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Items: 19


Ablation of α2δ-1 inhibits cell-surface trafficking of endogenous N-type calcium channels in the pain pathway in vivo.

Nieto-Rostro M, Ramgoolam K, Pratt WS, Kulik A, Dolphin AC.

Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E12043-E12052. doi: 10.1073/pnas.1811212115. Epub 2018 Nov 28.


LRP1 influences trafficking of N-type calcium channels via interaction with the auxiliary α2δ-1 subunit.

Kadurin I, Rothwell SW, Lana B, Nieto-Rostro M, Dolphin AC.

Sci Rep. 2017 Mar 3;7:43802. doi: 10.1038/srep43802.


Proteolytic maturation of α2δ represents a checkpoint for activation and neuronal trafficking of latent calcium channels.

Kadurin I, Ferron L, Rothwell SW, Meyer JO, Douglas LR, Bauer CS, Lana B, Margas W, Alexopoulos O, Nieto-Rostro M, Pratt WS, Dolphin AC.

Elife. 2016 Oct 26;5. pii: e21143. doi: 10.7554/eLife.21143.


Effect of knockout of α2δ-1 on action potentials in mouse sensory neurons.

Margas W, Ferron L, Nieto-Rostro M, Schwartz A, Dolphin AC.

Philos Trans R Soc Lond B Biol Sci. 2016 Aug 5;371(1700). pii: 20150430. doi: 10.1098/rstb.2015.0430.


A CaV2.1 N-terminal fragment relieves the dominant-negative inhibition by an Episodic ataxia 2 mutant.

Dahimene S, Page KM, Nieto-Rostro M, Pratt WS, D'Arco M, Dolphin AC.

Neurobiol Dis. 2016 Sep;93:243-56. doi: 10.1016/j.nbd.2016.05.020. Epub 2016 May 31.


Fragile X mental retardation protein controls synaptic vesicle exocytosis by modulating N-type calcium channel density.

Ferron L, Nieto-Rostro M, Cassidy JS, Dolphin AC.

Nat Commun. 2014 Apr 7;5:3628. doi: 10.1038/ncomms4628.


Altered expression of the voltage-gated calcium channel subunit α₂δ-1: a comparison between two experimental models of epilepsy and a sensory nerve ligation model of neuropathic pain.

Nieto-Rostro M, Sandhu G, Bauer CS, Jiruska P, Jefferys JG, Dolphin AC.

Neuroscience. 2014 Dec 26;283:124-37. doi: 10.1016/j.neuroscience.2014.03.013. Epub 2014 Mar 15.


α2δ-1 gene deletion affects somatosensory neuron function and delays mechanical hypersensitivity in response to peripheral nerve damage.

Patel R, Bauer CS, Nieto-Rostro M, Margas W, Ferron L, Chaggar K, Crews K, Ramirez JD, Bennett DL, Schwartz A, Dickenson AH, Dolphin AC.

J Neurosci. 2013 Oct 16;33(42):16412-26. doi: 10.1523/JNEUROSCI.1026-13.2013.


The alpha2delta subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function.

Davies A, Kadurin I, Alvarez-Laviada A, Douglas L, Nieto-Rostro M, Bauer CS, Pratt WS, Dolphin AC.

Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1654-9. doi: 10.1073/pnas.0908735107. Epub 2010 Jan 4.


N terminus is key to the dominant negative suppression of Ca(V)2 calcium channels: implications for episodic ataxia type 2.

Page KM, Heblich F, Margas W, Pratt WS, Nieto-Rostro M, Chaggar K, Sandhu K, Davies A, Dolphin AC.

J Biol Chem. 2010 Jan 8;285(2):835-44. doi: 10.1074/jbc.M109.065045. Epub 2009 Nov 10.


Labelling of the 3D structure of the cardiac L-type voltage-gated calcium channel.

Walsh CP, Davies A, Nieto-Rostro M, Dolphin AC, Kitmitto A.

Channels (Austin). 2009 Nov;3(6):387-92.


The increased trafficking of the calcium channel subunit alpha2delta-1 to presynaptic terminals in neuropathic pain is inhibited by the alpha2delta ligand pregabalin.

Bauer CS, Nieto-Rostro M, Rahman W, Tran-Van-Minh A, Ferron L, Douglas L, Kadurin I, Sri Ranjan Y, Fernandez-Alacid L, Millar NS, Dickenson AH, Lujan R, Dolphin AC.

J Neurosci. 2009 Apr 1;29(13):4076-88. doi: 10.1523/JNEUROSCI.0356-09.2009.


Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin.

Hendrich J, Van Minh AT, Heblich F, Nieto-Rostro M, Watschinger K, Striessnig J, Wratten J, Davies A, Dolphin AC.

Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3628-33. doi: 10.1073/pnas.0708930105. Epub 2008 Feb 25.


The ducky(2J) mutation in Cacna2d2 results in reduced spontaneous Purkinje cell activity and altered gene expression.

Donato R, Page KM, Koch D, Nieto-Rostro M, Foucault I, Davies A, Wilkinson T, Rees M, Edwards FA, Dolphin AC.

J Neurosci. 2006 Nov 29;26(48):12576-86.


The metal-ion-dependent adhesion site in the Von Willebrand factor-A domain of alpha2delta subunits is key to trafficking voltage-gated Ca2+ channels.

Cantí C, Nieto-Rostro M, Foucault I, Heblich F, Wratten J, Richards MW, Hendrich J, Douglas L, Page KM, Davies A, Dolphin AC.

Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11230-5. Epub 2005 Aug 1.


Interaction via a key tryptophan in the I-II linker of N-type calcium channels is required for beta1 but not for palmitoylated beta2, implicating an additional binding site in the regulation of channel voltage-dependent properties.

Leroy J, Richards MW, Butcher AJ, Nieto-Rostro M, Pratt WS, Davies A, Dolphin AC.

J Neurosci. 2005 Jul 27;25(30):6984-96. Erratum in: J Neurosci. 2005 Oct 5;25(40):table of contents. Richards, Mark S [corrected to Richards, Mark W].


COI1 links jasmonate signalling and fertility to the SCF ubiquitin-ligase complex in Arabidopsis.

Devoto A, Nieto-Rostro M, Xie D, Ellis C, Harmston R, Patrick E, Davis J, Sherratt L, Coleman M, Turner JG.

Plant J. 2002 Nov;32(4):457-66.


COI1: an Arabidopsis gene required for jasmonate-regulated defense and fertility.

Xie DX, Feys BF, James S, Nieto-Rostro M, Turner JG.

Science. 1998 May 15;280(5366):1091-4.

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