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Items: 1 to 50 of 68

1.

Therapeutic potential of targeting the Eph/ephrin signaling complex.

Saha N, Robev D, Mason EO, Himanen JP, Nikolov DB.

Int J Biochem Cell Biol. 2018 Dec;105:123-133. doi: 10.1016/j.biocel.2018.10.006. Epub 2018 Oct 19. Review.

PMID:
30343150
2.

Binding of EphrinA5 to RET receptor tyrosine kinase: An in vitro study.

Liu Y, Kaljunen H, Pavić A, Saarenpää T, Himanen JP, Nikolov DB, Goldman A.

PLoS One. 2018 Jun 11;13(6):e0198291. doi: 10.1371/journal.pone.0198291. eCollection 2018.

3.

Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10.

Seegar TCM, Killingsworth LB, Saha N, Meyer PA, Patra D, Zimmerman B, Janes PW, Rubinstein E, Nikolov DB, Skiniotis G, Kruse AC, Blacklow SC.

Cell. 2017 Dec 14;171(7):1638-1648.e7. doi: 10.1016/j.cell.2017.11.014. Epub 2017 Dec 7.

4.

An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth.

Atapattu L, Saha N, Chheang C, Eissman MF, Xu K, Vail ME, Hii L, Llerena C, Liu Z, Horvay K, Abud HE, Kusebauch U, Moritz RL, Ding BS, Cao Z, Rafii S, Ernst M, Scott AM, Nikolov DB, Lackmann M, Janes PW.

J Exp Med. 2016 Aug 22;213(9):1741-57. doi: 10.1084/jem.20151095. Epub 2016 Aug 8.

5.

Crystal Structure of the Pre-fusion Nipah Virus Fusion Glycoprotein Reveals a Novel Hexamer-of-Trimers Assembly.

Xu K, Chan YP, Bradel-Tretheway B, Akyol-Ataman Z, Zhu Y, Dutta S, Yan L, Feng Y, Wang LF, Skiniotis G, Lee B, Zhou ZH, Broder CC, Aguilar HC, Nikolov DB.

PLoS Pathog. 2015 Dec 8;11(12):e1005322. doi: 10.1371/journal.ppat.1005322. eCollection 2015 Dec.

6.

The crystal structure of DR6 in complex with the amyloid precursor protein provides insight into death receptor activation.

Xu K, Olsen O, Tzvetkova-Robev D, Tessier-Lavigne M, Nikolov DB.

Genes Dev. 2015 Apr 15;29(8):785-90. doi: 10.1101/gad.257675.114. Epub 2015 Apr 2.

7.

Homotypic receptor-receptor interactions regulating Eph signaling.

Nikolov DB, Xu K, Himanen JP.

Cell Adh Migr. 2014;8(4):360-5. doi: 10.4161/19336918.2014.971684. Review.

8.

Generation and characterization of a single-chain anti-EphA2 antibody.

Goldgur Y, Susi P, Karelehto E, Sanmark H, Lamminmäki U, Oricchio E, Wendel HG, Nikolov DB, Himanen JP.

Growth Factors. 2014 Dec;32(6):214-22. doi: 10.3109/08977194.2014.983225. Epub 2014 Nov 19.

9.

Structural features of the Nogo receptor signaling complexes at the neuron/myelin interface.

Saha N, Kolev M, Nikolov DB.

Neurosci Res. 2014 Oct;87:1-7. doi: 10.1016/j.neures.2014.06.003. Epub 2014 Jun 20. Review.

PMID:
24956133
10.

Neural migration. Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism.

Xu K, Wu Z, Renier N, Antipenko A, Tzvetkova-Robev D, Xu Y, Minchenko M, Nardi-Dei V, Rajashankar KR, Himanen J, Tessier-Lavigne M, Nikolov DB.

Science. 2014 Jun 13;344(6189):1275-9. doi: 10.1126/science.1255149. Epub 2014 May 29.

11.

Tie2 and Eph receptor tyrosine kinase activation and signaling.

Barton WA, Dalton AC, Seegar TC, Himanen JP, Nikolov DB.

Cold Spring Harb Perspect Biol. 2014 Mar 1;6(3). pii: a009142. doi: 10.1101/cshperspect.a009142. Review.

12.

Crystal structure of the Hendra virus attachment G glycoprotein bound to a potent cross-reactive neutralizing human monoclonal antibody.

Xu K, Rockx B, Xie Y, DeBuysscher BL, Fusco DL, Zhu Z, Chan YP, Xu Y, Luu T, Cer RZ, Feldmann H, Mokashi V, Dimitrov DS, Bishop-Lilly KA, Broder CC, Nikolov DB.

PLoS Pathog. 2013;9(10):e1003684. doi: 10.1371/journal.ppat.1003684. Epub 2013 Oct 10.

13.

Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5.

Xu K, Tzvetkova-Robev D, Xu Y, Goldgur Y, Chan YP, Himanen JP, Nikolov DB.

Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14634-9. doi: 10.1073/pnas.1311000110. Epub 2013 Aug 19.

14.

Crystal structures of Lgr4 and its complex with R-spondin1.

Xu K, Xu Y, Rajashankar KR, Robev D, Nikolov DB.

Structure. 2013 Sep 3;21(9):1683-9. doi: 10.1016/j.str.2013.07.001. Epub 2013 Jul 25.

15.

A treatment for and vaccine against the deadly Hendra and Nipah viruses.

Broder CC, Xu K, Nikolov DB, Zhu Z, Dimitrov DS, Middleton D, Pallister J, Geisbert TW, Bossart KN, Wang LF.

Antiviral Res. 2013 Oct;100(1):8-13. doi: 10.1016/j.antiviral.2013.06.012. Epub 2013 Jul 6. Review.

16.

Biological and structural characterization of glycosylation on ephrin-A1, a preferred ligand for EphA2 receptor tyrosine kinase.

Ferluga S, Hantgan R, Goldgur Y, Himanen JP, Nikolov DB, Debinski W.

J Biol Chem. 2013 Jun 21;288(25):18448-57. doi: 10.1074/jbc.M113.464008. Epub 2013 May 9.

17.

Eph/ephrin recognition and the role of Eph/ephrin clusters in signaling initiation.

Nikolov DB, Xu K, Himanen JP.

Biochim Biophys Acta. 2013 Oct;1834(10):2160-5. doi: 10.1016/j.bbapap.2013.04.020. Epub 2013 Apr 26. Review.

18.

Structural basis for angiopoietin-1-mediated signaling initiation.

Yu X, Seegar TC, Dalton AC, Tzvetkova-Robev D, Goldgur Y, Rajashankar KR, Nikolov DB, Barton WA.

Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7205-10. doi: 10.1073/pnas.1216890110. Epub 2013 Apr 16.

19.

New insights into the Hendra virus attachment and entry process from structures of the virus G glycoprotein and its complex with Ephrin-B2.

Xu K, Chan YP, Rajashankar KR, Khetawat D, Yan L, Kolev MV, Broder CC, Nikolov DB.

PLoS One. 2012;7(11):e48742. doi: 10.1371/journal.pone.0048742. Epub 2012 Nov 5.

20.

Antibodies binding the ADAM10 substrate recognition domain inhibit Eph function.

Atapattu L, Saha N, Llerena C, Vail ME, Scott AM, Nikolov DB, Lackmann M, Janes PW.

J Cell Sci. 2012 Dec 15;125(Pt 24):6084-93. doi: 10.1242/jcs.112631. Epub 2012 Oct 29.

21.

Following experimental stroke, the recovering brain is vulnerable to lipoxygenase-dependent semaphorin signaling.

Pekcec A, Yigitkanli K, Jung JE, Pallast S, Xing C, Antipenko A, Minchenko M, Nikolov DB, Holman TR, Lo EH, van Leyen K.

FASEB J. 2013 Feb;27(2):437-45. doi: 10.1096/fj.12-206896. Epub 2012 Oct 15.

22.

Biochemical, conformational, and immunogenic analysis of soluble trimeric forms of henipavirus fusion glycoproteins.

Chan YP, Lu M, Dutta S, Yan L, Barr J, Flora M, Feng YR, Xu K, Nikolov DB, Wang LF, Skiniotis G, Broder CC.

J Virol. 2012 Nov;86(21):11457-71. doi: 10.1128/JVI.01318-12. Epub 2012 Aug 22.

23.

Immunization strategies against henipaviruses.

Broder CC, Geisbert TW, Xu K, Nikolov DB, Wang LF, Middleton D, Pallister J, Bossart KN.

Curr Top Microbiol Immunol. 2012;359:197-223. doi: 10.1007/82_2012_213. Review.

24.

Henipavirus mediated membrane fusion, virus entry and targeted therapeutics.

Steffen DL, Xu K, Nikolov DB, Broder CC.

Viruses. 2012 Feb;4(2):280-308. doi: 10.3390/v4020280. Epub 2012 Feb 13. Review.

25.

Ephrin-B2 and ephrin-B3 as functional henipavirus receptors.

Xu K, Broder CC, Nikolov DB.

Semin Cell Dev Biol. 2012 Feb;23(1):116-23. doi: 10.1016/j.semcdb.2011.12.005. Epub 2011 Dec 30. Review.

26.

Site occupancy and glycan compositional analysis of two soluble recombinant forms of the attachment glycoprotein of Hendra virus.

Colgrave ML, Snelling HJ, Shiell BJ, Feng YR, Chan YP, Bossart KN, Xu K, Nikolov DB, Broder CC, Michalski WP.

Glycobiology. 2012 Apr;22(4):572-84. doi: 10.1093/glycob/cwr180. Epub 2011 Dec 14.

27.

Ganglioside mediate the interaction between Nogo receptor 1 and LINGO-1.

Saha N, Kolev MV, Semavina M, Himanen J, Nikolov DB.

Biochem Biophys Res Commun. 2011 Sep 16;413(1):92-7. doi: 10.1016/j.bbrc.2011.08.060. Epub 2011 Aug 22.

PMID:
21872576
28.

A semisynthetic Eph receptor tyrosine kinase provides insight into ligand-induced kinase activation.

Singla N, Erdjument-Bromage H, Himanen JP, Muir TW, Nikolov DB.

Chem Biol. 2011 Mar 25;18(3):361-71. doi: 10.1016/j.chembiol.2011.01.011.

29.

Crystal structure of the Nogo-receptor-2.

Semavina M, Saha N, Kolev MV, Goldgur Y, Giger RJ, Himanen JP, Nikolov DB.

Protein Sci. 2011 Apr;20(4):684-9. doi: 10.1002/pro.597.

30.

Crystal structure of the ligand-binding domain of the promiscuous EphA4 receptor reveals two distinct conformations.

Singla N, Goldgur Y, Xu K, Paavilainen S, Nikolov DB, Himanen JP.

Biochem Biophys Res Commun. 2010 Sep 3;399(4):555-9. doi: 10.1016/j.bbrc.2010.07.109. Epub 2010 Aug 1.

31.

Architecture of Eph receptor clusters.

Himanen JP, Yermekbayeva L, Janes PW, Walker JR, Xu K, Atapattu L, Rajashankar KR, Mensinga A, Lackmann M, Nikolov DB, Dhe-Paganon S.

Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):10860-5. doi: 10.1073/pnas.1004148107. Epub 2010 May 26.

32.

Tie1-Tie2 interactions mediate functional differences between angiopoietin ligands.

Seegar TC, Eller B, Tzvetkova-Robev D, Kolev MV, Henderson SC, Nikolov DB, Barton WA.

Mol Cell. 2010 Mar 12;37(5):643-55. doi: 10.1016/j.molcel.2010.02.007.

33.

Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex.

Himanen JP, Goldgur Y, Miao H, Myshkin E, Guo H, Buck M, Nguyen M, Rajashankar KR, Wang B, Nikolov DB.

EMBO Rep. 2009 Jul;10(7):722-8. doi: 10.1038/embor.2009.91. Epub 2009 Jun 12.

34.

Host cell recognition by the henipaviruses: crystal structures of the Nipah G attachment glycoprotein and its complex with ephrin-B3.

Xu K, Rajashankar KR, Chan YP, Himanen JP, Broder CC, Nikolov DB.

Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):9953-8. doi: 10.1073/pnas.0804797105. Epub 2008 Jul 16.

35.

Toward the semisynthesis of multidomain transmembrane receptors: modification of Eph tyrosine kinases.

Singla N, Himanen JP, Muir TW, Nikolov DB.

Protein Sci. 2008 Oct;17(10):1740-7. doi: 10.1110/ps.035659.108. Epub 2008 Jul 14.

36.

Cell-cell signaling via Eph receptors and ephrins.

Himanen JP, Saha N, Nikolov DB.

Curr Opin Cell Biol. 2007 Oct;19(5):534-42. Epub 2007 Oct 24. Review.

37.

Kinetic analysis of the binding of monomeric and dimeric ephrins to Eph receptors: correlation to function in a growth cone collapse assay.

Pabbisetty KB, Yue X, Li C, Himanen JP, Zhou R, Nikolov DB, Hu L.

Protein Sci. 2007 Mar;16(3):355-61.

38.

Highly efficient selenomethionine labeling of recombinant proteins produced in mammalian cells.

Barton WA, Tzvetkova-Robev D, Erdjument-Bromage H, Tempst P, Nikolov DB.

Protein Sci. 2006 Aug;15(8):2008-13. Epub 2006 Jul 5.

39.

Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex.

Barton WA, Tzvetkova-Robev D, Miranda EP, Kolev MV, Rajashankar KR, Himanen JP, Nikolov DB.

Nat Struct Mol Biol. 2006 Jun;13(6):524-32. Epub 2006 May 28.

PMID:
16732286
40.

Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans.

Janes PW, Saha N, Barton WA, Kolev MV, Wimmer-Kleikamp SH, Nievergall E, Blobel CP, Himanen JP, Lackmann M, Nikolov DB.

Cell. 2005 Oct 21;123(2):291-304.

41.

Crystal structure of the ephrin-B1 ectodomain: implications for receptor recognition and signaling.

Nikolov DB, Li C, Barton WA, Himanen JP.

Biochemistry. 2005 Aug 23;44(33):10947-53.

PMID:
16101278
42.

Three distinct molecular surfaces in ephrin-A5 are essential for a functional interaction with EphA3.

Day B, To C, Himanen JP, Smith FM, Nikolov DB, Boyd AW, Lackmann M.

J Biol Chem. 2005 Jul 15;280(28):26526-32. Epub 2005 May 18.

43.
44.

Structures of axon guidance molecules and their neuronal receptors.

Barton WA, Himanen JP, Antipenko A, Nikolov DB.

Adv Protein Chem. 2004;68:65-106. Review. No abstract available.

PMID:
15500859
45.

Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling.

Himanen JP, Chumley MJ, Lackmann M, Li C, Barton WA, Jeffrey PD, Vearing C, Geleick D, Feldheim DA, Boyd AW, Henkemeyer M, Nikolov DB.

Nat Neurosci. 2004 May;7(5):501-9. Epub 2004 Apr 25.

PMID:
15107857
46.

GABARAP: lessons for synaptogenesis.

Coyle JE, Nikolov DB.

Neuroscientist. 2003 Jun;9(3):205-16. Review.

PMID:
15065816
47.

Structure-based enzyme engineering and its impact on in vitro glycorandomization.

Thorson JS, Barton WA, Hoffmeister D, Albermann C, Nikolov DB.

Chembiochem. 2004 Jan 3;5(1):16-25. Review. No abstract available.

PMID:
14695508
48.

Structural and functional features of the Escherichia coli hydroperoxide resistance protein OsmC.

Lesniak J, Barton WA, Nikolov DB.

Protein Sci. 2003 Dec;12(12):2838-43.

49.

Structure of the semaphorin-3A receptor binding module.

Antipenko A, Himanen JP, van Leyen K, Nardi-Dei V, Lesniak J, Barton WA, Rajashankar KR, Lu M, Hoemme C, Püschel AW, Nikolov DB.

Neuron. 2003 Aug 14;39(4):589-98.

50.

Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins.

Barton WA, Liu BP, Tzvetkova D, Jeffrey PD, Fournier AE, Sah D, Cate R, Strittmatter SM, Nikolov DB.

EMBO J. 2003 Jul 1;22(13):3291-302.

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