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Development and evaluation of a health-related quality-of-life tool for dogs with Cushing's syndrome.

Schofield I, O'Neill DG, Brodbelt DC, Church DB, Geddes RF, Niessen SJM.

J Vet Intern Med. 2019 Nov;33(6):2595-2604. doi: 10.1111/jvim.15639. Epub 2019 Oct 29.


Survival analysis of 219 dogs with hyperadrenocorticism attending primary care practice in England.

Schofield I, Brodbelt DC, Wilson ARL, Niessen S, Church D, O'Neill D.

Vet Rec. 2019 Sep 20. pii: vetrec-2018-105159. doi: 10.1136/vr.105159. [Epub ahead of print]


Regulation and Function of C-Type Natriuretic Peptide (CNP) in Gonadotrope-Derived Cell Lines.

Mirczuk SM, Lessey AJ, Catterick AR, Perrett RM, Scudder CJ, Read JE, Lipscomb VJ, Niessen SJ, Childs AJ, McArdle CA, McGonnell IM, Fowkes RC.

Cells. 2019 Sep 14;8(9). pii: E1086. doi: 10.3390/cells8091086.


Pituitary Pathology and Gene Expression in Acromegalic Cats.

Scudder CJ, Mirczuk SM, Richardson KM, Crossley VJ, Regan JTC, Gostelow R, Forcada Y, Hazuchova K, Harrington N, McGonnell IM, Church DB, Kenny PJ, Korbonits M, Fowkes RC, Niessen SJM.

J Endocr Soc. 2018 Oct 16;3(1):181-200. doi: 10.1210/js.2018-00226. eCollection 2019 Jan 1.


Radiotherapy and pasireotide treatment of a growth hormone producing pituitary tumor in a diabetic dog.

Zublena F, Tamborini A, Mooney CT, North SM, Lobacz MA, Andrew D, Woolhead V, Covey H, Schmid HA, Church DB, Niessen SJM.

Can Vet J. 2018 Oct;59(10):1089-1093.


Anaesthetic management and complications during hypophysectomy in 37 cats with acromegaly.

Neilson DM, Viscasillas J, Alibhai HI, Kenny PJ, Niessen SJ, Sanchis-Mora S.

J Feline Med Surg. 2019 Apr;21(4):347-352. doi: 10.1177/1098612X18778697. Epub 2018 May 31.


Diabetes mellitus remission in a cat with pituitary-dependent hyperadrenocorticism after trilostane treatment.

Muschner AC, Varela FV, Hazuchova K, Niessen SJ, Pöppl ÁG.

JFMS Open Rep. 2018 Apr 16;4(1):2055116918767708. doi: 10.1177/2055116918767708. eCollection 2018 Jan-Jun.


Time spent with cats is never wasted: Lessons learned from feline acromegalic cardiomyopathy, a naturally occurring animal model of the human disease.

Borgeat K, Niessen SJM, Wilkie L, Harrington N, Church DB, Luis Fuentes V, Connolly DJ.

PLoS One. 2018 Mar 29;13(3):e0194342. doi: 10.1371/journal.pone.0194342. eCollection 2018.


Prospective evaluation of a protocol for transitioning porcine lente insulin-treated diabetic cats to human recombinant protamine zinc insulin.

Gostelow R, Hazuchova K, Scudder C, Forcada Y, Church D, Niessen SJ.

J Feline Med Surg. 2018 Feb;20(2):114-121. doi: 10.1177/1098612X17697482. Epub 2017 Mar 15.


The Big Pet Diabetes Survey: Perceived Frequency and Triggers for Euthanasia.

Niessen SJM, Hazuchova K, Powney SL, Guitian J, Niessen APM, Pion PD, Shaw JA, Church DB.

Vet Sci. 2017 May 14;4(2). pii: E27. doi: 10.3390/vetsci4020027.


Proteome-wide Map of Targets of T790M-EGFR-Directed Covalent Inhibitors.

Niessen S, Dix MM, Barbas S, Potter ZE, Lu S, Brodsky O, Planken S, Behenna D, Almaden C, Gajiwala KS, Ryan K, Ferre R, Lazear MR, Hayward MM, Kath JC, Cravatt BF.

Cell Chem Biol. 2017 Nov 16;24(11):1388-1400.e7. doi: 10.1016/j.chembiol.2017.08.017. Epub 2017 Sep 28.


Acceptance of home blood glucose monitoring by owners of recently diagnosed diabetic cats and impact on quality of life changes in cat and owner.

Hazuchova K, Gostelow R, Scudder C, Forcada Y, Church DB, Niessen SJ.

J Feline Med Surg. 2018 Aug;20(8):711-720. doi: 10.1177/1098612X17727692. Epub 2017 Sep 15.


Natriuretic peptide activation of extracellular regulated kinase 1/2 (ERK1/2) pathway by particulate guanylyl cyclases in GH3 somatolactotropes.

Jonas KC, Melrose T, Thompson IR, Baxter GF, Lipscomb VJ, Niessen SJ, Lawson C, McArdle CA, Roberson MS, McGonnell IM, Wheeler-Jones CP, Fowkes RC.

Cell Tissue Res. 2017 Sep;369(3):567-578. doi: 10.1007/s00441-017-2624-x. Epub 2017 Apr 27.


Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR.

Planken S, Behenna DC, Nair SK, Johnson TO, Nagata A, Almaden C, Bailey S, Ballard TE, Bernier L, Cheng H, Cho-Schultz S, Dalvie D, Deal JG, Dinh DM, Edwards MP, Ferre RA, Gajiwala KS, Hemkens M, Kania RS, Kath JC, Matthews J, Murray BW, Niessen S, Orr ST, Pairish M, Sach NW, Shen H, Shi M, Solowiej J, Tran K, Tseng E, Vicini P, Wang Y, Weinrich SL, Zhou R, Zientek M, Liu L, Luo Y, Xin S, Zhang C, Lafontaine J.

J Med Chem. 2017 Apr 13;60(7):3002-3019. doi: 10.1021/acs.jmedchem.6b01894. Epub 2017 Mar 29.


Pasireotide Long-Acting Release Treatment for Diabetic Cats with Underlying Hypersomatotropism.

Gostelow R, Scudder C, Keyte S, Forcada Y, Fowkes RC, Schmid HA, Church DB, Niessen SJ.

J Vet Intern Med. 2017 Mar;31(2):355-364. doi: 10.1111/jvim.14662. Epub 2017 Feb 1.


Feline hypersomatotropism and acromegaly tumorigenesis: a potential role for the AIP gene.

Scudder CJ, Niessen SJ, Catchpole B, Fowkes RC, Church DB, Forcada Y.

Domest Anim Endocrinol. 2017 Apr;59:134-139. doi: 10.1016/j.domaniend.2016.11.005. Epub 2016 Dec 8.


Major Cys protease activities are not essential for senescence in individually darkened Arabidopsis leaves.

Pružinská A, Shindo T, Niessen S, Kaschani F, Tóth R, Millar AH, van der Hoorn RA.

BMC Plant Biol. 2017 Jan 6;17(1):4. doi: 10.1186/s12870-016-0955-5.


Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis.

Fadeyi O, Parikh MD, Chen MZ, Kyne RE Jr, Taylor AP, O'Doherty I, Kaiser SE, Barbas S, Niessen S, Shi M, Weinrich SL, Kath JC, Jones LH, Robinson RP.

Chembiochem. 2016 Oct 17;17(20):1925-1930. doi: 10.1002/cbic.201600427. Epub 2016 Aug 30.


Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitors.

Zuhl AM, Nolan CE, Brodney MA, Niessen S, Atchison K, Houle C, Karanian DA, Ambroise C, Brulet JW, Beck EM, Doran SD, O'Neill BT, Am Ende CW, Chang C, Geoghegan KF, West GM, Judkins JC, Hou X, Riddell DR, Johnson DS.

Nat Commun. 2016 Oct 11;7:13042. doi: 10.1038/ncomms13042.


Discovery of Enzymatic Targets of Transcriptional Activators via in Vivo Covalent Chemical Capture.

Dugan A, Majmudar CY, Pricer R, Niessen S, Lancia JK, Fung HY, Cravatt BF, Mapp AK.

J Am Chem Soc. 2016 Sep 28;138(38):12629-35. doi: 10.1021/jacs.6b07680. Epub 2016 Sep 20.


Increasing remission in diabetic cats.

Hazuchova K, Niessen S.

Vet Rec. 2016 Aug 6;179(6):152. doi: 10.1136/vr.i4282. No abstract available.


What's in a Name? Classification of Diabetes Mellitus in Veterinary Medicine and Why It Matters.

Gilor C, Niessen SJ, Furrow E, DiBartola SP.

J Vet Intern Med. 2016 Jul;30(4):927-40. doi: 10.1111/jvim.14357. Review.


Serum N-Terminal Type III Procollagen Propeptide: An Indicator of Growth Hormone Excess and Response to Treatment in Feline Hypersomatotropism.

Keyte SV, Kenny PJ, Forcada Y, Church DB, Niessen SJ.

J Vet Intern Med. 2016 Jul;30(4):973-82. doi: 10.1111/jvim.14373. Epub 2016 Jul 18.


Epidemiology of Diabetes Mellitus among 193,435 Cats Attending Primary-Care Veterinary Practices in England.

O'Neill DG, Gostelow R, Orme C, Church DB, Niessen SJ, Verheyen K, Brodbelt DC.

J Vet Intern Med. 2016 Jul;30(4):964-72. doi: 10.1111/jvim.14365. Epub 2016 Jun 29.


Hypersomatotropism in 3 Cats without Concurrent Diabetes Mellitus.

Fletcher JM, Scudder CJ, Kiupel M, Pipe-Martin HN, Kenny PJ, Mantis P, Fenn J, Smith K, Blair RV, Granger LA, Niessen SJ.

J Vet Intern Med. 2016 Jul;30(4):1216-21. doi: 10.1111/jvim.14360. Epub 2016 Jun 3. No abstract available.


Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants.

Cheng H, Nair SK, Murray BW, Almaden C, Bailey S, Baxi S, Behenna D, Cho-Schultz S, Dalvie D, Dinh DM, Edwards MP, Feng JL, Ferre RA, Gajiwala KS, Hemkens MD, Jackson-Fisher A, Jalaie M, Johnson TO, Kania RS, Kephart S, Lafontaine J, Lunney B, Liu KK, Liu Z, Matthews J, Nagata A, Niessen S, Ornelas MA, Orr ST, Pairish M, Planken S, Ren S, Richter D, Ryan K, Sach N, Shen H, Smeal T, Solowiej J, Sutton S, Tran K, Tseng E, Vernier W, Walls M, Wang S, Weinrich SL, Xin S, Xu H, Yin MJ, Zientek M, Zhou R, Kath JC.

J Med Chem. 2016 Mar 10;59(5):2005-24. doi: 10.1021/acs.jmedchem.5b01633. Epub 2016 Jan 28.


Effects of Activating Mutations on EGFR Cellular Protein Turnover and Amino Acid Recycling Determined Using SILAC Mass Spectrometry.

Greig MJ, Niessen S, Weinrich SL, Feng JL, Shi M, Johnson TO.

Int J Cell Biol. 2015;2015:798936. doi: 10.1155/2015/798936. Epub 2015 Nov 24.


Psychometric Validation of a General Health Quality of Life Tool for Cats Used to Compare Healthy Cats and Cats with Chronic Kidney Disease.

Bijsmans ES, Jepson RE, Syme HM, Elliott J, Niessen SJ.

J Vet Intern Med. 2016 Jan-Feb;30(1):183-91. doi: 10.1111/jvim.13656. Epub 2015 Nov 14.


Anti-Mullerian-Hormone during pregnancy and peripartum using the new Beckman Coulter AMH Gen II Assay.

Köninger A, Schmidt B, Mach P, Damaske D, Nießen S, Kimmig R, Strowitzki T, Gellhaus A.

Reprod Biol Endocrinol. 2015 Aug 7;13:86. doi: 10.1186/s12958-015-0082-4.


Studying Cat (Felis catus) Diabetes: Beware of the Acromegalic Imposter.

Niessen SJ, Forcada Y, Mantis P, Lamb CR, Harrington N, Fowkes R, Korbonits M, Smith K, Church DB.

PLoS One. 2015 May 29;10(5):e0127794. doi: 10.1371/journal.pone.0127794. eCollection 2015.


Pasireotide for the Medical Management of Feline Hypersomatotropism.

Scudder CJ, Gostelow R, Forcada Y, Schmid HA, Church D, Niessen SJ.

J Vet Intern Med. 2015 Jul-Aug;29(4):1074-80. doi: 10.1111/jvim.12608. Epub 2015 May 6.


Preventing farnesylation of the dynein adaptor Spindly contributes to the mitotic defects caused by farnesyltransferase inhibitors.

Holland AJ, Reis RM, Niessen S, Pereira C, Andres DA, Spielmann HP, Cleveland DW, Desai A, Gassmann R.

Mol Biol Cell. 2015 May 15;26(10):1845-56. doi: 10.1091/mbc.E14-11-1560. Epub 2015 Mar 25.


Evaluation and diagnostic potential of serum ghrelin in feline hypersomatotropism and diabetes mellitus.

Jensen KB, Forcada Y, Church DB, Niessen SJ.

J Vet Intern Med. 2015 Jan;29(1):14-20. doi: 10.1111/jvim.12536.


Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival.

Chang JW, Zuhl AM, Speers AE, Niessen S, Brown SJ, Mulvihill MM, Fan YC, Spicer TP, Southern M, Scampavia L, Fernandez-Vega V, Dix MM, Cameron MD, Hodder PS, Rosen H, Nomura DK, Kwon O, Hsu KL, Cravatt BF.

ACS Chem Biol. 2015 Apr 17;10(4):925-32. doi: 10.1021/cb500893q. Epub 2015 Jan 20.


Systematic review of feline diabetic remission: separating fact from opinion.

Gostelow R, Forcada Y, Graves T, Church D, Niessen S.

Vet J. 2014 Nov;202(2):208-21. doi: 10.1016/j.tvjl.2014.08.014. Epub 2014 Aug 19. Review.


Intraindividual right-left comparison of sonographic features in polycystic ovary syndrome (PCOS) diagnosis.

Köninger A, Koch L, Edimiris P, Nießen S, Kasimir-Bauer S, Kimmig R, Strowitzki T, Schmidt B.

Eur J Obstet Gynecol Reprod Biol. 2014 Oct;181:124-9. doi: 10.1016/j.ejogrb.2014.07.029. Epub 2014 Aug 4.


A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors.

Lanning BR, Whitby LR, Dix MM, Douhan J, Gilbert AM, Hett EC, Johnson TO, Joslyn C, Kath JC, Niessen S, Roberts LR, Schnute ME, Wang C, Hulce JJ, Wei B, Whiteley LO, Hayward MM, Cravatt BF.

Nat Chem Biol. 2014 Sep;10(9):760-767. doi: 10.1038/nchembio.1582. Epub 2014 Jul 13.


A structurally distinct human mycoplasma protein that generically blocks antigen-antibody union.

Grover RK, Zhu X, Nieusma T, Jones T, Boreo I, MacLeod AS, Mark A, Niessen S, Kim HJ, Kong L, Assad-Garcia N, Kwon K, Chesi M, Smider VV, Salomon DR, Jelinek DF, Kyle RA, Pyles RB, Glass JI, Ward AB, Wilson IA, Lerner RA.

Science. 2014 Feb 7;343(6171):656-661. doi: 10.1126/science.1246135.


Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes.

Dominguez E, Galmozzi A, Chang JW, Hsu KL, Pawlak J, Li W, Godio C, Thomas J, Partida D, Niessen S, O'Brien PE, Russell AP, Watt MJ, Nomura DK, Cravatt BF, Saez E.

Nat Chem Biol. 2014 Feb;10(2):113-21. doi: 10.1038/nchembio.1429. Epub 2013 Dec 22.


X-ray attenuation of the liver and kidney in cats considered at varying risk of hepatic lipidosis.

Lam R, Niessen SJ, Lamb CR.

Vet Radiol Ultrasound. 2014 Mar-Apr;55(2):141-6. doi: 10.1111/vru.12113. Epub 2013 Oct 17.


Chemoproteomic discovery of AADACL1 as a regulator of human platelet activation.

Holly SP, Chang JW, Li W, Niessen S, Phillips RM, Piatt R, Black JL, Smith MC, Boulaftali Y, Weyrich AS, Bergmeier W, Cravatt BF, Parise LV.

Chem Biol. 2013 Sep 19;20(9):1125-34. doi: 10.1016/j.chembiol.2013.07.011. Epub 2013 Aug 29.


A chemical biology approach to interrogate quorum-sensing regulated behaviors at the molecular and cellular level.

Lowery CA, Matamouros S, Niessen S, Zhu J, Scolnick J, Lively JM, Cravatt BF, Miller SI, Kaufmann GF, Janda KD.

Chem Biol. 2013 Jul 25;20(7):903-11. doi: 10.1016/j.chembiol.2013.05.009.


Computed tomographic signs of acromegaly in 68 diabetic cats with hypersomatotropism.

Lamb CR, Ciasca TC, Mantis P, Forcada Y, Potter M, Church DB, Niessen SJ.

J Feline Med Surg. 2014 Feb;16(2):99-108. doi: 10.1177/1098612X13497212. Epub 2013 Jul 11.


Screening diabetic cats for hypersomatotropism: performance of an enzyme-linked immunosorbent assay for insulin-like growth factor 1.

Rosca M, Forcada Y, Solcan G, Church DB, Niessen SJ.

J Feline Med Surg. 2014 Feb;16(2):82-8. doi: 10.1177/1098612X13496246. Epub 2013 Jul 4.


Direct binding of SAS-6 to ZYG-1 recruits SAS-6 to the mother centriole for cartwheel assembly.

Lettman MM, Wong YL, Viscardi V, Niessen S, Chen SH, Shiau AK, Zhou H, Desai A, Oegema K.

Dev Cell. 2013 May 13;25(3):284-98. doi: 10.1016/j.devcel.2013.03.011.


Organohalogenated contaminants in domestic cats' plasma in relation to spontaneous acromegaly and type 2 diabetes mellitus: a clue for endocrine disruption in humans?

Dirtu AC, Niessen SJ, Jorens PG, Covaci A.

Environ Int. 2013 Jul;57-58:60-7. doi: 10.1016/j.envint.2013.04.004. Epub 2013 May 11.


PRMT5 modulates the metabolic response to fasting signals.

Tsai WW, Niessen S, Goebel N, Yates JR 3rd, Guccione E, Montminy M.

Proc Natl Acad Sci U S A. 2013 May 28;110(22):8870-5. doi: 10.1073/pnas.1304602110. Epub 2013 May 13.


Pseudomonas syringae pv. syringae uses proteasome inhibitor syringolin A to colonize from wound infection sites.

Misas-Villamil JC, Kolodziejek I, Crabill E, Kaschani F, Niessen S, Shindo T, Kaiser M, Alfano JR, van der Hoorn RA.

PLoS Pathog. 2013 Mar;9(3):e1003281. doi: 10.1371/journal.ppat.1003281. Epub 2013 Mar 28.


Hypersomatotropism, acromegaly, and hyperadrenocorticism and feline diabetes mellitus.

Niessen SJ, Church DB, Forcada Y.

Vet Clin North Am Small Anim Pract. 2013 Mar;43(2):319-50. doi: 10.1016/j.cvsm.2012.12.004. Review.


Hsp70/Hsp90 chaperone machinery is involved in the assembly of the purinosome.

French JB, Zhao H, An S, Niessen S, Deng Y, Cravatt BF, Benkovic SJ.

Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2528-33. doi: 10.1073/pnas.1300173110. Epub 2013 Jan 28.

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