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Items: 48

1.

KLF9-dependent ROS regulate melanoma progression in stage-specific manner.

Bagati A, Moparthy S, Fink EE, Bianchi-Smiraglia A, Yun DH, Kolesnikova M, Udartseva OO, Wolff DW, Roll MV, Lipchick BC, Han Z, Kozlova NI, Jowdy P, Berman AE, Box NF, Rodriguez C, Bshara W, Kandel ES, Soengas MS, Paragh G, Nikiforov MA.

Oncogene. 2019 May;38(19):3585-3597. doi: 10.1038/s41388-019-0689-6. Epub 2019 Jan 21.

PMID:
30664687
2.

XBP1-KLF9 Axis Acts as a Molecular Rheostat to Control the Transition from Adaptive to Cytotoxic Unfolded Protein Response.

Fink EE, Moparthy S, Bagati A, Bianchi-Smiraglia A, Lipchick BC, Wolff DW, Roll MV, Wang J, Liu S, Bakin AV, Kandel ES, Lee AH, Nikiforov MA.

Cell Rep. 2018 Oct 2;25(1):212-223.e4. doi: 10.1016/j.celrep.2018.09.013.

3.

Inhibition of the aryl hydrocarbon receptor/polyamine biosynthesis axis suppresses multiple myeloma.

Bianchi-Smiraglia A, Bagati A, Fink EE, Affronti HC, Lipchick BC, Moparthy S, Long MD, Rosario SR, Lightman SM, Moparthy K, Wolff DW, Yun DH, Han Z, Polechetti A, Roll MV, Gitlin II, Leonova KI, Rowsam AM, Kandel ES, Gudkov AV, Bergsagel PL, Lee KP, Smiraglia DJ, Nikiforov MA.

J Clin Invest. 2018 Oct 1;128(10):4682-4696. doi: 10.1172/JCI70712. Epub 2018 Sep 10.

4.

FOXQ1 controls the induced differentiation of melanocytic cells.

Bagati A, Bianchi-Smiraglia A, Moparthy S, Kolesnikova K, Fink EE, Kolesnikova M, Roll MV, Jowdy P, Wolff DW, Polechetti A, Yun DH, Lipchick BC, Paul LM, Wrazen B, Moparthy K, Mudambi S, Morozevich GE, Georgieva SG, Wang J, Shafirstein G, Liu S, Kandel ES, Berman AE, Box NF, Paragh G, Nikiforov MA.

Cell Death Differ. 2018 Jun;25(6):1040-1049. doi: 10.1038/s41418-018-0066-y. Epub 2018 Feb 20.

5.

Melanoma Suppressor Functions of the Carcinoma Oncogene FOXQ1.

Bagati A, Bianchi-Smiraglia A, Moparthy S, Kolesnikova K, Fink EE, Lipchick BC, Kolesnikova M, Jowdy P, Polechetti A, Mahpour A, Ross J, Wawrzyniak JA, Yun DH, Paragh G, Kozlova NI, Berman AE, Wang J, Liu S, Nemeth MJ, Nikiforov MA.

Cell Rep. 2017 Sep 19;20(12):2820-2832. doi: 10.1016/j.celrep.2017.08.057.

6.

Internally ratiometric fluorescent sensors for evaluation of intracellular GTP levels and distribution.

Bianchi-Smiraglia A, Rana MS, Foley CE, Paul LM, Lipchick BC, Moparthy S, Moparthy K, Fink EE, Bagati A, Hurley E, Affronti HC, Bakin AV, Kandel ES, Smiraglia DJ, Feltri ML, Sousa R, Nikiforov MA.

Nat Methods. 2017 Oct;14(10):1003-1009. doi: 10.1038/nmeth.4404. Epub 2017 Sep 4.

7.

Detection of Nucleotide Disbalance in Cells Undergoing Oncogene-Induced Senescence.

Nikiforov MA, Shewach DS.

Methods Mol Biol. 2017;1534:165-173.

8.

The Immortal Senescence.

Bianchi-Smiraglia A, Lipchick BC, Nikiforov MA.

Methods Mol Biol. 2017;1534:1-15. Review.

9.

Microphthalmia-associated transcription factor suppresses invasion by reducing intracellular GTP pools.

Bianchi-Smiraglia A, Bagati A, Fink EE, Moparthy S, Wawrzyniak JA, Marvin EK, Battaglia S, Jowdy P, Kolesnikova M, Foley CE, Berman AE, Kozlova NI, Lipchick BC, Paul-Rosner LM, Bshara W, Ackroyd JJ, Shewach DS, Nikiforov MA.

Oncogene. 2017 Jan 5;36(1):84-96. doi: 10.1038/onc.2016.178. Epub 2016 May 16.

10.

Slowing down the Grand Touring Prototype speed of cancer cells.

Bianchi-Smiraglia A, Nikiforov MA.

Mol Cell Oncol. 2016 Jan 2;3(1). pii: e1052181. Epub 2015 Jun 10.

11.

Oxidative stress and proteasome inhibitors in multiple myeloma.

Lipchick BC, Fink EE, Nikiforov MA.

Pharmacol Res. 2016 Mar;105:210-5. doi: 10.1016/j.phrs.2016.01.029. Epub 2016 Jan 29. Review.

12.

Mitochondrial thioredoxin reductase regulates major cytotoxicity pathways of proteasome inhibitors in multiple myeloma cells.

Fink EE, Mannava S, Bagati A, Bianchi-Smiraglia A, Nair JR, Moparthy K, Lipchick BC, Drokov M, Utley A, Ross J, Mendeleeva LP, Savchenko VG, Lee KP, Nikiforov MA.

Leukemia. 2016 Jan;30(1):104-11. doi: 10.1038/leu.2015.190. Epub 2015 Jul 24.

13.

Pharmacological targeting of guanosine monophosphate synthase suppresses melanoma cell invasion and tumorigenicity.

Bianchi-Smiraglia A, Wawrzyniak JA, Bagati A, Marvin EK, Ackroyd J, Moparthy S, Bshara W, Fink EE, Foley CE, Morozevich GE, Berman AE, Shewach DS, Nikiforov MA.

Cell Death Differ. 2015 Nov;22(11):1858-64. doi: 10.1038/cdd.2015.47. Epub 2015 Apr 24.

14.

Nrf2 amplifies oxidative stress via induction of Klf9.

Zucker SN, Fink EE, Bagati A, Mannava S, Bianchi-Smiraglia A, Bogner PN, Wawrzyniak JA, Foley C, Leonova KI, Grimm MJ, Moparthy K, Ionov Y, Wang J, Liu S, Sexton S, Kandel ES, Bakin AV, Zhang Y, Kaminski N, Segal BH, Nikiforov MA.

Mol Cell. 2014 Mar 20;53(6):916-928. doi: 10.1016/j.molcel.2014.01.033. Epub 2014 Mar 6.

15.

A purine nucleotide biosynthesis enzyme guanosine monophosphate reductase is a suppressor of melanoma invasion.

Wawrzyniak JA, Bianchi-Smiraglia A, Bshara W, Mannava S, Ackroyd J, Bagati A, Omilian AR, Im M, Fedtsova N, Miecznikowski JC, Moparthy KC, Zucker SN, Zhu Q, Kozlova NI, Berman AE, Hoek KS, Gudkov AV, Shewach DS, Morrison CD, Nikiforov MA.

Cell Rep. 2013 Oct 31;5(2):493-507. doi: 10.1016/j.celrep.2013.09.015. Epub 2013 Oct 17.

16.

Cell-based methods for the identification of MYC-inhibitory small molecules.

Burkhart CA, Haber M, Norris MD, Gudkov AV, Nikiforov MA.

Methods Mol Biol. 2013;1012:255-64. doi: 10.1007/978-1-62703-429-6_18.

17.

Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes.

Berman AE, Leontieva OV, Natarajan V, McCubrey JA, Demidenko ZN, Nikiforov MA.

Oncotarget. 2012 Dec;3(12):1522-32. Review.

18.

Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C-MYC depletion.

Mannava S, Moparthy KC, Wheeler LJ, Leonova KI, Wawrzyniak JA, Bianchi-Smiraglia A, Berman AE, Flanagan S, Shewach DS, Zeitouni NC, Gudkov AV, Mathews CK, Nikiforov MA.

Aging (Albany NY). 2012 Dec;4(12):917-22.

19.

Depletion of deoxyribonucleotide pools is an endogenous source of DNA damage in cells undergoing oncogene-induced senescence.

Mannava S, Moparthy KC, Wheeler LJ, Natarajan V, Zucker SN, Fink EE, Im M, Flanagan S, Burhans WC, Zeitouni NC, Shewach DS, Mathews CK, Nikiforov MA.

Am J Pathol. 2013 Jan;182(1):142-51. doi: 10.1016/j.ajpath.2012.09.011. Epub 2012 Dec 12.

20.

Controversial aspects of oncogene-induced senescence.

Bianchi-Smiraglia A, Nikiforov MA.

Cell Cycle. 2012 Nov 15;11(22):4147-51. doi: 10.4161/cc.22589. Epub 2012 Oct 24. Review.

21.

Short hairpin RNA suppression of thymidylate synthase produces DNA mismatches and results in excellent radiosensitization.

Flanagan SA, Cooper KS, Mannava S, Nikiforov MA, Shewach DS.

Int J Radiat Oncol Biol Phys. 2012 Dec 1;84(5):e613-20. doi: 10.1016/j.ijrobp.2012.06.050. Epub 2012 Aug 3.

22.

Krüppel-like factor 9 and progesterone receptor coregulation of decidualizing endometrial stromal cells: implications for the pathogenesis of endometriosis.

Pabona JM, Simmen FA, Nikiforov MA, Zhuang D, Shankar K, Velarde MC, Zelenko Z, Giudice LC, Simmen RC.

J Clin Endocrinol Metab. 2012 Mar;97(3):E376-92. doi: 10.1210/jc.2011-2562. Epub 2012 Jan 18.

23.

KLF9 is a novel transcriptional regulator of bortezomib- and LBH589-induced apoptosis in multiple myeloma cells.

Mannava S, Zhuang D, Nair JR, Bansal R, Wawrzyniak JA, Zucker SN, Fink EE, Moparthy KC, Hu Q, Liu S, Boise LH, Lee KP, Nikiforov MA.

Blood. 2012 Feb 9;119(6):1450-8. doi: 10.1182/blood-2011-04-346676. Epub 2011 Dec 5.

24.

PP2A-B56α controls oncogene-induced senescence in normal and tumor human melanocytic cells.

Mannava S, Omilian AR, Wawrzyniak JA, Fink EE, Zhuang D, Miecznikowski JC, Marshall JR, Soengas MS, Sears RC, Morrison CD, Nikiforov MA.

Oncogene. 2012 Mar 22;31(12):1484-92. doi: 10.1038/onc.2011.339. Epub 2011 Aug 8.

25.

Transcriptional Regulation of CRD-BP by c-myc: Implications for c-myc Functions.

Noubissi FK, Nikiforov MA, Colburn N, Spiegelman VS.

Genes Cancer. 2010 Oct;1(10):1074-82. doi: 10.1177/1947601910395581.

26.

Pathways of oncogene-induced senescence in human melanocytic cells.

Bansal R, Nikiforov MA.

Cell Cycle. 2010 Jul 15;9(14):2782-8. Epub 2010 Jul 3. Review. No abstract available.

27.

C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cells.

Zhuang D, Mannava S, Grachtchouk V, Tang WH, Patil S, Wawrzyniak JA, Berman AE, Giordano TJ, Prochownik EV, Soengas MS, Nikiforov MA.

Oncogene. 2008 Nov 6;27(52):6623-34. doi: 10.1038/onc.2008.258. Epub 2008 Aug 4.

28.

Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells.

Mannava S, Grachtchouk V, Wheeler LJ, Im M, Zhuang D, Slavina EG, Mathews CK, Shewach DS, Nikiforov MA.

Cell Cycle. 2008 Aug;7(15):2392-400. Epub 2008 Jun 3.

29.

MLH1 deficiency enhances radiosensitization with 5-fluorodeoxyuridine by increasing DNA mismatches.

Flanagan SA, Krokosky CM, Mannava S, Nikiforov MA, Shewach DS.

Mol Pharmacol. 2008 Sep;74(3):863-71. doi: 10.1124/mol.107.043349. Epub 2008 Jun 5.

30.

Tumor cell-selective regulation of NOXA by c-MYC in response to proteasome inhibition.

Nikiforov MA, Riblett M, Tang WH, Gratchouck V, Zhuang D, Fernandez Y, Verhaegen M, Varambally S, Chinnaiyan AM, Jakubowiak AJ, Soengas MS.

Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19488-93. Epub 2007 Nov 27.

31.

c-Myc depletion inhibits proliferation of human tumor cells at various stages of the cell cycle.

Wang H, Mannava S, Grachtchouk V, Zhuang D, Soengas MS, Gudkov AV, Prochownik EV, Nikiforov MA.

Oncogene. 2008 Mar 20;27(13):1905-15. Epub 2007 Oct 1.

32.

Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway.

Denoyelle C, Abou-Rjaily G, Bezrookove V, Verhaegen M, Johnson TM, Fullen DR, Pointer JN, Gruber SB, Su LD, Nikiforov MA, Kaufman RJ, Bastian BC, Soengas MS.

Nat Cell Biol. 2006 Oct;8(10):1053-63. Epub 2006 Sep 10. Erratum in: Nat Cell Biol. 2006 Nov;8(11):1309.

PMID:
16964246
33.

Transcriptional activation by the Myc oncoprotein.

Cole MD, Nikiforov MA.

Curr Top Microbiol Immunol. 2006;302:33-50. Review.

PMID:
16620024
34.

The Mad and Myc basic domains are functionally equivalent.

Nikiforov MA, Popov N, Kotenko I, Henriksson M, Cole MD.

J Biol Chem. 2003 Mar 28;278(13):11094-9. Epub 2003 Jan 21.

35.

Apoptosis inhibitor as a suppressor of tumor progression: expression of Bcl-2 eliminates selective advantages for p53-deficient cells in the tumor.

Gurova KV, Kwek SS, Koman IE, Komarov AP, Kandel E, Nikiforov MA, Gudkov AV.

Cancer Biol Ther. 2002 Jan-Feb;1(1):39-44.

PMID:
12170763
36.

A functional screen for Myc-responsive genes reveals serine hydroxymethyltransferase, a major source of the one-carbon unit for cell metabolism.

Nikiforov MA, Chandriani S, O'Connell B, Petrenko O, Kotenko I, Beavis A, Sedivy JM, Cole MD.

Mol Cell Biol. 2002 Aug;22(16):5793-800.

37.

TRRAP-dependent and TRRAP-independent transcriptional activation by Myc family oncoproteins.

Nikiforov MA, Chandriani S, Park J, Kotenko I, Matheos D, Johnsson A, McMahon SB, Cole MD.

Mol Cell Biol. 2002 Jul;22(14):5054-63.

38.

Complementation of Myc-dependent cell proliferation by cDNA expression library screening.

Nikiforov MA, Kotenko I, Petrenko O, Beavis A, Valenick L, Lemischka I, Cole MD.

Oncogene. 2000 Oct 5;19(42):4828-31.

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43.

Cell transforming genes and tumor progression: in vivo unified secondary phenotypic cell changes.

Deichman GJ, Matveeva VA, Kashkina LM, Dyakova NA, Uvarova EN, Nikiforov MA, Gudkov AV.

Int J Cancer. 1998 Jan 19;75(2):277-83.

44.

Suppression of apoptosis by bcl-2 does not prevent p53-mediated control of experimental metastasis and anchorage dependence.

Nikiforov MA, Kwek SS, Mehta R, Artwohl JE, Lowe SW, Gupta TD, Deichman GI, Gudkov AV.

Oncogene. 1997 Dec 18;15(25):3007-12.

45.

p53 modulation of anchorage independent growth and experimental metastasis.

Nikiforov MA, Hagen K, Ossovskaya VS, Connor TM, Lowe SW, Deichman GI, Gudkov AV.

Oncogene. 1996 Oct 17;13(8):1709-19.

PMID:
8895517
46.

Mechanisms of unusually high antioxidant activity of RSV-SR-transformed cells and of its suppression by activated p21ras.

Deichman GI, Kashkina LM, Mizenina OA, Gorojanskaya EG, Nikiforov MA, Gudkov AV, Dyakova NA, Komelkov AV, Prilutskaya MO, Kushlinsky NE, Tatosyan AG.

Int J Cancer. 1996 Jun 11;66(6):747-52.

47.

ART-CH: a VL30 in chickens?

Nikiforov MA, Gudkov AV.

J Virol. 1994 Feb;68(2):846-53.

48.

ART-CH, a new chicken retroviruslike element.

Gudkov AV, Komarova EA, Nikiforov MA, Zaitsevskaya TE.

J Virol. 1992 Mar;66(3):1726-36.

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