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Items: 1 to 50 of 123

1.

Follicle-stimulating hormone and luteinizing hormone increase Ca2+ in the granulosa cells of mouse ovarian follicles†.

Egbert JR, Fahey PG, Reimer J, Owen CM, Evsikov AV, Nikolaev VO, Griesbeck O, Ray RS, Tolias AS, Jaffe LA.

Biol Reprod. 2019 May 14. pii: ioz085. doi: 10.1093/biolre/ioz085. [Epub ahead of print]

PMID:
31087036
2.

Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death.

Silvestre-Roig C, Braster Q, Wichapong K, Lee EY, Teulon JM, Berrebeh N, Winter J, Adrover JM, Santos GS, Froese A, Lemnitzer P, Ortega-Gómez A, Chevre R, Marschner J, Schumski A, Winter C, Perez-Olivares L, Pan C, Paulin N, Schoufour T, Hartwig H, González-Ramos S, Kamp F, Megens RTA, Mowen KA, Gunzer M, Maegdefessel L, Hackeng T, Lutgens E, Daemen M, von Blume J, Anders HJ, Nikolaev VO, Pellequer JL, Weber C, Hidalgo A, Nicolaes GAF, Wong GCL, Soehnlein O.

Nature. 2019 May;569(7755):236-240. doi: 10.1038/s41586-019-1167-6. Epub 2019 May 1.

PMID:
31043745
3.

Optogenetic Monitoring of the Glutathione Redox State in Engineered Human Myocardium.

Trautsch I, Heta E, Soong PL, Levent E, Nikolaev VO, Bogeski I, Katschinski DM, Mayr M, Zimmermann WH.

Front Physiol. 2019 Apr 4;10:272. doi: 10.3389/fphys.2019.00272. eCollection 2019.

4.

P2X7-mediated ATP secretion is accompanied by depletion of cytosolic ATP.

Johnsen B, Kaschubowski KE, Nader S, Schneider E, Nicola JA, Fliegert R, Wolf IMA, Guse AH, Nikolaev VO, Koch-Nolte F, Haag F.

Purinergic Signal. 2019 Apr 23. doi: 10.1007/s11302-019-09654-5. [Epub ahead of print]

PMID:
31016551
5.

Protein kinase/phosphatase balance mediates the effects of increased late sodium current on ventricular calcium cycling.

Eiringhaus J, Herting J, Schatter F, Nikolaev VO, Sprenger J, Wang Y, Köhn M, Zabel M, El-Armouche A, Hasenfuss G, Sossalla S, Fischer TH.

Basic Res Cardiol. 2019 Feb 20;114(2):13. doi: 10.1007/s00395-019-0720-7.

PMID:
30788598
6.

Phosphodiesterases as therapeutic targets for respiratory diseases.

Zuo H, Cattani-Cavalieri I, Musheshe N, Nikolaev VO, Schmidt M.

Pharmacol Ther. 2019 May;197:225-242. doi: 10.1016/j.pharmthera.2019.02.002. Epub 2019 Feb 10.

7.

Adenine nucleotides as paracrine mediators and intracellular second messengers in immunity and inflammation.

Fliegert R, Heeren J, Koch-Nolte F, Nikolaev VO, Lohr C, Meier C, Guse AH.

Biochem Soc Trans. 2019 Feb 28;47(1):329-337. doi: 10.1042/BST20180419. Epub 2019 Jan 23. Review.

PMID:
30674608
8.

Membrane-Permeable Octanoyloxybenzyl-Masked cNMPs As Novel Tools for Non-Invasive Cell Assays.

Ruthenbeck A, Marangoni E, Diercks BP, Krüger A, Froese A, Bork NI, Nikolaev VO, Guse AH, Meier C.

Molecules. 2018 Nov 13;23(11). pii: E2960. doi: 10.3390/molecules23112960.

9.

Heart failure leads to altered β2-adrenoceptor/cyclic adenosine monophosphate dynamics in the sarcolemmal phospholemman/Na,K ATPase microdomain.

Bastug-Özel Z, Wright PT, Kraft AE, Pavlovic D, Howie J, Froese A, Fuller W, Gorelik J, Shattock MJ, Nikolaev VO.

Cardiovasc Res. 2019 Mar 1;115(3):546-555. doi: 10.1093/cvr/cvy221.

PMID:
30165515
10.

Distinct submembrane localisation compartmentalises cardiac NPR1 and NPR2 signalling to cGMP.

Subramanian H, Froese A, Jönsson P, Schmidt H, Gorelik J, Nikolaev VO.

Nat Commun. 2018 Jun 22;9(1):2446. doi: 10.1038/s41467-018-04891-5.

11.

Impact of Intracardiac Neurons on Cardiac Electrophysiology and Arrhythmogenesis in an Ex Vivo Langendorff System.

Jungen C, Scherschel K, Bork NI, Kuklik P, Eickholt C, Kniep H, Klatt N, Willems S, Nikolaev VO, Meyer C.

J Vis Exp. 2018 May 22;(135). doi: 10.3791/57617.

PMID:
29889210
12.

Cigarette smoke up-regulates PDE3 and PDE4 to decrease cAMP in airway cells.

Zuo H, Han B, Poppinga WJ, Ringnalda L, Kistemaker LEM, Halayko AJ, Gosens R, Nikolaev VO, Schmidt M.

Br J Pharmacol. 2018 Jul;175(14):2988-3006. doi: 10.1111/bph.14347. Epub 2018 Jun 3.

13.

Cardiomyocyte Membrane Structure and cAMP Compartmentation Produce Anatomical Variation in β2AR-cAMP Responsiveness in Murine Hearts.

Wright PT, Bhogal NK, Diakonov I, Pannell LMK, Perera RK, Bork NI, Schobesberger S, Lucarelli C, Faggian G, Alvarez-Laviada A, Zaccolo M, Kamp TJ, Balijepalli RC, Lyon AR, Harding SE, Nikolaev VO, Gorelik J.

Cell Rep. 2018 Apr 10;23(2):459-469. doi: 10.1016/j.celrep.2018.03.053.

14.

Endothelial C-Type Natriuretic Peptide Acts on Pericytes to Regulate Microcirculatory Flow and Blood Pressure.

Špiranec K, Chen W, Werner F, Nikolaev VO, Naruke T, Koch F, Werner A, Eder-Negrin P, Diéguez-Hurtado R, Adams RH, Baba HA, Schmidt H, Schuh K, Skryabin BV, Movahedi K, Schweda F, Kuhn M.

Circulation. 2018 Jul 31;138(5):494-508. doi: 10.1161/CIRCULATIONAHA.117.033383.

PMID:
29626067
15.

RoMo: An efficient strategy for functional mosaic analysis via stochastic Cre recombination and gene targeting in the ROSA26 locus.

Movahedi K, Wiegmann R, De Vlaminck K, Van Ginderachter JA, Nikolaev VO.

Biotechnol Bioeng. 2018 Jul;115(7):1778-1792. doi: 10.1002/bit.26594. Epub 2018 Mar 31.

PMID:
29573361
16.

cGMP Signaling in the Cardiovascular System-The Role of Compartmentation and Its Live Cell Imaging.

Bork NI, Nikolaev VO.

Int J Mol Sci. 2018 Mar 10;19(3). pii: E801. doi: 10.3390/ijms19030801. Review.

17.

Imaging of PDE2- and PDE3-Mediated cGMP-to-cAMP Cross-Talk in Cardiomyocytes.

Pavlaki N, Nikolaev VO.

J Cardiovasc Dev Dis. 2018 Jan 19;5(1). pii: E4. doi: 10.3390/jcdd5010004. Review.

18.

Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4.

Perera RK, Fischer TH, Wagner M, Dewenter M, Vettel C, Bork NI, Maier LS, Conti M, Wess J, El-Armouche A, Hasenfuß G, Nikolaev VO.

Sci Rep. 2017 Nov 9;7(1):15222. doi: 10.1038/s41598-017-15632-x.

19.

cGMP-Elevating Compounds and Ischemic Conditioning Provide Cardioprotection Against Ischemia and Reperfusion Injury via Cardiomyocyte-Specific BK Channels.

Frankenreiter S, Bednarczyk P, Kniess A, Bork NI, Straubinger J, Koprowski P, Wrzosek A, Mohr E, Logan A, Murphy MP, Gawaz M, Krieg T, Szewczyk A, Nikolaev VO, Ruth P, Lukowski R.

Circulation. 2017 Dec 12;136(24):2337-2355. doi: 10.1161/CIRCULATIONAHA.117.028723. Epub 2017 Oct 19.

PMID:
29051185
20.

Oxidant sensor in the cGMP-binding pocket of PKGIα regulates nitroxyl-mediated kinase activity.

Donzelli S, Goetz M, Schmidt K, Wolters M, Stathopoulou K, Diering S, Prysyazhna O, Polat V, Scotcher J, Dees C, Subramanian H, Butt E, Kamynina A, Schobesberger S, King SB, Nikolaev VO, de Wit C, Leichert LI, Feil R, Eaton P, Cuello F.

Sci Rep. 2017 Aug 30;7(1):9938. doi: 10.1038/s41598-017-09275-1.

21.

Catecholamine-Dependent β-Adrenergic Signaling in a Pluripotent Stem Cell Model of Takotsubo Cardiomyopathy.

Borchert T, Hübscher D, Guessoum CI, Lam TD, Ghadri JR, Schellinger IN, Tiburcy M, Liaw NY, Li Y, Haas J, Sossalla S, Huber MA, Cyganek L, Jacobshagen C, Dressel R, Raaz U, Nikolaev VO, Guan K, Thiele H, Meder B, Wollnik B, Zimmermann WH, Lüscher TF, Hasenfuss G, Templin C, Streckfuss-Bömeke K.

J Am Coll Cardiol. 2017 Aug 22;70(8):975-991. doi: 10.1016/j.jacc.2017.06.061.

22.

Protein kinase A activation by the anti-cancer drugs ABT-737 and thymoquinone is caspase-3-dependent and correlates with platelet inhibition and apoptosis.

Rukoyatkina N, Butt E, Subramanian H, Nikolaev VO, Mindukshev I, Walter U, Gambaryan S, Benz PM.

Cell Death Dis. 2017 Jun 29;8(6):e2898. doi: 10.1038/cddis.2017.290.

23.

T-tubule remodelling disturbs localized β2-adrenergic signalling in rat ventricular myocytes during the progression of heart failure.

Schobesberger S, Wright P, Tokar S, Bhargava A, Mansfield C, Glukhov AV, Poulet C, Buzuk A, Monszpart A, Sikkel M, Harding SE, Nikolaev VO, Lyon AR, Gorelik J.

Cardiovasc Res. 2017 Jun 1;113(7):770-782. doi: 10.1093/cvr/cvx074.

24.

FRET Microscopy for Real-Time Visualization of Second Messengers in Living Cells.

Kraft AE, Nikolaev VO.

Methods Mol Biol. 2017;1563:85-90. doi: 10.1007/978-1-4939-6810-7_6.

PMID:
28324603
25.

Cyclic nucleotide imaging and cardiovascular disease.

Berisha F, Nikolaev VO.

Pharmacol Ther. 2017 Jul;175:107-115. doi: 10.1016/j.pharmthera.2017.02.038. Epub 2017 Feb 16. Review.

PMID:
28216026
26.

Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias.

Jungen C, Scherschel K, Eickholt C, Kuklik P, Klatt N, Bork N, Salzbrunn T, Alken F, Angendohr S, Klene C, Mester J, Klöcker N, Veldkamp MW, Schumacher U, Willems S, Nikolaev VO, Meyer C.

Nat Commun. 2017 Jan 27;8:14155. doi: 10.1038/ncomms14155.

27.

Dysferlin mediates membrane tubulation and links T-tubule biogenesis to muscular dystrophy.

Hofhuis J, Bersch K, Büssenschütt R, Drzymalski M, Liebetanz D, Nikolaev VO, Wagner S, Maier LS, Gärtner J, Klinge L, Thoms S.

J Cell Sci. 2017 Mar 1;130(5):841-852. doi: 10.1242/jcs.198861. Epub 2017 Jan 19.

28.

Interactions of Calcium Fluctuations during Cardiomyocyte Contraction with Real-Time cAMP Dynamics Detected by FRET.

Sprenger JU, Bork NI, Herting J, Fischer TH, Nikolaev VO.

PLoS One. 2016 Dec 8;11(12):e0167974. doi: 10.1371/journal.pone.0167974. eCollection 2016.

29.

Nucleoside Diphosphate Kinase-C Suppresses cAMP Formation in Human Heart Failure.

Abu-Taha IH, Heijman J, Hippe HJ, Wolf NM, El-Armouche A, Nikolaev VO, Schäfer M, Würtz CM, Neef S, Voigt N, Baczkó I, Varró A, Müller M, Meder B, Katus HA, Spiger K, Vettel C, Lehmann LH, Backs J, Skolnik EY, Lutz S, Dobrev D, Wieland T.

Circulation. 2017 Feb 28;135(9):881-897. doi: 10.1161/CIRCULATIONAHA.116.022852. Epub 2016 Dec 7.

PMID:
27927712
30.

Internalized Receptor for Glucose-dependent Insulinotropic Peptide stimulates adenylyl cyclase on early endosomes.

Ismail S, Gherardi MJ, Froese A, Zanoun M, Gigoux V, Clerc P, Gaits-Iacovoni F, Steyaert J, Nikolaev VO, Fourmy D.

Biochem Pharmacol. 2016 Nov 15;120:33-45. doi: 10.1016/j.bcp.2016.09.009. Epub 2016 Sep 15.

PMID:
27641811
31.

Axial tubule junctions control rapid calcium signaling in atria.

Brandenburg S, Kohl T, Williams GS, Gusev K, Wagner E, Rog-Zielinska EA, Hebisch E, Dura M, Didié M, Gotthardt M, Nikolaev VO, Hasenfuss G, Kohl P, Ward CW, Lederer WJ, Lehnart SE.

J Clin Invest. 2016 Oct 3;126(10):3999-4015. doi: 10.1172/JCI88241. Epub 2016 Sep 19.

32.

Microdomain-Specific Modulation of L-Type Calcium Channels Leads to Triggered Ventricular Arrhythmia in Heart Failure.

Sanchez-Alonso JL, Bhargava A, O'Hara T, Glukhov AV, Schobesberger S, Bhogal N, Sikkel MB, Mansfield C, Korchev YE, Lyon AR, Punjabi PP, Nikolaev VO, Trayanova NA, Gorelik J.

Circ Res. 2016 Sep 30;119(8):944-55. doi: 10.1161/CIRCRESAHA.116.308698. Epub 2016 Aug 29.

33.

Redox Imaging Using Cardiac Myocyte-Specific Transgenic Biosensor Mice.

Swain L, Kesemeyer A, Meyer-Roxlau S, Vettel C, Zieseniss A, Güntsch A, Jatho A, Becker A, Nanadikar MS, Morgan B, Dennerlein S, Shah AM, El-Armouche A, Nikolaev VO, Katschinski DM.

Circ Res. 2016 Oct 14;119(9):1004-1016. Epub 2016 Aug 23.

PMID:
27553648
34.

Cyclic Nucleotide Control of Microtubule Dynamics for Axon Guidance.

Akiyama H, Fukuda T, Tojima T, Nikolaev VO, Kamiguchi H.

J Neurosci. 2016 May 18;36(20):5636-49. doi: 10.1523/JNEUROSCI.3596-15.2016.

35.

Endothelial Actions of ANP Enhance Myocardial Inflammatory Infiltration in the Early Phase After Acute Infarction.

Chen W, Spitzl A, Mathes D, Nikolaev VO, Werner F, Weirather J, Špiranec K, Röck K, Fischer JW, Kämmerer U, Stegner D, Baba HA, Hofmann U, Frantz S, Kuhn M.

Circ Res. 2016 Jul 8;119(2):237-48. doi: 10.1161/CIRCRESAHA.115.307196. Epub 2016 May 3.

PMID:
27142162
36.

Structure of smAKAP and its regulation by PKA-mediated phosphorylation.

Burgers PP, Bruystens J, Burnley RJ, Nikolaev VO, Keshwani M, Wu J, Janssen BJ, Taylor SS, Heck AJ, Scholten A.

FEBS J. 2016 Jun;283(11):2132-48. doi: 10.1111/febs.13726. Epub 2016 May 6.

37.

POPDC1(S201F) causes muscular dystrophy and arrhythmia by affecting protein trafficking.

Schindler RF, Scotton C, Zhang J, Passarelli C, Ortiz-Bonnin B, Simrick S, Schwerte T, Poon KL, Fang M, Rinné S, Froese A, Nikolaev VO, Grunert C, Müller T, Tasca G, Sarathchandra P, Drago F, Dallapiccola B, Rapezzi C, Arbustini E, Di Raimo FR, Neri M, Selvatici R, Gualandi F, Fattori F, Pietrangelo A, Li W, Jiang H, Xu X, Bertini E, Decher N, Wang J, Brand T, Ferlini A.

J Clin Invest. 2016 Jan;126(1):239-53. doi: 10.1172/JCI79562. Epub 2015 Dec 7.

38.

GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation.

Shigeto M, Ramracheya R, Tarasov AI, Cha CY, Chibalina MV, Hastoy B, Philippaert K, Reinbothe T, Rorsman N, Salehi A, Sones WR, Vergari E, Weston C, Gorelik J, Katsura M, Nikolaev VO, Vennekens R, Zaccolo M, Galione A, Johnson PR, Kaku K, Ladds G, Rorsman P.

J Clin Invest. 2015 Dec;125(12):4714-28. doi: 10.1172/JCI81975. Epub 2015 Nov 16.

39.

Imaging alterations of cardiomyocyte cAMP microdomains in disease.

Froese A, Nikolaev VO.

Front Pharmacol. 2015 Aug 25;6:172. doi: 10.3389/fphar.2015.00172. eCollection 2015. Review.

40.

Sildenafil Does Not Prevent Heart Hypertrophy and Fibrosis Induced by Cardiomyocyte Angiotensin II Type 1 Receptor Signaling.

Straubinger J, Schöttle V, Bork N, Subramanian H, Dünnes S, Russwurm M, Gawaz M, Friebe A, Nemer M, Nikolaev VO, Lukowski R.

J Pharmacol Exp Ther. 2015 Sep;354(3):406-16. doi: 10.1124/jpet.115.226092. Epub 2015 Jul 8.

PMID:
26157043
41.

Late INa increases diastolic SR-Ca2+-leak in atrial myocardium by activating PKA and CaMKII.

Fischer TH, Herting J, Mason FE, Hartmann N, Watanabe S, Nikolaev VO, Sprenger JU, Fan P, Yao L, Popov AF, Danner BC, Schöndube F, Belardinelli L, Hasenfuss G, Maier LS, Sossalla S.

Cardiovasc Res. 2015 Jul 1;107(1):184-96. doi: 10.1093/cvr/cvv153. Epub 2015 May 18.

42.

Adenylyl cyclases 5 and 6 underlie PIP3-dependent regulation.

Reddy GR, Subramanian H, Birk A, Milde M, Nikolaev VO, Bünemann M.

FASEB J. 2015 Aug;29(8):3458-71. doi: 10.1096/fj.14-268466. Epub 2015 Apr 30.

43.

In vivo model with targeted cAMP biosensor reveals changes in receptor-microdomain communication in cardiac disease.

Sprenger JU, Perera RK, Steinbrecher JH, Lehnart SE, Maier LS, Hasenfuss G, Nikolaev VO.

Nat Commun. 2015 Apr 28;6:6965. doi: 10.1038/ncomms7965.

PMID:
25917898
44.

Generation of transgenic mice expressing FRET biosensors.

Hübscher D, Nikolaev VO.

Methods Mol Biol. 2015;1294:117-29. doi: 10.1007/978-1-4939-2537-7_9.

PMID:
25783881
45.

Intercellular signaling via cyclic GMP diffusion through gap junctions restarts meiosis in mouse ovarian follicles.

Shuhaibar LC, Egbert JR, Norris RP, Lampe PD, Nikolaev VO, Thunemann M, Wen L, Feil R, Jaffe LA.

Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5527-32. doi: 10.1073/pnas.1423598112. Epub 2015 Mar 16.

46.

Novel receptor-derived cyclopeptides to treat heart failure caused by anti-β1-adrenoceptor antibodies in a human-analogous rat model.

Boivin V, Beyersdorf N, Palm D, Nikolaev VO, Schlipp A, Müller J, Schmidt D, Kocoski V, Kerkau T, Hünig T, Ertl G, Lohse MJ, Jahns R.

PLoS One. 2015 Feb 20;10(2):e0117589. doi: 10.1371/journal.pone.0117589. eCollection 2015.

47.

Microdomain switch of cGMP-regulated phosphodiesterases leads to ANP-induced augmentation of β-adrenoceptor-stimulated contractility in early cardiac hypertrophy.

Perera RK, Sprenger JU, Steinbrecher JH, Hübscher D, Lehnart SE, Abesser M, Schuh K, El-Armouche A, Nikolaev VO.

Circ Res. 2015 Apr 10;116(8):1304-11. doi: 10.1161/CIRCRESAHA.116.306082. Epub 2015 Feb 16.

PMID:
25688144
48.

Functional non-nucleoside adenylyl cyclase inhibitors.

Lelle M, Hameed A, Ackermann LM, Kaloyanova S, Wagner M, Berisha F, Nikolaev VO, Peneva K.

Chem Biol Drug Des. 2015 May;85(5):633-7. doi: 10.1111/cbdd.12452. Epub 2014 Nov 6.

PMID:
25319071
49.

Atrial natriuretic peptide locally counteracts the deleterious effects of cardiomyocyte mineralocorticoid receptor activation.

Nakagawa H, Oberwinkler H, Nikolaev VO, Gaßner B, Umbenhauer S, Wagner H, Saito Y, Baba HA, Frantz S, Kuhn M.

Circ Heart Fail. 2014 Sep;7(5):814-21. doi: 10.1161/CIRCHEARTFAILURE.113.000885. Epub 2014 Jul 15.

PMID:
25027872
50.

Tubulin polymerization disrupts cardiac β-adrenergic regulation of late INa.

Dybkova N, Wagner S, Backs J, Hund TJ, Mohler PJ, Sowa T, Nikolaev VO, Maier LS.

Cardiovasc Res. 2014 Jul 1;103(1):168-77. doi: 10.1093/cvr/cvu120. Epub 2014 May 8.

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