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Items: 1 to 50 of 279

1.

Platelets as Modulators of Cerebral Ischemia/Reperfusion Injury.

Stegner D, Klaus V, Nieswandt B.

Front Immunol. 2019 Nov 1;10:2505. doi: 10.3389/fimmu.2019.02505. eCollection 2019. Review.

2.

Platelet lamellipodia formation is not required for thrombus formation and stability.

Schurr Y, Sperr A, Volz J, Beck S, Reil L, Kusch C, Eiring P, Bryson S, Sauer M, Nieswandt B, Machesky L, Bender M.

Blood. 2019 Oct 11. pii: blood.2019002105. doi: 10.1182/blood.2019002105. [Epub ahead of print]

PMID:
31697813
3.

Interspecies differences in protein expression do not impact the spatiotemporal regulation of GPVI mediated activation.

Dunster JL, Unsworth AJ, Bye AP, Haining EJ, Sowa MA, Di Y, Sage T, Pallini C, Pike JA, Hardy AT, Nieswandt B, García Á, Watson SP, Poulter NS, Gibbins JM, Pollitt AY.

J Thromb Haemost. 2019 Nov 4. doi: 10.1111/jth.14673. [Epub ahead of print]

PMID:
31680418
4.

Coactosin-like 1 integrates signaling critical for shear-dependent thrombus formation in mouse platelets.

Scheller I, Stritt S, Beck S, Peng B, Pleines I, Heinze KG, Braun A, Otto O, Ahrends R, Sickmann A, Bender M, Nieswandt B.

Haematologica. 2019 Oct 3. pii: haematol.2019.225516. doi: 10.3324/haematol.2019.225516. [Epub ahead of print]

5.

Pivotal role of PDK1 in megakaryocyte cytoskeletal dynamics and polarization during platelet biogenesis.

Geue S, Aurbach K, Manke MC, Manukjan G, Münzer P, Stegner D, Brähler C, Walker-Allgaier B, Märklin M, Borst CE, Quintanilla-Fend L, Rath D, Geisler T, Salih HR, Seizer P, Lang F, Nieswandt B, Gawaz M, Schulze H, Pleines I, Borst O.

Blood. 2019 Nov 21;134(21):1847-1858. doi: 10.1182/blood.2019000185.

PMID:
31578203
6.

Loss of Orai2-Mediated Capacitative Ca2+ Entry Is Neuroprotective in Acute Ischemic Stroke.

Stegner D, Hofmann S, Schuhmann MK, Kraft P, Herrmann AM, Popp S, Höhn M, Popp M, Klaus V, Post A, Kleinschnitz C, Braun A, Meuth SG, Lesch KP, Stoll G, Kraft R, Nieswandt B.

Stroke. 2019 Nov;50(11):3238-3245. doi: 10.1161/STROKEAHA.119.025357. Epub 2019 Sep 25.

PMID:
31551038
7.

Genetic platelet depletion is superior in platelet transfusion compared to current models.

Salzmann M, Schrottmaier WC, Kral-Pointner JB, Mussbacher M, Volz J, Hoesel B, Moser B, Bleichert S, Morava S, Nieswandt B, Schmid JA, Assinger A.

Haematologica. 2019 Sep 19. pii: haematol.2019.222448. doi: 10.3324/haematol.2019.222448. [Epub ahead of print]

8.

Comparative Analysis of Microfluidics Thrombus Formation in Multiple Genetically Modified Mice: Link to Thrombosis and Hemostasis.

Nagy M, van Geffen JP, Stegner D, Adams DJ, Braun A, de Witt SM, Elvers M, Geer MJ, Kuijpers MJE, Kunzelmann K, Mori J, Oury C, Pircher J, Pleines I, Poole AW, Senis YA, Verdoold R, Weber C, Nieswandt B, Heemskerk JWM, Baaten CCFMJ.

Front Cardiovasc Med. 2019 Jul 30;6:99. doi: 10.3389/fcvm.2019.00099. eCollection 2019.

9.

Thrombo-inflammation in acute ischaemic stroke - implications for treatment.

Stoll G, Nieswandt B.

Nat Rev Neurol. 2019 Aug;15(8):473-481. doi: 10.1038/s41582-019-0221-1. Epub 2019 Jul 1. Review.

PMID:
31263257
10.

Defective Zn2+ homeostasis in mouse and human platelets with α- and δ-storage pool diseases.

Kiran Gotru S, van Geffen JP, Nagy M, Mammadova-Bach E, Eilenberger J, Volz J, Manukjan G, Schulze H, Wagner L, Eber S, Schambeck C, Deppermann C, Brouns S, Nurden P, Greinacher A, Sachs U, Nieswandt B, Hermanns HM, Heemskerk JWM, Braun A.

Sci Rep. 2019 Jun 6;9(1):8333. doi: 10.1038/s41598-019-44751-w.

11.

Identification of a Clinically Relevant Signature for Early Progression in KRAS-Driven Lung Adenocarcinoma.

Neidler S, Kruspig B, Hewit K, Monteverde T, Gyuraszova K, Braun A, Clark W, James D, Hedley A, Nieswandt B, Shanks E, Dick C, Murphy DJ.

Cancers (Basel). 2019 Apr 29;11(5). pii: E600. doi: 10.3390/cancers11050600.

12.

Targeting Platelet GPVI Plus rt-PA Administration but Not α2β1-Mediated Collagen Binding Protects against Ischemic Brain Damage in Mice.

Schuhmann MK, Kraft P, Bieber M, Kollikowski AM, Schulze H, Nieswandt B, Pham M, Stegner D, Stoll G.

Int J Mol Sci. 2019 Apr 24;20(8). pii: E2019. doi: 10.3390/ijms20082019.

13.

Inhibition of platelet GPVI induces intratumor hemorrhage and increases efficacy of chemotherapy in mice.

Volz J, Mammadova-Bach E, Gil-Pulido J, Nandigama R, Remer K, Sorokin L, Zernecke A, Abrams SI, Ergün S, Henke E, Nieswandt B.

Blood. 2019 Jun 20;133(25):2696-2706. doi: 10.1182/blood.2018877043. Epub 2019 Apr 5.

PMID:
30952674
14.

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer.

Malehmir M, Pfister D, Gallage S, Szydlowska M, Inverso D, Kotsiliti E, Leone V, Peiseler M, Surewaard BGJ, Rath D, Ali A, Wolf MJ, Drescher H, Healy ME, Dauch D, Kroy D, Krenkel O, Kohlhepp M, Engleitner T, Olkus A, Sijmonsma T, Volz J, Deppermann C, Stegner D, Helbling P, Nombela-Arrieta C, Rafiei A, Hinterleitner M, Rall M, Baku F, Borst O, Wilson CL, Leslie J, O'Connor T, Weston CJ, Adams DH, Sheriff L, Teijeiro A, Prinz M, Bogeska R, Anstee N, Bongers MN, Notohamiprodjo M, Geisler T, Withers DJ, Ware J, Mann DA, Augustin HG, Vegiopoulos A, Milsom MD, Rose AJ, Lalor PF, Llovet JM, Pinyol R, Tacke F, Rad R, Matter M, Djouder N, Kubes P, Knolle PA, Unger K, Zender L, Nieswandt B, Gawaz M, Weber A, Heikenwalder M.

Nat Med. 2019 Apr;25(4):641-655. doi: 10.1038/s41591-019-0379-5. Epub 2019 Apr 1.

15.

Functional significance of the platelet immune receptors GPVI and CLEC-2.

Rayes J, Watson SP, Nieswandt B.

J Clin Invest. 2019 Jan 2;129(1):12-23. doi: 10.1172/JCI122955. Epub 2019 Jan 2. Review.

16.

Tspan18 is a novel regulator of the Ca2+ channel Orai1 and von Willebrand factor release in endothelial cells.

Noy PJ, Gavin RL, Colombo D, Haining EJ, Reyat JS, Payne H, Thielmann I, Lokman AB, Neag G, Yang J, Lloyd T, Harrison N, Heath VL, Gardiner C, Whitworth KM, Robinson J, Koo CZ, Di Maio A, Harrison P, Lee SP, Michelangeli F, Kalia N, Rainger GE, Nieswandt B, Brill A, Watson SP, Tomlinson MG.

Haematologica. 2019 Sep;104(9):1892-1905. doi: 10.3324/haematol.2018.194241. Epub 2018 Dec 20.

17.

Description of a Novel Phosphodiesterase (PDE)-3 Inhibitor Protecting Mice From Ischemic Stroke Independent From Platelet Function.

Bieber M, Schuhmann MK, Volz J, Kumar GJ, Vaidya JR, Nieswandt B, Pham M, Stoll G, Kleinschnitz C, Kraft P.

Stroke. 2019 Feb;50(2):478-486. doi: 10.1161/STROKEAHA.118.023664.

18.

Store-operated calcium entry in thrombosis and thrombo-inflammation.

Mammadova-Bach E, Nagy M, Heemskerk JWM, Nieswandt B, Braun A.

Cell Calcium. 2019 Jan;77:39-48. doi: 10.1016/j.ceca.2018.11.005. Epub 2018 Nov 23. Review.

PMID:
30530092
19.

How is the formation of microthrombi after traumatic brain injury linked to inflammation?

Albert-Weissenberger C, Hopp S, Nieswandt B, Sirén AL, Kleinschnitz C, Stetter C.

J Neuroimmunol. 2019 Jan 15;326:9-13. doi: 10.1016/j.jneuroim.2018.10.011. Epub 2018 Oct 31. Review.

PMID:
30445364
20.

Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis.

Welz M, Eickhoff S, Abdullah Z, Trebicka J, Gartlan KH, Spicer JA, Demetris AJ, Akhlaghi H, Anton M, Manske K, Zehn D, Nieswandt B, Kurts C, Trapani JA, Knolle P, Wohlleber D, Kastenmüller W.

Nat Commun. 2018 Nov 15;9(1):4805. doi: 10.1038/s41467-018-07213-x.

21.

C-type lectin-like receptor 2 (CLEC-2)-dependent dendritic cell migration is controlled by tetraspanin CD37.

de Winde CM, Matthews AL, van Deventer S, van der Schaaf A, Tomlinson ND, Jansen E, Eble JA, Nieswandt B, McGettrick HM, Figdor CG, Tomlinson MG, Acton SE, van Spriel AB.

J Cell Sci. 2018 Oct 2;131(19). pii: jcs214551. doi: 10.1242/jcs.214551.

22.

ADAP deficiency impairs megakaryocyte polarization with ectopic proplatelet release and causes microthrombocytopenia.

Spindler M, van Eeuwijk JMM, Schurr Y, Nurden P, Nieswandt B, Stegner D, Reinhold A, Bender M.

Blood. 2018 Aug 9;132(6):635-646. doi: 10.1182/blood-2018-01-829259. Epub 2018 Jun 27.

PMID:
29950291
23.

Antibody-mediated inhibition of FXIIa blocks downstream bradykinin generation.

Cao H, Biondo M, Lioe H, Busfield S, Rayzman V, Nieswandt B, Bork K, Harrison LC, Auyeung P, Farkas H, Csuka D, Pelzing M, Dower S, Wilson MJ, Nash A, Nolte MW, Panousis C.

J Allergy Clin Immunol. 2018 Oct;142(4):1355-1358. doi: 10.1016/j.jaci.2018.06.014. Epub 2018 Jun 21. No abstract available.

PMID:
29936101
24.

Profilin 1-mediated cytoskeletal rearrangements regulate integrin function in mouse platelets.

Stritt S, Birkholz I, Beck S, Sorrentino S, Sapra KT, Viaud J, Heck J, Gaits-Iacovoni F, Schulze H, Du X, Hartwig JH, Braun A, Bender M, Medalia O, Nieswandt B.

Blood Adv. 2018 May 8;2(9):1040-1045. doi: 10.1182/bloodadvances.2017014001. No abstract available.

25.

Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation.

Pircher J, Czermak T, Ehrlich A, Eberle C, Gaitzsch E, Margraf A, Grommes J, Saha P, Titova A, Ishikawa-Ankerhold H, Stark K, Petzold T, Stocker T, Weckbach LT, Novotny J, Sperandio M, Nieswandt B, Smith A, Mannell H, Walzog B, Horst D, Soehnlein O, Massberg S, Schulz C.

Nat Commun. 2018 Apr 18;9(1):1523. doi: 10.1038/s41467-018-03925-2.

26.

Cutting Edge: Imbalanced Cation Homeostasis in MAGT1-Deficient B Cells Dysregulates B Cell Development and Signaling in Mice.

Gotru SK, Gil-Pulido J, Beyersdorf N, Diefenbach A, Becker IC, Vögtle T, Remer K, Chubanov V, Gudermann T, Hermanns HM, Nieswandt B, Kerkau T, Zernecke A, Braun A.

J Immunol. 2018 Apr 15;200(8):2529-2534. doi: 10.4049/jimmunol.1701467. Epub 2018 Mar 26.

27.

The contribution of platelet glycoprotein receptors to inflammatory bleeding prevention is stimulus and organ dependent.

Rayes J, Jadoui S, Lax S, Gros A, Wichaiyo S, Ollivier V, Denis CV, Ware J, Nieswandt B, Jandrot-Perrus M, Watson SP, Ho-Tin-Noé B.

Haematologica. 2018 Jun;103(6):e256-e258. doi: 10.3324/haematol.2017.182162. Epub 2018 Feb 1. No abstract available.

28.

Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration.

Cloutier N, Allaeys I, Marcoux G, Machlus KR, Mailhot B, Zufferey A, Levesque T, Becker Y, Tessandier N, Melki I, Zhi H, Poirier G, Rondina MT, Italiano JE, Flamand L, McKenzie SE, Cote F, Nieswandt B, Khan WI, Flick MJ, Newman PJ, Lacroix S, Fortin PR, Boilard E.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1550-E1559. doi: 10.1073/pnas.1720553115. Epub 2018 Jan 31.

29.

Neutrophil infiltration to the brain is platelet-dependent, and is reversed by blockade of platelet GPIbα.

Giles JA, Greenhalgh AD, Denes A, Nieswandt B, Coutts G, McColl BW, Allan SM.

Immunology. 2018 Jun;154(2):322-328. doi: 10.1111/imm.12892. Epub 2018 Feb 8.

30.

Influence of Thrombolysis on the Safety and Efficacy of Blocking Platelet Adhesion or Secretory Activity in Acute Ischemic Stroke in Mice.

Schuhmann MK, Kraft P, Bieber M, Haarmann A, Homola GA, Pham M, Nieswandt B, Stoll G.

Transl Stroke Res. 2018 Oct;9(5):493-498. doi: 10.1007/s12975-017-0606-7. Epub 2018 Jan 10.

PMID:
29322481
31.

GPVI signaling is compromised in newly formed platelets after acute thrombocytopenia in mice.

Gupta S, Cherpokova D, Spindler M, Morowski M, Bender M, Nieswandt B.

Blood. 2018 Mar 8;131(10):1106-1110. doi: 10.1182/blood-2017-08-800136. Epub 2018 Jan 2.

32.

Platelet glycoprotein VI aids in local immunity during pneumonia-derived sepsis caused by gram-negative bacteria.

Claushuis TAM, de Vos AF, Nieswandt B, Boon L, Roelofs JJTH, de Boer OJ, van 't Veer C, van der Poll T.

Blood. 2018 Feb 22;131(8):864-876. doi: 10.1182/blood-2017-06-788067. Epub 2017 Nov 29.

PMID:
29187378
33.

TRPM7 Kinase Controls Calcium Responses in Arterial Thrombosis and Stroke in Mice.

Gotru SK, Chen W, Kraft P, Becker IC, Wolf K, Stritt S, Zierler S, Hermanns HM, Rao D, Perraud AL, Schmitz C, Zahedi RP, Noy PJ, Tomlinson MG, Dandekar T, Matsushita M, Chubanov V, Gudermann T, Stoll G, Nieswandt B, Braun A.

Arterioscler Thromb Vasc Biol. 2018 Feb;38(2):344-352. doi: 10.1161/ATVBAHA.117.310391. Epub 2017 Nov 16.

PMID:
29146750
34.

CK2β regulates thrombopoiesis and Ca2+-triggered platelet activation in arterial thrombosis.

Münzer P, Walker-Allgaier B, Geue S, Langhauser F, Geuss E, Stegner D, Aurbach K, Semeniak D, Chatterjee M, Gonzalez Menendez I, Märklin M, Quintanilla-Martinez L, Salih HR, Litchfield DW, Buchou T, Kleinschnitz C, Lang F, Nieswandt B, Pleines I, Schulze H, Gawaz M, Borst O.

Blood. 2017 Dec 21;130(25):2774-2785. doi: 10.1182/blood-2017-05-784413. Epub 2017 Sep 19.

PMID:
28928125
35.

The Neurobeachin-like 2 Protein Regulates Mast Cell Homeostasis.

Drube S, Grimlowski R, Deppermann C, Fröbel J, Kraft F, Andreas N, Stegner D, Dudeck J, Weber F, Rödiger M, Göpfert C, Drube J, Reich D, Nieswandt B, Dudeck A, Kamradt T.

J Immunol. 2017 Oct 15;199(8):2948-2957. doi: 10.4049/jimmunol.1700556. Epub 2017 Sep 8.

36.

CLEC-2 contributes to hemostasis independently of classical hemITAM signaling in mice.

Haining EJ, Cherpokova D, Wolf K, Becker IC, Beck S, Eble JA, Stegner D, Watson SP, Nieswandt B.

Blood. 2017 Nov 16;130(20):2224-2228. doi: 10.1182/blood-2017-03-771907. Epub 2017 Aug 23.

PMID:
28835437
37.

Thrombopoiesis is spatially regulated by the bone marrow vasculature.

Stegner D, vanEeuwijk JMM, Angay O, Gorelashvili MG, Semeniak D, Pinnecker J, Schmithausen P, Meyer I, Friedrich M, Dütting S, Brede C, Beilhack A, Schulze H, Nieswandt B, Heinze KG.

Nat Commun. 2017 Jul 25;8(1):127. doi: 10.1038/s41467-017-00201-7.

38.

Twinfilin 2a regulates platelet reactivity and turnover in mice.

Stritt S, Beck S, Becker IC, Vögtle T, Hakala M, Heinze KG, Du X, Bender M, Braun A, Lappalainen P, Nieswandt B.

Blood. 2017 Oct 12;130(15):1746-1756. doi: 10.1182/blood-2017-02-770768. Epub 2017 Jul 25.

PMID:
28743718
39.

A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis.

Dütting S, Gaits-Iacovoni F, Stegner D, Popp M, Antkowiak A, van Eeuwijk JMM, Nurden P, Stritt S, Heib T, Aurbach K, Angay O, Cherpokova D, Heinz N, Baig AA, Gorelashvili MG, Gerner F, Heinze KG, Ware J, Krohne G, Ruggeri ZM, Nurden AT, Schulze H, Modlich U, Pleines I, Brakebusch C, Nieswandt B.

Nat Commun. 2017 Jun 15;8:15838. doi: 10.1038/ncomms15838.

40.

Platelet receptors as therapeutic targets: Past, present and future.

Jamasbi J, Ayabe K, Goto S, Nieswandt B, Peter K, Siess W.

Thromb Haemost. 2017 Jun 28;117(7):1249-1257. doi: 10.1160/TH16-12-0911. Epub 2017 Jun 9. Review.

PMID:
28597906
41.

Blocking of platelet glycoprotein receptor Ib reduces "thrombo-inflammation" in mice with acute ischemic stroke.

Schuhmann MK, Guthmann J, Stoll G, Nieswandt B, Kraft P, Kleinschnitz C.

J Neuroinflammation. 2017 Jan 21;14(1):18. doi: 10.1186/s12974-017-0792-y.

42.

Platelet secretion is crucial to prevent bleeding in the ischemic brain but not in the inflamed skin or lung in mice.

Deppermann C, Kraft P, Volz J, Schuhmann MK, Beck S, Wolf K, Stegner D, Stoll G, Nieswandt B.

Blood. 2017 Mar 23;129(12):1702-1706. doi: 10.1182/blood-2016-12-750711. Epub 2017 Jan 11.

PMID:
28077416
43.

RhoA/ROCK guides NMII on the way to MK polyploidy.

Pleines I, Nieswandt B.

Blood. 2016 Dec 29;128(26):3025-3026. doi: 10.1182/blood-2016-11-746685. No abstract available.

PMID:
28034868
44.

Tetraspanin Tspan9 regulates platelet collagen receptor GPVI lateral diffusion and activation.

Haining EJ, Matthews AL, Noy PJ, Romanska HM, Harris HJ, Pike J, Morowski M, Gavin RL, Yang J, Milhiet PE, Berditchevski F, Nieswandt B, Poulter NS, Watson SP, Tomlinson MG.

Platelets. 2017 Nov;28(7):629-642. doi: 10.1080/09537104.2016.1254175. Epub 2016 Dec 29.

45.

Targeting expression to megakaryocytes and platelets by lineage-specific lentiviral vectors.

Latorre-Rey LJ, Wintterle S, Dütting S, Kohlscheen S, Abel T, Schenk F, Wingert S, Rieger MA, Nieswandt B, Heinz N, Modlich U.

J Thromb Haemost. 2017 Feb;15(2):341-355. doi: 10.1111/jth.13582.

46.

GPVI and Thromboxane Receptor on Platelets Promote Proinflammatory Macrophage Phenotypes during Cutaneous Inflammation.

Pierre S, Linke B, Suo J, Tarighi N, Del Turco D, Thomas D, Ferreiros N, Stegner D, Frölich S, Sisignano M, Meyer Dos Santos S, deBruin N, Nüsing RM, Deller T, Nieswandt B, Geisslinger G, Scholich K.

J Invest Dermatol. 2017 Mar;137(3):686-695. doi: 10.1016/j.jid.2016.09.036. Epub 2016 Nov 3.

47.

Congenital valvular defects associated with deleterious mutations in the PLD1 gene.

Ta-Shma A, Zhang K, Salimova E, Zernecke A, Sieiro-Mosti D, Stegner D, Furtado M, Shaag A, Perles Z, Nieswandt B, Rein AJ, Rosenthal N, Neiman AM, Elpeleg O.

J Med Genet. 2017 Apr;54(4):278-286. doi: 10.1136/jmedgenet-2016-104259. Epub 2016 Oct 31.

PMID:
27799408
48.

Coagulation factor XII induces pro-inflammatory cytokine responses in macrophages and promotes atherosclerosis in mice.

Vorlova S, Koch M, Manthey HD, Cochain C, Busch M, Chaudhari SM, Stegner D, Yepes M, Lorenz K, Nolte MW, Nieswandt B, Zernecke A.

Thromb Haemost. 2017 Jan 5;117(1):176-187. doi: 10.1160/TH16-06-0466. Epub 2016 Oct 27.

PMID:
27786338
49.

TMEM16F-Mediated Platelet Membrane Phospholipid Scrambling Is Critical for Hemostasis and Thrombosis but not Thromboinflammation in Mice-Brief Report.

Baig AA, Haining EJ, Geuss E, Beck S, Swieringa F, Wanitchakool P, Schuhmann MK, Stegner D, Kunzelmann K, Kleinschnitz C, Heemskerk JW, Braun A, Nieswandt B.

Arterioscler Thromb Vasc Biol. 2016 Nov;36(11):2152-2157. Epub 2016 Sep 15.

PMID:
27634832
50.

Peptidase inhibitor 16 is a membrane-tethered regulator of chemerin processing in the myocardium.

Regn M, Laggerbauer B, Jentzsch C, Ramanujam D, Ahles A, Sichler S, Calzada-Wack J, Koenen RR, Braun A, Nieswandt B, Engelhardt S.

J Mol Cell Cardiol. 2016 Oct;99:57-64. doi: 10.1016/j.yjmcc.2016.08.010. Epub 2016 Aug 15.

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