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Structural centrosome aberrations sensitize polarized epithelia to basal cell extrusion.

Ganier O, Schnerch D, Nigg EA.

Open Biol. 2018 Jun;8(6). pii: 180044. doi: 10.1098/rsob.180044.


Impact of Centrosome Aberrations on Chromosome Segregation and Tissue Architecture in Cancer.

Nigg EA, Schnerch D, Ganier O.

Cold Spring Harb Symp Quant Biol. 2017;82:137-144. doi: 10.1101/sqb.2017.82.034421. Epub 2018 Apr 2.


Structural centrosome aberrations promote non-cell-autonomous invasiveness.

Ganier O, Schnerch D, Oertle P, Lim RY, Plodinec M, Nigg EA.

EMBO J. 2018 May 2;37(9). pii: e98576. doi: 10.15252/embj.201798576. Epub 2018 Mar 22.


Quantitative proteomic and phosphoproteomic comparison of human colon cancer DLD-1 cells differing in ploidy and chromosome stability.

Viganó C, von Schubert C, Ahrné E, Schmidt A, Lorber T, Bubendorf L, De Vetter JRF, Zaman GJR, Storchova Z, Nigg EA.

Mol Biol Cell. 2018 May 1;29(9):1031-1047. doi: 10.1091/mbc.E17-10-0577.


The SKP1-Cullin-F-box E3 ligase βTrCP and CDK2 cooperate to control STIL abundance and centriole number.

Arquint C, Cubizolles F, Morand A, Schmidt A, Nigg EA.

Open Biol. 2018 Feb;8(2). pii: 170253. doi: 10.1098/rsob.170253.


New Editor-in-Chief-welcome to Simon Boulton!

Nigg EA, Boulton SJ.

Chromosoma. 2018 Mar;127(1):1. doi: 10.1007/s00412-018-0661-1. Epub 2018 Jan 29. No abstract available.


Once and only once: mechanisms of centriole duplication and their deregulation in disease.

Nigg EA, Holland AJ.

Nat Rev Mol Cell Biol. 2018 May;19(5):297-312. doi: 10.1038/nrm.2017.127. Epub 2018 Jan 24. Review.


A novel TPR-BEN domain interaction mediates PICH-BEND3 association.

Pitchai GP, Kaulich M, Bizard AH, Mesa P, Yao Q, Sarlos K, Streicher WW, Nigg EA, Montoya G, Hickson ID.

Nucleic Acids Res. 2017 Nov 2;45(19):11413-11424. doi: 10.1093/nar/gkx792.


Cellular Prion Protein PrPC and Ecto-5'-Nucleotidase Are Markers of the Cellular Stress Response to Aneuploidy.

Domingues PH, Nanduri LSY, Seget K, Venkateswaran SV, Agorku D, Viganó C, von Schubert C, Nigg EA, Swanton C, Sotillo R, Bosio A, Storchová Z, Hardt O.

Cancer Res. 2017 Jun 1;77(11):2914-2926. doi: 10.1158/0008-5472.CAN-16-3052. Epub 2017 Apr 4.


The PIDDosome activates p53 in response to supernumerary centrosomes.

Fava LL, Schuler F, Sladky V, Haschka MD, Soratroi C, Eiterer L, Demetz E, Weiss G, Geley S, Nigg EA, Villunger A.

Genes Dev. 2017 Jan 1;31(1):34-45. doi: 10.1101/gad.289728.116.


The PLK4-STIL-SAS-6 module at the core of centriole duplication.

Arquint C, Nigg EA.

Biochem Soc Trans. 2016 Oct 15;44(5):1253-1263. Review.


The Ska complex promotes Aurora B activity to ensure chromosome biorientation.

Redli PM, Gasic I, Meraldi P, Nigg EA, Santamaria A.

J Cell Biol. 2016 Oct 10;215(1):77-93. Epub 2016 Oct 3.


Ska3 Ensures Timely Mitotic Progression by Interacting Directly With Microtubules and Ska1 Microtubule Binding Domain.

Abad MA, Zou J, Medina-Pritchard B, Nigg EA, Rappsilber J, Santamaria A, Jeyaprakash AA.

Sci Rep. 2016 Sep 26;6:34042. doi: 10.1038/srep34042.


Quantitative analysis of human centrosome architecture by targeted proteomics and fluorescence imaging.

Bauer M, Cubizolles F, Schmidt A, Nigg EA.

EMBO J. 2016 Oct 4;35(19):2152-2166. Epub 2016 Aug 18.


Evaluation and Improvement of Quantification Accuracy in Isobaric Mass Tag-Based Protein Quantification Experiments.

Ahrné E, Glatter T, Viganò C, Schubert Cv, Nigg EA, Schmidt A.

J Proteome Res. 2016 Aug 5;15(8):2537-47. doi: 10.1021/acs.jproteome.6b00066. Epub 2016 Jul 7.


21st International Chromosome Conference-Foz do Iguaçu, Brazil.

Nigg EA, Martins C.

Chromosoma. 2016 Jun;125(3):353. doi: 10.1007/s00412-016-0584-7. Epub 2016 Mar 19. No abstract available.


Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524.

Baron AP, von Schubert C, Cubizolles F, Siemeister G, Hitchcock M, Mengel A, Schröder J, Fernández-Montalván A, von Nussbaum F, Mumberg D, Nigg EA.

Elife. 2016 Feb 17;5. pii: e12187. doi: 10.7554/eLife.12187.


PICH promotes sister chromatid disjunction and co-operates with topoisomerase II in mitosis.

Nielsen CF, Huttner D, Bizard AH, Hirano S, Li TN, Palmai-Pallag T, Bjerregaard VA, Liu Y, Nigg EA, Wang LH, Hickson ID.

Nat Commun. 2015 Dec 8;6:8962. doi: 10.1038/ncomms9962.


A bacterial type III secretion-based protein delivery tool for broad applications in cell biology.

Ittig SJ, Schmutz C, Kasper CA, Amstutz M, Schmidt A, Sauteur L, Vigano MA, Low SH, Affolter M, Cornelis GR, Nigg EA, Arrieumerlou C.

J Cell Biol. 2015 Nov 23;211(4):913-31. doi: 10.1083/jcb.201502074.


Assessment of current mass spectrometric workflows for the quantification of low abundant proteins and phosphorylation sites.

Bauer M, Ahrné E, Baron AP, Glatter T, Fava LL, Santamaria A, Nigg EA, Schmidt A.

Data Brief. 2015 Sep 4;5:297-304. doi: 10.1016/j.dib.2015.08.015. eCollection 2015 Dec.


Bub1 autophosphorylation feeds back to regulate kinetochore docking and promote localized substrate phosphorylation.

Asghar A, Lajeunesse A, Dulla K, Combes G, Thebault P, Nigg EA, Elowe S.

Nat Commun. 2015 Sep 24;6:8364. doi: 10.1038/ncomms9364.


STIL binding to Polo-box 3 of PLK4 regulates centriole duplication.

Arquint C, Gabryjonczyk AM, Imseng S, Böhm R, Sauer E, Hiller S, Nigg EA, Maier T.

Elife. 2015 Jul 18;4. doi: 10.7554/eLife.07888.


Plk1 and Mps1 Cooperatively Regulate the Spindle Assembly Checkpoint in Human Cells.

von Schubert C, Cubizolles F, Bracher JM, Sliedrecht T, Kops GJPL, Nigg EA.

Cell Rep. 2015 Jul 7;12(1):66-78. doi: 10.1016/j.celrep.2015.06.007. Epub 2015 Jun 25.


In memoriam--Walter J. Gehring.

Affolter M, Nigg EA.

Chromosoma. 2015 Sep;124(3):291. doi: 10.1007/s00412-015-0523-z. Epub 2015 May 30. No abstract available.


C-Nap1 mutation affects centriole cohesion and is associated with a Seckel-like syndrome in cattle.

Floriot S, Vesque C, Rodriguez S, Bourgain-Guglielmetti F, Karaiskou A, Gautier M, Duchesne A, Barbey S, Fritz S, Vasilescu A, Bertaud M, Moudjou M, Halliez S, Cormier-Daire V, Hokayem JE, Nigg EA, Manciaux L, Guatteo R, Cesbron N, Toutirais G, Eggen A, Schneider-Maunoury S, Boichard D, Sobczak-Thépot J, Schibler L.

Nat Commun. 2015 Apr 23;6:6894. doi: 10.1038/ncomms7894.


The E3 ubiquitin ligase Mib1 regulates Plk4 and centriole biogenesis.

Čajánek L, Glatter T, Nigg EA.

J Cell Sci. 2015 May 1;128(9):1674-82. doi: 10.1242/jcs.166496. Epub 2015 Mar 20.


Evaluation of data-dependent and -independent mass spectrometric workflows for sensitive quantification of proteins and phosphorylation sites.

Bauer M, Ahrné E, Baron AP, Glatter T, Fava LL, Santamaria A, Nigg EA, Schmidt A.

J Proteome Res. 2014 Dec 5;13(12):5973-88. doi: 10.1021/pr500860c. Epub 2014 Nov 13.


Centrosomes as signalling centres.

Arquint C, Gabryjonczyk AM, Nigg EA.

Philos Trans R Soc Lond B Biol Sci. 2014 Sep 5;369(1650). pii: 20130464. doi: 10.1098/rstb.2013.0464. Review.


Cep164 triggers ciliogenesis by recruiting Tau tubulin kinase 2 to the mother centriole.

Čajánek L, Nigg EA.

Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):E2841-50. doi: 10.1073/pnas.1401777111. Epub 2014 Jun 30.


The centrosome duplication cycle in health and disease.

Nigg EA, Čajánek L, Arquint C.

FEBS Lett. 2014 Aug 1;588(15):2366-72. doi: 10.1016/j.febslet.2014.06.030. Epub 2014 Jun 18. Review.


Seventy-five years of Chromosoma: Ivory Towers, citation metrics, and longevity of research.

Nigg EA.

Chromosoma. 2014 Mar;123(1-2):1-2. doi: 10.1007/s00412-014-0453-1. No abstract available.


STIL microcephaly mutations interfere with APC/C-mediated degradation and cause centriole amplification.

Arquint C, Nigg EA.

Curr Biol. 2014 Feb 17;24(4):351-60. doi: 10.1016/j.cub.2013.12.016. Epub 2014 Jan 30.


Structural basis for microtubule recognition by the human kinetochore Ska complex.

Abad MA, Medina B, Santamaria A, Zou J, Plasberg-Hill C, Madhumalar A, Jayachandran U, Redli PM, Rappsilber J, Nigg EA, Jeyaprakash AA.

Nat Commun. 2014;5:2964. doi: 10.1038/ncomms3964.


Molecular basis of tubulin transport within the cilium by IFT74 and IFT81.

Bhogaraju S, Cajanek L, Fort C, Blisnick T, Weber K, Taschner M, Mizuno N, Lamla S, Bastin P, Nigg EA, Lorentzen E.

Science. 2013 Aug 30;341(6149):1009-12. doi: 10.1126/science.1240985.


PICH: a DNA translocase specially adapted for processing anaphase bridge DNA.

Biebricher A, Hirano S, Enzlin JH, Wiechens N, Streicher WW, Huttner D, Wang LH, Nigg EA, Owen-Hughes T, Liu Y, Peterman E, Wuite GJL, Hickson ID.

Mol Cell. 2013 Sep 12;51(5):691-701. doi: 10.1016/j.molcel.2013.07.016. Epub 2013 Aug 22.


Aurora B suppresses microtubule dynamics and limits central spindle size by locally activating KIF4A.

Nunes Bastos R, Gandhi SR, Baron RD, Gruneberg U, Nigg EA, Barr FA.

J Cell Biol. 2013 Aug 19;202(4):605-21. doi: 10.1083/jcb.201301094. Epub 2013 Aug 12.


PI 3-kinase-dependent phosphorylation of Plk1-Ser99 promotes association with 14-3-3γ and is required for metaphase-anaphase transition.

Kasahara K, Goto H, Izawa I, Kiyono T, Watanabe N, Elowe S, Nigg EA, Inagaki M.

Nat Commun. 2013;4:1882. doi: 10.1038/ncomms2879.


Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication.

Sonnen KF, Gabryjonczyk AM, Anselm E, Stierhof YD, Nigg EA.

J Cell Sci. 2013 Jul 15;126(Pt 14):3223-33. doi: 10.1242/jcs.129502. Epub 2013 May 2.


Polo-like kinases.

von Schubert C, Nigg EA.

Curr Biol. 2013 Mar 18;23(6):R225-7. doi: 10.1016/j.cub.2013.01.066. No abstract available.


The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle.

Holland AJ, Fachinetti D, Zhu Q, Bauer M, Verma IM, Nigg EA, Cleveland DW.

Genes Dev. 2012 Dec 15;26(24):2684-9. doi: 10.1101/gad.207027.112.


3D-structured illumination microscopy provides novel insight into architecture of human centrosomes.

Sonnen KF, Schermelleh L, Leonhardt H, Nigg EA.

Biol Open. 2012 Oct 15;1(10):965-76. doi: 10.1242/bio.20122337. Epub 2012 Aug 8.


Acentrosomal spindle organization renders cancer cells dependent on the kinesin HSET.

Kleylein-Sohn J, Pöllinger B, Ohmer M, Hofmann F, Nigg EA, Hemmings BA, Wartmann M.

J Cell Sci. 2012 Nov 15;125(Pt 22):5391-402. doi: 10.1242/jcs.107474. Epub 2012 Sep 3.


On the regulation, function, and localization of the DNA-dependent ATPase PICH.

Kaulich M, Cubizolles F, Nigg EA.

Chromosoma. 2012 Aug;121(4):395-408. doi: 10.1007/s00412-012-0370-0. Epub 2012 Apr 25.


Structural and functional organization of the Ska complex, a key component of the kinetochore-microtubule interface.

Jeyaprakash AA, Santamaria A, Jayachandran U, Chan YW, Benda C, Nigg EA, Conti E.

Mol Cell. 2012 May 11;46(3):274-86. doi: 10.1016/j.molcel.2012.03.005. Epub 2012 Apr 5.


Uncovering the molecular machinery of the human spindle--an integration of wet and dry systems biology.

Rojas AM, Santamaria A, Malik R, Jensen TS, Körner R, Morilla I, de Juan D, Krallinger M, Hansen DA, Hoffmann R, Lees J, Reid A, Yeats C, Wehner A, Elowe S, Clegg AB, Brunak S, Nigg EA, Orengo C, Valencia A, Ranea JA.

PLoS One. 2012;7(3):e31813. doi: 10.1371/journal.pone.0031813. Epub 2012 Mar 9.


Aurora B controls kinetochore-microtubule attachments by inhibiting Ska complex-KMN network interaction.

Chan YW, Jeyaprakash AA, Nigg EA, Santamaria A.

J Cell Biol. 2012 Mar 5;196(5):563-71. doi: 10.1083/jcb.201109001. Epub 2012 Feb 27.


Cell-cycle-regulated expression of STIL controls centriole number in human cells.

Arquint C, Sonnen KF, Stierhof YD, Nigg EA.

J Cell Sci. 2012 Mar 1;125(Pt 5):1342-52. doi: 10.1242/jcs.099887. Epub 2012 Feb 20.


Direct regulation of tRNA and 5S rRNA gene transcription by Polo-like kinase 1.

Fairley JA, Mitchell LE, Berg T, Kenneth NS, von Schubert C, Silljé HH, Medema RH, Nigg EA, White RJ.

Mol Cell. 2012 Feb 24;45(4):541-52. doi: 10.1016/j.molcel.2011.11.030. Epub 2012 Jan 25. Erratum in: Mol Cell. 2012 Jul 13;47(1):148-9.


Editorial Note on Carlberg and Seuter (2010) Dynamics of nuclear receptor target gene regulation, Chromosoma (2010) 119: 479-484.

Nigg EA.

Chromosoma. 2011 Dec;120(6):531. doi: 10.1007/s00412-011-0345-6. No abstract available.


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