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Origin of Th17 Cells in Type 2 Diabetes-Potentiated Periodontal Disease.

Nikolajczyk BS, Dawson DR 3rd.

Adv Exp Med Biol. 2019;1197:45-54. doi: 10.1007/978-3-030-28524-1_4. Review.


Tissue Immune Cells Fuel Obesity-Associated Inflammation in Adipose Tissue and Beyond.

Liu R, Nikolajczyk BS.

Front Immunol. 2019 Jul 17;10:1587. doi: 10.3389/fimmu.2019.01587. eCollection 2019. Review.


Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes.

Nicholas DA, Proctor EA, Agrawal M, Belkina AC, Van Nostrand SC, Panneerseelan-Bharath L, Jones AR 4th, Raval F, Ip BC, Zhu M, Cacicedo JM, Habib C, Sainz-Rueda N, Persky L, Sullivan PG, Corkey BE, Apovian CM, Kern PA, Lauffenburger DA, Nikolajczyk BS.

Cell Metab. 2019 Sep 3;30(3):447-461.e5. doi: 10.1016/j.cmet.2019.07.004. Epub 2019 Aug 1.


Saturated Fatty Acid Activates T Cell Inflammation Through a Nicotinamide Nucleotide Transhydrogenase (NNT)-Dependent Mechanism.

McCambridge G, Agrawal M, Keady A, Kern PA, Hasturk H, Nikolajczyk BS, Bharath LP.

Biomolecules. 2019 Feb 25;9(2). pii: E79. doi: 10.3390/biom9020079.


Metabolic reprogramming of natural killer cells in obesity limits antitumor responses.

Michelet X, Dyck L, Hogan A, Loftus RM, Duquette D, Wei K, Beyaz S, Tavakkoli A, Foley C, Donnelly R, O'Farrelly C, Raverdeau M, Vernon A, Pettee W, O'Shea D, Nikolajczyk BS, Mills KHG, Brenner MB, Finlay D, Lynch L.

Nat Immunol. 2018 Dec;19(12):1330-1340. doi: 10.1038/s41590-018-0251-7. Epub 2018 Nov 12.


Type 1 diabetes alters lipid handling and metabolism in human fibroblasts and peripheral blood mononuclear cells.

Jones AR IV, Coleman EL, Husni NR, Deeney JT, Raval F, Steenkamp D, Dooms H, Nikolajczyk BS, Corkey BE.

PLoS One. 2017 Dec 4;12(12):e0188474. doi: 10.1371/journal.pone.0188474. eCollection 2017.


Adaptive Immunity and Metabolic Health: Harmony Becomes Dissonant in Obesity and Aging.

Bharath LP, Ip BC, Nikolajczyk BS.

Compr Physiol. 2017 Sep 12;7(4):1307-1337. doi: 10.1002/cphy.c160042. Review.


The Immune System in Obesity: Developing Paradigms Amidst Inconvenient Truths.

Agrawal M, Kern PA, Nikolajczyk BS.

Curr Diab Rep. 2017 Aug 15;17(10):87. doi: 10.1007/s11892-017-0917-9. Review.


Advances in the quantification of mitochondrial function in primary human immune cells through extracellular flux analysis.

Nicholas D, Proctor EA, Raval FM, Ip BC, Habib C, Ritou E, Grammatopoulos TN, Steenkamp D, Dooms H, Apovian CM, Lauffenburger DA, Nikolajczyk BS.

PLoS One. 2017 Feb 8;12(2):e0170975. doi: 10.1371/journal.pone.0170975. eCollection 2017.


Inhibition of Ubc13-mediated Ubiquitination by GPS2 Regulates Multiple Stages of B Cell Development.

Lentucci C, Belkina AC, Cederquist CT, Chan M, Johnson HE, Prasad S, Lopacinski A, Nikolajczyk BS, Monti S, Snyder-Cappione J, Tanasa B, Cardamone MD, Perissi V.

J Biol Chem. 2017 Feb 17;292(7):2754-2772. doi: 10.1074/jbc.M116.755132. Epub 2016 Dec 30.


BET bromodomain proteins and epigenetic regulation of inflammation: implications for type 2 diabetes and breast cancer.

Nicholas DA, Andrieu G, Strissel KJ, Nikolajczyk BS, Denis GV.

Cell Mol Life Sci. 2017 Jan;74(2):231-243. doi: 10.1007/s00018-016-2320-0. Epub 2016 Aug 4. Review.


The impact of bariatric surgery on inflammation: quenching the fire of obesity?

Hafida S, Mirshahi T, Nikolajczyk BS.

Curr Opin Endocrinol Diabetes Obes. 2016 Oct;23(5):373-8. doi: 10.1097/MED.0000000000000277. Review.


B cells shed light on diminished vaccine responses in obesity.

Nicholas DA, Nikolajczyk BS.

Obesity (Silver Spring). 2016 Mar;24(3):551. doi: 10.1002/oby.21429. Epub 2016 Feb 5. No abstract available.


Th17 cytokines differentiate obesity from obesity-associated type 2 diabetes and promote TNFα production.

Ip B, Cilfone NA, Belkina AC, DeFuria J, Jagannathan-Bogdan M, Zhu M, Kuchibhatla R, McDonnell ME, Xiao Q, Kepler TB, Apovian CM, Lauffenburger DA, Nikolajczyk BS.

Obesity (Silver Spring). 2016 Jan;24(1):102-12. doi: 10.1002/oby.21243. Epub 2015 Nov 18.


An updated h-index measures both the primary and total scientific output of a researcher.

Bucur O, Almasan A, Zubarev R, Friedman M, Nicolson GL, Sumazin P, Leabu M, Nikolajczyk BS, Avram D, Kunej T, Calin GA, Godwin AK, Adami HO, Zaphiropoulos PG, Richardson DR, Schmitt-Ulms G, Westerblad H, Keniry M, Grau GE, Carbonetto S, Stan RV, Popa-Wagner A, Takhar K, Baron BW, Galardy PJ, Yang F, Data D, Fadare O, Yeo KJ, Gabreanu GR, Andrei S, Soare GR, Nelson MA, Liehn EA.

Discoveries (Craiova). 2015 Jul-Sep;3(3). pii: e50. Epub 2015 Sep 30.


Lymphocyte roles in metabolic dysfunction: of men and mice.

Ip BC, Hogan AE, Nikolajczyk BS.

Trends Endocrinol Metab. 2015 Feb;26(2):91-100. doi: 10.1016/j.tem.2014.12.001. Epub 2015 Jan 5. Review.


Immune regulators of inflammation in obesity-associated type 2 diabetes and coronary artery disease.

Strissel KJ, Denis GV, Nikolajczyk BS.

Curr Opin Endocrinol Diabetes Obes. 2014 Oct;21(5):330-8. doi: 10.1097/MED.0000000000000085. Review.


B cells promote obesity-associated periodontitis and oral pathogen-associated inflammation.

Zhu M, Belkina AC, DeFuria J, Carr JD, Van Dyke TE, Gyurko R, Nikolajczyk BS.

J Leukoc Biol. 2014 Aug;96(2):349-57. doi: 10.1189/jlb.4A0214-095R. Epub 2014 Apr 29.


Immune cells link obesity-associated type 2 diabetes and periodontitis.

Zhu M, Nikolajczyk BS.

J Dent Res. 2014 Apr;93(4):346-52. doi: 10.1177/0022034513518943. Epub 2014 Jan 6. Review.


The double bromodomain protein Brd2 promotes B cell expansion and mitogenesis.

Belkina AC, Blanton WP, Nikolajczyk BS, Denis GV.

J Leukoc Biol. 2014 Mar;95(3):451-60. doi: 10.1189/jlb.1112588. Epub 2013 Dec 6.


B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile.

DeFuria J, Belkina AC, Jagannathan-Bogdan M, Snyder-Cappione J, Carr JD, Nersesova YR, Markham D, Strissel KJ, Watkins AA, Zhu M, Allen J, Bouchard J, Toraldo G, Jasuja R, Obin MS, McDonnell ME, Apovian C, Denis GV, Nikolajczyk BS.

Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5133-8. doi: 10.1073/pnas.1215840110. Epub 2013 Mar 11.


BET protein function is required for inflammation: Brd2 genetic disruption and BET inhibitor JQ1 impair mouse macrophage inflammatory responses.

Belkina AC, Nikolajczyk BS, Denis GV.

J Immunol. 2013 Apr 1;190(7):3670-8. doi: 10.4049/jimmunol.1202838. Epub 2013 Feb 18.


The Bidirectional Relationship between Metabolism and Immune Responses.

Raval FM, Nikolajczyk BS.

Discoveries (Craiova). 2013;1(1):e6.


When diet and exercise are not enough, think immunomodulation.

Snyder-Cappione JE, Nikolajczyk BS.

Mol Aspects Med. 2013 Feb;34(1):30-8. doi: 10.1016/j.mam.2012.10.003. Epub 2012 Oct 16. Review.


The outliers become a stampede as immunometabolism reaches a tipping point.

Nikolajczyk BS, Jagannathan-Bogdan M, Denis GV.

Immunol Rev. 2012 Sep;249(1):253-75. doi: 10.1111/j.1600-065X.2012.01142.x. Review.


State of the union between metabolism and the immune system in type 2 diabetes.

Nikolajczyk BS, Jagannathan-Bogdan M, Shin H, Gyurko R.

Genes Immun. 2011 Jun;12(4):239-50. doi: 10.1038/gene.2011.14. Epub 2011 Mar 10. Review.


Elevated proinflammatory cytokine production by a skewed T cell compartment requires monocytes and promotes inflammation in type 2 diabetes.

Jagannathan-Bogdan M, McDonnell ME, Shin H, Rehman Q, Hasturk H, Apovian CM, Nikolajczyk BS.

J Immunol. 2011 Jan 15;186(2):1162-72. doi: 10.4049/jimmunol.1002615. Epub 2010 Dec 17.


Differential regulation of TLR4 expression in human B cells and monocytes.

Ganley-Leal LM, Liang Y, Jagannathan-Bogdan M, Farraye FA, Nikolajczyk BS.

Mol Immunol. 2010 Nov-Dec;48(1-3):82-8. doi: 10.1016/j.molimm.2010.09.008. Epub 2010 Oct 16.


An emerging role for bromodomain-containing proteins in chromatin regulation and transcriptional control of adipogenesis.

Denis GV, Nikolajczyk BS, Schnitzler GR.

FEBS Lett. 2010 Aug 4;584(15):3260-8. doi: 10.1016/j.febslet.2010.05.030. Epub 2010 May 21. Review.


Toll-like receptors regulate B cell cytokine production in patients with diabetes.

Jagannathan M, McDonnell M, Liang Y, Hasturk H, Hetzel J, Rubin D, Kantarci A, Van Dyke TE, Ganley-Leal LM, Nikolajczyk BS.

Diabetologia. 2010 Jul;53(7):1461-71. doi: 10.1007/s00125-010-1730-z. Epub 2010 Apr 11.


B cells as under-appreciated mediators of non-auto-immune inflammatory disease.

Nikolajczyk BS.

Cytokine. 2010 Jun;50(3):234-42. doi: 10.1016/j.cyto.2010.02.022. Epub 2010 Apr 10. Review.


TLR cross-talk specifically regulates cytokine production by B cells from chronic inflammatory disease patients.

Jagannathan M, Hasturk H, Liang Y, Shin H, Hetzel JT, Kantarci A, Rubin D, McDonnell ME, Van Dyke TE, Ganley-Leal LM, Nikolajczyk BS.

J Immunol. 2009 Dec 1;183(11):7461-70. doi: 10.4049/jimmunol.0901517. Epub 2009 Nov 16.


Hyperactivated B cells in human inflammatory bowel disease.

Noronha AM, Liang Y, Hetzel JT, Hasturk H, Kantarci A, Stucchi A, Zhang Y, Nikolajczyk BS, Farraye FA, Ganley-Leal LM.

J Leukoc Biol. 2009 Oct;86(4):1007-16. doi: 10.1189/jlb.0309203. Epub 2009 Jul 9.


B cells from periodontal disease patients express surface Toll-like receptor 4.

Shin H, Zhang Y, Jagannathan M, Hasturk H, Kantarci A, Liu H, Van Dyke TE, Ganley-Leal LM, Nikolajczyk BS.

J Leukoc Biol. 2009 Apr;85(4):648-55. doi: 10.1189/jlb.0708428. Epub 2008 Dec 31.


Dynamic protein associations define two phases of IL-1beta transcriptional activation.

Zhang Y, Saccani S, Shin H, Nikolajczyk BS.

J Immunol. 2008 Jul 1;181(1):503-12.


Immunoglobulin kappa enhancers are differentially regulated at the level of chromatin structure.

Nikolajczyk BS, Sardi SH, Tumang JR, Ganley-Leal LM.

Mol Immunol. 2007 Jul;44(13):3407-15. Epub 2007 Mar 26.


The interleukin-1beta gene is transcribed from a poised promoter architecture in monocytes.

Liang MD, Zhang Y, McDevit D, Marecki S, Nikolajczyk BS.

J Biol Chem. 2006 Apr 7;281(14):9227-37. Epub 2006 Jan 26.


Changes in immunoglobulin-nucleoprotein complex structure mapped by chromatin immunoprecipitation.

McDevit DC, Nikolajczyk BS.

Mol Immunol. 2006 Apr;43(10):1541-8. Epub 2005 Nov 28.


The Ig kappa 3' enhancer is activated by gradients of chromatin accessibility and protein association.

McDevit DC, Perkins L, Atchison ML, Nikolajczyk BS.

J Immunol. 2005 Mar 1;174(5):2834-42.


PU.1 as a chromatin accessibility factor for immunoglobulin genes.

Marecki S, McCarthy KM, Nikolajczyk BS.

Mol Immunol. 2004 Jan;40(10):723-31.


HMGA1 co-activates transcription in B cells through indirect association with DNA.

McCarthy KM, McDevit D, Andreucci A, Reeves R, Nikolajczyk BS.

J Biol Chem. 2003 Oct 24;278(43):42106-14. Epub 2003 Aug 7.


Dominant-negative HMGA1 blocks mu enhancer activation through a novel mechanism.

Andreucci A, Reeves R, McCarthy KM, Nikolajczyk BS.

Biochem Biophys Res Commun. 2002 Mar 29;292(2):427-33.


Splenic and peritoneal B-1 cells differ in terms of transcriptional and proliferative features that separate peritoneal B-1 from splenic B-2 cells.

Fischer GM, Solt LA, Hastings WD, Yang K, Gerstein RM, Nikolajczyk BS, Clarke SH, Rothstein TL.

Cell Immunol. 2001 Oct 10;213(1):62-71.


Mechanisms of mu enhancer regulation in B lymphocytes.

Nikolajczyk BS, Dang W, Sen R.

Cold Spring Harb Symp Quant Biol. 1999;64:99-107. No abstract available.


PU.1-mediated transcription is enhanced by HMG-I(Y)-dependent structural mechanisms.

Lewis RT, Andreucci A, Nikolajczyk BS.

J Biol Chem. 2001 Mar 23;276(12):9550-7. Epub 2000 Dec 20.


ETS protein-dependent accessibility changes at the immunoglobulin mu heavy chain enhancer.

Nikolajczyk BS, Sanchez JA, Sen R.

Immunity. 1999 Jul;11(1):11-20.


Exploring functional redundancy in the immunoglobulin mu heavy-chain gene enhancer.

Dang W, Nikolajczyk BS, Sen R.

Mol Cell Biol. 1998 Nov;18(11):6870-8.


ETS-core binding factor: a common composite motif in antigen receptor gene enhancers.

Erman B, Cortes M, Nikolajczyk BS, Speck NA, Sen R.

Mol Cell Biol. 1998 Mar;18(3):1322-30.


Combinatorial determinants of tissue-specific transcription in B cells and macrophages.

Nikolajczyk BS, Cortes M, Feinman R, Sen R.

Mol Cell Biol. 1997 Jul;17(7):3527-35.

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