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Items: 22

1.

Applications of Quantitative Systems Pharmacology in Model-Informed Drug Discovery: Perspective on Impact and Opportunities.

Bradshaw EL, Spilker ME, Zang R, Bansal L, He H, Jones RDO, Le K, Penney M, Schuck E, Topp B, Tsai A, Xu C, Nijsen MJMA, Chan JR.

CPT Pharmacometrics Syst Pharmacol. 2019 Sep 19. doi: 10.1002/psp4.12463. [Epub ahead of print]

2.

Mathematical and Experimental Validation of Flux Dialysis Method: An Improved Approach to Measure Unbound Fraction for Compounds with High Protein Binding and Other Challenging Properties.

Kalvass JC, Phipps C, Jenkins GJ, Stuart P, Zhang X, Heinle L, Nijsen MJMA, Fischer V.

Drug Metab Dispos. 2018 Apr;46(4):458-469. doi: 10.1124/dmd.117.078915. Epub 2018 Feb 2.

PMID:
29437872
3.

Preclinical QSP Modeling in the Pharmaceutical Industry: An IQ Consortium Survey Examining the Current Landscape.

Nijsen MJMA, Wu F, Bansal L, Bradshaw-Pierce E, Chan JR, Liederer BM, Mettetal JT, Schroeder P, Schuck E, Tsai A, Xu C, Chimalakonda A, Le K, Penney M, Topp B, Yamada A, Spilker ME.

CPT Pharmacometrics Syst Pharmacol. 2018 Mar;7(3):135-146. doi: 10.1002/psp4.12282. Epub 2018 Feb 1. Review.

4.

Mechanisms and Predictions of Drug-Drug Interactions of the Hepatitis C Virus Three Direct-Acting Antiviral Regimen: Paritaprevir/Ritonavir, Ombitasvir, and Dasabuvir.

Shebley M, Liu J, Kavetskaia O, Sydor J, de Morais SM, Fischer V, Nijsen MJMA, Bow DAJ.

Drug Metab Dispos. 2017 Jul;45(7):755-764. doi: 10.1124/dmd.116.074518. Epub 2017 May 8.

PMID:
28483778
5.

Translational pharmacokinetic-pharmacodynamic analysis in the pharmaceutical industry: an IQ Consortium PK-PD Discussion Group perspective.

Wong H, Bohnert T, Damian-Iordache V, Gibson C, Hsu CP, Krishnatry AS, Liederer BM, Lin J, Lu Q, Mettetal JT, Mudra DR, Nijsen MJMA, Schroeder P, Schuck E, Suryawanshi S, Trapa P, Tsai A, Wang H, Wu F.

Drug Discov Today. 2017 Oct;22(10):1447-1459. doi: 10.1016/j.drudis.2017.04.015. Epub 2017 May 2. Review.

PMID:
28476536
6.

Preclinical pharmacokinetic/pharmacodynamic modeling and simulation in the pharmaceutical industry: an IQ consortium survey examining the current landscape.

Schuck E, Bohnert T, Chakravarty A, Damian-Iordache V, Gibson C, Hsu CP, Heimbach T, Krishnatry AS, Liederer BM, Lin J, Maurer T, Mettetal JT, Mudra DR, Nijsen MJ, Raybon J, Schroeder P, Schuck V, Suryawanshi S, Su Y, Trapa P, Tsai A, Vakilynejad M, Wang S, Wong H.

AAPS J. 2015 Mar;17(2):462-73. doi: 10.1208/s12248-014-9716-2. Epub 2015 Jan 29.

7.

5-sulfonyl-benzimidazoles as selective CB2 agonists-part 2.

Gijsen HJ, De Cleyn MA, Surkyn M, Van Lommen GR, Verbist BM, Nijsen MJ, Meert T, Wauwe JV, Aerssens J.

Bioorg Med Chem Lett. 2012 Jan 1;22(1):547-52. doi: 10.1016/j.bmcl.2011.10.091. Epub 2011 Nov 6.

PMID:
22130134
8.

Cardio-vascular safety beyond hERG: in silico modelling of a guinea pig right atrium assay.

Fenu LA, Teisman A, De Buck SS, Sinha VK, Gilissen RA, Nijsen MJ, Mackie CE, Sanderson WE.

J Comput Aided Mol Des. 2009 Dec;23(12):883-95. doi: 10.1007/s10822-009-9306-z. Epub 2009 Nov 5.

PMID:
19890608
9.

5-Sulfonyl-benzimidazoles as selective CB2 agonists.

Verbist BM, De Cleyn MA, Surkyn M, Fraiponts E, Aerssens J, Nijsen MJ, Gijsen HJ.

Bioorg Med Chem Lett. 2008 Apr 15;18(8):2574-9. doi: 10.1016/j.bmcl.2008.03.048. Epub 2008 Mar 20.

PMID:
18394887
10.

Prediction of human pharmacokinetics using physiologically based modeling: a retrospective analysis of 26 clinically tested drugs.

De Buck SS, Sinha VK, Fenu LA, Nijsen MJ, Mackie CE, Gilissen RA.

Drug Metab Dispos. 2007 Oct;35(10):1766-80. Epub 2007 Jul 9.

PMID:
17620347
11.
12.

Telemetric animal model to evaluate visceral pain in the freely moving rat.

Nijsen MJ, Ongenae NG, Coulie B, Meulemans AL.

Pain. 2003 Sep;105(1-2):115-23.

PMID:
14499427
13.

Effect of gamma-melanocyte-stimulating hormones on baroreflex sensitivity and cerebral blood flow autoregulation in rats.

Nijsen MJ, de Ruiter GJ, Kasbergen CM, de Wildt DJ.

Cardiovasc Res. 2001 Jan;49(1):226-33.

PMID:
11121815
14.

CRH signalling in the bed nucleus of the stria terminalis is involved in stress-induced cardiac vagal activation in conscious rats.

Nijsen MJ, Croiset G, Diamant M, De Wied D, Wiegant VM.

Neuropsychopharmacology. 2001 Jan;24(1):1-10.

15.
16.

Role of corticotropin-releasing factor, vasopressin and the autonomic nervous system in learning and memory.

Croiset G, Nijsen MJ, Kamphuis PJ.

Eur J Pharmacol. 2000 Sep 29;405(1-3):225-34. Review.

PMID:
11033330
17.

The role of the CRH type 1 receptor in autonomic responses to corticotropin- releasing hormone in the rat.

Nijsen MJ, Croiset G, Stam R, Bruijnzeel A, Diamant M, de Wied D, Wiegant VM.

Neuropsychopharmacology. 2000 Apr;22(4):388-99.

18.

Endogenous corticotropin-releasing hormone inhibits conditioned-fear-induced vagal activation in the rat.

Nijsen MJ, Croiset G, Diamant M, Stam R, Kamphuis PJ, Bruijnzeel A, de Wied D, Wiegant VM.

Eur J Pharmacol. 2000 Feb 11;389(1):89-98.

PMID:
10686300
19.

Conditioned fear-induced tachycardia in the rat: vagal involvement.

Nijsen MJ, Croiset G, Diamant M, Stam R, Delsing D, de Wied D, Wiegant VM.

Eur J Pharmacol. 1998 Jun 5;350(2-3):211-22.

PMID:
9696410
20.

Vagal activation in novelty-induced tachycardia during the light phase in the rat.

Nijsen MJ, Croiset G, Diamant M, Broekhoven MH, De Wied D, Wiegant VM.

Physiol Behav. 1998 Jan;63(2):233-9.

PMID:
9423964
21.

Cisplatin-induced autonomic neuropathy: does it really exist?

Vandertop WP, de Vries WB, Notermans NC, Nijsen MJ, de Wildt DJ, Tulleken CA, Gispen WH.

J Neurooncol. 1996 Jan;27(1):53-60.

PMID:
8699226
22.

PVH lesions do not inhibit stressor-induced grooming in the rat.

van Erp AM, Kruk MR, Willekens-Bramer DC, Fermont PC, Nijsen MJ.

Physiol Behav. 1995 May;57(5):887-92.

PMID:
7610140

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