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BMJ Case Rep. 2019 Aug 1;12(7). pii: e223843. doi: 10.1136/bcr-2017-223843.

Cortical blindness due to cerebral infarct in advanced pancreatic cancer.

Author information

1
Ophthalmology, King George's Medical University, Lucknow, Uttar Pradesh, India.
2
Pediatrics, King George's Medical University, Lucknow, Uttar Pradesh, India.

Abstract

A 65-year-old man, a known case of advanced pancreatic cancer on cisplatin and gemcitabine-based chemotherapy, presented with sudden bilateral painless loss of vision with altered sensorium. Clinical examination showed a normal pupillary light reaction, normal anterior segment and normal fundus. MRI brain showed bilateral parieto-occipital infarct. This report highlights the incidence of cortical blindness due to thromboembolism at the cerebral level in pancreatic cancer. Cerebral ischaemic events occur at an advanced stage of pancreatic cancer already diagnosed at stroke onset and portend a poor prognosis. Anticoagulation therapy, especially low molecular weight heparin, remains the best strategy to prevent recurrences.

KEYWORDS:

pancreatic cancer; stroke; venous thromboembolism; visual pathway

PMID:
31371327
DOI:
10.1136/bcr-2017-223843

Conflict of interest statement

Competing interests: None declared.

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