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A Comprehensive Peptidomic Approach to Characterize the Protein Profile of Selected Durum Wheat Genotypes: Implication for Coeliac Disease and Wheat Allergy.

Pilolli R, Gadaleta A, Di Stasio L, Lamonaca A, De Angelis E, Nigro D, De Angelis M, Mamone G, Monaci L.

Nutrients. 2019 Oct 1;11(10). pii: E2321. doi: 10.3390/nu11102321.


Durum wheat genome highlights past domestication signatures and future improvement targets.

Maccaferri M, Harris NS, Twardziok SO, Pasam RK, Gundlach H, Spannagl M, Ormanbekova D, Lux T, Prade VM, Milner SG, Himmelbach A, Mascher M, Bagnaresi P, Faccioli P, Cozzi P, Lauria M, Lazzari B, Stella A, Manconi A, Gnocchi M, Moscatelli M, Avni R, Deek J, Biyiklioglu S, Frascaroli E, Corneti S, Salvi S, Sonnante G, Desiderio F, Marè C, Crosatti C, Mica E, Özkan H, Kilian B, De Vita P, Marone D, Joukhadar R, Mazzucotelli E, Nigro D, Gadaleta A, Chao S, Faris JD, Melo ATO, Pumphrey M, Pecchioni N, Milanesi L, Wiebe K, Ens J, MacLachlan RP, Clarke JM, Sharpe AG, Koh CS, Liang KYH, Taylor GJ, Knox R, Budak H, Mastrangelo AM, Xu SS, Stein N, Hale I, Distelfeld A, Hayden MJ, Tuberosa R, Walkowiak S, Mayer KFX, Ceriotti A, Pozniak CJ, Cattivelli L.

Nat Genet. 2019 May;51(5):885-895. doi: 10.1038/s41588-019-0381-3. Epub 2019 Apr 8.


Scouting for Naturally Low-Toxicity Wheat Genotypes by a Multidisciplinary Approach.

Pilolli R, Gadaleta A, Mamone G, Nigro D, De Angelis E, Montemurro N, Monaci L.

Sci Rep. 2019 Feb 7;9(1):1646. doi: 10.1038/s41598-018-36845-8.


Candidate genes and genome-wide association study of grain protein content and protein deviation in durum wheat.

Nigro D, Gadaleta A, Mangini G, Colasuonno P, Marcotuli I, Giancaspro A, Giove SL, Simeone R, Blanco A.

Planta. 2019 Apr;249(4):1157-1175. doi: 10.1007/s00425-018-03075-1. Epub 2019 Jan 2.


Thermo-viscous damping of acoustic waves in narrow channels: A comparison of effects in air and water.

Cotterill PA, Nigro D, Abrahams ID, Garcia-Neefjes E, Parnell WJ.

J Acoust Soc Am. 2018 Dec;144(6):3421. doi: 10.1121/1.5078528.


Fructose liquid and solid formulations differently affect gut integrity, microbiota composition and related liver toxicity: a comparative in vivo study.

Mastrocola R, Ferrocino I, Liberto E, Chiazza F, Cento AS, Collotta D, Querio G, Nigro D, Bitonto V, Cutrin JC, Rantsiou K, Durante M, Masini E, Aragno M, Cordero C, Cocolin L, Collino M.

J Nutr Biochem. 2018 May;55:185-199. doi: 10.1016/j.jnutbio.2018.02.003. Epub 2018 Feb 13.


Effects of vitamin D on insulin resistance and myosteatosis in diet-induced obese mice.

Benetti E, Mastrocola R, Chiazza F, Nigro D, D'Antona G, Bordano V, Fantozzi R, Aragno M, Collino M, Minetto MA.

PLoS One. 2018 Jan 17;13(1):e0189707. doi: 10.1371/journal.pone.0189707. eCollection 2018.


Protective Effects of Pyridoxamine Supplementation in the Early Stages of Diet-Induced Kidney Dysfunction.

Chiazza F, Cento AS, Collotta D, Nigro D, Rosa G, Baratta F, Bitonto V, Cutrin JC, Aragno M, Mastrocola R, Collino M.

Biomed Res Int. 2017;2017:2682861. doi: 10.1155/2017/2682861. Epub 2017 Oct 29.


A lake-centric geospatial database to guide research and inform management decisions in an Arctic watershed in northern Alaska experiencing climate and land-use changes.

Jones BM, Arp CD, Whitman MS, Nigro D, Nitze I, Beaver J, Gädeke A, Zuck C, Liljedahl A, Daanen R, Torvinen E, Fritz S, Grosse G.

Ambio. 2017 Nov;46(7):769-786. doi: 10.1007/s13280-017-0915-9. Epub 2017 Mar 25.


Chronic administration of saturated fats and fructose differently affect SREBP activity resulting in different modulation of Nrf2 and Nlrp3 inflammasome pathways in mice liver.

Nigro D, Menotti F, Cento AS, Serpe L, Chiazza F, Dal Bello F, Romaniello F, Medana C, Collino M, Aragno M, Mastrocola R.

J Nutr Biochem. 2017 Apr;42:160-171. doi: 10.1016/j.jnutbio.2017.01.010. Epub 2017 Jan 28.


The carotenoid biosynthetic and catabolic genes in wheat and their association with yellow pigments.

Colasuonno P, Lozito ML, Marcotuli I, Nigro D, Giancaspro A, Mangini G, De Vita P, Mastrangelo AM, Pecchioni N, Houston K, Simeone R, Gadaleta A, Blanco A.

BMC Genomics. 2017 Jan 31;18(1):122. doi: 10.1186/s12864-016-3395-6.


Pharmacological Inhibition of NLRP3 Inflammasome Attenuates Myocardial Ischemia/Reperfusion Injury by Activation of RISK and Mitochondrial Pathways.

Mastrocola R, Penna C, Tullio F, Femminò S, Nigro D, Chiazza F, Serpe L, Collotta D, Alloatti G, Cocco M, Bertinaria M, Pagliaro P, Aragno M, Collino M.

Oxid Med Cell Longev. 2016;2016:5271251. doi: 10.1155/2016/5271251. Epub 2016 Dec 8.


Glutamine synthetase in Durum Wheat: Genotypic Variation and Relationship with Grain Protein Content.

Nigro D, Fortunato S, Giove SL, Paradiso A, Gu YQ, Blanco A, de Pinto MC, Gadaleta A.

Front Plant Sci. 2016 Jul 13;7:971. doi: 10.3389/fpls.2016.00971. eCollection 2016.


Empagliflozin Protects against Diet-Induced NLRP-3 Inflammasome Activation and Lipid Accumulation.

Benetti E, Mastrocola R, Vitarelli G, Cutrin JC, Nigro D, Chiazza F, Mayoux E, Collino M, Fantozzi R.

J Pharmacol Exp Ther. 2016 Oct;359(1):45-53. doi: 10.1124/jpet.116.235069. Epub 2016 Jul 20.


Identification and Characterization of the Sucrose Synthase 2 Gene (Sus2) in Durum Wheat.

Volpicella M, Fanizza I, Leoni C, Gadaleta A, Nigro D, Gattulli B, Mangini G, Blanco A, Ceci LR.

Front Plant Sci. 2016 Mar 10;7:266. doi: 10.3389/fpls.2016.00266. eCollection 2016.


High-fructose intake as risk factor for neurodegeneration: Key role for carboxy methyllysine accumulation in mice hippocampal neurons.

Mastrocola R, Nigro D, Cento AS, Chiazza F, Collino M, Aragno M.

Neurobiol Dis. 2016 May;89:65-75. doi: 10.1016/j.nbd.2016.02.005. Epub 2016 Feb 3.


Maladaptive Modulations of NLRP3 Inflammasome and Cardioprotective Pathways Are Involved in Diet-Induced Exacerbation of Myocardial Ischemia/Reperfusion Injury in Mice.

Mastrocola R, Collino M, Penna C, Nigro D, Chiazza F, Fracasso V, Tullio F, Alloatti G, Pagliaro P, Aragno M.

Oxid Med Cell Longev. 2016;2016:3480637. doi: 10.1155/2016/3480637. Epub 2015 Dec 14.


Fructose-derived advanced glycation end-products drive lipogenesis and skeletal muscle reprogramming via SREBP-1c dysregulation in mice.

Mastrocola R, Nigro D, Chiazza F, Medana C, Dal Bello F, Boccuzzi G, Collino M, Aragno M.

Free Radic Biol Med. 2016 Feb;91:224-35. doi: 10.1016/j.freeradbiomed.2015.12.022. Epub 2015 Dec 22.


Targeting the NLRP3 Inflammasome to Reduce Diet-Induced Metabolic Abnormalities in Mice.

Chiazza F, Couturier-Maillard A, Benetti E, Mastrocola R, Nigro D, Cutrin JC, Serpe L, Aragno M, Fantozzi R, Ryffel B, Thiemermann C, Collino M.

Mol Med. 2016 Mar;21(1):1025-1037. doi: 10.2119/molmed.2015.00104. Epub 2016 May 9.


Dynamics of a recovering Arctic bird population: the importance of climate, density dependence, and site quality.

Bruggeman JE, Swem T, Andersen DE, Kennedy PL, Nigro D.

Ecol Appl. 2015 Oct;25(7):1932-43.


Effects of chronic sugar consumption on lipid accumulation and autophagy in the skeletal muscle.

De Stefanis D, Mastrocola R, Nigro D, Costelli P, Aragno M.

Eur J Nutr. 2017 Feb;56(1):363-373. doi: 10.1007/s00394-015-1086-8. Epub 2015 Oct 20.


Initial recommendations for higher-tier risk assessment protocols for bumble bees, Bombus spp. (Hymenoptera: Apidae).

Cabrera AR, Almanza MT, Cutler GC, Fischer DL, Hinarejos S, Lewis G, Nigro D, Olmstead A, Overmyer J, Potter DA, Raine NE, Stanley-Stahr C, Thompson H, van der Steen J.

Integr Environ Assess Manag. 2016 Apr;12(2):222-9. doi: 10.1002/ieam.1675. Epub 2015 Sep 8.


Accumulation of advanced glycation end-products and activation of the SCAP/SREBP Lipogenetic pathway occur in diet-induced obese mouse skeletal muscle.

Mastrocola R, Collino M, Nigro D, Chiazza F, D'Antona G, Aragno M, Minetto MA.

PLoS One. 2015 Mar 9;10(3):e0119587. doi: 10.1371/journal.pone.0119587. eCollection 2015.


Variability in myosteatosis and insulin resistance induced by high-fat diet in mouse skeletal muscles.

Collino M, Mastrocola R, Nigro D, Chiazza F, Aragno M, D'Antona G, Minetto MA.

Biomed Res Int. 2014;2014:569623. doi: 10.1155/2014/569623. Epub 2014 Aug 14.


A non-erythropoietic peptide derivative of erythropoietin decreases susceptibility to diet-induced insulin resistance in mice.

Collino M, Benetti E, Rogazzo M, Chiazza F, Mastrocola R, Nigro D, Cutrin JC, Aragno M, Fantozzi R, Minetto MA, Thiemermann C.

Br J Pharmacol. 2014 Dec;171(24):5802-15. doi: 10.1111/bph.12888. Epub 2014 Nov 24.


Characterization of ferredoxin-dependent glutamine-oxoglutarate amidotransferase (Fd-GOGAT) genes and their relationship with grain protein content QTL in wheat.

Nigro D, Blanco A, Anderson OD, Gadaleta A.

PLoS One. 2014 Aug 6;9(8):e103869. doi: 10.1371/journal.pone.0103869. eCollection 2014.


Structural analysis of the wheat genes encoding NADH-dependent glutamine-2-oxoglutarate amidotransferases and correlation with grain protein content.

Nigro D, Gu YQ, Huo N, Marcotuli I, Blanco A, Gadaleta A, Anderson OD.

PLoS One. 2013 Sep 17;8(9):e73751. doi: 10.1371/journal.pone.0073751. eCollection 2013.


Advanced glycation end products promote hepatosteatosis by interfering with SCAP-SREBP pathway in fructose-drinking mice.

Mastrocola R, Collino M, Rogazzo M, Medana C, Nigro D, Boccuzzi G, Aragno M.

Am J Physiol Gastrointest Liver Physiol. 2013 Sep 15;305(6):G398-407. doi: 10.1152/ajpgi.00450.2012. Epub 2013 Jul 18.


Development of a deletion and genetic linkage map for the 5A and 5B chromosomes of wheat (Triticum aestivum).

Gadaleta A, Giancaspro A, Giove SL, Zacheo S, Incerti O, Simeone R, Colasuonno P, Nigro D, Valè G, Cattivelli L, Stanca M, Blanco A.

Genome. 2012 Jun;55(6):417-27. doi: 10.1139/g2012-028. Epub 2012 May 25.


The glutamine synthetase (GS2) genes in relation to grain protein content of durum wheat.

Gadaleta A, Nigro D, Giancaspro A, Blanco A.

Funct Integr Genomics. 2011 Dec;11(4):665-70. doi: 10.1007/s10142-011-0235-2. Epub 2011 Jul 14.


Chlorpropamide treatment restores the reduced carrageenan-induced paw edema and pleural exudate volume in diabetic rats.

Sartoretto JL, Melo GA, Bersani-Amado CA, Oliveira MA, Santos RA, Passaglia RT, Nigro D, Cuman RK, Carvalho MH, Fortes ZB.

Inflamm Res. 2008 Sep;57(9):438-43. doi: 10.1007/s00011-008-7211-x.


Amlodipine reduces the antimigratory effect of diclofenac in spontaneously hypertensive rats.

Rodrigues SF, Dossantos RA, de Oliveira MA, Rastelli VM, Nucci Gd, Tostes Rde C, Nigro D, Carvalho MH, Fortes ZB.

J Cardiovasc Pharmacol. 2008 May;51(5):492-504. doi: 10.1097/FJC.0b013e31816d1d37.


Enalapril treatment corrects the reduced response to bradykinin in diabetes increasing the B2 protein expression.

Rastelli VM, Oliveira MA, dos Santos R, de Cássia Tostes Passaglia R, Nigro D, de Carvalho MH, Fortes ZB.

Peptides. 2008 Mar;29(3):404-11. doi: 10.1016/j.peptides.2007.11.022. Epub 2007 Dec 7.


Constrictor responses to noradrenaline, hemodynamic profile, and superoxide levels measured by hydroethidine oxidation in diabetic rats.

Sartoretto JL, Oliveira MA, Nigro D, Carvalho MH, Tostes RC, Fortes ZB.

Biol Pharm Bull. 2007 Oct;30(10):1938-42.


The influence of improved glycaemic control with chlorpropamide on microvascular reactivity and nitric oxide synthase activity in diabetic rats.

Sartoretto JL, Santos RA, Scavone C, Tostes RC, Nigro D, Carvalho MH, Cuman RK, Fortes ZB.

J Pharm Pharmacol. 2007 Aug;59(8):1117-23.


Lack of potentiation of bradykinin by angiotensin-(1-7) in a type 2 diabetes model: role of insulin.

Rastelli VM, Oliveira MA, dos Santos R, de Cássia Tostes Passaglia R, Nigro D, de Carvalho MH, Fortes ZB.

Peptides. 2007 May;28(5):1040-9. Epub 2007 Feb 14.


Enalapril and losartan restored blood pressure and vascular reactivity in intrauterine undernourished rats.

Ceravolo GS, Franco MC, Carneiro-Ramos MS, Barreto-Chaves ML, Tostes RC, Nigro D, Fortes ZB, Carvalho MH.

Life Sci. 2007 Jan 30;80(8):782-7. Epub 2006 Nov 10.


Long-term effects of intrauterine malnutrition on vascular function in female offspring: implications of oxidative stress.

Franco MC, Akamine EH, Rebouças N, Carvalho MH, Tostes RC, Nigro D, Fortes ZB.

Life Sci. 2007 Jan 30;80(8):709-15. Epub 2006 Nov 11.


Mechanisms involved in the reduced leukocyte migration in intrauterine undernourishment.

Landgraf MA, Tostes Rde C, Borelli P, Zorn TM, Nigro D, Carvalho MH, Fortes ZB.

Nutrition. 2007 Feb;23(2):145-56. Epub 2006 Dec 5.


Decreased endothelium-dependent vasodilation in diabetic female rats: role of prostanoids.

Akamine EH, Urakawa TA, de Oliveira MA, Nigro D, de Carvalho MH, de Cássia A Tostes R, Fortes ZB.

J Vasc Res. 2006;43(5):401-10. Epub 2006 Jul 27.


Differential effects of chloral hydrate- and ketamine/xylazine-induced anesthesia by the s.c. route.

Rodrigues SF, de Oliveira MA, Martins JO, Sannomiya P, de Cássia Tostes R, Nigro D, Carvalho MH, Fortes ZB.

Life Sci. 2006 Sep 20;79(17):1630-7. Epub 2006 May 26.


Correction of endothelial dysfunction in diabetic female rats by tetrahydrobiopterin and chronic insulin.

Akamine EH, Kawamoto EM, Scavone C, Nigro D, Carvalho MH, de Cássia A Tostes R, Britto LR, Fortes ZB.

J Vasc Res. 2006;43(4):309-20. Epub 2006 May 8.


Role of the kallikrein-kinin system in Ang-(1-7)-induced vasodilation in mesenteric arterioles of Wistar rats studied in vivo-in situ.

Marangoni RA, Carmona AK, Passaglia RC, Nigro D, Fortes ZB, de Carvalho MH.

Peptides. 2006 Jul;27(7):1770-5. Epub 2006 Apr 3.


Differential effect of losartan in female and male spontaneously hypertensive rats.

de P Rodrigues SF, dos Santos RA, Silva-Antonialli MM, Scavone C, Nigro D, Carvalho MH, de Cássia Tostes R, Fortes ZB.

Life Sci. 2006 Apr 4;78(19):2280-5. Epub 2005 Dec 6.


Losartan attenuates the antimigratory effect of diclofenac in spontaneously hypertensive rats.

Martinez LL, Oliveira MA, Miguel AS, Rastelli VM, Cruz JW, Tostes RC, Carvalho MH, Nigro D, Fortes ZB.

J Cardiovasc Pharmacol. 2005 Aug;46(2):190-9.


Angiotensin II-induced venoconstriction involves both AT1 and AT2 receptors and is counterbalanced by nitric oxide.

Fernandes L, Loiola RA, Tostes RC, Nigro D, Fortes ZB, de Carvalho MH.

Peptides. 2005 Dec;26(12):2458-63. Epub 2005 Jul 25.


Endothelin-1 contributes to the sexual differences in renal damage in DOCA-salt rats.

Montezano AC, Callera GE, Mota AL, Fortes ZB, Nigro D, Carvalho MH, Zorn TM, Tostes RC.

Peptides. 2005 Aug;26(8):1454-62. Epub 2005 Apr 19.


Metformin treatment restores the altered microvascular reactivity in neonatal streptozotocin-induced diabetic rats increasing NOS activity, but not NOS expression.

Sartoretto JL, Melo GA, Carvalho MH, Nigro D, Passaglia RT, Scavone C, Cuman RK, Fortes ZB.

Life Sci. 2005 Oct 7;77(21):2676-89.


Intrauterine undernutrition in rats interferes with leukocyte migration, decreasing adhesion molecule expression in leukocytes and endothelial cells.

Landgraf MA, Martinez LL, Rastelli VM, Franco Mdo C, Soto-Suazo M, Tostes Rde C, Carvalho MH, Nigro D, Fortes ZB.

J Nutr. 2005 Jun;135(6):1480-5.


Influence of insulin on the microvascular response to inflammatory mediators in neonatal streptozotocin diabetic rats.

Rastelli VM, Akamine EH, Oliveira MA, Nigro D, Passaglia Rde C, Carvalho MH, Fortes ZB.

Inflamm Res. 2005 Apr;54(4):173-9.


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