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Items: 1 to 50 of 316

1.

Gray Matter Age Prediction as a Biomarker for Risk of Dementia.

Wang J, Knol MJ, Tiulpin A, Dubost F, de Bruijne M, Vernooij MW, Adams HHH, Ikram MA, Niessen WJ, Roshchupkin GV.

Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):21213-21218. doi: 10.1073/pnas.1902376116. Epub 2019 Oct 1.

PMID:
31575746
2.

Predicting the 1p/19q co-deletion status of presumed low grade glioma with an externally validated machine learning algorithm.

van der Voort SR, Incekara F, Wijnenga MM, Kapsas G, Gardeniers M, Schouten JW, Starmans MP, Nandoe Tewarie R, Lycklama GJ, French PJ, Dubbink HJ, van den Bent MJ, Vincent AJ, Niessen WJ, Klein S, Smits M.

Clin Cancer Res. 2019 Sep 23. pii: clincanres.1127.2019. doi: 10.1158/1078-0432.CCR-19-1127. [Epub ahead of print]

PMID:
31548344
3.

Normative brain volumetry derived from different reference populations: impact on single-subject diagnostic assessment in dementia.

Vinke EJ, Huizinga W, Bergtholdt M, Adams HH, Steketee RME, Papma JM, de Jong FJ, Niessen WJ, Ikram MA, Wenzel F, Vernooij MW; Alzheimer's Disease Neuroimaging Initiative.

Neurobiol Aging. 2019 Jul 23;84:9-16. doi: 10.1016/j.neurobiolaging.2019.07.008. [Epub ahead of print]

4.

A genome-wide association study identifies genetic loci associated with specific lobar brain volumes.

van der Lee SJ, Knol MJ, Chauhan G, Satizabal CL, Smith AV, Hofer E, Bis JC, Hibar DP, Hilal S, van den Akker EB, Arfanakis K, Bernard M, Yanek LR, Amin N, Crivello F, Cheung JW, Harris TB, Saba Y, Lopez OL, Li S, van der Grond J, Yu L, Paus T, Roshchupkin GV, Amouyel P, Jahanshad N, Taylor KD, Yang Q, Mathias RA, Boehringer S, Mazoyer B, Rice K, Cheng CY, Maillard P, van Heemst D, Wong TY, Niessen WJ, Beiser AS, Beekman M, Zhao W, Nyquist PA, Chen C, Launer LJ, Psaty BM, Ikram MK, Vernooij MW, Schmidt H, Pausova Z, Becker DM, De Jager PL, Thompson PM, van Duijn CM, Bennett DA, Slagboom PE, Schmidt R, Longstreth WT, Ikram MA, Seshadri S, Debette S, Gudnason V, Adams HHH, DeCarli C.

Commun Biol. 2019 Aug 2;2:285. doi: 10.1038/s42003-019-0537-9. eCollection 2019.

5.

Prevalence and clinical relevance of diffusion-weighted imaging lesions: The Rotterdam study.

Hilal S, Baaij LGA, de Groot M, Niessen WJ, Ikram MK, Ikram MA, Vernooij MW.

Neurology. 2019 Sep 10;93(11):e1058-e1067. doi: 10.1212/WNL.0000000000008090. Epub 2019 Aug 7.

PMID:
31391244
6.

High-Dimensional Mapping of Cognition to the Brain Using Voxel-Based Morphometry and Subcortical Shape Analysis.

Zonneveld HI, Roshchupkin GV, Adams HHH, Gutman BA, van der Lugt A, Niessen WJ, Vernooij MW, Ikram MA.

J Alzheimers Dis. 2019;71(1):141-152. doi: 10.3233/JAD-181297.

PMID:
31356202
7.

Aortic valve calcification volumes and chronic brain infarctions in patients undergoing transcatheter aortic valve implantation.

Vlastra W, van den Boogert TPW, Krommenhoek T, Bronzwaer AGT, Mutsaerts HJMM, Achterberg HC, Bron EE, Niessen WJ, Majoie CBLM, Nederveen AJ, Baan J, van Lieshout JJ, Piek JJ, Planken RN, Henriques JPS, Delewi R.

Int J Cardiovasc Imaging. 2019 Jul 16. doi: 10.1007/s10554-019-01663-0. [Epub ahead of print]

PMID:
31312998
8.

The value of hippocampal volume, shape, and texture for 11-year prediction of dementia: a population-based study.

Achterberg HC, Sørensen L, Wolters FJ, Niessen WJ, Vernooij MW, Ikram MA, Nielsen M, de Bruijne M.

Neurobiol Aging. 2019 Sep;81:58-66. doi: 10.1016/j.neurobiolaging.2019.05.007. Epub 2019 May 28.

9.

Orientation Prior and Consistent Model Selection Increase Sensitivity of Tract-Based Spatial Statistics in Crossing-Fiber Regions.

Arkesteijn GAM, Poot DHJ, Ikram MA, Niessen WJ, van Vliet LJ, Vernooij MW, Vos FM.

IEEE Trans Med Imaging. 2019 Jun 13. doi: 10.1109/TMI.2019.2922615. [Epub ahead of print]

PMID:
31217096
10.

Multi-Site Meta-Analysis of Morphometry.

Jahanshad N, Faskowitz J, Roshchupkin G, Hibar DP, Gutman BA, Tustison NJ, Adams HHH, Niessen WJ, Vernooij MW, Ikram MA, Zwiers MP, Vasquez AA, Franke B, Kroll JL, Mwangi B, Soares JC, Ing A, Desrivieres S, Schumann G, Hansell NK, de Zubicaray GI, McMahon KL, Martin NG, Wright MJ, Thompson PM.

IEEE/ACM Trans Comput Biol Bioinform. 2019 Sep-Oct;16(5):1508-1514. doi: 10.1109/TCBB.2019.2914905. Epub 2019 May 23.

PMID:
31135366
11.

Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia.

Meeter LHH, Steketee RME, Salkovic D, Vos ME, Grossman M, McMillan CT, Irwin DJ, Boxer AL, Rojas JC, Olney NT, Karydas A, Miller BL, Pijnenburg YAL, Barkhof F, Sánchez-Valle R, Lladó A, Borrego-Ecija S, Diehl-Schmid J, Grimmer T, Goldhardt O, Santillo AF, Hansson O, Vestberg S, Borroni B, Padovani A, Galimberti D, Scarpini E, Rohrer JD, Woollacott IOC, Synofzik M, Wilke C, de Mendonca A, Vandenberghe R, Benussi L, Ghidoni R, Binetti G, Niessen WJ, Papma JM, Seelaar H, Jiskoot LC, de Jong FJ, Donker Kaat L, Del Campo M, Teunissen CE, Bron EE, Van den Berg E, Van Swieten JC.

J Neurol Neurosurg Psychiatry. 2019 Sep;90(9):997-1004. doi: 10.1136/jnnp-2018-319784. Epub 2019 May 23.

12.

Independent Multiple Factor Association Analysis for Multiblock Data in Imaging Genetics.

Vilor-Tejedor N, Ikram MA, Roshchupkin GV, Cáceres A, Alemany S, Vernooij MW, Niessen WJ, van Duijn CM, Sunyer J, Adams HH, González JR.

Neuroinformatics. 2019 Mar 22. doi: 10.1007/s12021-019-09416-z. [Epub ahead of print]

PMID:
30903541
13.

Genetic variation underlying cognition and its relation with neurological outcomes and brain imaging.

Knol MJ, Heshmatollah A, Cremers LGM, Ikram MK, Uitterlinden AG, van Duijn CM, Niessen WJ, Vernooij MW, Ikram MA, Adams HHH.

Aging (Albany NY). 2019 Mar 4;11(5):1440-1456. doi: 10.18632/aging.101844.

14.

Detection of mild cognitive impairment in a community-dwelling population using quantitative, multiparametric MRI-based classification.

Bouts MJRJ, van der Grond J, Vernooij MW, Koini M, Schouten TM, de Vos F, Feis RA, Cremers LGM, Lechner A, Schmidt R, de Rooij M, Niessen WJ, Ikram MA, Rombouts SARB.

Hum Brain Mapp. 2019 Jun 15;40(9):2711-2722. doi: 10.1002/hbm.24554. Epub 2019 Feb 25.

15.

Multiple-correlation similarity for block-matching based fast CT to ultrasound registration in liver interventions.

Banerjee J, Sun Y, Klink C, Gahrmann R, Niessen WJ, Moelker A, van Walsum T.

Med Image Anal. 2019 Apr;53:132-141. doi: 10.1016/j.media.2019.02.003. Epub 2019 Feb 7.

PMID:
30772666
16.

Patterns of functional connectivity in an aging population: The Rotterdam Study.

Zonneveld HI, Pruim RH, Bos D, Vrooman HA, Muetzel RL, Hofman A, Rombouts SA, van der Lugt A, Niessen WJ, Ikram MA, Vernooij MW.

Neuroimage. 2019 Apr 1;189:432-444. doi: 10.1016/j.neuroimage.2019.01.041. Epub 2019 Jan 16.

17.

Practical Small Vessel Disease Score Relates to Stroke, Dementia, and Death.

Yilmaz P, Ikram MK, Niessen WJ, Ikram MA, Vernooij MW.

Stroke. 2018 Dec;49(12):2857-2865. doi: 10.1161/STROKEAHA.118.022485.

PMID:
30571403
18.

Disease progression timeline estimation for Alzheimer's disease using discriminative event based modeling.

Venkatraghavan V, Bron EE, Niessen WJ, Klein S; Alzheimer's Disease Neuroimaging Initiative.

Neuroimage. 2019 Feb 1;186:518-532. doi: 10.1016/j.neuroimage.2018.11.024. Epub 2018 Nov 22.

19.

Aortic stiffness and brain integrity in elderly patients with cognitive and functional complaints.

Tap L, van Opbroek A, Niessen WJ, Smits M, Mattace-Raso FU.

Clin Interv Aging. 2018 Oct 26;13:2161-2167. doi: 10.2147/CIA.S181437. eCollection 2018.

20.

C-Reactive Protein, Plasma Amyloid-β Levels, and Their Interaction With Magnetic Resonance Imaging Markers.

Hilal S, Ikram MA, Verbeek MM, Franco OH, Stoops E, Vanderstichele H, Niessen WJ, Vernooij MW.

Stroke. 2018 Nov;49(11):2692-2698. doi: 10.1161/STROKEAHA.118.022317.

PMID:
30355213
21.

Evaluation of 2D and 3D ultrasound tracking algorithms and impact on ultrasound-guided liver radiotherapy margins.

De Luca V, Banerjee J, Hallack A, Kondo S, Makhinya M, Nouri D, Royer L, Cifor A, Dardenne G, Goksel O, Gooding MJ, Klink C, Krupa A, Le Bras A, Marchal M, Moelker A, Niessen WJ, Papiez BW, Rothberg A, Schnabel J, van Walsum T, Harris E, Lediju Bell MA, Tanner C.

Med Phys. 2018 Nov;45(11):4986-5003. doi: 10.1002/mp.13152. Epub 2018 Oct 1.

PMID:
30168159
22.

Groupwise image registration based on a total correlation dissimilarity measure for quantitative MRI and dynamic imaging data.

Guyader JM, Huizinga W, Poot DHJ, van Kranenburg M, Uitterdijk A, Niessen WJ, Klein S.

Sci Rep. 2018 Aug 30;8(1):13112. doi: 10.1038/s41598-018-31474-7.

23.

Disconnection due to white matter hyperintensities is associated with lower cognitive scores.

Langen CD, Cremers LGM, de Groot M, White T, Ikram MA, Niessen WJ, Vernooij MW.

Neuroimage. 2018 Dec;183:745-756. doi: 10.1016/j.neuroimage.2018.08.037. Epub 2018 Aug 23.

PMID:
30144572
24.

Automatic normative quantification of brain tissue volume to support the diagnosis of dementia: A clinical evaluation of diagnostic accuracy.

Vernooij MW, Jasperse B, Steketee R, Koek M, Vrooman H, Ikram MA, Papma J, van der Lugt A, Smits M, Niessen WJ.

Neuroimage Clin. 2018 Aug 9;20:374-379. doi: 10.1016/j.nicl.2018.08.004. eCollection 2018.

25.

Trajectories of imaging markers in brain aging: the Rotterdam Study.

Vinke EJ, de Groot M, Venkatraghavan V, Klein S, Niessen WJ, Ikram MA, Vernooij MW.

Neurobiol Aging. 2018 Nov;71:32-40. doi: 10.1016/j.neurobiolaging.2018.07.001. Epub 2018 Jul 17.

26.

Exome Chip Analysis Identifies Low-Frequency and Rare Variants in MRPL38 for White Matter Hyperintensities on Brain Magnetic Resonance Imaging.

Jian X, Satizabal CL, Smith AV, Wittfeld K, Bis JC, Smith JA, Hsu FC, Nho K, Hofer E, Hagenaars SP, Nyquist PA, Mishra A, Adams HHH, Li S, Teumer A, Zhao W, Freedman BI, Saba Y, Yanek LR, Chauhan G, van Buchem MA, Cushman M, Royle NA, Bryan RN, Niessen WJ, Windham BG, DeStefano AL, Habes M, Heckbert SR, Palmer ND, Lewis CE, Eiriksdottir G, Maillard P, Mathias RA, Homuth G, Valdés-Hernández MDC, Divers J, Beiser AS, Langner S, Rice KM, Bastin ME, Yang Q, Maldjian JA, Starr JM, Sidney S, Risacher SL, Uitterlinden AG, Gudnason VG, Nauck M, Rotter JI, Schreiner PJ, Boerwinkle E, van Duijn CM, Mazoyer B, von Sarnowski B, Gottesman RF, Levy D, Sigurdsson S, Vernooij MW, Turner ST, Schmidt R, Wardlaw JM, Psaty BM, Mosley TH, DeCarli CS, Saykin AJ, Bowden DW, Becker DM, Deary IJ, Schmidt H, Kardia SLR, Ikram MA, Debette S, Grabe HJ, Longstreth WT Jr, Seshadri S, Launer LJ, Fornage M; neuroCHARGE Working Group.

Stroke. 2018 Aug;49(8):1812-1819. doi: 10.1161/STROKEAHA.118.020689.

27.

Groupwise Multichannel Image Registration.

Guyader JM, Huizinga W, Fortunati V, Poot DHJ, Veenland JF, Paulides MM, Niessen WJ, Klein S.

IEEE J Biomed Health Inform. 2019 May;23(3):1171-1180. doi: 10.1109/JBHI.2018.2844361. Epub 2018 Jun 6.

PMID:
29994230
28.

Differential patterns of age-related cortical and subcortical functional connectivity in 6-to-10 year old children: A connectome-wide association study.

Langen CD, Muetzel R, Blanken L, van der Lugt A, Tiemeier H, Verhulst F, Niessen WJ, White T.

Brain Behav. 2018 Aug;8(8):e01031. doi: 10.1002/brb3.1031. Epub 2018 Jun 30.

29.

Thinner retinal layers are associated with changes in the visual pathway: A population-based study.

Mutlu U, Ikram MK, Roshchupkin GV, Bonnemaijer PWM, Colijn JM, Vingerling JR, Niessen WJ, Ikram MA, Klaver CCW, Vernooij MW.

Hum Brain Mapp. 2018 Nov;39(11):4290-4301. doi: 10.1002/hbm.24246. Epub 2018 Jun 23.

PMID:
29935103
30.

Cerebellar Growth Impairment Characterizes School-Aged Children Born Preterm without Perinatal Brain Lesions.

Pieterman K, White TJ, van den Bosch GE, Niessen WJ, Reiss IKM, Tibboel D, Hoebeek FE, Dudink J.

AJNR Am J Neuroradiol. 2018 May;39(5):956-962. doi: 10.3174/ajnr.A5589. Epub 2018 Mar 22.

31.

Intrasubject multimodal groupwise registration with the conditional template entropy.

Polfliet M, Klein S, Huizinga W, Paulides MM, Niessen WJ, Vandemeulebroucke J.

Med Image Anal. 2018 May;46:15-25. doi: 10.1016/j.media.2018.02.003. Epub 2018 Feb 17.

32.

Meditation and yoga practice are associated with smaller right amygdala volume: the Rotterdam study.

Gotink RA, Vernooij MW, Ikram MA, Niessen WJ, Krestin GP, Hofman A, Tiemeier H, Hunink MGM.

Brain Imaging Behav. 2018 Dec;12(6):1631-1639. doi: 10.1007/s11682-018-9826-z.

33.

Brain Volumes and Longitudinal Cognitive Change: A Population-based Study.

Vibha D, Tiemeier H, Mirza SS, Adams HHH, Niessen WJ, Hofman A, Prasad K, van der Lugt A, Vernooij MW, Ikram MA.

Alzheimer Dis Assoc Disord. 2018 Jan-Mar;32(1):43-49. doi: 10.1097/WAD.0000000000000235.

PMID:
29278559
34.

A spatio-temporal reference model of the aging brain.

Huizinga W, Poot DHJ, Vernooij MW, Roshchupkin GV, Bron EE, Ikram MA, Rueckert D, Niessen WJ, Klein S; Alzheimer's Disease Neuroimaging Initiative.

Neuroimage. 2018 Apr 1;169:11-22. doi: 10.1016/j.neuroimage.2017.10.040. Epub 2017 Dec 5.

PMID:
29203452
35.

Design of the ExCersion-VCI study: The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment.

Leeuwis AE, Hooghiemstra AM, Amier R, Ferro DA, Franken L, Nijveldt R, Kuijer JPA, Bronzwaer AGT, van Lieshout JJ, Rietberg MB, Veerbeek JM, Huijsmans RJ, Backx FJG, Teunissen CE, Bron EE, Barkhof F, Prins ND, Shahzad R, Niessen WJ, de Roos A, van Osch MJP, van Rossum AC, Biessels GJ, van der Flier WM; Heart Brain Connection study group.

Alzheimers Dement (N Y). 2017 Mar 6;3(2):157-165. doi: 10.1016/j.trci.2017.02.002. eCollection 2017 Jun.

36.

White-matter microstructure and hearing acuity in older adults: a population-based cross-sectional DTI study.

Rigters SC, Cremers LGM, Ikram MA, van der Schroeff MP, de Groot M, Roshchupkin GV, Niessen WJN, Baatenburg de Jong RJ, Goedegebure A, Vernooij MW.

Neurobiol Aging. 2018 Jan;61:124-131. doi: 10.1016/j.neurobiolaging.2017.09.018. Epub 2017 Sep 27.

PMID:
29059595
37.

Age-dependent association of thyroid function with brain morphology and microstructural organization: evidence from brain imaging.

Chaker L, Cremers LGM, Korevaar TIM, de Groot M, Dehghan A, Franco OH, Niessen WJ, Ikram MA, Peeters RP, Vernooij MW.

Neurobiol Aging. 2018 Jan;61:44-51. doi: 10.1016/j.neurobiolaging.2017.09.014. Epub 2017 Sep 22.

PMID:
29032192
38.

The Missing Link in the Pathophysiology of Vascular Cognitive Impairment: Design of the Heart-Brain Study.

Hooghiemstra AM, Bertens AS, Leeuwis AE, Bron EE, Bots ML, Brunner-La Rocca HP, de Craen AJM, van der Geest RJ, Greving JP, Kappelle LJ, Niessen WJ, van Oostenbrugge RJ, van Osch MJP, de Roos A, van Rossum AC, Biessels GJ, van Buchem MA, Daemen MJAP, van der Flier WM; Heart-Brain Connection Consortium.

Cerebrovasc Dis Extra. 2017;7(3):140-152. doi: 10.1159/000480738. Epub 2017 Oct 10.

39.

Plasma Amyloid-β Levels, Cerebral Small Vessel Disease, and Cognition: The Rotterdam Study.

Hilal S, Akoudad S, van Duijn CM, Niessen WJ, Verbeek MM, Vanderstichele H, Stoops E, Ikram MA, Vernooij MW.

J Alzheimers Dis. 2017;60(3):977-987. doi: 10.3233/JAD-170458.

PMID:
28984600
40.

Retinal neurodegeneration and brain MRI markers: the Rotterdam Study.

Mutlu U, Bonnemaijer PWM, Ikram MA, Colijn JM, Cremers LGM, Buitendijk GHS, Vingerling JR, Niessen WJ, Vernooij MW, Klaver CCW, Ikram MK.

Neurobiol Aging. 2017 Dec;60:183-191. doi: 10.1016/j.neurobiolaging.2017.09.003. Epub 2017 Sep 14.

PMID:
28974335
41.

Added value of multiphase CTA imaging for thrombus perviousness assessment.

Santos EMM, d'Esterre CD, Treurniet KM, Niessen WJ, Najm M, Goyal M, Demchuk AM, Majoie CB, Menon BK, Marquering HA; PRove-IT investigators.

Neuroradiology. 2018 Jan;60(1):71-79. doi: 10.1007/s00234-017-1907-y. Epub 2017 Sep 30.

42.

Contrast-enhancement influences skeletal muscle density, but not skeletal muscle mass, measurements on computed tomography.

van Vugt JLA, Coebergh van den Braak RRJ, Schippers HJW, Veen KM, Levolger S, de Bruin RWF, Koek M, Niessen WJ, IJzermans JNM, Willemsen FEJA.

Clin Nutr. 2018 Oct;37(5):1707-1714. doi: 10.1016/j.clnu.2017.07.007. Epub 2017 Jul 14.

PMID:
28743427
43.

Carotid Plaque Morphology and Ischemic Vascular Brain Disease on MRI.

van den Bouwhuijsen QJA, Vernooij MW, Verhaaren BFJ, Vrooman HA, Niessen WJ, Krestin GP, Ikram MA, Franco OH, van der Lugt A.

AJNR Am J Neuroradiol. 2017 Sep;38(9):1776-1782. doi: 10.3174/ajnr.A5288. Epub 2017 Jul 13.

44.

Automatic online layer separation for vessel enhancement in X-ray angiograms for percutaneous coronary interventions.

Ma H, Hoogendoorn A, Regar E, Niessen WJ, van Walsum T.

Med Image Anal. 2017 Jul;39:145-161. doi: 10.1016/j.media.2017.04.011. Epub 2017 May 5.

PMID:
28501700
45.

The effect of hippocampal function, volume and connectivity on posterior cingulate cortex functioning during episodic memory fMRI in mild cognitive impairment.

Papma JM, Smits M, de Groot M, Mattace Raso FU, van der Lugt A, Vrooman HA, Niessen WJ, Koudstaal PJ, van Swieten JC, van der Veen FM, Prins ND.

Eur Radiol. 2017 Sep;27(9):3716-3724. doi: 10.1007/s00330-017-4768-1. Epub 2017 Mar 13.

46.

Genetic susceptibility to multiple sclerosis: Brain structure and cognitive function in the general population.

Ikram MA, Vernooij MW, Roshchupkin GV, Hofman A, van Duijn CM, Uitterlinden AG, Niessen WJ, Hintzen RQ, Adams HH.

Mult Scler. 2017 Nov;23(13):1697-1706. doi: 10.1177/1352458516682104. Epub 2016 Dec 21.

PMID:
28273768
47.

Automatic segmentation and quantification of the cardiac structures from non-contrast-enhanced cardiac CT scans.

Shahzad R, Bos D, Budde RP, Pellikaan K, Niessen WJ, van der Lugt A, van Walsum T.

Phys Med Biol. 2017 May 7;62(9):3798-3813. doi: 10.1088/1361-6560/aa63cb. Epub 2017 Mar 1.

PMID:
28248196
48.

Brain MRI-markers Associate Differentially with Cognitive Versus Functional Decline Leading to Dementia.

Verlinden VJA, van der Geest JN, Hofman A, Niessen WJ, van der Lugt A, Vernooij MW, Ikram MA.

J Am Geriatr Soc. 2017 Jun;65(6):1258-1266. doi: 10.1111/jgs.14775. Epub 2017 Feb 6.

PMID:
28165615
49.

Gray matter heritability in family-based and population-based studies using voxel-based morphometry.

van der Lee SJ, Roshchupkin GV, Adams HH, Schmidt H, Hofer E, Saba Y, Schmidt R, Hofman A, Amin N, van Duijn CM, Vernooij MW, Ikram MA, Niessen WJ.

Hum Brain Mapp. 2017 May;38(5):2408-2423. doi: 10.1002/hbm.23528. Epub 2017 Feb 1.

PMID:
28145022
50.

Classification of hemodynamically significant stenoses from dynamic CT perfusion and CTA myocardial territories.

Giordano M, Poot DH, Coenen A, van Walsum T, Tezza M, Nieman K, Niessen WJ.

Med Phys. 2017 Apr;44(4):1347-1358. doi: 10.1002/mp.12126. Epub 2017 Mar 22.

PMID:
28130886

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