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Items: 1 to 50 of 112

1.

Life-long control of cytomegalovirus (CMV) by T resident memory cells in the adipose tissue results in inflammation and hyperglycemia.

Contreras NA, Sitnik KM, Jeftic I, Coplen CP, Čičin-Šain L, Nikolich-Žugich J.

PLoS Pathog. 2019 Jun 20;15(6):e1007890. doi: 10.1371/journal.ppat.1007890. eCollection 2019 Jun.

2.

Menopause and FOXP3+ Treg cell depletion eliminate female protection against T cell-mediated angiotensin II hypertension.

Pollow DP Jr, Uhlorn JA, Sylvester MA, Romero-Aleshire MJ, Uhrlaub JL, Lindsey ML, Nikolich-Zugich J, Brooks HL.

Am J Physiol Heart Circ Physiol. 2019 Aug 1;317(2):H415-H423. doi: 10.1152/ajpheart.00792.2018. Epub 2019 May 17.

PMID:
31099612
3.

Do cytomegalovirus-specific memory T cells interfere with new immune responses in lymphoid tissues?

Jergović M, Uhrlaub JL, Contreras NA, Nikolich-Žugich J.

Geroscience. 2019 Apr;41(2):155-163. doi: 10.1007/s11357-019-00068-0. Epub 2019 May 8.

4.

Impact of CMV upon immune aging: facts and fiction.

Jergović M, Contreras NA, Nikolich-Žugich J.

Med Microbiol Immunol. 2019 Aug;208(3-4):263-269. doi: 10.1007/s00430-019-00605-w. Epub 2019 Apr 19. Review.

PMID:
31004198
5.

Frailty as a prognostic factor for the critically ill older adult trauma patients.

Hamidi M, Zeeshan M, Leon-Risemberg V, Nikolich-Zugich J, Hanna K, Kulvatunyou N, Saljuqi AT, Fain M, Joseph B.

Am J Surg. 2019 Feb 22. pii: S0002-9610(18)31690-8. doi: 10.1016/j.amjsurg.2019.01.035. [Epub ahead of print]

PMID:
30833015
6.

The acute inflammatory response after trauma is heightened by frailty: A prospective evaluation of inflammatory and endocrine system alterations in frailty.

Palmer J, Pandit V, Zeeshan M, Kulvatunyou N, Hamidi M, Hanna K, Fain M, Nikolich-Zugich J, Zakaria ER, Joseph B.

J Trauma Acute Care Surg. 2019 Jul;87(1):54-60. doi: 10.1097/TA.0000000000002229.

PMID:
30768559
7.

Lymph nodes as barriers to T-cell rejuvenation in aging mice and nonhuman primates.

Thompson HL, Smithey MJ, Uhrlaub JL, Jeftić I, Jergović M, White SE, Currier N, Lang AM, Okoye A, Park B, Picker LJ, Surh CD, Nikolich-Žugich J.

Aging Cell. 2019 Feb;18(1):e12865. doi: 10.1111/acel.12865. Epub 2018 Nov 14.

8.

Prospective evaluation of frailty and functional independence in older adult trauma patients.

Hamidi M, Zeeshan M, O'Keeffe T, Nisbet B, Northcutt A, Nikolich-Zugich J, Khan M, Kulvatunyou N, Fain M, Joseph B.

Am J Surg. 2018 Dec;216(6):1070-1075. doi: 10.1016/j.amjsurg.2018.10.023. Epub 2018 Oct 16.

PMID:
30343875
9.

Impact of early life exposure to ionizing radiation on influenza vaccine response in an elderly Japanese cohort.

Hayashi T, Lynch HE, Geyer S, Yoshida K, Furudoi K, Sasaki K, Morishita Y, Nagamura H, Maki M, Hu Y, Hayashi I, Kyoizumi S, Kusunoki Y, Ohishi W, Fujiwara S, Misumi M, Shterev I, Nikolich-Žugich J, Murasko D, Hale LP, Sempowski GD, Nakachi K.

Vaccine. 2018 Oct 29;36(45):6650-6659. doi: 10.1016/j.vaccine.2018.09.054. Epub 2018 Sep 28.

PMID:
30274868
10.

Author Correction: The twilight of immunity: emerging concepts in aging of the immune system.

Nikolich-Žugich J.

Nat Immunol. 2018 Oct;19(10):1146. doi: 10.1038/s41590-018-0205-0.

PMID:
30177814
11.

Lifelong CMV infection improves immune defense in old mice by broadening the mobilized TCR repertoire against third-party infection.

Smithey MJ, Venturi V, Davenport MP, Buntzman AS, Vincent BG, Frelinger JA, Nikolich-Žugich J.

Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6817-E6825. doi: 10.1073/pnas.1719451115. Epub 2018 Jul 2.

12.

A disconnect between precursor frequency, expansion potential, and site-specific CD4+ T cell responses in aged mice.

Deshpande NR, Uhrlaub JL, Way SS, Nikolich-Žugich J, Kuhns MS.

PLoS One. 2018 Jun 4;13(6):e0198354. doi: 10.1371/journal.pone.0198354. eCollection 2018.

13.

Calorie restriction induces reversible lymphopenia and lymphoid organ atrophy due to cell redistribution.

Contreras NA, Fontana L, Tosti V, Nikolich-Žugich J.

Geroscience. 2018 Jun;40(3):279-291. doi: 10.1007/s11357-018-0022-2. Epub 2018 May 26.

14.

The Contribution of Cytomegalovirus Infection to Immune Senescence Is Set by the Infectious Dose.

Redeker A, Remmerswaal EBM, van der Gracht ETI, Welten SPM, Höllt T, Koning F, Cicin-Sain L, Nikolich-Žugich J, Ten Berge IJM, van Lier RAW, van Unen V, Arens R.

Front Immunol. 2018 Jan 10;8:1953. doi: 10.3389/fimmu.2017.01953. eCollection 2017.

15.

Intrinsic and extrinsic contributors to defective CD8+ T cell responses with aging.

Jergović M, Smithey MJ, Nikolich-Žugich J.

Exp Gerontol. 2018 May;105:140-145. doi: 10.1016/j.exger.2018.01.011. Epub 2018 Jan 11. Review.

PMID:
29337070
16.

The twilight of immunity: emerging concepts in aging of the immune system.

Nikolich-Žugich J.

Nat Immunol. 2018 Jan;19(1):10-19. doi: 10.1038/s41590-017-0006-x. Epub 2017 Dec 14. Review. Erratum in: Nat Immunol. 2018 Oct;19(10):1146.

PMID:
29242543
17.

Author Correction: Charles D. Surh 1960-2017.

Nikolich-Žugich J.

Nat Immunol. 2018 Sep;19(9):1035. doi: 10.1038/s41590-017-0025-7.

PMID:
29222498
18.

Transcriptome-wide characterization of human cytomegalovirus in natural infection and experimental latency.

Cheng S, Caviness K, Buehler J, Smithey M, Nikolich-Žugich J, Goodrum F.

Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):E10586-E10595. doi: 10.1073/pnas.1710522114. Epub 2017 Nov 20.

19.

Charles D. Surh 1960-2017.

Nikolich-Žugich J.

Nat Immunol. 2017 Nov 16;18(12):1273. doi: 10.1038/ni.3871. No abstract available. Erratum in: Nat Immunol. 2017 Dec 8;:.

PMID:
29144495
20.

Known unknowns: how might the persistent herpesvirome shape immunity and aging?

Nikolich-Zugich J, Goodrum F, Knox K, Smithey MJ.

Curr Opin Immunol. 2017 Oct;48:23-30. doi: 10.1016/j.coi.2017.07.011. Epub 2017 Aug 4. Review.

21.

Human Monocyte Subsets Are Transcriptionally and Functionally Altered in Aging in Response to Pattern Recognition Receptor Agonists.

Metcalf TU, Wilkinson PA, Cameron MJ, Ghneim K, Chiang C, Wertheimer AM, Hiscott JB, Nikolich-Zugich J, Haddad EK.

J Immunol. 2017 Aug 15;199(4):1405-1417. doi: 10.4049/jimmunol.1700148. Epub 2017 Jul 10.

22.

Functional and Homeostatic Impact of Age-Related Changes in Lymph Node Stroma.

Thompson HL, Smithey MJ, Surh CD, Nikolich-Žugich J.

Front Immunol. 2017 Jun 14;8:706. doi: 10.3389/fimmu.2017.00706. eCollection 2017. Review.

23.

Cytomegalovirus (CMV) research in immune senescence comes of age: overview of the 6th International Workshop on CMV and Immunosenescence.

Nikolich-Žugich J, van Lier RAW.

Geroscience. 2017 Jun;39(3):245-249. doi: 10.1007/s11357-017-9984-8. Epub 2017 Jun 17. Review.

24.

Cutting Edge: The Aging Immune System Reveals the Biological Impact of Direct Antigen Presentation on CD8 T Cell Responses.

Uhrlaub JL, Smithey MJ, Nikolich-Žugich J.

J Immunol. 2017 Jul 15;199(2):403-407. doi: 10.4049/jimmunol.1700625. Epub 2017 Jun 14.

25.

Role of Cell-Intrinsic and Environmental Age-Related Changes in Altered Maintenance of Murine T Cells in Lymphoid Organs.

Davies JS, Thompson HL, Pulko V, Padilla Torres J, Nikolich-Žugich J.

J Gerontol A Biol Sci Med Sci. 2018 Jul 9;73(8):1018-1026. doi: 10.1093/gerona/glx102.

26.

Homeostatic migration and distribution of innate immune cells in primary and secondary lymphoid organs with ageing.

Nikolich-Žugich J, Davies JS.

Clin Exp Immunol. 2017 Mar;187(3):337-344. doi: 10.1111/cei.12920. Review.

27.

Dysregulated TGF-β Production Underlies the Age-Related Vulnerability to Chikungunya Virus.

Uhrlaub JL, Pulko V, DeFilippis VR, Broeckel R, Streblow DN, Coleman GD, Park BS, Lindo JF, Vickers I, Anzinger JJ, Nikolich-Žugich J.

PLoS Pathog. 2016 Oct 13;12(10):e1005891. doi: 10.1371/journal.ppat.1005891. eCollection 2016 Oct.

28.

Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses.

Pulko V, Davies JS, Martinez C, Lanteri MC, Busch MP, Diamond MS, Knox K, Bush EC, Sims PA, Sinari S, Billheimer D, Haddad EK, Murray KO, Wertheimer AM, Nikolich-Žugich J.

Nat Immunol. 2016 Aug;17(8):966-75. doi: 10.1038/ni.3483. Epub 2016 Jun 6.

29.

Acute systemic DNA damage in youth does not impair immune defense with aging.

Pugh JL, Foster SA, Sukhina AS, Petravic J, Uhrlaub JL, Padilla-Torres J, Hayashi T, Nakachi K, Smithey MJ, Nikolich-Žugich J.

Aging Cell. 2016 Aug;15(4):686-93. doi: 10.1111/acel.12478. Epub 2016 Apr 13.

30.

An interlaboratory comparison of dosimetry for a multi-institutional radiobiological research project: Observations, problems, solutions and lessons learned.

Seed TM, Xiao S, Manley N, Nikolich-Zugich J, Pugh J, Van den Brink M, Hirabayashi Y, Yasutomo K, Iwama A, Koyasu S, Shterev I, Sempowski G, Macchiarini F, Nakachi K, Kunugi KC, Hammer CG, Dewerd LA.

Int J Radiat Biol. 2016;92(2):59-70. doi: 10.3109/09553002.2015.1106024. Epub 2015 Nov 17.

31.

Preparing for an Aging World: Engaging Biogerontologists, Geriatricians, and the Society.

Nikolich-Žugich J, Goldman DP, Cohen PR, Cortese D, Fontana L, Kennedy BK, Mohler MJ, Olshansky SJ, Perls T, Perry D, Richardson A, Ritchie C, Wertheimer AM, Faragher RG, Fain MJ.

J Gerontol A Biol Sci Med Sci. 2016 Apr;71(4):435-44. doi: 10.1093/gerona/glv164. Epub 2015 Sep 29.

32.

Effect of IL-7 Therapy on Naive and Memory T Cell Homeostasis in Aged Rhesus Macaques.

Okoye AA, Rohankhedkar M, Konfe AL, Abana CO, Reyes MD, Clock JA, Duell DM, Sylwester AW, Sammader P, Legasse AW, Park BS, Axthelm MK, Nikolich-Žugich J, Picker LJ.

J Immunol. 2015 Nov 1;195(9):4292-305. doi: 10.4049/jimmunol.1500609. Epub 2015 Sep 28.

33.

Immune Protection against Virus Challenge in Aging Mice Is Not Affected by Latent Herpesviral Infections.

Marandu TF, Oduro JD, Borkner L, Dekhtiarenko I, Uhrlaub JL, Drabig A, Kröger A, Nikolich-Zugich J, Cicin-Sain L.

J Virol. 2015 Nov;89(22):11715-7. doi: 10.1128/JVI.01989-15. Epub 2015 Sep 2.

34.

Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors.

Metcalf TU, Cubas RA, Ghneim K, Cartwright MJ, Grevenynghe JV, Richner JM, Olagnier DP, Wilkinson PA, Cameron MJ, Park BS, Hiscott JB, Diamond MS, Wertheimer AM, Nikolich-Zugich J, Haddad EK.

Aging Cell. 2015 Jun;14(3):421-32. doi: 10.1111/acel.12320. Epub 2015 Feb 27.

35.

Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms.

Goldberg EL, Romero-Aleshire MJ, Renkema KR, Ventevogel MS, Chew WM, Uhrlaub JL, Smithey MJ, Limesand KH, Sempowski GD, Brooks HL, Nikolich-Žugich J.

Aging Cell. 2015 Feb;14(1):130-8. doi: 10.1111/acel.12280. Epub 2014 Nov 26.

36.

Aging of the T cell compartment in mice and humans: from no naive expectations to foggy memories.

Nikolich-Žugich J.

J Immunol. 2014 Sep 15;193(6):2622-9. doi: 10.4049/jimmunol.1401174. Review.

37.

Lost in translation: mice, men and cutaneous immunity in old age.

Smithey MJ, Uhrlaub JL, Li G, Vukmanovic-Stejic M, Akbar AN, Nikolich-Zugich J.

Biogerontology. 2015 Apr;16(2):203-8. doi: 10.1007/s10522-014-9517-0. Epub 2014 Jul 16. Review.

PMID:
25027761
38.

Histone deacetylation critically determines T cell subset radiosensitivity.

Pugh JL, Sukhina AS, Seed TM, Manley NR, Sempowski GD, van den Brink MR, Smithey MJ, Nikolich-Žugich J.

J Immunol. 2014 Aug 1;193(3):1451-8. doi: 10.4049/jimmunol.1400434. Epub 2014 Jul 2.

39.

Immune memory-boosting dose of rapamycin impairs macrophage vesicle acidification and curtails glycolysis in effector CD8 cells, impairing defense against acute infections.

Goldberg EL, Smithey MJ, Lutes LK, Uhrlaub JL, Nikolich-Žugich J.

J Immunol. 2014 Jul 15;193(2):757-63. doi: 10.4049/jimmunol.1400188. Epub 2014 Jun 9.

40.

Sex differences in T-lymphocyte tissue infiltration and development of angiotensin II hypertension.

Pollow DP, Uhrlaub J, Romero-Aleshire M, Sandberg K, Nikolich-Zugich J, Brooks HL, Hay M.

Hypertension. 2014 Aug;64(2):384-390. doi: 10.1161/HYPERTENSIONAHA.114.03581. Epub 2014 Jun 2.

41.

New advances in CMV and immunosenescence.

Sansoni P, Vescovini R, Fagnoni FF, Akbar A, Arens R, Chiu YL, Cičin-Šain L, Dechanet-Merville J, Derhovanessian E, Ferrando-Martinez S, Franceschi C, Frasca D, Fulöp T, Furman D, Gkrania-Klotsas E, Goodrum F, Grubeck-Loebenstein B, Hurme M, Kern F, Lilleri D, López-Botet M, Maier AB, Marandu T, Marchant A, Matheï C, Moss P, Muntasell A, Remmerswaal EB, Riddell NE, Rothe K, Sauce D, Shin EC, Simanek AM, Smithey MJ, Söderberg-Nauclér C, Solana R, Thomas PG, van Lier R, Pawelec G, Nikolich-Zugich J.

Exp Gerontol. 2014 Jul;55:54-62. doi: 10.1016/j.exger.2014.03.020. Epub 2014 Apr 3.

42.

The Frailty syndrome: clinical measurements and basic underpinnings in humans and animals.

Mohler MJ, Fain MJ, Wertheimer AM, Najafi B, Nikolich-Žugich J.

Exp Gerontol. 2014 Jun;54:6-13. doi: 10.1016/j.exger.2014.01.024. Epub 2014 Feb 4. Review.

PMID:
24503059
43.

Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans.

Wertheimer AM, Bennett MS, Park B, Uhrlaub JL, Martinez C, Pulko V, Currier NL, Nikolich-Žugich D, Kaye J, Nikolich-Žugich J.

J Immunol. 2014 Mar 1;192(5):2143-55. doi: 10.4049/jimmunol.1301721. Epub 2014 Feb 5.

44.

Naïve and memory CD8 T cell pool homeostasis in advanced aging: impact of age and of antigen-specific responses to cytomegalovirus.

Vescovini R, Fagnoni FF, Telera AR, Bucci L, Pedrazzoni M, Magalini F, Stella A, Pasin F, Medici MC, Calderaro A, Volpi R, Monti D, Franceschi C, Nikolich-Žugich J, Sansoni P.

Age (Dordr). 2014 Apr;36(2):625-40. doi: 10.1007/s11357-013-9594-z. Epub 2013 Dec 8.

45.

Two separate defects affecting true naive or virtual memory T cell precursors combine to reduce naive T cell responses with aging.

Renkema KR, Li G, Wu A, Smithey MJ, Nikolich-Žugich J.

J Immunol. 2014 Jan 1;192(1):151-9. doi: 10.4049/jimmunol.1301453. Epub 2013 Nov 29.

46.

Acute neonatal infections 'lock-in' a suboptimal CD8+ T cell repertoire with impaired recall responses.

Rudd BD, Venturi V, Smith NL, Nzingha K, Goldberg EL, Li G, Nikolich-Zugich J, Davenport MP.

PLoS Pathog. 2013 Sep;9(9):e1003572. doi: 10.1371/journal.ppat.1003572. Epub 2013 Sep 12.

47.

Contrasting effects of chronic, systemic treatment with mTOR inhibitors rapamycin and metformin on adult neural progenitors in mice.

Kusne Y, Goldberg EL, Parker SS, Hapak SM, Maskaykina IY, Chew WM, Limesand KH, Brooks HL, Price TJ, Sanai N, Nikolich-Zugich J, Ghosh S.

Age (Dordr). 2014 Feb;36(1):199-212. doi: 10.1007/s11357-013-9572-5. Epub 2013 Aug 16.

48.

Age-associated increase of low-avidity cytomegalovirus-specific CD8+ T cells that re-express CD45RA.

Griffiths SJ, Riddell NE, Masters J, Libri V, Henson SM, Wertheimer A, Wallace D, Sims S, Rivino L, Larbi A, Kemeny DM, Nikolich-Zugich J, Kern F, Klenerman P, Emery VC, Akbar AN.

J Immunol. 2013 Jun 1;190(11):5363-72. doi: 10.4049/jimmunol.1203267. Epub 2013 May 1.

49.

IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling.

Lazear HM, Lancaster A, Wilkins C, Suthar MS, Huang A, Vick SC, Clepper L, Thackray L, Brassil MM, Virgin HW, Nikolich-Zugich J, Moses AV, Gale M Jr, Früh K, Diamond MS.

PLoS Pathog. 2013 Jan;9(1):e1003118. doi: 10.1371/journal.ppat.1003118. Epub 2013 Jan 3. Erratum in: PLoS Pathog. 2013 May;9(5). :10.1371/annotation/4de7ddfd-52df-4f87-8ca4-d48afe646ca8.

50.

Varicella zoster-specific CD4+Foxp3+ T cells accumulate after cutaneous antigen challenge in humans.

Vukmanovic-Stejic M, Sandhu D, Sobande TO, Agius E, Lacy KE, Riddell N, Montez S, Dintwe OB, Scriba TJ, Breuer J, Nikolich-Zugich J, Ogg G, Rustin MH, Akbar AN.

J Immunol. 2013 Feb 1;190(3):977-86. doi: 10.4049/jimmunol.1201331. Epub 2013 Jan 2.

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