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Items: 33

1.

UHRF1 depletion and HDAC inhibition reactivate epigenetically silenced genes in colorectal cancer cells.

Niinuma T, Kitajima H, Kai M, Yamamoto E, Yorozu A, Ishiguro K, Sasaki H, Sudo G, Toyota M, Hatahira T, Maruyama R, Tokino T, Nakase H, Sugai T, Suzuki H.

Clin Epigenetics. 2019 May 7;11(1):70. doi: 10.1186/s13148-019-0668-3.

2.

DOT1L inhibition blocks multiple myeloma cell proliferation by suppressing IRF4-MYC signaling.

Ishiguro K, Kitajima H, Niinuma T, Ishida T, Maruyama R, Ikeda H, Hayashi T, Sasaki H, Wakasugi H, Nishiyama K, Shindo T, Yamamoto E, Kai M, Sasaki Y, Tokino T, Nakase H, Suzuki H.

Haematologica. 2019 Jan;104(1):155-165. doi: 10.3324/haematol.2018.191262. Epub 2018 Aug 31.

3.

Screening for long noncoding RNAs associated with oral squamous cell carcinoma reveals the potentially oncogenic actions of DLEU1.

Nishiyama K, Maruyama R, Niinuma T, Kai M, Kitajima H, Toyota M, Hatanaka Y, Igarashi T, Kobayashi JI, Ogi K, Dehari H, Miyazaki A, Yorozu A, Yamamoto E, Idogawa M, Sasaki Y, Sugai T, Tokino T, Hiratsuka H, Suzuki H.

Cell Death Dis. 2018 Aug 1;9(8):826. doi: 10.1038/s41419-018-0893-2.

4.

Dysregulation of miRNA in chronic hepatitis B is associated with hepatocellular carcinoma risk after nucleos(t)ide analogue treatment.

Wakasugi H, Takahashi H, Niinuma T, Kitajima H, Oikawa R, Matsumoto N, Takeba Y, Otsubo T, Takagi M, Ariizumi Y, Suzuki M, Okuse C, Iwabuchi S, Nakano M, Akutsu N, Kang JH, Matsui T, Yamada N, Sasaki H, Yamamoto E, Kai M, Sasaki Y, Sasaki S, Tanaka Y, Yotsuyanagi H, Tsutsumi T, Yamamoto H, Tokino T, Nakase H, Suzuki H, Itoh F.

Cancer Lett. 2018 Oct 10;434:91-100. doi: 10.1016/j.canlet.2018.07.019. Epub 2018 Jul 17.

PMID:
30026054
5.

Surface microstructures are associated with mutational intratumoral heterogeneity in colorectal tumors.

Harada T, Yamamoto E, Yamano HO, Aoki H, Matsushita HO, Yoshikawa K, Takagi R, Harada E, Tanaka Y, Yoshida Y, Eizuka M, Yorozu A, Sudo G, Kitajima H, Niinuma T, Kai M, Sasaki Y, Tokino T, Sugai T, Nakase H, Suzuki H.

J Gastroenterol. 2018 Dec;53(12):1241-1252. doi: 10.1007/s00535-018-1481-z. Epub 2018 Jun 11.

PMID:
29948303
6.

Epigenetic silencing of miR-200b is associated with cisplatin resistance in bladder cancer.

Shindo T, Niinuma T, Nishiyama N, Shinkai N, Kitajima H, Kai M, Maruyama R, Tokino T, Masumori N, Suzuki H.

Oncotarget. 2018 May 11;9(36):24457-24469. doi: 10.18632/oncotarget.25326. eCollection 2018 May 11.

7.

Translational regulation by miR-301b upregulates AMP deaminase in diabetic hearts.

Tatekoshi Y, Tanno M, Kouzu H, Abe K, Miki T, Kuno A, Yano T, Ishikawa S, Ohwada W, Sato T, Niinuma T, Suzuki H, Miura T.

J Mol Cell Cardiol. 2018 Jun;119:138-146. doi: 10.1016/j.yjmcc.2018.05.003. Epub 2018 May 4.

PMID:
29733818
8.

Subtypes of the Type II Pit Pattern Reflect Distinct Molecular Subclasses in the Serrated Neoplastic Pathway.

Aoki H, Yamamoto E, Yamano HO, Sugai T, Kimura T, Tanaka Y, Matsushita HO, Yoshikawa K, Takagi R, Harada E, Nakaoka M, Yoshida Y, Harada T, Sudo G, Eizuka M, Yorozu A, Kitajima H, Niinuma T, Kai M, Nojima M, Suzuki H, Nakase H.

Dig Dis Sci. 2018 Jul;63(7):1920-1928. doi: 10.1007/s10620-018-5016-5. Epub 2018 Mar 15.

PMID:
29546645
9.

Molecular characterization and pathogenesis of gastrointestinal stromal tumor.

Niinuma T, Suzuki H, Sugai T.

Transl Gastroenterol Hepatol. 2018 Jan 9;3:2. doi: 10.21037/tgh.2018.01.02. eCollection 2018. Review.

10.

Epigenetic silencing of SMOC1 in traditional serrated adenoma and colorectal cancer.

Aoki H, Yamamoto E, Takasawa A, Niinuma T, Yamano HO, Harada T, Matsushita HO, Yoshikawa K, Takagi R, Harada E, Tanaka Y, Yoshida Y, Aoyama T, Eizuka M, Yorozu A, Kitajima H, Kai M, Sawada N, Sugai T, Nakase H, Suzuki H.

Oncotarget. 2017 Dec 20;9(4):4707-4721. doi: 10.18632/oncotarget.23523. eCollection 2018 Jan 12.

11.

Evaluation of Urinary DNA Methylation as a Marker for Recurrent Bladder Cancer: A 2-Center Prospective Study.

Shindo T, Shimizu T, Nojima M, Niinuma T, Maruyama R, Kitajima H, Kai M, Itoh N, Suzuki H, Masumori N.

Urology. 2018 Mar;113:71-78. doi: 10.1016/j.urology.2017.11.025. Epub 2017 Nov 28.

PMID:
29196070
12.

Downregulation of miR-186 is associated with metastatic recurrence of gastrointestinal stromal tumors.

Niinuma T, Kai M, Kitajima H, Yamamoto E, Harada T, Maruyama R, Nobuoka T, Nishida T, Kanda T, Hasegawa T, Tokino T, Sugai T, Shinomura Y, Nakase H, Suzuki H.

Oncol Lett. 2017 Nov;14(5):5703-5710. doi: 10.3892/ol.2017.6911. Epub 2017 Sep 8.

13.

Epigenetic silencing of diacylglycerol kinase gamma in colorectal cancer.

Kai M, Yamamoto E, Sato A, Yamano HO, Niinuma T, Kitajima H, Harada T, Aoki H, Maruyama R, Toyota M, Hatahira T, Nakase H, Sugai T, Yamashita T, Toyota M, Suzuki H.

Mol Carcinog. 2017 Jul;56(7):1743-1752. doi: 10.1002/mc.22631. Epub 2017 Mar 6.

PMID:
28218473
14.

TET1 Depletion Induces Aberrant CpG Methylation in Colorectal Cancer Cells.

Kai M, Niinuma T, Kitajima H, Yamamoto E, Harada T, Aoki H, Maruyama R, Toyota M, Sasaki Y, Sugai T, Tokino T, Nakase H, Suzuki H.

PLoS One. 2016 Dec 15;11(12):e0168281. doi: 10.1371/journal.pone.0168281. eCollection 2016.

15.

Relationship Between Noncoding RNA Dysregulation and Epigenetic Mechanisms in Cancer.

Suzuki H, Maruyama R, Yamamoto E, Niinuma T, Kai M.

Adv Exp Med Biol. 2016;927:109-35. doi: 10.1007/978-981-10-1498-7_4. Review.

PMID:
27376733
16.

A genomic screen for long noncoding RNA genes epigenetically silenced by aberrant DNA methylation in colorectal cancer.

Kumegawa K, Maruyama R, Yamamoto E, Ashida M, Kitajima H, Tsuyada A, Niinuma T, Kai M, Yamano HO, Sugai T, Tokino T, Shinomura Y, Imai K, Suzuki H.

Sci Rep. 2016 May 24;6:26699. doi: 10.1038/srep26699.

17.

Assessment of epigenetic alterations in early colorectal lesions containing BRAF mutations.

Sawada T, Yamamoto E, Yamano HO, Nojima M, Harada T, Maruyama R, Ashida M, Aoki H, Matsushita HO, Yoshikawa K, Harada E, Tanaka Y, Wakita S, Niinuma T, Kai M, Eizuka M, Sugai T, Suzuki H.

Oncotarget. 2016 Jun 7;7(23):35106-18. doi: 10.18632/oncotarget.9044.

18.

Low-Frequency IL23R Coding Variant Associated with Crohn's Disease Susceptibility in Japanese Subjects Identified by Personal Genomics Analysis.

Onodera K, Arimura Y, Isshiki H, Kawakami K, Nagaishi K, Yamashita K, Yamamoto E, Niinuma T, Naishiro Y, Suzuki H, Imai K, Shinomura Y.

PLoS One. 2015 Sep 16;10(9):e0137801. doi: 10.1371/journal.pone.0137801. eCollection 2015.

19.

Epigenetic silencing of NTSR1 is associated with lateral and noninvasive growth of colorectal tumors.

Kamimae S, Yamamoto E, Kai M, Niinuma T, Yamano HO, Nojima M, Yoshikawa K, Kimura T, Takagi R, Harada E, Harada T, Maruyama R, Sasaki Y, Tokino T, Shinomura Y, Sugai T, Imai K, Suzuki H.

Oncotarget. 2015 Oct 6;6(30):29975-90. doi: 10.18632/oncotarget.5034.

20.

A Screen for Epigenetically Silenced microRNA Genes in Gastrointestinal Stromal Tumors.

Isosaka M, Niinuma T, Nojima M, Kai M, Yamamoto E, Maruyama R, Nobuoka T, Nishida T, Kanda T, Taguchi T, Hasegawa T, Tokino T, Hirata K, Suzuki H, Shinomura Y.

PLoS One. 2015 Jul 27;10(7):e0133754. doi: 10.1371/journal.pone.0133754. eCollection 2015.

21.

Analysis of DNA methylation in bowel lavage fluid for detection of colorectal cancer.

Harada T, Yamamoto E, Yamano HO, Nojima M, Maruyama R, Kumegawa K, Ashida M, Yoshikawa K, Kimura T, Harada E, Takagi R, Tanaka Y, Aoki H, Nishizono M, Nakaoka M, Tsuyada A, Niinuma T, Kai M, Shimoda K, Shinomura Y, Sugai T, Imai K, Suzuki H.

Cancer Prev Res (Phila). 2014 Oct;7(10):1002-10. doi: 10.1158/1940-6207.CAPR-14-0162. Epub 2014 Aug 19.

22.

Biological significance of the CpG island methylator phenotype.

Suzuki H, Yamamoto E, Maruyama R, Niinuma T, Kai M.

Biochem Biophys Res Commun. 2014 Dec 5;455(1-2):35-42. doi: 10.1016/j.bbrc.2014.07.007. Epub 2014 Jul 10. Review.

PMID:
25016183
23.

Aberrant methylation of microRNA-34b/c is a predictive marker of metachronous gastric cancer risk.

Suzuki R, Yamamoto E, Nojima M, Maruyama R, Yamano HO, Yoshikawa K, Kimura T, Harada T, Ashida M, Niinuma T, Sato A, Nosho K, Yamamoto H, Kai M, Sugai T, Imai K, Suzuki H, Shinomura Y.

J Gastroenterol. 2014 Jul;49(7):1135-44. doi: 10.1007/s00535-013-0861-7. Epub 2013 Aug 13.

24.

Pyogenic granuloma of the small bowel.

Yamashita K, Arimura Y, Saito M, Iida T, Suzuki R, Niinuma T, Furuhata T, Kimura K, Ohta T, Shinomura Y.

Endoscopy. 2013;45 Suppl 2 UCTN:E9-10. doi: 10.1055/s-0032-1326119. Epub 2013 Mar 6. No abstract available.

PMID:
23468156
25.

Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors.

Niinuma T, Suzuki H, Nojima M, Nosho K, Yamamoto H, Takamaru H, Yamamoto E, Maruyama R, Nobuoka T, Miyazaki Y, Nishida T, Bamba T, Kanda T, Ajioka Y, Taguchi T, Okahara S, Takahashi H, Nishida Y, Hosokawa M, Hasegawa T, Tokino T, Hirata K, Imai K, Toyota M, Shinomura Y.

Cancer Res. 2012 Mar 1;72(5):1126-36. doi: 10.1158/0008-5472.CAN-11-1803. Epub 2012 Jan 18.

26.

A novel correlation between LINE-1 hypomethylation and the malignancy of gastrointestinal stromal tumors.

Igarashi S, Suzuki H, Niinuma T, Shimizu H, Nojima M, Iwaki H, Nobuoka T, Nishida T, Miyazaki Y, Takamaru H, Yamamoto E, Yamamoto H, Tokino T, Hasegawa T, Hirata K, Imai K, Toyota M, Shinomura Y.

Clin Cancer Res. 2010 Nov 1;16(21):5114-23. doi: 10.1158/1078-0432.CCR-10-0581. Epub 2010 Oct 26.

27.

Methylation-associated silencing of microRNA-34b/c in gastric cancer and its involvement in an epigenetic field defect.

Suzuki H, Yamamoto E, Nojima M, Kai M, Yamano HO, Yoshikawa K, Kimura T, Kudo T, Harada E, Sugai T, Takamaru H, Niinuma T, Maruyama R, Yamamoto H, Tokino T, Imai K, Toyota M, Shinomura Y.

Carcinogenesis. 2010 Dec;31(12):2066-73. doi: 10.1093/carcin/bgq203. Epub 2010 Oct 5.

PMID:
20924086
28.

Genetic analysis of advanced colon cancer of 8 mm with liver metastasis.

Nosho K, Yamamoto H, Suzuki C, Niinuma T, Satoh A, Yoshida M, Nakahara S, Goto A, Yamashita K, Yoshida Y, Adachi Y, Arimura Y, Endo T, Hirata K, Imai K.

Int J Colorectal Dis. 2005 Jan;20(1):81-2. Epub 2004 Aug 18. No abstract available.

PMID:
15322837
29.

Parvovirus B19 infection induces apoptosis of erythroid cells in vitro and in vivo.

Yaegashi N, Niinuma T, Chisaka H, Uehara S, Moffatt S, Tada K, Iwabuchi M, Matsunaga Y, Nakayama M, Yutani C, Osamura Y, Hirayama E, Okamura K, Sugamura K, Yajima A.

J Infect. 1999 Jul;39(1):68-76.

PMID:
10468132
30.

Serologic study of human parvovirus B19 infection in pregnancy in Japan.

Yaegashi N, Niinuma T, Chisaka H, Uehara S, Okamura K, Shinkawa O, Tsunoda A, Moffatt S, Sugamura K, Yajima A.

J Infect. 1999 Jan;38(1):30-5.

PMID:
10090504
31.

The incidence of, and factors leading to, parvovirus B19-related hydrops fetalis following maternal infection; report of 10 cases and meta-analysis.

Yaegashi N, Niinuma T, Chisaka H, Watanabe T, Uehara S, Okamura K, Moffatt S, Sugamura K, Yajima A.

J Infect. 1998 Jul;37(1):28-35.

PMID:
9733374
32.

A Turner syndrome woman with a ring X chromosome [45,X/46,X,r(X)(p22.3q27)] whose child also had a ring X chromosome.

Uehara S, Nata M, Obara Y, Niinuma T, Funato T, Yajima A.

Fertil Steril. 1997 Mar;67(3):576-9.

PMID:
9091352
33.

Scanning electron microscopy of fragmentary marker chromosomes observed by light microscopy.

Uehara S, Niinuma T, Senoo M, Okamura K, Yajima A.

Tohoku J Exp Med. 1996 Jun;179(2):131-9.

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