation.

Fickentscher C, Magorivska I, Janko C, Biermann M, Bilyy R, Nalli C, Tincani A, Medeghini V, Meini A, Nimmerjahn F, Schett G, Muñoz LE, Andreoli L, Herrmann M.

J Immunol Res. 2015;2015:638129. doi: 10.1155/2015/638129. Epub 2015 Jun 22.


Three blocks are not enough--Blocking of the murine IgG receptor FcγRIV is crucial for proper characterization of cells by FACS analysis.

Biburger M, Trenkwald I, Nimmerjahn F.

Eur J Immunol. 2015 Sep;45(9):2694-7. doi: 10.1002/eji.201545463. Epub 2015 Jul 21. No abstract available.


Siglec-G Deficiency Leads to Autoimmunity in Aging C57BL/6 Mice.

Müller J, Lunz B, Schwab I, Acs A, Nimmerjahn F, Daniel C, Nitschke L.

J Immunol. 2015 Jul 1;195(1):51-60. doi: 10.4049/jimmunol.1403139. Epub 2015 May 18.

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