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Items: 1 to 50 of 76

1.

Mycobacterium tuberculosis inhibits human innate immune responses via the production of TLR2 antagonist glycolipids.

Blanc L, Gilleron M, Prandi J, Song OR, Jang MS, Gicquel B, Drocourt D, Neyrolles O, Brodin P, Tiraby G, Vercellone A, Nigou J.

Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11205-11210. doi: 10.1073/pnas.1707840114. Epub 2017 Oct 2.

2.

Microbe and host lipids.

Nigou J, Touqui L, Record M.

Biochimie. 2017 Oct;141:1-2. doi: 10.1016/j.biochi.2017.08.009. Epub 2017 Aug 19. No abstract available.

PMID:
28830710
3.

Mass spectrometry analysis of intact Francisella bacteria identifies lipid A structure remodeling in response to acidic pH stress.

Robert CB, Thomson M, Vercellone A, Gardner F, Ernst RK, Larrouy-Maumus G, Nigou J.

Biochimie. 2017 Oct;141:16-20. doi: 10.1016/j.biochi.2017.08.008. Epub 2017 Aug 12.

PMID:
28807561
4.

Scrutiny of Mycobacterium tuberculosis 19 kDa antigen proteoforms provides new insights in the lipoglycoprotein biogenesis paradigm.

Parra J, Marcoux J, Poncin I, Canaan S, Herrmann JL, Nigou J, Burlet-Schiltz O, Rivière M.

Sci Rep. 2017 Mar 8;7:43682. doi: 10.1038/srep43682.

5.

Rational design of adjuvants targeting the C-type lectin Mincle.

Decout A, Silva-Gomes S, Drocourt D, Barbe S, André I, Cueto FJ, Lioux T, Sancho D, Pérouzel E, Vercellone A, Prandi J, Gilleron M, Tiraby G, Nigou J.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2675-2680. doi: 10.1073/pnas.1612421114. Epub 2017 Feb 21.

6.

Biosynthesis of the Methylthioxylose Capping Motif of Lipoarabinomannan in Mycobacterium tuberculosis.

Angala SK, McNeil MR, Shi L, Joe M, Pham H, Zuberogoitia S, Nigou J, Boot CM, Lowary TL, Gilleron M, Jackson M.

ACS Chem Biol. 2017 Mar 17;12(3):682-691. doi: 10.1021/acschembio.6b01071. Epub 2017 Jan 20.

7.

C-type lectin receptor DCIR modulates immunity to tuberculosis by sustaining type I interferon signaling in dendritic cells.

Troegeler A, Mercier I, Cougoule C, Pietretti D, Colom A, Duval C, Vu Manh TP, Capilla F, Poincloux R, Pingris K, Nigou J, Rademann J, Dalod M, Verreck FA, Al Saati T, Lugo-Villarino G, Lepenies B, Hudrisier D, Neyrolles O.

Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E540-E549. doi: 10.1073/pnas.1613254114. Epub 2017 Jan 9.

8.

Disruption of Mycobacterial AftB Results in Complete Loss of Terminal β(1 → 2) Arabinofuranose Residues of Lipoarabinomannan.

Jankute M, Alderwick LJ, Noack S, Veerapen N, Nigou J, Besra GS.

ACS Chem Biol. 2017 Jan 20;12(1):183-190. doi: 10.1021/acschembio.6b00898. Epub 2016 Dec 5.

9.

Mycobacterium tuberculosis LppM Displays an Original Structure and Domain Composition Linked to a Dual Localization.

Barthe P, Veyron-Churlet R, de Visch A, Gilleron M, Saliou JM, Tomavo S, Nigou J, Brodin P, Cohen-Gonsaud M.

Structure. 2016 Oct 4;24(10):1788-1794. doi: 10.1016/j.str.2016.07.009. Epub 2016 Aug 25.

10.

LppM impact on the colonization of macrophages by Mycobacterium tuberculosis.

Deboosère N, Iantomasi R, Queval CJ, Song OR, Deloison G, Jouny S, Debrie AS, Chamaillard M, Nigou J, Cohen-Gonsaud M, Locht C, Brodin P, Veyron-Churlet R.

Cell Microbiol. 2017 Jan;19(1). doi: 10.1111/cmi.12619. Epub 2016 Jul 11.

11.

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota.

Vétizou M, Pitt JM, Daillère R, Lepage P, Waldschmitt N, Flament C, Rusakiewicz S, Routy B, Roberti MP, Duong CP, Poirier-Colame V, Roux A, Becharef S, Formenti S, Golden E, Cording S, Eberl G, Schlitzer A, Ginhoux F, Mani S, Yamazaki T, Jacquelot N, Enot DP, Bérard M, Nigou J, Opolon P, Eggermont A, Woerther PL, Chachaty E, Chaput N, Robert C, Mateus C, Kroemer G, Raoult D, Boneca IG, Carbonnel F, Chamaillard M, Zitvogel L.

Science. 2015 Nov 27;350(6264):1079-84. doi: 10.1126/science.aad1329. Epub 2015 Nov 5.

12.

A glycomic approach reveals a new mycobacterial polysaccharide.

Larrouy-Maumus G, Gilleron M, Skovierová H, Zuberogoitia S, Brennan PJ, Puzo G, Jackson M, Nigou J.

Glycobiology. 2015 Nov;25(11):1163-71. doi: 10.1093/glycob/cwv061. Epub 2015 Aug 10.

13.

Collectin CL-LK Is a Novel Soluble Pattern Recognition Receptor for Mycobacterium tuberculosis.

Troegeler A, Lugo-Villarino G, Hansen S, Rasolofo V, Henriksen ML, Mori K, Ohtani K, Duval C, Mercier I, Bénard A, Nigou J, Hudrisier D, Wakamiya N, Neyrolles O.

PLoS One. 2015 Jul 14;10(7):e0132692. doi: 10.1371/journal.pone.0132692. eCollection 2015.

14.

The presence of a galactosamine substituent on the arabinogalactan of Mycobacterium tuberculosis abrogates full maturation of human peripheral blood monocyte-derived dendritic cells and increases secretion of IL-10.

Wheat WH, Dhouib R, Angala SK, Larrouy-Maumus G, Dobos K, Nigou J, Spencer JS, Jackson M.

Tuberculosis (Edinb). 2015 Jul;95(4):476-89. doi: 10.1016/j.tube.2015.04.002. Epub 2015 May 14.

15.

Lipid and lipoarabinomannan isolation and characterization.

Lanéelle MA, Nigou J, Daffé M.

Methods Mol Biol. 2015;1285:77-103. doi: 10.1007/978-1-4939-2450-9_5.

PMID:
25779311
16.

Manipulation of the endocytic pathway and phagocyte functions by Mycobacterium tuberculosis lipoarabinomannan.

Vergne I, Gilleron M, Nigou J.

Front Cell Infect Microbiol. 2015 Jan 12;4:187. doi: 10.3389/fcimb.2014.00187. eCollection 2014. Review.

17.

Gram-positive bacterial lipoglycans based on a glycosylated diacylglycerol lipid anchor are microbe-associated molecular patterns recognized by TLR2.

Blanc L, Castanier R, Mishra AK, Ray A, Besra GS, Sutcliffe I, Vercellone A, Nigou J.

PLoS One. 2013 Nov 21;8(11):e81593. doi: 10.1371/journal.pone.0081593. eCollection 2013.

18.

Mannodendrimers prevent acute lung inflammation by inhibiting neutrophil recruitment.

Blattes E, Vercellone A, Eutamène H, Turrin CO, Théodorou V, Majoral JP, Caminade AM, Prandi J, Nigou J, Puzo G.

Proc Natl Acad Sci U S A. 2013 May 28;110(22):8795-800. doi: 10.1073/pnas.1221708110. Epub 2013 May 13.

19.

Bacterial protein-O-mannosylating enzyme is crucial for virulence of Mycobacterium tuberculosis.

Liu CF, Tonini L, Malaga W, Beau M, Stella A, Bouyssié D, Jackson MC, Nigou J, Puzo G, Guilhot C, Burlet-Schiltz O, Rivière M.

Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6560-5. doi: 10.1073/pnas.1219704110. Epub 2013 Apr 2.

20.

Tuberculosis 2012: biology, pathogenesis and intervention strategies; an update from the city of light.

Gouzy A, Nigou J, Gilleron M, Neyrolles O, Tailleux L, Gordon SV.

Res Microbiol. 2013 Apr;164(3):270-80. doi: 10.1016/j.resmic.2012.12.006. Epub 2012 Dec 20.

PMID:
23266372
21.

Differential arabinan capping of lipoarabinomannan modulates innate immune responses and impacts T helper cell differentiation.

Mishra AK, Alves JE, Krumbach K, Nigou J, Castro AG, Geurtsen J, Eggeling L, Saraiva M, Besra GS.

J Biol Chem. 2012 Dec 28;287(53):44173-83. doi: 10.1074/jbc.M112.402396. Epub 2012 Nov 9.

22.

Lipoarabinomannan mannose caps do not affect mycobacterial virulence or the induction of protective immunity in experimental animal models of infection and have minimal impact on in vitro inflammatory responses.

Afonso-Barroso A, Clark SO, Williams A, Rosa GT, Nóbrega C, Silva-Gomes S, Vale-Costa S, Ummels R, Stoker N, Movahedzadeh F, van der Ley P, Sloots A, Cot M, Appelmelk BJ, Puzo G, Nigou J, Geurtsen J, Appelberg R.

Cell Microbiol. 2013 Apr;15(4):660-74. doi: 10.1111/cmi.12065. Epub 2012 Nov 21.

PMID:
23121245
23.

A small multidrug resistance-like transporter involved in the arabinosylation of arabinogalactan and lipoarabinomannan in mycobacteria.

Larrouy-Maumus G, Škovierová H, Dhouib R, Angala SK, Zuberogoitia S, Pham H, Villela AD, Mikušová K, Noguera A, Gilleron M, Valentínová L, Korduláková J, Brennan PJ, Puzo G, Nigou J, Jackson M.

J Biol Chem. 2012 Nov 16;287(47):39933-41. doi: 10.1074/jbc.M112.400986. Epub 2012 Oct 4.

24.

Bacterial cell wall macroamphiphiles: pathogen-/microbe-associated molecular patterns detected by mammalian innate immune system.

Ray A, Cot M, Puzo G, Gilleron M, Nigou J.

Biochimie. 2013 Jan;95(1):33-42. doi: 10.1016/j.biochi.2012.06.007. Epub 2012 Jun 15. Review.

PMID:
22706280
25.

Lipoglycans contribute to innate immune detection of mycobacteria.

Krishna S, Ray A, Dubey SK, Larrouy-Maumus G, Chalut C, Castanier R, Noguera A, Gilleron M, Puzo G, Vercellone A, Nampoothiri KM, Nigou J.

PLoS One. 2011;6(12):e28476. doi: 10.1371/journal.pone.0028476. Epub 2011 Dec 2.

26.

Lipoteichoic acid in Streptomyces hygroscopicus: structural model and immunomodulatory activities.

Cot M, Ray A, Gilleron M, Vercellone A, Larrouy-Maumus G, Armau E, Gauthier S, Tiraby G, Puzo G, Nigou J.

PLoS One. 2011;6(10):e26316. doi: 10.1371/journal.pone.0026316. Epub 2011 Oct 18.

27.

Lipoarabinomannan biosynthesis in Corynebacterineae: the interplay of two α(1→2)-mannopyranosyltransferases MptC and MptD in mannan branching.

Mishra AK, Krumbach K, Rittmann D, Appelmelk B, Pathak V, Pathak AK, Nigou J, Geurtsen J, Eggeling L, Besra GS.

Mol Microbiol. 2011 Jun;80(5):1241-59. doi: 10.1111/j.1365-2958.2011.07640.x. Epub 2011 Apr 4.

28.

Overexpression of proinflammatory TLR-2-signalling lipoproteins in hypervirulent mycobacterial variants.

Roux AL, Ray A, Pawlik A, Medjahed H, Etienne G, Rottman M, Catherinot E, Coppée JY, Chaoui K, Monsarrat B, Toubert A, Daffé M, Puzo G, Gaillard JL, Brosch R, Dulphy N, Nigou J, Herrmann JL.

Cell Microbiol. 2011 May;13(5):692-704. doi: 10.1111/j.1462-5822.2010.01565.x. Epub 2011 Jan 5.

PMID:
21143571
29.

Biosynthetic origin of the galactosamine substituent of Arabinogalactan in Mycobacterium tuberculosis.

Skovierová H, Larrouy-Maumus G, Pham H, Belanová M, Barilone N, Dasgupta A, Mikusová K, Gicquel B, Gilleron M, Brennan PJ, Puzo G, Nigou J, Jackson M.

J Biol Chem. 2010 Dec 31;285(53):41348-55. doi: 10.1074/jbc.M110.188110. Epub 2010 Oct 28.

30.

Mycobacterium marinum MMAR_2380, a predicted transmembrane acyltransferase, is essential for the presence of the mannose cap on lipoarabinomannan.

Driessen NN, Stoop EJ, Ummels R, Gurcha SS, Mishra AK, Larrouy-Maumus G, Nigou J, Gilleron M, Puzo G, Maaskant JJ, Sparrius M, Besra GS, Bitter W, Vandenbroucke-Grauls CM, Appelmelk BJ.

Microbiology. 2010 Nov;156(Pt 11):3492-502. doi: 10.1099/mic.0.037507-0. Epub 2010 Aug 5.

31.

A truncated lipoglycan from mycobacteria with altered immunological properties.

Birch HL, Alderwick LJ, Appelmelk BJ, Maaskant J, Bhatt A, Singh A, Nigou J, Eggeling L, Geurtsen J, Besra GS.

Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2634-9. doi: 10.1073/pnas.0915082107. Epub 2010 Jan 25.

32.

Identification of mycobacterial alpha-glucan as a novel ligand for DC-SIGN: involvement of mycobacterial capsular polysaccharides in host immune modulation.

Geurtsen J, Chedammi S, Mesters J, Cot M, Driessen NN, Sambou T, Kakutani R, Ummels R, Maaskant J, Takata H, Baba O, Terashima T, Bovin N, Vandenbroucke-Grauls CM, Nigou J, Puzo G, Lemassu A, Daffé M, Appelmelk BJ.

J Immunol. 2009 Oct 15;183(8):5221-31. doi: 10.4049/jimmunol.0900768. Epub 2009 Sep 25.

33.

A murine DC-SIGN homologue contributes to early host defense against Mycobacterium tuberculosis.

Tanne A, Ma B, Boudou F, Tailleux L, Botella H, Badell E, Levillain F, Taylor ME, Drickamer K, Nigou J, Dobos KM, Puzo G, Vestweber D, Wild MK, Marcinko M, Sobieszczuk P, Stewart L, Lebus D, Gicquel B, Neyrolles O.

J Exp Med. 2009 Sep 28;206(10):2205-20. doi: 10.1084/jem.20090188. Epub 2009 Sep 21.

34.

AftD, a novel essential arabinofuranosyltransferase from mycobacteria.

Skovierová H, Larrouy-Maumus G, Zhang J, Kaur D, Barilone N, Korduláková J, Gilleron M, Guadagnini S, Belanová M, Prevost MC, Gicquel B, Puzo G, Chatterjee D, Brennan PJ, Nigou J, Jackson M.

Glycobiology. 2009 Nov;19(11):1235-47. doi: 10.1093/glycob/cwp116. Epub 2009 Aug 4.

35.

The immunomodulatory lipoglycans, lipoarabinomannan and lipomannan, are exposed at the mycobacterial cell surface.

Pitarque S, Larrouy-Maumus G, Payré B, Jackson M, Puzo G, Nigou J.

Tuberculosis (Edinb). 2008 Nov;88(6):560-5. doi: 10.1016/j.tube.2008.04.002. Epub 2008 Jun 9.

36.

Mannan chain length controls lipoglycans signaling via and binding to TLR2.

Nigou J, Vasselon T, Ray A, Constant P, Gilleron M, Besra GS, Sutcliffe I, Tiraby G, Puzo G.

J Immunol. 2008 May 15;180(10):6696-702.

37.

The mannose cap of mycobacterial lipoarabinomannan does not dominate the Mycobacterium-host interaction.

Appelmelk BJ, den Dunnen J, Driessen NN, Ummels R, Pak M, Nigou J, Larrouy-Maumus G, Gurcha SS, Movahedzadeh F, Geurtsen J, Brown EJ, Eysink Smeets MM, Besra GS, Willemsen PT, Lowary TL, van Kooyk Y, Maaskant JJ, Stoker NG, van der Ley P, Puzo G, Vandenbroucke-Grauls CM, Wieland CW, van der Poll T, Geijtenbeek TB, van der Sar AM, Bitter W.

Cell Microbiol. 2008 Apr;10(4):930-44. Epub 2007 Dec 5.

PMID:
18070119
38.

Dimerization of inositol monophosphatase Mycobacterium tuberculosis SuhB is not constitutive, but induced by binding of the activator Mg2+.

Brown AK, Meng G, Ghadbane H, Scott DJ, Dover LG, Nigou J, Besra GS, Fütterer K.

BMC Struct Biol. 2007 Aug 28;7:55.

39.

Identification of an alpha(1-->6) mannopyranosyltransferase (MptA), involved in Corynebacterium glutamicum lipomanann biosynthesis, and identification of its orthologue in Mycobacterium tuberculosis.

Mishra AK, Alderwick LJ, Rittmann D, Tatituri RV, Nigou J, Gilleron M, Eggeling L, Besra GS.

Mol Microbiol. 2007 Sep;65(6):1503-17. Epub 2007 Aug 21.

40.

Structural characterization of a partially arabinosylated lipoarabinomannan variant isolated from a Corynebacterium glutamicum ubiA mutant.

Tatituri RV, Alderwick LJ, Mishra AK, Nigou J, Gilleron M, Krumbach K, Hitchen P, Giordano A, Morris HR, Dell A, Eggeling L, Besra GS.

Microbiology. 2007 Aug;153(Pt 8):2621-9.

41.
42.

Mycobacterial lipomannan induces granuloma macrophage fusion via a TLR2-dependent, ADAM9- and beta1 integrin-mediated pathway.

Puissegur MP, Lay G, Gilleron M, Botella L, Nigou J, Marrakchi H, Mari B, Duteyrat JL, Guerardel Y, Kremer L, Barbry P, Puzo G, Altare F.

J Immunol. 2007 Mar 1;178(5):3161-9.

43.

Intermediate maturation of Mycobacterium tuberculosis LAM-activated human dendritic cells.

Dulphy N, Herrmann JL, Nigou J, Réa D, Boissel N, Puzo G, Charron D, Lagrange PH, Toubert A.

Cell Microbiol. 2007 Jun;9(6):1412-25. Epub 2007 Jan 23.

PMID:
17253979
44.

Inactivation of Corynebacterium glutamicum NCgl0452 and the role of MgtA in the biosynthesis of a novel mannosylated glycolipid involved in lipomannan biosynthesis.

Tatituri RV, Illarionov PA, Dover LG, Nigou J, Gilleron M, Hitchen P, Krumbach K, Morris HR, Spencer N, Dell A, Eggeling L, Besra GS.

J Biol Chem. 2007 Feb 16;282(7):4561-72. Epub 2006 Dec 19.

45.

Signature-tagged transposon mutagenesis identifies novel Mycobacterium tuberculosis genes involved in the parasitism of human macrophages.

Rosas-Magallanes V, Stadthagen-Gomez G, Rauzier J, Barreiro LB, Tailleux L, Boudou F, Griffin R, Nigou J, Jackson M, Gicquel B, Neyrolles O.

Infect Immun. 2007 Jan;75(1):504-7. Epub 2006 Oct 9.

46.

[The role of human dendritic cells in tuberculosis: protector or non-protector?].

Herrmann JL, Tailleux L, Nigou J, Giquel B, Puzo G, Lagrange PH, Neyrolles O.

Rev Mal Respir. 2006 Jun;23(3 Suppl):6S21-6S28. Review. French.

PMID:
16820745
47.

Comparative investigation of the pathogenicity of three Mycobacterium tuberculosis mutants defective in the synthesis of p-hydroxybenzoic acid derivatives.

Stadthagen G, Jackson M, Charles P, Boudou F, Barilone N, Huerre M, Constant P, Liav A, Bottova I, Nigou J, Brando T, Puzo G, Daffé M, Benjamin P, Coade S, Buxton RS, Tascon RE, Rae A, Robertson BD, Lowrie DB, Young DB, Gicquel B, Griffin R.

Microbes Infect. 2006 Jul;8(8):2245-53. Epub 2006 May 30.

48.

The acylation state of mycobacterial lipomannans modulates innate immunity response through toll-like receptor 2.

Gilleron M, Nigou J, Nicolle D, Quesniaux V, Puzo G.

Chem Biol. 2006 Jan;13(1):39-47.

49.

Deciphering the molecular bases of Mycobacterium tuberculosis binding to the lectin DC-SIGN reveals an underestimated complexity.

Pitarque S, Herrmann JL, Duteyrat JL, Jackson M, Stewart GR, Lecointe F, Payre B, Schwartz O, Young DB, Marchal G, Lagrange PH, Puzo G, Gicquel B, Nigou J, Neyrolles O.

Biochem J. 2005 Dec 15;392(Pt 3):615-24.

50.

A lipomannan variant with strong TLR-2-dependent pro-inflammatory activity in Saccharothrix aerocolonigenes.

Gibson KJ, Gilleron M, Constant P, Sichi B, Puzo G, Besra GS, Nigou J.

J Biol Chem. 2005 Aug 5;280(31):28347-56. Epub 2005 Jun 14.

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