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Proteasomal Degradation of the EWS-FLI1 Fusion Protein Is Regulated by a Single Lysine Residue.

Gierisch ME, Pfistner F, Lopez-Garcia LA, Harder L, Schäfer BW, Niggli FK.

J Biol Chem. 2016 Dec 23;291(52):26922-26933. doi: 10.1074/jbc.M116.752063. Epub 2016 Nov 8.


Pencil Beam Scanning Proton Therapy for Pediatric Parameningeal Rhabdomyosarcomas: Clinical Outcome of Patients Treated at the Paul Scherrer Institute.

Weber DC, Ares C, Albertini F, Frei-Welte M, Niggli FK, Schneider R, Lomax AJ.

Pediatr Blood Cancer. 2016 Oct;63(10):1731-6. doi: 10.1002/pbc.25864. Epub 2015 Dec 23.


Targeting the EWS-ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma.

Hensel T, Giorgi C, Schmidt O, Calzada-Wack J, Neff F, Buch T, Niggli FK, Schäfer BW, Burdach S, Richter GH.

Oncotarget. 2016 Jan 12;7(2):1451-63. doi: 10.18632/oncotarget.6385.


PI3K/AKT signaling modulates transcriptional expression of EWS/FLI1 through specificity protein 1.

Giorgi C, Boro A, Rechfeld F, Lopez-Garcia LA, Gierisch ME, Schäfer BW, Niggli FK.

Oncotarget. 2015 Oct 6;6(30):28895-910. doi: 10.18632/oncotarget.5000.


Exploring the association of hemoglobin level and adverse events in children with cancer presenting with fever in neutropenia.

Ammann RA, Niggli FK, Leibundgut K, Teuffel O, Bodmer N.

PLoS One. 2014 Jul 14;9(7):e101696. doi: 10.1371/journal.pone.0101696. eCollection 2014.


Mental health-care utilization in survivors of childhood cancer and siblings: the Swiss childhood cancer survivor study.

Gianinazzi ME, Rueegg CS, von der Weid NX, Niggli FK, Kuehni CE, Michel G; Swiss Paediatric Oncology Group (SPOG).

Support Care Cancer. 2014 Feb;22(2):339-49. doi: 10.1007/s00520-013-1976-3. Epub 2013 Oct 1.


Treatment and outcome of patients suffering from perineal/perianal rhabdomyosarcoma: results from the CWS trials--retrospective clinical study.

Fuchs J, Dantonello TM, Blumenstock G, Kosztyla D, Klingebiel T, Leuschner I, Schuck A, Niggli FK, Koscielniak E, Seitz G.

Ann Surg. 2014 Jun;259(6):1166-72. doi: 10.1097/SLA.0b013e3182a6f320.


Serum Concentrations of Mannan-Binding Lectin (MBL) and MBL-Associated Serine Protease-2 and the Risk of Adverse Events in Pediatric Patients With Cancer and Fever in Neutropenia.

Ammann RA, Bodmer N, Simon A, Agyeman P, Leibundgut K, Schlapbach LJ, Niggli FK.

J Pediatric Infect Dis Soc. 2013 Jun;2(2):155-61. doi: 10.1093/jpids/pit005. Epub 2013 Feb 13.


Different fever definitions and the rate of fever and neutropenia diagnosed in children with cancer: a retrospective two-center cohort study.

Binz P, Bodmer N, Leibundgut K, Teuffel O, Niggli FK, Ammann RA.

Pediatr Blood Cancer. 2013 May;60(5):799-805. doi: 10.1002/pbc.24380. Epub 2012 Nov 28.


Cohort profile: the Swiss childhood cancer survivor study.

Kuehni CE, Rueegg CS, Michel G, Rebholz CE, Strippoli MP, Niggli FK, Egger M, von der Weid NX; Swiss Paediatric Oncology Group (SPOG).

Int J Epidemiol. 2012 Dec;41(6):1553-64. doi: 10.1093/ije/dyr142. Epub 2011 Oct 27. No abstract available.


Health-related quality of life in long-term survivors of relapsed childhood acute lymphoblastic leukemia.

Essig S, von der Weid NX, Strippoli MP, Rebholz CE, Michel G, Rueegg CS, Niggli FK, Kuehni CE; Swiss Pediatric Oncology Group (SPOG).

PLoS One. 2012;7(5):e38015. doi: 10.1371/journal.pone.0038015. Epub 2012 May 25.


Small-molecule screen identifies modulators of EWS/FLI1 target gene expression and cell survival in Ewing's sarcoma.

Boro A, Prêtre K, Rechfeld F, Thalhammer V, Oesch S, Wachtel M, Schäfer BW, Niggli FK.

Int J Cancer. 2012 Nov 1;131(9):2153-64. doi: 10.1002/ijc.27472. Epub 2012 Mar 29.


First-day step-down to oral outpatient treatment versus continued standard treatment in children with cancer and low-risk fever in neutropenia. A randomized controlled trial within the multicenter SPOG 2003 FN study.

Brack E, Bodmer N, Simon A, Leibundgut K, Kühne T, Niggli FK, Ammann RA.

Pediatr Blood Cancer. 2012 Sep;59(3):423-30. doi: 10.1002/pbc.24076. Epub 2012 Jan 23.


Serious medical complications in children with cancer and fever in chemotherapy-induced neutropenia: results of the prospective multicenter SPOG 2003 FN study.

Lüthi F, Leibundgut K, Niggli FK, Nadal D, Aebi C, Bodmer N, Ammann RA.

Pediatr Blood Cancer. 2012 Jul 15;59(1):90-5. doi: 10.1002/pbc.23277. Epub 2011 Aug 11.


Xenografts of highly resistant leukemia recapitulate the clonal composition of the leukemogenic compartment.

Schmitz M, Breithaupt P, Scheidegger N, Cario G, Bonapace L, Meissner B, Mirkowska P, Tchinda J, Niggli FK, Stanulla M, Schrappe M, Schrauder A, Bornhauser BC, Bourquin JP.

Blood. 2011 Aug 18;118(7):1854-64. doi: 10.1182/blood-2010-11-320309. Epub 2011 Jun 13.


CD133 positive embryonal rhabdomyosarcoma stem-like cell population is enriched in rhabdospheres.

Walter D, Satheesha S, Albrecht P, Bornhauser BC, D'Alessandro V, Oesch SM, Rehrauer H, Leuschner I, Koscielniak E, Gengler C, Moch H, Bernasconi M, Niggli FK, Schäfer BW; CWS Study Group.

PLoS One. 2011;6(5):e19506. doi: 10.1371/journal.pone.0019506. Epub 2011 May 13.


Predicting bacteremia in children with cancer and fever in chemotherapy-induced neutropenia: results of the prospective multicenter SPOG 2003 FN study.

Agyeman P, Aebi C, Hirt A, Niggli FK, Nadal D, Simon A, Ozsahin H, Kontny U, Kühne T, Beck Popovic M, Leibundgut K, Bodmer N, Ammann RA.

Pediatr Infect Dis J. 2011 Jul;30(7):e114-9. doi: 10.1097/INF.0b013e318215a290.


Generation of a novel rtTA transgenic mouse to induce time-controlled, tissue-specific alterations in Pax2-expressing cells.

Burger A, Koesters R, Schäfer BW, Niggli FK.

Genesis. 2011 Oct;49(10):797-802. doi: 10.1002/dvg.20701. Epub 2011 Sep 23.


Follow-up care amongst long-term childhood cancer survivors: a report from the Swiss Childhood Cancer Survivor Study.

Rebholz CE, von der Weid NX, Michel G, Niggli FK, Kuehni CE; Swiss Pediatric Oncology Group (SPOG).

Eur J Cancer. 2011 Jan;47(2):221-9. doi: 10.1016/j.ejca.2010.09.017. Epub 2010 Oct 11.


Furin targeted drug delivery for treatment of rhabdomyosarcoma in a mouse model.

Hajdin K, D'Alessandro V, Niggli FK, Schäfer BW, Bernasconi M.

PLoS One. 2010 May 3;5(5):e10445. doi: 10.1371/journal.pone.0010445.


p21 Downregulation is an important component of PAX3/FKHR oncogenicity and its reactivation by HDAC inhibitors enhances combination treatment.

Hecker RM, Amstutz RA, Wachtel M, Walter D, Niggli FK, Schäfer BW.

Oncogene. 2010 Jul 8;29(27):3942-52. doi: 10.1038/onc.2010.145. Epub 2010 May 10.


Predicting adverse events in children with fever and chemotherapy-induced neutropenia: the prospective multicenter SPOG 2003 FN study.

Ammann RA, Bodmer N, Hirt A, Niggli FK, Nadal D, Simon A, Ozsahin H, Kontny U, Kühne T, Popovic MB, Lüthy AR, Aebi C.

J Clin Oncol. 2010 Apr 20;28(12):2008-14. doi: 10.1200/JCO.2009.25.8988. Epub 2010 Mar 15.


Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance.

Bonapace L, Bornhauser BC, Schmitz M, Cario G, Ziegler U, Niggli FK, Schäfer BW, Schrappe M, Stanulla M, Bourquin JP.

J Clin Invest. 2010 Apr;120(4):1310-23. doi: 10.1172/JCI39987.


Immunohistochemical detection of EGFR, fibrillin-2, P-cadherin and AP2beta as biomarkers for rhabdomyosarcoma diagnostics.

Grass B, Wachtel M, Behnke S, Leuschner I, Niggli FK, Schäfer BW.

Histopathology. 2009 Jun;54(7):873-9. doi: 10.1111/j.1365-2559.2009.03303.x. Epub 2009 May 11.


The Wnt receptor FZD1 mediates chemoresistance in neuroblastoma through activation of the Wnt/beta-catenin pathway.

Flahaut M, Meier R, Coulon A, Nardou KA, Niggli FK, Martinet D, Beckmann JS, Joseph JM, Mühlethaler-Mottet A, Gross N.

Oncogene. 2009 Jun 11;28(23):2245-56. doi: 10.1038/onc.2009.80. Epub 2009 May 4.


Prognosis in pediatric hematologic malignancies is associated with serum concentration of mannose-binding lectin-associated serine protease-2 (MASP-2).

Zehnder A, Fisch U, Hirt A, Niggli FK, Simon A, Ozsahin H, Schlapbach LJ, Ammann RA.

Pediatr Blood Cancer. 2009 Jul;53(1):53-7. doi: 10.1002/pbc.22028.


Non-classical karyotypic features in relapsed childhood B-cell precursor acute lymphoblastic leukemia.

Wehrli LA, Braun J, Buetti LN, Hagleitner N, Hengartner H, Kühne T, Lüer S, Ozsahin H, Popovic MB, Niggli FK, Betts DR, Bourquin JP.

Cancer Genet Cytogenet. 2009 Feb;189(1):29-36. doi: 10.1016/j.cancergencyto.2008.10.002.


Identification of a rhabdomyosarcoma targeting peptide by phage display with sequence similarities to the tumour lymphatic-homing peptide LyP-1.

Witt H, Hajdin K, Iljin K, Greiner O, Niggli FK, Schäfer BW, Bernasconi M.

Int J Cancer. 2009 May 1;124(9):2026-32. doi: 10.1002/ijc.24170.


Anemia and survival in childhood acute lymphoblastic leukemia.

Teuffel O, Stanulla M, Cario G, Ludwig WD, Rottgers S, Schafer BW, Zimmermann M, Schrappe M, Niggli FK.

Haematologica. 2008 Nov;93(11):1652-7. doi: 10.3324/haematol.13156. Epub 2008 Sep 24.


An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice.

Traykova-Brauch M, Schönig K, Greiner O, Miloud T, Jauch A, Bode M, Felsher DW, Glick AB, Kwiatkowski DJ, Bujard H, Horst J, von Knebel Doeberitz M, Niggli FK, Kriz W, Gröne HJ, Koesters R.

Nat Med. 2008 Sep;14(9):979-84. doi: 10.1038/nm.1865.


A psychoeducational intervention reduces the need for anesthesia during radiotherapy for young childhood cancer patients.

Haeberli S, Grotzer MA, Niggli FK, Landolt MA, Linsenmeier C, Ammann RA, Bodmer N.

Radiat Oncol. 2008 Jun 4;3:17. doi: 10.1186/1748-717X-3-17.


Phosphorylation regulates transcriptional activity of PAX3/FKHR and reveals novel therapeutic possibilities.

Amstutz R, Wachtel M, Troxler H, Kleinert P, Ebauer M, Haneke T, Oehler-Jänne C, Fabbro D, Niggli FK, Schäfer BW.

Cancer Res. 2008 May 15;68(10):3767-76. doi: 10.1158/0008-5472.CAN-07-2447.


Minimal residual disease-directed risk stratification using real-time quantitative PCR analysis of immunoglobulin and T-cell receptor gene rearrangements in the international multicenter trial AIEOP-BFM ALL 2000 for childhood acute lymphoblastic leukemia.

Flohr T, Schrauder A, Cazzaniga G, Panzer-Grümayer R, van der Velden V, Fischer S, Stanulla M, Basso G, Niggli FK, Schäfer BW, Sutton R, Koehler R, Zimmermann M, Valsecchi MG, Gadner H, Masera G, Schrappe M, van Dongen JJ, Biondi A, Bartram CR; International BFM Study Group (I-BFM-SG).

Leukemia. 2008 Apr;22(4):771-82. doi: 10.1038/leu.2008.5. Epub 2008 Jan 31.


Karyotypic characterization of infant embryonal rhabdomyosarcoma.

Muntean A, Bergsträsser E, Diepold M, Niggli FK, Betts DR.

Cancer Genet Cytogenet. 2008 Jan 15;180(2):145-8. doi: 10.1016/j.cancergencyto.2007.09.020.


Low-dose arsenic trioxide sensitizes glucocorticoid-resistant acute lymphoblastic leukemia cells to dexamethasone via an Akt-dependent pathway.

Bornhauser BC, Bonapace L, Lindholm D, Martinez R, Cario G, Schrappe M, Niggli FK, Schäfer BW, Bourquin JP.

Blood. 2007 Sep 15;110(6):2084-91. Epub 2007 May 30.


Comparative expression profiling identifies an in vivo target gene signature with TFAP2B as a mediator of the survival function of PAX3/FKHR.

Ebauer M, Wachtel M, Niggli FK, Schäfer BW.

Oncogene. 2007 Nov 8;26(51):7267-81. Epub 2007 May 21.


Loss of i(8)(q10) at relapse in two cases of childhood acute myeloid leukaemia.

Seppa L, Hengartner H, Leibundgut K, Kuhne T, Niggli FK, Betts DR.

Leuk Lymphoma. 2007 May;48(5):1045-7. No abstract available.


The prognostic significance of cytogenetic aberrations in childhood acute myeloid leukaemia. A study of the Swiss Paediatric Oncology Group (SPOG).

Betts DR, Ammann RA, Hirt A, Hengartner H, Beck-Popovic M, Kuhne T, Nobile L, Caflisch U, Wacker P, Niggli FK.

Eur J Haematol. 2007 Jun;78(6):468-76. Epub 2007 Apr 5.


Immune activation suppresses initiation of lytic Epstein-Barr virus infection.

Ladell K, Dorner M, Zauner L, Berger C, Zucol F, Bernasconi M, Niggli FK, Speck RF, Nadal D.

Cell Microbiol. 2007 Aug;9(8):2055-69. Epub 2007 Apr 5.


SKY reveals a high frequency of unbalanced translocations involving chromosome 6 in t(12;21)-positive acute lymphoblastic leukemia.

Betts DR, Stanchescu R, Niggli FK, Cohen N, Rechavi G, Amariglio N, Trakhtenbrot L.

Leuk Res. 2008 Jan;32(1):39-43. Epub 2007 Apr 6.


Real-time broad-range PCR versus blood culture. A prospective pilot study in pediatric cancer patients with fever and neutropenia.

Ammann RA, Zucol F, Aebi C, Niggli FK, Kühne T, Nadal D.

Support Care Cancer. 2007 Jun;15(6):637-641. doi: 10.1007/s00520-007-0235-x. Epub 2007 Mar 1.


Array comparative genomic hybridization reveals unbalanced gain of the MYCN region in Wilms tumors.

Schaub R, Burger A, Bausch D, Niggli FK, Schäfer BW, Betts DR.

Cancer Genet Cytogenet. 2007 Jan 1;172(1):61-5.


Cytogenetics of pineoblastoma: four new cases and a literature review.

Brown AE, Leibundgut K, Niggli FK, Betts DR.

Cancer Genet Cytogenet. 2006 Oct 15;170(2):175-9. Review.


Health-related quality of life in children with newly diagnosed cancer: a one year follow-up study.

Landolt MA, Vollrath M, Niggli FK, Gnehm HE, Sennhauser FH.

Health Qual Life Outcomes. 2006 Sep 20;4:63.


Real-time quantitative broad-range PCR assay for detection of the 16S rRNA gene followed by sequencing for species identification.

Zucol F, Ammann RA, Berger C, Aebi C, Altwegg M, Niggli FK, Nadal D.

J Clin Microbiol. 2006 Aug;44(8):2750-9.


Favorable outcome of triploid neuroblastomas: a contribution to the special oncogenesis of neuroblastoma.

Spitz R, Betts DR, Simon T, Boensch M, Oestreich J, Niggli FK, Ernestus K, Berthold F, Hero B.

Cancer Genet Cytogenet. 2006 May;167(1):51-6.


The MLL recombinome of acute leukemias.

Meyer C, Schneider B, Jakob S, Strehl S, Attarbaschi A, Schnittger S, Schoch C, Jansen MW, van Dongen JJ, den Boer ML, Pieters R, Ennas MG, Angelucci E, Koehl U, Greil J, Griesinger F, Zur Stadt U, Eckert C, Szczepański T, Niggli FK, Schäfer BW, Kempski H, Brady HJ, Zuna J, Trka J, Nigro LL, Biondi A, Delabesse E, Macintyre E, Stanulla M, Schrappe M, Haas OA, Burmeister T, Dingermann T, Klingebiel T, Marschalek R.

Leukemia. 2006 May;20(5):777-84.


A t(12;17)(p13;q12) identifies a distinct TEL rearrangement-negative subtype of precursor-B acute lymphoblastic leukemia.

Reid AG, Seppa L, von der Weid N, Niggli FK, Betts DR.

Cancer Genet Cytogenet. 2006 Feb;165(1):64-9.


Subtype and prognostic classification of rhabdomyosarcoma by immunohistochemistry.

Wachtel M, Runge T, Leuschner I, Stegmaier S, Koscielniak E, Treuner J, Odermatt B, Behnke S, Niggli FK, Schäfer BW.

J Clin Oncol. 2006 Feb 10;24(5):816-22. Epub 2006 Jan 3.


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