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An integrated transcriptomics and metabolomics analysis of the Cucurbita pepo nectary implicates key modules of primary metabolism involved in nectar synthesis and secretion.

Solhaug EM, Roy R, Chatt EC, Klinkenberg PM, Mohd-Fadzil NA, Hampton M, Nikolau BJ, Carter CJ.

Plant Direct. 2019 Feb 28;3(2):e00120. doi: 10.1002/pld3.120. eCollection 2019 Feb.


Altering the Substrate Specificity of Acetyl-CoA Synthetase by Rational Mutagenesis of the Carboxylate Binding Pocket.

Sofeo N, Hart JH, Butler B, Oliver DJ, Yandeau-Nelson MD, Nikolau BJ.

ACS Synth Biol. 2019 Jun 21;8(6):1325-1336. doi: 10.1021/acssynbio.9b00008. Epub 2019 May 30.


A single-cell platform for reconstituting and characterizing fatty acid elongase component enzymes.

Campbell AA, Stenback KE, Flyckt K, Hoang T, Perera MAD, Nikolau BJ.

PLoS One. 2019 Mar 11;14(3):e0213620. doi: 10.1371/journal.pone.0213620. eCollection 2019.


Combined use of cutinase and high-resolution mass-spectrometry to query the molecular architecture of cutin.

Bhunia RK, Showman LJ, Jose A, Nikolau BJ.

Plant Methods. 2018 Dec 26;14:117. doi: 10.1186/s13007-018-0384-6. eCollection 2018.


Identification of active site residues implies a two-step catalytic mechanism for acyl-ACP thioesterase.

Jing F, Yandeau-Nelson MD, Nikolau BJ.

Biochem J. 2018 Dec 10;475(23):3861-3873. doi: 10.1042/BCJ20180470.


Heterotrimeric G-Protein-Dependent Proteome and Phosphoproteome in Unstimulated Arabidopsis Roots.

Song G, Brachova L, Nikolau BJ, Jones AM, Walley JW.

Proteomics. 2018 Dec;18(24):e1800323. doi: 10.1002/pmic.201800323.


Sex-Dependent Variation of Pumpkin (Cucurbita maxima cv. Big Max) Nectar and Nectaries as Determined by Proteomics and Metabolomics.

Chatt EC, von Aderkas P, Carter CJ, Smith D, Elliott M, Nikolau BJ.

Front Plant Sci. 2018 Jun 29;9:860. doi: 10.3389/fpls.2018.00860. eCollection 2018.


Characterizing virus-induced gene silencing at the cellular level with in situ multimodal imaging.

Burkhow SJ, Stephens NM, Mei Y, Dueñas ME, Freppon DJ, Ding G, Smith SC, Lee YJ, Nikolau BJ, Whitham SA, Smith EA.

Plant Methods. 2018 May 25;14:37. doi: 10.1186/s13007-018-0306-7. eCollection 2018.


Two distinct domains contribute to the substrate acyl chain length selectivity of plant acyl-ACP thioesterase.

Jing F, Zhao L, Yandeau-Nelson MD, Nikolau BJ.

Nat Commun. 2018 Feb 28;9(1):860. doi: 10.1038/s41467-018-03310-z.


A robust and efficient method for the extraction of plant extracellular surface lipids as applied to the analysis of silks and seedling leaves of maize.

Loneman DM, Peddicord L, Al-Rashid A, Nikolau BJ, Lauter N, Yandeau-Nelson MD.

PLoS One. 2017 Jul 11;12(7):e0180850. doi: 10.1371/journal.pone.0180850. eCollection 2017.


Spatial Mapping and Profiling of Metabolite Distributions during Germination.

Feenstra AD, Alexander LE, Song Z, Korte AR, Yandeau-Nelson MD, Nikolau BJ, Lee YJ.

Plant Physiol. 2017 Aug;174(4):2532-2548. doi: 10.1104/pp.17.00652. Epub 2017 Jun 20.


Discovery and Characterization of the 3-Hydroxyacyl-ACP Dehydratase Component of the Plant Mitochondrial Fatty Acid Synthase System.

Guan X, Okazaki Y, Lithio A, Li L, Zhao X, Jin H, Nettleton D, Saito K, Nikolau BJ.

Plant Physiol. 2017 Apr;173(4):2010-2028. doi: 10.1104/pp.16.01732. Epub 2017 Feb 15.


High spatial resolution mass spectrometry imaging reveals the genetically programmed, developmental modification of the distribution of thylakoid membrane lipids among individual cells of maize leaf.

Dueñas ME, Klein AT, Alexander LE, Yandeau-Nelson MD, Nikolau BJ, Lee YJ.

Plant J. 2017 Feb;89(4):825-838. doi: 10.1111/tpj.13422. Epub 2017 Feb 3.


Integrating metabolomics and transcriptomics data to discover a biocatalyst that can generate the amine precursors for alkamide biosynthesis.

Rizhsky L, Jin H, Shepard MR, Scott HW, Teitgen AM, Perera MA, Mhaske V, Jose A, Zheng X, Crispin M, Wurtele ES, Jones D, Hur M, Góngora-Castillo E, Buell CR, Minto RE, Nikolau BJ.

Plant J. 2016 Dec;88(5):775-793. doi: 10.1111/tpj.13295. Epub 2016 Sep 27.


Microbial production of bi-functional molecules by diversification of the fatty acid pathway.

Garg S, Rizhsky L, Jin H, Yu X, Jing F, Yandeau-Nelson MD, Nikolau BJ.

Metab Eng. 2016 May;35:9-20. doi: 10.1016/j.ymben.2016.01.003. Epub 2016 Jan 28.


A Role for GIBBERELLIN 2-OXIDASE6 and Gibberellins in Regulating Nectar Production.

Wiesen LB, Bender RL, Paradis T, Larson A, Perera MADN, Nikolau BJ, Olszewski NE, Carter CJ.

Mol Plant. 2016 May 2;9(5):753-756. doi: 10.1016/j.molp.2015.12.019. Epub 2015 Dec 31. No abstract available.


Correction: Metabolomic Profiling of the Nectars of Aquilegia pubescens and A. Canadensis.

Noutsos C, Perera AM, Nikolau BJ, Seaver SM, Ware DH.

PLoS One. 2015 Oct 22;10(10):e0141384. doi: 10.1371/journal.pone.0141384. eCollection 2015. No abstract available.


A phosphopantetheinyl transferase that is essential for mitochondrial fatty acid biosynthesis.

Guan X, Chen H, Abramson A, Man H, Wu J, Yu O, Nikolau BJ.

Plant J. 2015 Nov;84(4):718-32. doi: 10.1111/tpj.13034.


Metabolomic Profiling of the Nectars of Aquilegia pubescens and A. Canadensis.

Noutsos C, Perera AM, Nikolau BJ, Seaver SM, Ware DH.

PLoS One. 2015 May 1;10(5):e0124501. doi: 10.1371/journal.pone.0124501. eCollection 2015. Erratum in: PLoS One. 2015;10(10):e0141384.


Patterns of metabolite changes identified from large-scale gene perturbations in Arabidopsis using a genome-scale metabolic network.

Kim T, Dreher K, Nilo-Poyanco R, Lee I, Fiehn O, Lange BM, Nikolau BJ, Sumner L, Welti R, Wurtele ES, Rhee SY.

Plant Physiol. 2015 Apr;167(4):1685-98. doi: 10.1104/pp.114.252361. Epub 2015 Feb 10.


Subcellular-level resolution MALDI-MS imaging of maize leaf metabolites by MALDI-linear ion trap-Orbitrap mass spectrometer.

Korte AR, Yandeau-Nelson MD, Nikolau BJ, Lee YJ.

Anal Bioanal Chem. 2015 Mar;407(8):2301-9. doi: 10.1007/s00216-015-8460-5. Epub 2015 Jan 25.


Modern plant metabolomics: advanced natural product gene discoveries, improved technologies, and future prospects.

Sumner LW, Lei Z, Nikolau BJ, Saito K.

Nat Prod Rep. 2015 Feb;32(2):212-29. doi: 10.1039/c4np00072b. Review.


Evaluating PHA productivity of bioengineered Rhodosprillum rubrum.

Jin H, Nikolau BJ.

PLoS One. 2014 May 19;9(5):e96621. doi: 10.1371/journal.pone.0096621. eCollection 2014.


Metabolomic Characterization of Knockout Mutants in Arabidopsis: Development of a Metabolite Profiling Database for Knockout Mutants in Arabidopsis.

Fukushima A, Kusano M, Mejia RF, Iwasa M, Kobayashi M, Hayashi N, Watanabe-Takahashi A, Narisawa T, Tohge T, Hur M, Wurtele ES, Nikolau BJ, Saito K.

Plant Physiol. 2014 Jul;165(3):948-961. Epub 2014 May 14.


High-throughput fluorescence-activated cell sorting for lipid hyperaccumulating Chlamydomonas reinhardtii mutants.

Xie B, Stessman D, Hart JH, Dong H, Wang Y, Wright DA, Nikolau BJ, Spalding MH, Halverson LJ.

Plant Biotechnol J. 2014 Sep;12(7):872-82. doi: 10.1111/pbi.12190. Epub 2014 Apr 7.


PIN6 is required for nectary auxin response and short stamen development.

Bender RL, Fekete ML, Klinkenberg PM, Hampton M, Bauer B, Malecha M, Lindgren K, A Maki J, Perera MA, Nikolau BJ, Carter CJ.

Plant J. 2013 Jun;74(6):893-904. doi: 10.1111/tpj.12184. Epub 2013 May 2.


A global approach to analysis and interpretation of metabolic data for plant natural product discovery.

Hur M, Campbell AA, Almeida-de-Macedo M, Li L, Ransom N, Jose A, Crispin M, Nikolau BJ, Wurtele ES.

Nat Prod Rep. 2013 Apr;30(4):565-83. doi: 10.1039/c3np20111b. Review.


Role of genetic redundancy in polyhydroxyalkanoate (PHA) polymerases in PHA biosynthesis in Rhodospirillum rubrum.

Jin H, Nikolau BJ.

J Bacteriol. 2012 Oct;194(20):5522-9. Epub 2012 Aug 3. Erratum in: J Bacteriol. 2012 Dec;194(23):6699.


Developmental changes in the metabolic network of snapdragon flowers.

Muhlemann JK, Maeda H, Chang CY, San Miguel P, Baxter I, Cooper B, Perera MA, Nikolau BJ, Vitek O, Morgan JA, Dudareva N.

PLoS One. 2012;7(7):e40381. doi: 10.1371/journal.pone.0040381. Epub 2012 Jul 11.


Metabolomics as a Hypothesis-Generating Functional Genomics Tool for the Annotation of Arabidopsis thaliana Genes of "Unknown Function".

Quanbeck SM, Brachova L, Campbell AA, Guan X, Perera A, He K, Rhee SY, Bais P, Dickerson JA, Dixon P, Wohlgemuth G, Fiehn O, Barkan L, Lange I, Lange BM, Lee I, Cortes D, Salazar C, Shuman J, Shulaev V, Huhman DV, Sumner LW, Roth MR, Welti R, Ilarslan H, Wurtele ES, Nikolau BJ.

Front Plant Sci. 2012 Feb 10;3:15. doi: 10.3389/fpls.2012.00015. eCollection 2012.


Use of mass spectrometry for imaging metabolites in plants.

Lee YJ, Perdian DC, Song Z, Yeung ES, Nikolau BJ.

Plant J. 2012 Apr;70(1):81-95. doi: 10.1111/j.1365-313X.2012.04899.x. Review.


Reverse genetic characterization of two paralogous acetoacetyl CoA thiolase genes in Arabidopsis reveals their importance in plant growth and development.

Jin H, Song Z, Nikolau BJ.

Plant J. 2012 Jun;70(6):1015-32. doi: 10.1111/j.1365-313X.2012.04942.x. Epub 2012 Mar 31.


The inhibition of lipopolysaccharide-induced macrophage inflammation by 4 compounds in Hypericum perforatum extract is partially dependent on the activation of SOCS3.

Huang N, Rizshsky L, Hauck CC, Nikolau BJ, Murphy PA, Birt DF.

Phytochemistry. 2012 Apr;76:106-16. doi: 10.1016/j.phytochem.2011.12.001. Epub 2012 Jan 13.


Genetic dissection of methylcrotonyl CoA carboxylase indicates a complex role for mitochondrial leucine catabolism during seed development and germination.

Ding G, Che P, Ilarslan H, Wurtele ES, Nikolau BJ.

Plant J. 2012 May;70(4):562-77. doi: 10.1111/j.1365-313X.2011.04893.x. Epub 2012 Feb 6.


Medicinal plants: a public resource for metabolomics and hypothesis development.

Wurtele ES, Chappell J, Jones AD, Celiz MD, Ransom N, Hur M, Rizshsky L, Crispin M, Dixon P, Liu J, P Widrlechner M, Nikolau BJ.

Metabolites. 2012 Nov 21;2(4):1031-59. doi: 10.3390/metabo2041031.


Bauer ketones 23 and 24 from Echinacea paradoxa var. paradoxa inhibit lipopolysaccharide-induced nitric oxide, prostaglandin E2 and cytokines in RAW264.7 mouse macrophages.

Zhang X, Rizshsky L, Hauck C, Qu L, Widrlechner MP, Nikolau BJ, Murphy PA, Birt DF.

Phytochemistry. 2012 Feb;74:146-58. doi: 10.1016/j.phytochem.2011.10.013. Epub 2011 Nov 29.

39. mass spectrometry-based Arabidopsis metabolomics--database and tools update.

Bais P, Moon-Quanbeck SM, Nikolau BJ, Dickerson JA.

Nucleic Acids Res. 2012 Jan;40(Database issue):D1216-20. doi: 10.1093/nar/gkr969. Epub 2011 Nov 10.


Identification of anti-inflammatory constituents in Hypericum perforatum and Hypericum gentianoides extracts using RAW 264.7 mouse macrophages.

Huang N, Rizshsky L, Hauck C, Nikolau BJ, Murphy PA, Birt DF.

Phytochemistry. 2011 Nov;72(16):2015-23. doi: 10.1016/j.phytochem.2011.07.016. Epub 2011 Aug 17.


Phylogenetic and experimental characterization of an acyl-ACP thioesterase family reveals significant diversity in enzymatic specificity and activity.

Jing F, Cantu DC, Tvaruzkova J, Chipman JP, Nikolau BJ, Yandeau-Nelson MD, Reilly PJ.

BMC Biochem. 2011 Aug 10;12:44. doi: 10.1186/1471-2091-12-44.


A nuclear magnetic resonance based approach to accurate functional annotation of putative enzymes in the methanogen Methanosarcina acetivorans.

Chen Y, Apolinario E, Brachova L, Kelman Z, Li Z, Nikolau BJ, Showman L, Sowers K, Orban J.

BMC Genomics. 2011 Jun 15;12 Suppl 1:S7. doi: 10.1186/1471-2164-12-S1-S7.


Silencing of soybean seed storage proteins results in a rebalanced protein composition preserving seed protein content without major collateral changes in the metabolome and transcriptome.

Schmidt MA, Barbazuk WB, Sandford M, May G, Song Z, Zhou W, Nikolau BJ, Herman EM.

Plant Physiol. 2011 May;156(1):330-45. doi: 10.1104/pp.111.173807. Epub 2011 Mar 10.


Echinacea-induced cytosolic Ca2+ elevation in HEK293.

Wu L, Rowe EW, Jeftinija K, Jeftinija S, Rizshsky L, Nikolau BJ, McKay J, Kohut M, Wurtele ES.

BMC Complement Altern Med. 2010 Nov 23;10:72. doi: 10.1186/1472-6882-10-72.


Biological origins of normal-chain hydrocarbons: a pathway model based on cuticular wax analyses of maize silks.

Perera MA, Qin W, Yandeau-Nelson M, Fan L, Dixon P, Nikolau BJ.

Plant J. 2010 Nov;64(4):618-32. doi: 10.1111/j.1365-313X.2010.04355.x. Epub 2010 Oct 26.


Reverse-genetic analysis of the two biotin-containing subunit genes of the heteromeric acetyl-coenzyme A carboxylase in Arabidopsis indicates a unidirectional functional redundancy.

Li X, Ilarslan H, Brachova L, Qian HR, Li L, Che P, Wurtele ES, Nikolau BJ.

Plant Physiol. 2011 Jan;155(1):293-314. doi: 10.1104/pp.110.165910. Epub 2010 Oct 28.


Enrichment of Echinacea angustifolia with Bauer alkylamide 11 and Bauer ketone 23 increased anti-inflammatory potential through interference with cox-2 enzyme activity.

Lalone CA, Huang N, Rizshsky L, Yum MY, Singh N, Hauck C, Nikolau BJ, Wurtele ES, Kohut ML, Murphy PA, Birt DF.

J Agric Food Chem. 2010 Aug 11;58(15):8573-84. doi: 10.1021/jf1014268.


High-spatial and high-mass resolution imaging of surface metabolites of Arabidopsis thaliana by laser desorption-ionization mass spectrometry using colloidal silver.

Jun JH, Song Z, Liu Z, Nikolau BJ, Yeung ES, Lee YJ.

Anal Chem. 2010 Apr 15;82(8):3255-65. doi: 10.1021/ac902990p.

49. a web portal for plant metabolomics experiments.

Bais P, Moon SM, He K, Leitao R, Dreher K, Walk T, Sucaet Y, Barkan L, Wohlgemuth G, Roth MR, Wurtele ES, Dixon P, Fiehn O, Lange BM, Shulaev V, Sumner LW, Welti R, Nikolau BJ, Rhee SY, Dickerson JA.

Plant Physiol. 2010 Apr;152(4):1807-16. doi: 10.1104/pp.109.151027. Epub 2010 Feb 10.


Rosmarinic acid in Prunella vulgaris ethanol extract inhibits lipopolysaccharide-induced prostaglandin E2 and nitric oxide in RAW 264.7 mouse macrophages.

Huang N, Hauck C, Yum MY, Rizshsky L, Widrlechner MP, McCoy JA, Murphy PA, Dixon PM, Nikolau BJ, Birt DF.

J Agric Food Chem. 2009 Nov 25;57(22):10579-89. doi: 10.1021/jf9023728.

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