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Items: 1 to 50 of 341

1.

P cycle cannot be a general mechanism for energy production, and it does not sensitize bacteria toward aminoglycosides.

Nikaido H.

Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):14801. doi: 10.1073/pnas.1811810115. Epub 2019 Jul 16. No abstract available.

PMID:
31311872
2.

RND transporters in the living world.

Nikaido H.

Res Microbiol. 2018 Sep - Oct;169(7-8):363-371. doi: 10.1016/j.resmic.2018.03.001. Epub 2018 Mar 22. Review.

3.

Determining Ligand Path Through a Major Drug Transporter, AcrB, in Escherichia coli.

Husain F, Nikaido H.

Methods Mol Biol. 2018;1700:167-175. doi: 10.1007/978-1-4939-7454-2_10.

PMID:
29177831
5.

Effect of site-directed mutations in multidrug efflux pump AcrB examined by quantitative efflux assays.

Kinana AD, Vargiu AV, Nikaido H.

Biochem Biophys Res Commun. 2016 Nov 25;480(4):552-557. doi: 10.1016/j.bbrc.2016.10.083. Epub 2016 Oct 24.

6.
7.

Editorial: Bad Bugs in the XXIst Century: Resistance Mediated by Multi-Drug Efflux Pumps in Gram-Negative Bacteria.

Vargiu AV, Pos KM, Poole K, Nikaido H.

Front Microbiol. 2016 May 31;7:833. doi: 10.3389/fmicb.2016.00833. eCollection 2016. No abstract available.

8.

Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives.

Sjuts H, Vargiu AV, Kwasny SM, Nguyen ST, Kim HS, Ding X, Ornik AR, Ruggerone P, Bowlin TL, Nikaido H, Pos KM, Opperman TJ.

Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3509-14. doi: 10.1073/pnas.1602472113. Epub 2016 Mar 14.

9.

Aminoacyl β-naphthylamides as substrates and modulators of AcrB multidrug efflux pump.

Kinana AD, Vargiu AV, May T, Nikaido H.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1405-10. doi: 10.1073/pnas.1525143113. Epub 2016 Jan 19.

10.

Modification of Salmonella Lipopolysaccharides Prevents the Outer Membrane Penetration of Novobiocin.

Nobre TM, Martynowycz MW, Andreev K, Kuzmenko I, Nikaido H, Gidalevitz D.

Biophys J. 2015 Dec 15;109(12):2537-2545. doi: 10.1016/j.bpj.2015.10.013.

11.

Reversal of the Drug Binding Pocket Defects of the AcrB Multidrug Efflux Pump Protein of Escherichia coli.

Soparkar K, Kinana AD, Weeks JW, Morrison KD, Nikaido H, Misra R.

J Bacteriol. 2015 Oct;197(20):3255-64. doi: 10.1128/JB.00547-15. Epub 2015 Aug 3.

12.

Structure-activity relationships of a novel pyranopyridine series of Gram-negative bacterial efflux pump inhibitors.

Nguyen ST, Kwasny SM, Ding X, Cardinale SC, McCarthy CT, Kim HS, Nikaido H, Peet NP, Williams JD, Bowlin TL, Opperman TJ.

Bioorg Med Chem. 2015 May 1;23(9):2024-34. doi: 10.1016/j.bmc.2015.03.016. Epub 2015 Mar 13.

13.

The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria.

Li XZ, Plésiat P, Nikaido H.

Clin Microbiol Rev. 2015 Apr;28(2):337-418. doi: 10.1128/CMR.00117-14. Review.

14.

Quality assurance monitoring of a citywide transportation protocol improves clinical indicators of intravenous tissue plasminogen activator therapy: a community-based, longitudinal study.

Atsumi C, Hasegawa Y, Tsumura K, Ueda T, Suzuki K, Sugiyama M, Nozaki H, Suzuki S, Nakane M, Nagashima G, Kitamura T, Nikaido H, Sasanuma J.

J Stroke Cerebrovasc Dis. 2015 Jan;24(1):183-8. doi: 10.1016/j.jstrokecerebrovasdis.2014.08.013. Epub 2014 Nov 6.

PMID:
25440326
15.

Properties of AdeABC and AdeIJK efflux systems of Acinetobacter baumannii compared with those of the AcrAB-TolC system of Escherichia coli.

Sugawara E, Nikaido H.

Antimicrob Agents Chemother. 2014 Dec;58(12):7250-7. doi: 10.1128/AAC.03728-14. Epub 2014 Sep 22.

16.

Molecular mechanism of MBX2319 inhibition of Escherichia coli AcrB multidrug efflux pump and comparison with other inhibitors.

Vargiu AV, Ruggerone P, Opperman TJ, Nguyen ST, Nikaido H.

Antimicrob Agents Chemother. 2014 Oct;58(10):6224-34. doi: 10.1128/AAC.03283-14. Epub 2014 Aug 11.

17.

High salt concentrations increase permeability through OmpC channels of Escherichia coli.

Kojima S, Nikaido H.

J Biol Chem. 2014 Sep 19;289(38):26464-73. doi: 10.1074/jbc.M114.585869. Epub 2014 Aug 1.

18.

Mycobacterial outer membrane is a lipid bilayer and the inner membrane is unusually rich in diacyl phosphatidylinositol dimannosides.

Bansal-Mutalik R, Nikaido H.

Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4958-63. doi: 10.1073/pnas.1403078111. Epub 2014 Mar 17.

19.

Characterization of a novel pyranopyridine inhibitor of the AcrAB efflux pump of Escherichia coli.

Opperman TJ, Kwasny SM, Kim HS, Nguyen ST, Houseweart C, D'Souza S, Walker GC, Peet NP, Nikaido H, Bowlin TL.

Antimicrob Agents Chemother. 2014;58(2):722-33. doi: 10.1128/AAC.01866-13. Epub 2013 Nov 18.

20.

Some ligands enhance the efflux of other ligands by the Escherichia coli multidrug pump AcrB.

Kinana AD, Vargiu AV, Nikaido H.

Biochemistry. 2013 Nov 19;52(46):8342-51. doi: 10.1021/bi401303v. Epub 2013 Nov 11.

21.

Permeation rates of penicillins indicate that Escherichia coli porins function principally as nonspecific channels.

Kojima S, Nikaido H.

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):E2629-34. doi: 10.1073/pnas.1310333110. Epub 2013 Jun 24.

22.

Prediction of thrombolytic therapy after stroke-bypass transportation: the Maria Prehospital Stroke Scale score.

Hasegawa Y, Sasaki N, Yamada K, Ono H, Kumai J, Tsumura K, Suzuki K, Nozaki H, Nakayama H, Takumi I, Nikaido H, Katabami T, Ueda T, Suzuki S, Iwai R, Takahashi H, Shigeno T.

J Stroke Cerebrovasc Dis. 2013 May;22(4):514-9. doi: 10.1016/j.jstrokecerebrovasdis.2013.02.007. Epub 2013 Mar 13.

PMID:
23489953
23.

Christian Raetz: scientist and friend extraordinaire.

Dowhan W, Nikaido H, Stubbe J, Kozarich JW, Wickner WT, Russell DW, Garrett TA, Brozek K, Modrich P.

Annu Rev Biochem. 2013;82:1-24. doi: 10.1146/annurev-biochem-012512-091530. Epub 2013 Mar 7.

PMID:
23472605
24.

Multidrug binding properties of the AcrB efflux pump characterized by molecular dynamics simulations.

Vargiu AV, Nikaido H.

Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20637-42. doi: 10.1073/pnas.1218348109. Epub 2012 Nov 21.

25.

OmpA is the principal nonspecific slow porin of Acinetobacter baumannii.

Sugawara E, Nikaido H.

J Bacteriol. 2012 Aug;194(15):4089-96. doi: 10.1128/JB.00435-12. Epub 2012 May 25.

26.

Identification and gene expression analyses of ghrelin in the stomach of Pacific bluefin tuna (Thunnus orientalis).

Suda A, Kaiya H, Nikaido H, Shiozawa S, Mishiro K, Ando H.

Gen Comp Endocrinol. 2012 Aug 1;178(1):89-97. doi: 10.1016/j.ygcen.2012.04.026. Epub 2012 Apr 30.

PMID:
22569173
27.

Different functions of MdtB and MdtC subunits in the heterotrimeric efflux transporter MdtB(2)C complex of Escherichia coli.

Kim HS, Nikaido H.

Biochemistry. 2012 May 22;51(20):4188-97. doi: 10.1021/bi300379y. Epub 2012 May 11.

28.

Alternative folding pathways of the major porin OprF of Pseudomonas aeruginosa.

Sugawara E, Nagano K, Nikaido H.

FEBS J. 2012 Mar;279(6):910-8. doi: 10.1111/j.1742-4658.2012.08481.x. Epub 2012 Feb 10. Review.

29.

Quantitative lipid composition of cell envelopes of Corynebacterium glutamicum elucidated through reverse micelle extraction.

Bansal-Mutalik R, Nikaido H.

Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15360-5. doi: 10.1073/pnas.1112572108. Epub 2011 Aug 29.

30.

Vestibules are part of the substrate path in the multidrug efflux transporter AcrB of Escherichia coli.

Husain F, Bikhchandani M, Nikaido H.

J Bacteriol. 2011 Oct;193(20):5847-9. doi: 10.1128/JB.05759-11. Epub 2011 Aug 19.

31.

Broad-specificity efflux pumps and their role in multidrug resistance of Gram-negative bacteria.

Nikaido H, Pagès JM.

FEMS Microbiol Rev. 2012 Mar;36(2):340-63. doi: 10.1111/j.1574-6976.2011.00290.x. Epub 2011 Jul 29. Review.

32.

Structure and mechanism of RND-type multidrug efflux pumps.

Nikaido H.

Adv Enzymol Relat Areas Mol Biol. 2011;77:1-60. Review. No abstract available.

33.

To the happy few.

Nikaido H.

Annu Rev Microbiol. 2011;65:1-18. doi: 10.1146/annurev-micro-090110-102920.

PMID:
21639787
34.

Factors affecting the folding of Pseudomonas aeruginosa OprF porin into the one-domain open conformer.

Sugawara E, Nagano K, Nikaido H.

MBio. 2010 Oct 19;1(4). pii: e00228-10. doi: 10.1128/mBio.00228-10.

35.

Substrate path in the AcrB multidrug efflux pump of Escherichia coli.

Husain F, Nikaido H.

Mol Microbiol. 2010 Oct;78(2):320-30. doi: 10.1111/j.1365-2958.2010.07330.x. Epub 2010 Aug 20.

37.

Optimized Nile Red efflux assay of AcrAB-TolC multidrug efflux system shows competition between substrates.

Bohnert JA, Karamian B, Nikaido H.

Antimicrob Agents Chemother. 2010 Sep;54(9):3770-5. doi: 10.1128/AAC.00620-10. Epub 2010 Jul 6.

38.

Mechanism of recognition of compounds of diverse structures by the multidrug efflux pump AcrB of Escherichia coli.

Takatsuka Y, Chen C, Nikaido H.

Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6559-65. doi: 10.1073/pnas.1001460107. Epub 2010 Mar 8.

39.

Kinetic parameters of efflux of penicillins by the multidrug efflux transporter AcrAB-TolC of Escherichia coli.

Lim SP, Nikaido H.

Antimicrob Agents Chemother. 2010 May;54(5):1800-6. doi: 10.1128/AAC.01714-09. Epub 2010 Feb 16.

40.

Multidrug efflux pump MdtBC of Escherichia coli is active only as a B2C heterotrimer.

Kim HS, Nagore D, Nikaido H.

J Bacteriol. 2010 Mar;192(5):1377-86. doi: 10.1128/JB.01448-09. Epub 2009 Dec 28.

41.

Efflux-mediated drug resistance in bacteria: an update.

Li XZ, Nikaido H.

Drugs. 2009 Aug 20;69(12):1555-623. doi: 10.2165/11317030-000000000-00000. Review.

42.

Kinetic behavior of the major multidrug efflux pump AcrB of Escherichia coli.

Nagano K, Nikaido H.

Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5854-8. doi: 10.1073/pnas.0901695106. Epub 2009 Mar 23.

43.

Multidrug resistance in bacteria.

Nikaido H.

Annu Rev Biochem. 2009;78:119-46. doi: 10.1146/annurev.biochem.78.082907.145923. Review.

44.

Covalently linked trimer of the AcrB multidrug efflux pump provides support for the functional rotating mechanism.

Takatsuka Y, Nikaido H.

J Bacteriol. 2009 Mar;191(6):1729-37. doi: 10.1128/JB.01441-08. Epub 2008 Dec 5.

45.

Mechanisms of RND multidrug efflux pumps.

Nikaido H, Takatsuka Y.

Biochim Biophys Acta. 2009 May;1794(5):769-81. doi: 10.1016/j.bbapap.2008.10.004. Epub 2008 Nov 3. Review.

46.

Ligand-transporter interaction in the AcrB multidrug efflux pump determined by fluorescence polarization assay.

Su CC, Yu EW.

FEBS Lett. 2007 Oct 16;581(25):4972-6. Epub 2007 Sep 25. Erratum in: FEBS Lett. 2007 Nov 27;581(28):5548.

48.

PhoPQ-mediated regulation produces a more robust permeability barrier in the outer membrane of Salmonella enterica serovar typhimurium.

Murata T, Tseng W, Guina T, Miller SI, Nikaido H.

J Bacteriol. 2007 Oct;189(20):7213-22. Epub 2007 Aug 10.

49.

Structural and functional analyses of the major outer membrane protein of Chlamydia trachomatis.

Sun G, Pal S, Sarcon AK, Kim S, Sugawara E, Nikaido H, Cocco MJ, Peterson EM, de la Maza LM.

J Bacteriol. 2007 Sep;189(17):6222-35. Epub 2007 Jun 29.

50.

Antibiotic efflux mechanisms.

Nikaido H, Zgurskaya HI.

Curr Opin Infect Dis. 1999 Dec;12(6):529-36.

PMID:
17035817

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