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A Network of SLC and ABC Transporter and DME Genes Involved in Remote Sensing and Signaling in the Gut-Liver-Kidney Axis.

Rosenthal SB, Bush KT, Nigam SK.

Sci Rep. 2019 Aug 15;9(1):11879. doi: 10.1038/s41598-019-47798-x.


Dynamics of Organic Anion Transporter-Mediated Tubular Secretion during Postnatal Human Kidney Development and Maturation.

Momper JD, Yang J, Gockenbach M, Vaida F, Nigam SK.

Clin J Am Soc Nephrol. 2019 Apr 5;14(4):540-548. doi: 10.2215/CJN.10350818. Epub 2019 Mar 18.


Uraemic syndrome of chronic kidney disease: altered remote sensing and signalling.

Nigam SK, Bush KT.

Nat Rev Nephrol. 2019 May;15(5):301-316. doi: 10.1038/s41581-019-0111-1. Review.


Gene-targeted deletion in mice of the Ets-1 transcription factor, a candidate gene in the Jacobsen syndrome kidney "critical region," causes abnormal kidney development.

Ye M, Xu L, Fu M, Chen D, Mattina T, Zufardi O, Rossi E, Bush KT, Nigam SK, Grossfeld P.

Am J Med Genet A. 2019 Jan;179(1):71-77. doi: 10.1002/ajmg.a.40481. Epub 2018 Nov 13.


The systems biology of uric acid transporters: the role of remote sensing and signaling.

Nigam SK, Bhatnagar V.

Curr Opin Nephrol Hypertens. 2018 Jul;27(4):305-313. doi: 10.1097/MNH.0000000000000427. Review.


Developmental regulation of kidney and liver solute carrier and ATP-binding cassette drug transporters and drug metabolizing enzymes: the role of remote organ communication.

Momper JD, Nigam SK.

Expert Opin Drug Metab Toxicol. 2018 Jun;14(6):561-570. doi: 10.1080/17425255.2018.1473376. Epub 2018 Jun 4. Review.


Organic anion transporter OAT3 enhances the glucosuric effect of the SGLT2 inhibitor empagliflozin.

Fu Y, Breljak D, Onishi A, Batz F, Patel R, Huang W, Song P, Freeman B, Mayoux E, Koepsell H, Anzai N, Nigam SK, Sabolic I, Vallon V.

Am J Physiol Renal Physiol. 2018 Aug 1;315(2):F386-F394. doi: 10.1152/ajprenal.00503.2017. Epub 2018 Feb 7.


The SLC22 Transporter Family: A Paradigm for the Impact of Drug Transporters on Metabolic Pathways, Signaling, and Disease.

Nigam SK.

Annu Rev Pharmacol Toxicol. 2018 Jan 6;58:663-687. doi: 10.1146/annurev-pharmtox-010617-052713. Review.


The drug transporter OAT3 (SLC22A8) and endogenous metabolite communication via the gut-liver-kidney axis.

Bush KT, Wu W, Lun C, Nigam SK.

J Biol Chem. 2017 Sep 22;292(38):15789-15803. doi: 10.1074/jbc.M117.796516. Epub 2017 Aug 1.


Key Role for the Organic Anion Transporters, OAT1 and OAT3, in the in vivo Handling of Uremic Toxins and Solutes.

Wu W, Bush KT, Nigam SK.

Sci Rep. 2017 Jul 10;7(1):4939. doi: 10.1038/s41598-017-04949-2.


Molecular Properties of Drugs Interacting with SLC22 Transporters OAT1, OAT3, OCT1, and OCT2: A Machine-Learning Approach.

Liu HC, Goldenberg A, Chen Y, Lun C, Wu W, Bush KT, Balac N, Rodriguez P, Abagyan R, Nigam SK.

J Pharmacol Exp Ther. 2016 Oct;359(1):215-29. doi: 10.1124/jpet.116.232660. Epub 2016 Aug 3.


An Organic Anion Transporter 1 (OAT1)-centered Metabolic Network.

Liu HC, Jamshidi N, Chen Y, Eraly SA, Cho SY, Bhatnagar V, Wu W, Bush KT, Abagyan R, Palsson BO, Nigam SK.

J Biol Chem. 2016 Sep 9;291(37):19474-86. doi: 10.1074/jbc.M116.745216. Epub 2016 Jul 20.


Analysis of ABCG2 and other urate transporters in uric acid homeostasis in chronic kidney disease: potential role of remote sensing and signaling.

Bhatnagar V, Richard EL, Wu W, Nievergelt CM, Lipkowitz MS, Jeff J, Maihofer AX, Nigam SK.

Clin Kidney J. 2016 Jun;9(3):444-53. doi: 10.1093/ckj/sfw010. Epub 2016 Apr 5.


Multispecific Organic Cation Transporter 1 (OCT1) from Bos taurus Has High Affinity and Slow Binding Kinetics towards Prostaglandin E2.

He X, Garza D, Nigam SK, Chang G.

PLoS One. 2016 Apr 5;11(4):e0152969. doi: 10.1371/journal.pone.0152969. eCollection 2016.


Kidney versus Liver Specification of SLC and ABC Drug Transporters, Tight Junction Molecules, and Biomarkers.

Martovetsky G, Bush KT, Nigam SK.

Drug Metab Dispos. 2016 Jul;44(7):1050-60. doi: 10.1124/dmd.115.068254. Epub 2016 Apr 4.


Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells.

Kumar N, Richter J, Cutts J, Bush KT, Trujillo C, Nigam SK, Gaasterland T, Brafman D, Willert K.

Elife. 2015 Nov 10;4. pii: e08413. doi: 10.7554/eLife.08413.


Evolutionary Analysis and Classification of OATs, OCTs, OCTNs, and Other SLC22 Transporters: Structure-Function Implications and Analysis of Sequence Motifs.

Zhu C, Nigam KB, Date RC, Bush KT, Springer SA, Saier MH Jr, Wu W, Nigam SK.

PLoS One. 2015 Nov 4;10(11):e0140569. doi: 10.1371/journal.pone.0140569. eCollection 2015.


Handling of Drugs, Metabolites, and Uremic Toxins by Kidney Proximal Tubule Drug Transporters.

Nigam SK, Wu W, Bush KT, Hoenig MP, Blantz RC, Bhatnagar V.

Clin J Am Soc Nephrol. 2015 Nov 6;10(11):2039-49. doi: 10.2215/CJN.02440314. Epub 2015 Oct 21.


Shared Ligands Between Organic Anion Transporters (OAT1 and OAT6) and Odorant Receptors.

Wu W, Bush KT, Liu HC, Zhu C, Abagyan R, Nigam SK.

Drug Metab Dispos. 2015 Dec;43(12):1855-63. doi: 10.1124/dmd.115.065250. Epub 2015 Sep 10.


Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group.

Brouwer KL, Aleksunes LM, Brandys B, Giacoia GP, Knipp G, Lukacova V, Meibohm B, Nigam SK, Rieder M, de Wildt SN; Pediatric Transporter Working Group.

Clin Pharmacol Ther. 2015 Sep;98(3):266-87. doi: 10.1002/cpt.176. Review.


The organic anion transporter (OAT) family: a systems biology perspective.

Nigam SK, Bush KT, Martovetsky G, Ahn SY, Liu HC, Richard E, Bhatnagar V, Wu W.

Physiol Rev. 2015 Jan;95(1):83-123. doi: 10.1152/physrev.00025.2013. Review.


What do drug transporters really do?

Nigam SK.

Nat Rev Drug Discov. 2015 Jan;14(1):29-44. doi: 10.1038/nrd4461. Epub 2014 Dec 5. Review.


Cellular and developmental strategies aimed at kidney tissue engineering.

Martovetsky G, Nigam SK.

Nephron Exp Nephrol. 2014;126(2):101. doi: 10.1159/000360680. Epub 2014 May 19. Review.


Pharmacological evaluation of the efficacy of Dysoxylum binectariferum stem bark and its active constituent rohitukine in regulation of dyslipidemia in rats.

Mishra SK, Tiwari S, Shrivastava S, Sonkar R, Mishra V, Nigam SK, Saxena AK, Bhatia G, Mir SS.

J Nat Med. 2018 Sep;72(4):837-845. doi: 10.1007/s11418-014-0830-3. Epub 2014 Mar 28.


Relevance of ureteric bud development and branching to tissue engineering, regeneration and repair in acute and chronic kidney disease.

Bush KT, Martovetsky G, Nigam SK.

Curr Opin Organ Transplant. 2014 Apr;19(2):153-61. doi: 10.1097/MOT.0000000000000053. Review.


Growth factor-heparan sulfate "switches" regulating stages of branching morphogenesis.

Nigam SK, Bush KT.

Pediatr Nephrol. 2014 Apr;29(4):727-35. doi: 10.1007/s00467-013-2725-z. Epub 2014 Feb 2. Review.


Concise review: can the intrinsic power of branching morphogenesis be used for engineering epithelial tissues and organs?

Nigam SK.

Stem Cells Transl Med. 2013 Dec;2(12):993-1000. doi: 10.5966/sctm.2013-0076. Epub 2013 Nov 4. Review.


GDNF-independent ureteric budding: role of PI3K-independent activation of AKT and FOSB/JUN/AP-1 signaling.

Tee JB, Choi Y, Dnyanmote A, Decambre M, Ito C, Bush KT, Nigam SK.

Biol Open. 2013 Jul 30;2(9):952-9. doi: 10.1242/bio.20135595. eCollection 2013.


Hepatocyte nuclear factors 4α and 1α regulate kidney developmental expression of drug-metabolizing enzymes and drug transporters.

Martovetsky G, Tee JB, Nigam SK.

Mol Pharmacol. 2013 Dec;84(6):808-23. doi: 10.1124/mol.113.088229. Epub 2013 Sep 13.


Metabolomics reveals signature of mitochondrial dysfunction in diabetic kidney disease.

Sharma K, Karl B, Mathew AV, Gangoiti JA, Wassel CL, Saito R, Pu M, Sharma S, You YH, Wang L, Diamond-Stanic M, Lindenmeyer MT, Forsblom C, Wu W, Ix JH, Ideker T, Kopp JB, Nigam SK, Cohen CD, Groop PH, Barshop BA, Natarajan L, Nyhan WL, Naviaux RK.

J Am Soc Nephrol. 2013 Nov;24(11):1901-12. doi: 10.1681/ASN.2013020126. Epub 2013 Oct 10.


Multispecific drug transporter Slc22a8 (Oat3) regulates multiple metabolic and signaling pathways.

Wu W, Jamshidi N, Eraly SA, Liu HC, Bush KT, Palsson BO, Nigam SK.

Drug Metab Dispos. 2013 Oct;41(10):1825-34. doi: 10.1124/dmd.113.052647. Epub 2013 Aug 6.


How much do we know about drug handling by SLC and ABC drug transporters in children?

Nigam SK, Bhatnagar V.

Clin Pharmacol Ther. 2013 Jul;94(1):27-9. doi: 10.1038/clpt.2013.82.


Assessment and quantification of plastics waste generation in major 60 cities of India.

Nalini R, Srinivasulu B, Shit SC, Nigam SK, Akolkar AB, Dwivedfi RK.

J Environ Sci Eng. 2013 Apr;55(2):153-66.


Analysis and Toxicity of Plain (PMP) and Blended (PMT) Indian Pan Masala (PM).

Nigam SK, Venkatakrishna-Bhatt H.

Eurasian J Med. 2013 Feb;45(1):21-33. doi: 10.5152/eajm.2013.04.


Organic anion transport pathways in antiviral handling in choroid plexus in Oat1 (Slc22a6) and Oat3 (Slc22a8) deficient tissue.

Nagle MA, Wu W, Eraly SA, Nigam SK.

Neurosci Lett. 2013 Feb 8;534:133-8. doi: 10.1016/j.neulet.2012.11.027. Epub 2012 Nov 27.


N-sulfation of heparan sulfate regulates early branching events in the developing mammary gland.

Bush KT, Crawford BE, Garner OB, Nigam KB, Esko JD, Nigam SK.

J Biol Chem. 2012 Dec 7;287(50):42064-70. doi: 10.1074/jbc.M112.423327. Epub 2012 Oct 11.


The storytelling brain. Commentary on "On social attribution: implications of recent cognitive neuroscience research for race, law, and politics".

Nigam SK.

Sci Eng Ethics. 2012 Sep;18(3):567-71. doi: 10.1007/s11948-012-9378-3. Epub 2012 Jul 28.


Organic anion and cation SLC22 "drug" transporter (Oat1, Oat3, and Oct1) regulation during development and maturation of the kidney proximal tubule.

Gallegos TF, Martovetsky G, Kouznetsova V, Bush KT, Nigam SK.

PLoS One. 2012;7(7):e40796. doi: 10.1371/journal.pone.0040796. Epub 2012 Jul 13.


In vitro culture of embryonic kidney rudiments and isolated ureteric buds.

Zhang X, Bush KT, Nigam SK.

Methods Mol Biol. 2012;886:13-21. doi: 10.1007/978-1-61779-851-1_2.


A role for the organic anion transporter OAT3 in renal creatinine secretion in mice.

Vallon V, Eraly SA, Rao SR, Gerasimova M, Rose M, Nagle M, Anzai N, Smith T, Sharma K, Nigam SK, Rieg T.

Am J Physiol Renal Physiol. 2012 May 15;302(10):F1293-9. doi: 10.1152/ajprenal.00013.2012. Epub 2012 Feb 15.


A protein kinase A and Wnt-dependent network regulating an intermediate stage in epithelial tubulogenesis during kidney development.

Gallegos TF, Kouznetsova V, Kudlicka K, Sweeney DE, Bush KT, Willert K, Farquhar MG, Nigam SK.

Dev Biol. 2012 Apr 1;364(1):11-21. doi: 10.1016/j.ydbio.2012.01.014. Epub 2012 Jan 24.


Linkage of organic anion transporter-1 to metabolic pathways through integrated "omics"-driven network and functional analysis.

Ahn SY, Jamshidi N, Mo ML, Wu W, Eraly SA, Dnyanmote A, Bush KT, Gallegos TF, Sweet DH, Palsson BØ, Nigam SK.

J Biol Chem. 2011 Sep 9;286(36):31522-31. doi: 10.1074/jbc.M111.272534. Epub 2011 Jul 12.


Deletion of multispecific organic anion transporter Oat1/Slc22a6 protects against mercury-induced kidney injury.

Torres AM, Dnyanmote AV, Bush KT, Wu W, Nigam SK.

J Biol Chem. 2011 Jul 29;286(30):26391-5. doi: 10.1074/jbc.M111.249292. Epub 2011 Jun 7.


Growth factor-dependent branching of the ureteric bud is modulated by selective 6-O sulfation of heparan sulfate.

Shah MM, Sakurai H, Gallegos TF, Sweeney DE, Bush KT, Esko JD, Nigam SK.

Dev Biol. 2011 Aug 1;356(1):19-27. doi: 10.1016/j.ydbio.2011.05.004. Epub 2011 May 11.


Stage-dependent regulation of mammary ductal branching by heparan sulfate and HGF-cMet signaling.

Garner OB, Bush KT, Nigam KB, Yamaguchi Y, Xu D, Esko JD, Nigam SK.

Dev Biol. 2011 Jul 15;355(2):394-403. doi: 10.1016/j.ydbio.2011.04.035. Epub 2011 May 7.


Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter-Organic anion transporter1 (Oat1).

Kouznetsova VL, Tsigelny IF, Nagle MA, Nigam SK.

Bioorg Med Chem. 2011 Jun 1;19(11):3320-40. doi: 10.1016/j.bmc.2011.04.045. Epub 2011 Apr 28.


Conformational changes of the multispecific transporter organic anion transporter 1 (OAT1/SLC22A6) suggests a molecular mechanism for initial stages of drug and metabolite transport.

Tsigelny IF, Kovalskyy D, Kouznetsova VL, Balinskyi O, Sharikov Y, Bhatnagar V, Nigam SK.

Cell Biochem Biophys. 2011 Nov;61(2):251-9. doi: 10.1007/s12013-011-9191-7.


Functional maturation of drug transporters in the developing, neonatal, and postnatal kidney.

Sweeney DE, Vallon V, Rieg T, Wu W, Gallegos TF, Nigam SK.

Mol Pharmacol. 2011 Jul;80(1):147-54. doi: 10.1124/mol.110.070680. Epub 2011 Apr 14.


Untargeted metabolomics identifies enterobiome metabolites and putative uremic toxins as substrates of organic anion transporter 1 (Oat1).

Wikoff WR, Nagle MA, Kouznetsova VL, Tsigelny IF, Nigam SK.

J Proteome Res. 2011 Jun 3;10(6):2842-51. doi: 10.1021/pr200093w. Epub 2011 Apr 22.

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