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Items: 1 to 50 of 135

1.

Arterial reconstruction with human bioengineered acellular blood vessels in patients with peripheral arterial disease.

Gutowski P, Gage SM, Guziewicz M, Ilzecki M, Kazimierczak A, Kirkton R, Niklason LE, Pilgrim A, Prichard HL, Przywara S, Samad R, Tente B, Turek J, Witkiewicz W, Zapotoczny N, Zubilewicz T, Lawson JH.

J Vasc Surg. 2020 Feb 21. pii: S0741-5214(19)32905-2. doi: 10.1016/j.jvs.2019.11.056. [Epub ahead of print]

PMID:
32093913
2.

Tissue-Engineered Vascular Grafts with Advanced Mechanical Strength from Human iPSCs.

Luo J, Qin L, Zhao L, Gui L, Ellis MW, Huang Y, Kural MH, Clark JA, Ono S, Wang J, Yuan Y, Zhang SM, Cong X, Li G, Riaz M, Lopez C, Hotta A, Campbell S, Tellides G, Dardik A, Niklason LE, Qyang Y.

Cell Stem Cell. 2020 Feb 6;26(2):251-261.e8. doi: 10.1016/j.stem.2019.12.012. Epub 2020 Jan 16.

PMID:
31956039
3.

Single-cell connectomic analysis of adult mammalian lungs.

Raredon MSB, Adams TS, Suhail Y, Schupp JC, Poli S, Neumark N, Leiby KL, Greaney AM, Yuan Y, Horien C, Linderman G, Engler AJ, Boffa DJ, Kluger Y, Rosas IO, Levchenko A, Kaminski N, Niklason LE.

Sci Adv. 2019 Dec 4;5(12):eaaw3851. doi: 10.1126/sciadv.aaw3851. eCollection 2019 Dec.

4.

Microvessel Network Formation and Interactions with Pancreatic Islets in Three-Dimensional Chip Cultures.

Rambøl MH, Han E, Niklason LE.

Tissue Eng Part A. 2020 Jan 20. doi: 10.1089/ten.TEA.2019.0186. [Epub ahead of print]

PMID:
31724494
5.

Reduced patency in left-sided arteriovenous grafts in a porcine model.

Liu S, Wang T, Wang J, Isaji T, Ono S, Fereydooni A, Taniguchi R, Matsubara Y, Niklason LE, Dardik A.

J Vasc Surg. 2019 Nov 4. pii: S0741-5214(19)32318-3. doi: 10.1016/j.jvs.2019.06.221. [Epub ahead of print]

PMID:
31699515
6.

Engineering of human brain organoids with a functional vascular-like system.

Cakir B, Xiang Y, Tanaka Y, Kural MH, Parent M, Kang YJ, Chapeton K, Patterson B, Yuan Y, He CS, Raredon MSB, Dengelegi J, Kim KY, Sun P, Zhong M, Lee S, Patra P, Hyder F, Niklason LE, Lee SH, Yoon YS, Park IH.

Nat Methods. 2019 Nov;16(11):1169-1175. doi: 10.1038/s41592-019-0586-5. Epub 2019 Oct 7.

PMID:
31591580
7.

Utilization of Natural Detergent Potassium Laurate for Decellularization in Lung Bioengineering.

Obata T, Tsuchiya T, Akita S, Kawahara T, Matsumoto K, Miyazaki T, Masumoto H, Kobayashi E, Niklason LE, Nagayasu T.

Tissue Eng Part C Methods. 2019 Aug;25(8):459-471. doi: 10.1089/ten.TEC.2019.0016.

PMID:
31317819
8.

Non-invasive and real-time measurement of microvascular barrier in intact lungs.

Engler AJ, Raredon MSB, Le AV, Yuan Y, Oczkowicz YA, Kan EL, Baevova P, Niklason LE.

Biomaterials. 2019 Oct;217:119313. doi: 10.1016/j.biomaterials.2019.119313. Epub 2019 Jun 30.

PMID:
31280072
9.

Fas ligand and nitric oxide combination to control smooth muscle growth while sparing endothelium.

Kural MH, Wang J, Gui L, Yuan Y, Li G, Leiby KL, Quijano E, Tellides G, Saltzman WM, Niklason LE.

Biomaterials. 2019 Aug;212:28-38. doi: 10.1016/j.biomaterials.2019.05.011. Epub 2019 May 7.

PMID:
31102854
10.

Bioengineered human acellular vessels recellularize and evolve into living blood vessels after human implantation.

Kirkton RD, Santiago-Maysonet M, Lawson JH, Tente WE, Dahl SLM, Niklason LE, Prichard HL.

Sci Transl Med. 2019 Mar 27;11(485). pii: eaau6934. doi: 10.1126/scitranslmed.aau6934.

PMID:
30918113
11.

Epac agonist improves barrier function in iPSC-derived endothelial colony forming cells for whole organ tissue engineering.

Yuan Y, Engler AJ, Raredon MS, Le A, Baevova P, Yoder MC, Niklason LE.

Biomaterials. 2019 Apr;200:25-34. doi: 10.1016/j.biomaterials.2019.02.005. Epub 2019 Feb 7.

PMID:
30754017
12.

An Ex Vivo Vessel Injury Model to Study Remodeling.

Kural MH, Dai G, Niklason LE, Gui L.

Cell Transplant. 2018 Sep;27(9):1375-1389. doi: 10.1177/0963689718792201. Epub 2018 Aug 10.

13.

Vascularization of Natural and Synthetic Bone Scaffolds.

Liu X, Jakus AE, Kural M, Qian H, Engler A, Ghaedi M, Shah R, Steinbacher DM, Niklason LE.

Cell Transplant. 2018 Aug;27(8):1269-1280. doi: 10.1177/0963689718782452. Epub 2018 Jul 16.

14.

Flow Preservation of Umbilical Vein for Autologous Shunt and Cardiovascular Reconstruction.

Hoganson DM, Cooper DA, Rich KN, Piekarski BL, Gui L, Gaut JP, Mayer JE, Aikawa E, Niklason LE, Emani SM.

Ann Thorac Surg. 2018 Jun;105(6):1809-1818. doi: 10.1016/j.athoracsur.2018.01.076. Epub 2018 Mar 3.

15.

Understanding the Extracellular Matrix to Enhance Stem Cell-Based Tissue Regeneration.

Niklason LE.

Cell Stem Cell. 2018 Mar 1;22(3):302-305. doi: 10.1016/j.stem.2018.02.001. Review.

16.

Neuropilin-1 Mediated Arterial Differentiation of Murine Pluripotent Stem Cells.

Kim D, Lee V, Dorsey TB, Niklason LE, Gui L, Dai G.

Stem Cells Dev. 2018 Apr 1;27(7):441-455. doi: 10.1089/scd.2017.0240. Epub 2018 Mar 13.

17.

Susceptibility of ePTFE vascular grafts and bioengineered human acellular vessels to infection.

Kirkton RD, Prichard HL, Santiago-Maysonet M, Niklason LE, Lawson JH, Dahl SLM.

J Surg Res. 2018 Jan;221:143-151. doi: 10.1016/j.jss.2017.08.035. Epub 2017 Sep 19.

18.

A short discourse on vascular tissue engineering.

Chang WG, Niklason LE.

NPJ Regen Med. 2017;2. pii: 7. doi: 10.1038/s41536-017-0011-6. Epub 2017 Mar 27.

19.

Bioengineered lungs generated from human iPSCs-derived epithelial cells on native extracellular matrix.

Ghaedi M, Le AV, Hatachi G, Beloiartsev A, Rocco K, Sivarapatna A, Mendez JJ, Baevova P, Dyal RN, Leiby KL, White ES, Niklason LE.

J Tissue Eng Regen Med. 2018 Mar;12(3):e1623-e1635. doi: 10.1002/term.2589. Epub 2017 Nov 28.

20.

Vascular smooth muscle cells derived from inbred swine induced pluripotent stem cells for vascular tissue engineering.

Luo J, Qin L, Kural MH, Schwan J, Li X, Bartulos O, Cong XQ, Ren Y, Gui L, Li G, Ellis MW, Li P, Kotton DN, Dardik A, Pober JS, Tellides G, Rolle M, Campbell S, Hawley RJ, Sachs DH, Niklason LE, Qyang Y.

Biomaterials. 2017 Dec;147:116-132. doi: 10.1016/j.biomaterials.2017.09.019. Epub 2017 Sep 19.

21.

Engineered Microvasculature in PDMS Networks Using Endothelial Cells Derived from Human Induced Pluripotent Stem Cells.

Sivarapatna A, Ghaedi M, Xiao Y, Han E, Aryal B, Zhou J, Fernandez-Hernando C, Qyang Y, Hirschi KK, Niklason LE.

Cell Transplant. 2017 Aug;26(8):1365-1379. doi: 10.1177/0963689717720282.

22.

Transplantation of bioengineered rat lungs recellularized with endothelial and adipose-derived stromal cells.

Doi R, Tsuchiya T, Mitsutake N, Nishimura S, Matsuu-Matsuyama M, Nakazawa Y, Ogi T, Akita S, Yukawa H, Baba Y, Yamasaki N, Matsumoto K, Miyazaki T, Kamohara R, Hatachi G, Sengyoku H, Watanabe H, Obata T, Niklason LE, Nagayasu T.

Sci Rep. 2017 Aug 16;7(1):8447. doi: 10.1038/s41598-017-09115-2.

23.

Improving in vivo outcomes of decellularized vascular grafts via incorporation of a novel extracellular matrix.

Kristofik NJ, Qin L, Calabro NE, Dimitrievska S, Li G, Tellides G, Niklason LE, Kyriakides TR.

Biomaterials. 2017 Oct;141:63-73. doi: 10.1016/j.biomaterials.2017.06.025. Epub 2017 Jun 22.

24.

Historical Perspective and Future Direction of Blood Vessel Developments.

Dimitrievska S, Niklason LE.

Cold Spring Harb Perspect Med. 2018 Feb 1;8(2). pii: a025742. doi: 10.1101/cshperspect.a025742. Review.

25.

Controlled gas exchange in whole lung bioreactors.

Engler AJ, Le AV, Baevova P, Niklason LE.

J Tissue Eng Regen Med. 2018 Jan;12(1):e119-e129. doi: 10.1002/term.2408. Epub 2017 Jun 15.

26.

Lung regeneration: steps toward clinical implementation and use.

Calle EA, Leiby KL, Raredon MB, Niklason LE.

Curr Opin Anaesthesiol. 2017 Feb;30(1):23-29. doi: 10.1097/ACO.0000000000000425. Review.

27.

Targeted proteomics effectively quantifies differences between native lung and detergent-decellularized lung extracellular matrices.

Calle EA, Hill RC, Leiby KL, Le AV, Gard AL, Madri JA, Hansen KC, Niklason LE.

Acta Biomater. 2016 Dec;46:91-100. doi: 10.1016/j.actbio.2016.09.043. Epub 2016 Sep 29.

28.

Human Pluripotent Stem Cells (iPSC) Generation, Culture, and Differentiation to Lung Progenitor Cells.

Ghaedi M, Niklason LE.

Methods Mol Biol. 2019;1576:55-92. doi: 10.1007/7651_2016_11.

29.

Engineered Tissue-Stent Biocomposites as Tracheal Replacements.

Zhao L, Sundaram S, Le AV, Huang AH, Zhang J, Hatachi G, Beloiartsev A, Caty MG, Yi T, Leiby K, Gard A, Kural MH, Gui L, Rocco KA, Sivarapatna A, Calle E, Greaney A, Urbani L, Maghsoudlou P, Burns A, DeCoppi P, Niklason LE.

Tissue Eng Part A. 2016 Sep;22(17-18):1086-97. doi: 10.1089/ten.TEA.2016.0132.

30.

Impaired von Willebrand factor adhesion and platelet response in thrombospondin-2 knockout mice.

Kristofik N, Calabro NE, Tian W, Meng A, MacLauchlan S, Wang Y, Breuer CK, Tellides G, Niklason LE, Kyriakides TR.

Blood. 2016 Sep 22;128(12):1642-50. doi: 10.1182/blood-2016-03-702845. Epub 2016 Jul 28.

31.

New Functional Tools for Antithrombogenic Activity Assessment of Live Surface Glycocalyx.

Dimitrievska S, Gui L, Weyers A, Lin T, Cai C, Wu W, Tuggle CT, Sundaram S, Balestrini JL, Slattery D, Tchouta L, Kyriakides TR, Tarbell JM, Linhardt RJ, Niklason LE.

Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1847-53. doi: 10.1161/ATVBAHA.116.308023. Epub 2016 Jul 7.

32.

Comparative biology of decellularized lung matrix: Implications of species mismatch in regenerative medicine.

Balestrini JL, Gard AL, Gerhold KA, Wilcox EC, Liu A, Schwan J, Le AV, Baevova P, Dimitrievska S, Zhao L, Sundaram S, Sun H, Rittié L, Dyal R, Broekelmann TJ, Mecham RP, Schwartz MA, Niklason LE, White ES.

Biomaterials. 2016 Sep;102:220-30. doi: 10.1016/j.biomaterials.2016.06.025. Epub 2016 Jun 16.

33.

Implantable tissue-engineered blood vessels from human induced pluripotent stem cells.

Gui L, Dash BC, Luo J, Qin L, Zhao L, Yamamoto K, Hashimoto T, Wu H, Dardik A, Tellides G, Niklason LE, Qyang Y.

Biomaterials. 2016 Sep;102:120-9. doi: 10.1016/j.biomaterials.2016.06.010. Epub 2016 Jun 14.

34.

Bioengineered human acellular vessels for dialysis access in patients with end-stage renal disease: two phase 2 single-arm trials.

Lawson JH, Glickman MH, Ilzecki M, Jakimowicz T, Jaroszynski A, Peden EK, Pilgrim AJ, Prichard HL, Guziewicz M, Przywara S, Szmidt J, Turek J, Witkiewicz W, Zapotoczny N, Zubilewicz T, Niklason LE.

Lancet. 2016 May 14;387(10032):2026-34. doi: 10.1016/S0140-6736(16)00557-2.

35.

Ventilation-Based Decellularization System of the Lung.

Tsuchiya T, Mendez J, Calle EA, Hatachi G, Doi R, Zhao L, Suematsu T, Nagayasu T, Niklason LE.

Biores Open Access. 2016 May 1;5(1):118-26. doi: 10.1089/biores.2016.0012. eCollection 2016.

36.

Biaxial Stretch Improves Elastic Fiber Maturation, Collagen Arrangement, and Mechanical Properties in Engineered Arteries.

Huang AH, Balestrini JL, Udelsman BV, Zhou KC, Zhao L, Ferruzzi J, Starcher BC, Levene MJ, Humphrey JD, Niklason LE.

Tissue Eng Part C Methods. 2016 Jun;22(6):524-33. doi: 10.1089/ten.TEC.2015.0309.

37.

Biomimetic Culture Reactor for Whole-Lung Engineering.

Raredon MS, Rocco KA, Gheorghe CP, Sivarapatna A, Ghaedi M, Balestrini JL, Raredon TL, Calle EA, Niklason LE.

Biores Open Access. 2016 Apr 1;5(1):72-83. doi: 10.1089/biores.2016.0006. eCollection 2016.

38.

A Rotating Bioreactor for Scalable Culture and Differentiation of Respiratory Epithelium.

Raredon MS, Ghaedi M, Calle EA, Niklason LE.

Cell Med. 2014 Dec 12;7(3):109-21. doi: 10.3727/215517914X681794. eCollection 2015 Oct 1.

39.

Netrin-1 Regulates Fibrocyte Accumulation in the Decellularized Fibrotic Sclerodermatous Lung Microenvironment and in Bleomycin-Induced Pulmonary Fibrosis.

Sun H, Zhu Y, Pan H, Chen X, Balestrini JL, Lam TT, Kanyo JE, Eichmann A, Gulati M, Fares WH, Bai H, Feghali-Bostwick CA, Gan Y, Peng X, Moore MW, White ES, Sava P, Gonzalez AL, Cheng Y, Niklason LE, Herzog EL.

Arthritis Rheumatol. 2016 May;68(5):1251-61. doi: 10.1002/art.39575.

40.

Sterilization of Lung Matrices by Supercritical Carbon Dioxide.

Balestrini JL, Liu A, Gard AL, Huie J, Blatt KM, Schwan J, Zhao L, Broekelmann TJ, Mecham RP, Wilcox EC, Niklason LE.

Tissue Eng Part C Methods. 2016 Mar;22(3):260-9. doi: 10.1089/ten.TEC.2015.0449. Epub 2016 Jan 29.

41.

Production of decellularized porcine lung scaffolds for use in tissue engineering.

Balestrini JL, Gard AL, Liu A, Leiby KL, Schwan J, Kunkemoeller B, Calle EA, Sivarapatna A, Lin T, Dimitrievska S, Cambpell SG, Niklason LE.

Integr Biol (Camb). 2015 Dec;7(12):1598-610. doi: 10.1039/c5ib00063g. Epub 2015 Oct 1.

42.

Tissue-Engineered Microvasculature to Reperfuse Isolated Renal Glomeruli.

Chang WG, Fornoni A, Tietjen G, Mendez JJ, Niklason LE, Saltzman WM, Pober JS.

Tissue Eng Part A. 2015 Nov;21(21-22):2673-9. doi: 10.1089/ten.TEA.2015.0060. Epub 2015 Oct 1.

43.

Bmk-1 regulates lifespan in Caenorhabditis elegans by activating hsp-16.

Qian H, Xu X, Niklason LE.

Oncotarget. 2015 Aug 7;6(22):18790-9.

44.

Development of Lung Epithelium from Induced Pluripotent Stem Cells.

Ghaedi M, Niklason LE, Williams J.

Curr Transplant Rep. 2015 Mar 1;2(1):81-89.

45.

Tissue Transglutaminase, Not Lysyl Oxidase, Dominates Early Calcium-Dependent Remodeling of Fibroblast-Populated Collagen Lattices.

Simon DD, Niklason LE, Humphrey JD.

Cells Tissues Organs. 2014;200(2):104-17. doi: 10.1159/000381015. Epub 2015 Apr 22.

46.

Arterial specification of endothelial cells derived from human induced pluripotent stem cells in a biomimetic flow bioreactor.

Sivarapatna A, Ghaedi M, Le AV, Mendez JJ, Qyang Y, Niklason LE.

Biomaterials. 2015;53:621-33. doi: 10.1016/j.biomaterials.2015.02.121. Epub 2015 Mar 24.

47.

Fate of distal lung epithelium cultured in a decellularized lung extracellular matrix.

Calle EA, Mendez JJ, Ghaedi M, Leiby KL, Bove PF, Herzog EL, Sundaram S, Niklason LE.

Tissue Eng Part A. 2015 Jun;21(11-12):1916-28. doi: 10.1089/ten.TEA.2014.0511. Epub 2015 May 4.

48.

Design and Use of a Novel Bioreactor for Regeneration of Biaxially Stretched Tissue-Engineered Vessels.

Huang AH, Lee YU, Calle EA, Boyle M, Starcher BC, Humphrey JD, Niklason LE.

Tissue Eng Part C Methods. 2015 Aug;21(8):841-51. doi: 10.1089/ten.TEC.2014.0287. Epub 2015 Mar 20.

49.

Osteogenic performance of donor-matched human adipose and bone marrow mesenchymal cells under dynamic culture.

Wu W, Le AV, Mendez JJ, Chang J, Niklason LE, Steinbacher DM.

Tissue Eng Part A. 2015 May;21(9-10):1621-32. doi: 10.1089/ten.TEA.2014.0115.

50.

Quantification of extracellular matrix proteins from a rat lung scaffold to provide a molecular readout for tissue engineering.

Hill RC, Calle EA, Dzieciatkowska M, Niklason LE, Hansen KC.

Mol Cell Proteomics. 2015 Apr;14(4):961-73. doi: 10.1074/mcp.M114.045260. Epub 2015 Feb 8.

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