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Items: 1 to 50 of 106

1.

Protein and RNA dynamical fingerprinting.

Niessen KA, Xu M, George DK, Chen MC, Ferré-D'Amaré AR, Snell EH, Cody V, Pace J, Schmidt M, Markelz AG.

Nat Commun. 2019 Mar 4;10(1):1026. doi: 10.1038/s41467-019-08926-3.

2.

Mothers' and fathers' sense of security in the context of pregnancy, childbirth and the postnatal period: an integrative literature review.

Werner-Bierwisch T, Pinkert C, Niessen K, Metzing S, Hellmers C.

BMC Pregnancy Childbirth. 2018 Dec 4;18(1):473. doi: 10.1186/s12884-018-2096-3. Review.

3.

Synthesis of a Series of Non-Symmetric Bispyridinium and Related Compounds and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor.

Rappenglück S, Sichler S, Höfner G, Wein T, Niessen KV, Seeger T, Paintner FF, Worek F, Thiermann H, Wanner KT.

ChemMedChem. 2018 Dec 20;13(24):2653-2663. doi: 10.1002/cmdc.201800539. Epub 2018 Nov 27.

PMID:
30362667
4.

Synthesis of a Series of Structurally Diverse MB327 Derivatives and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor.

Rappenglück S, Sichler S, Höfner G, Wein T, Niessen KV, Seeger T, Paintner FF, Worek F, Thiermann H, Wanner KT.

ChemMedChem. 2018 Sep 6;13(17):1806-1816. doi: 10.1002/cmdc.201800325. Epub 2018 Aug 1.

PMID:
29974635
5.

New Resensitizers for the Nicotinic Acetylcholine Receptor by Ligand-Based Pharmacophore Modeling.

Wein T, Wanner KT, Rappenglück S, Sichler S, Niessen KV, Seeger T, Worek F, Thiermann H.

Curr Comput Aided Drug Des. 2019;15(1):104-109. doi: 10.2174/1573409914666180703120201.

PMID:
29968541
6.

Counteracting desensitization of human α7-nicotinic acetylcholine receptors with bispyridinium compounds as an approach against organophosphorus poisoning.

Scheffel C, Niessen KV, Rappenglück S, Wanner KT, Thiermann H, Worek F, Seeger T.

Toxicol Lett. 2018 Sep 1;293:149-156. doi: 10.1016/j.toxlet.2017.12.005. Epub 2017 Dec 14.

PMID:
29248576
7.

Moving in the Right Direction: Protein Vibrations Steering Function.

Niessen KA, Xu M, Paciaroni A, Orecchini A, Snell EH, Markelz AG.

Biophys J. 2017 Dec 5;113(11):2573. doi: 10.1016/j.bpj.2017.10.038. No abstract available.

8.

Electrophysiological investigation of the effect of structurally different bispyridinium non-oxime compounds on human α7-nicotinic acetylcholine receptor activity-An in vitro structure-activity analysis.

Scheffel C, Niessen KV, Rappenglück S, Wanner KT, Thiermann H, Worek F, Seeger T.

Toxicol Lett. 2018 Sep 1;293:157-166. doi: 10.1016/j.toxlet.2017.11.025. Epub 2017 Nov 27.

PMID:
29191791
9.

Development of MS Binding Assays targeting the binding site of MB327 at the nicotinic acetylcholine receptor.

Sichler S, Höfner G, Rappenglück S, Wein T, Niessen KV, Seeger T, Worek F, Thiermann H, Paintner FF, Wanner KT.

Toxicol Lett. 2018 Sep 1;293:172-183. doi: 10.1016/j.toxlet.2017.11.013. Epub 2017 Nov 14.

PMID:
29146291
10.

Searching for putative binding sites of the bispyridinium compound MB327 in the nicotinic acetylcholine receptor.

Wein T, Höfner G, Rappenglück S, Sichler S, Niessen KV, Seeger T, Worek F, Thiermann H, Wanner KT.

Toxicol Lett. 2018 Sep 1;293:184-189. doi: 10.1016/j.toxlet.2017.10.024. Epub 2017 Oct 31.

PMID:
29097222
11.

In vitro pharmacological characterization of the bispyridinium non-oxime compound MB327 and its 2- and 3-regioisomers.

Niessen KV, Seeger T, Rappenglück S, Wein T, Höfner G, Wanner KT, Thiermann H, Worek F.

Toxicol Lett. 2018 Sep 1;293:190-197. doi: 10.1016/j.toxlet.2017.10.009. Epub 2017 Oct 10.

PMID:
29024789
12.

[Motherhood at the Age of 35 and Over: The Risk of Advanced Maternal Age as Perceived by Women - a Literature Study].

Niessen K, Werner-Bierwisch T, Metzing S, Sayn-Wittgenstein FZ.

Z Geburtshilfe Neonatol. 2017 Jun;221(3):111-121. doi: 10.1055/s-0043-104864. Epub 2017 Jun 30. Review. German.

PMID:
28666302
13.

Moving in the Right Direction: Protein Vibrations Steering Function.

Niessen KA, Xu M, Paciaroni A, Orecchini A, Snell EH, Markelz AG.

Biophys J. 2017 Mar 14;112(5):933-942. doi: 10.1016/j.bpj.2016.12.049. Erratum in: Biophys J. 2017 Dec 5;113(11):2573.

14.

Functional analysis of Torpedo californica nicotinic acetylcholine receptors in multiple activation states by SSM-based electrophysiology.

Niessen KV, Muschik S, Langguth F, Rappenglück S, Seeger T, Thiermann H, Worek F.

Toxicol Lett. 2016 Apr 15;247:1-10. doi: 10.1016/j.toxlet.2016.02.002. Epub 2016 Feb 3.

PMID:
26851639
15.

Terahertz optical measurements of correlated motions with possible allosteric function.

Niessen KA, Xu M, Markelz AG.

Biophys Rev. 2015 Jun;7(2):201-216. doi: 10.1007/s12551-015-0168-4. Epub 2015 Apr 7. Review.

16.

Optical measurements of long-range protein vibrations.

Acbas G, Niessen KA, Snell EH, Markelz AG.

Nat Commun. 2014;5:3076. doi: 10.1038/ncomms4076.

PMID:
24430203
17.

Affinities of bispyridinium non-oxime compounds to [(3)H]epibatidine binding sites of Torpedo californica nicotinic acetylcholine receptors depend on linker length.

Niessen KV, Seeger T, Tattersall JE, Timperley CM, Bird M, Green C, Thiermann H, Worek F.

Chem Biol Interact. 2013 Dec 5;206(3):545-54. doi: 10.1016/j.cbi.2013.10.012. Epub 2013 Oct 21.

PMID:
24157926
18.

L-selectin is a possible biomarker for individual PML risk in natalizumab-treated MS patients.

Schwab N, Schneider-Hohendorf T, Posevitz V, Breuer J, Göbel K, Windhagen S, Brochet B, Vermersch P, Lebrun-Frenay C, Posevitz-Fejfár A, Capra R, Imberti L, Straeten V, Haas J, Wildemann B, Havla J, Kümpfel T, Meinl I, Niessen K, Goelz S, Kleinschnitz C, Warnke C, Buck D, Gold R, Kieseier BC, Meuth SG, Foley J, Chan A, Brassat D, Wiendl H.

Neurology. 2013 Sep 3;81(10):865-71. doi: 10.1212/WNL.0b013e3182a351fb. Epub 2013 Aug 7.

PMID:
23925765
19.

Notch activation promotes endothelial survival through a PI3K-Slug axis.

Chang L, Wong F, Niessen K, Karsan A.

Microvasc Res. 2013 Sep;89:80-5. doi: 10.1016/j.mvr.2013.05.007. Epub 2013 Jun 3.

PMID:
23743248
20.

OTUB1 modulates c-IAP1 stability to regulate signalling pathways.

Goncharov T, Niessen K, de Almagro MC, Izrael-Tomasevic A, Fedorova AV, Varfolomeev E, Arnott D, Deshayes K, Kirkpatrick DS, Vucic D.

EMBO J. 2013 Apr 17;32(8):1103-14. doi: 10.1038/emboj.2013.62. Epub 2013 Mar 22.

21.

Competition radioligand binding assays for the investigation of bispyridinium compound affinities to the human muscarinic acetylcholine receptor subtype 5 (hM(5) ).

Niessen KV, Tattersall JE, Timperley CM, Bird M, Green C, Thiermann H, Worek F.

Drug Test Anal. 2012 Mar-Apr;4(3-4):292-7. doi: 10.1002/dta.410. Epub 2012 Feb 24.

PMID:
22362630
22.

Restoration of soman-blocked neuromuscular transmission in human and rat muscle by the bispyridinium non-oxime MB327 in vitro.

Seeger T, Eichhorn M, Lindner M, Niessen KV, Tattersall JE, Timperley CM, Bird M, Green AC, Thiermann H, Worek F.

Toxicology. 2012 Apr 11;294(2-3):80-4. doi: 10.1016/j.tox.2012.02.002. Epub 2012 Feb 13.

PMID:
22349640
23.

Notch initiates the endothelial-to-mesenchymal transition in the atrioventricular canal through autocrine activation of soluble guanylyl cyclase.

Chang AC, Fu Y, Garside VC, Niessen K, Chang L, Fuller M, Setiadi A, Smrz J, Kyle A, Minchinton A, Marra M, Hoodless PA, Karsan A.

Dev Cell. 2011 Aug 16;21(2):288-300. doi: 10.1016/j.devcel.2011.06.022.

24.

Restoration of nerve agent inhibited muscle force production in human intercostal muscle strips with HI 6.

Seeger T, Niessen KV, Langer P, Gerhardus J, Worek F, Friess H, Bumm R, Mihaljevic AL, Thiermann H.

Toxicol Lett. 2011 Sep 25;206(1):72-6. doi: 10.1016/j.toxlet.2011.07.016. Epub 2011 Jul 23.

PMID:
21803135
25.

Interaction of bispyridinium compounds with the orthosteric binding site of human α7 and Torpedo californica nicotinic acetylcholine receptors (nAChRs).

Niessen KV, Tattersall JE, Timperley CM, Bird M, Green C, Seeger T, Thiermann H, Worek F.

Toxicol Lett. 2011 Sep 25;206(1):100-4. doi: 10.1016/j.toxlet.2011.06.009. Epub 2011 Jun 16.

PMID:
21703337
26.

The Notch1-Dll4 signaling pathway regulates mouse postnatal lymphatic development.

Niessen K, Zhang G, Ridgway JB, Chen H, Kolumam G, Siebel CW, Yan M.

Blood. 2011 Aug 18;118(7):1989-97. doi: 10.1182/blood-2010-11-319129. Epub 2011 Jun 23.

27.

RUNX3 maintains the mesenchymal phenotype after termination of the Notch signal.

Fu Y, Chang AC, Fournier M, Chang L, Niessen K, Karsan A.

J Biol Chem. 2011 Apr 1;286(13):11803-13. doi: 10.1074/jbc.M111.222331. Epub 2011 Feb 2.

28.

Chronic DLL4 blockade induces vascular neoplasms.

Yan M, Callahan CA, Beyer JC, Allamneni KP, Zhang G, Ridgway JB, Niessen K, Plowman GD.

Nature. 2010 Feb 11;463(7282):E6-7. doi: 10.1038/nature08751.

PMID:
20147986
29.

Genomic analysis distinguishes phases of early development of the mouse atrio-ventricular canal.

Vrljicak P, Chang AC, Morozova O, Wederell ED, Niessen K, Marra MA, Karsan A, Hoodless PA.

Physiol Genomics. 2010 Feb 4;40(3):150-7. doi: 10.1152/physiolgenomics.00142.2009. Epub 2009 Dec 1.

30.

ALK1 signaling regulates early postnatal lymphatic vessel development.

Niessen K, Zhang G, Ridgway JB, Chen H, Yan M.

Blood. 2010 Feb 25;115(8):1654-61. doi: 10.1182/blood-2009-07-235655. Epub 2009 Nov 10.

31.

Differential regulation of transforming growth factor beta signaling pathways by Notch in human endothelial cells.

Fu Y, Chang A, Chang L, Niessen K, Eapen S, Setiadi A, Karsan A.

J Biol Chem. 2009 Jul 17;284(29):19452-62. doi: 10.1074/jbc.M109.011833. Epub 2009 May 27.

32.

Slug is a direct Notch target required for initiation of cardiac cushion cellularization.

Niessen K, Fu Y, Chang L, Hoodless PA, McFadden D, Karsan A.

J Cell Biol. 2008 Jul 28;182(2):315-25. doi: 10.1083/jcb.200710067.

33.

Notch signaling in cardiac development.

Niessen K, Karsan A.

Circ Res. 2008 May 23;102(10):1169-81. doi: 10.1161/CIRCRESAHA.108.174318. Review.

PMID:
18497317
34.

Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin.

Leong KG, Niessen K, Kulic I, Raouf A, Eaves C, Pollet I, Karsan A.

J Exp Med. 2007 Nov 26;204(12):2935-48. Epub 2007 Nov 5.

35.

Notch signaling in the developing cardiovascular system.

Niessen K, Karsan A.

Am J Physiol Cell Physiol. 2007 Jul;293(1):C1-11. Epub 2007 Mar 21. Review.

36.

Smooth Muscle alpha-actin is a direct target of Notch/CSL.

Noseda M, Fu Y, Niessen K, Wong F, Chang L, McLean G, Karsan A.

Circ Res. 2006 Jun 23;98(12):1468-70. Epub 2006 Jun 1.

PMID:
16741155
37.

Competitive MS binding assays for dopamine D2 receptors employing spiperone as a native marker.

Niessen KV, Höfner G, Wanner KT.

Chembiochem. 2005 Oct;6(10):1769-75.

PMID:
16149041
38.

Minimal contribution of marrow-derived endothelial precursors to tumor vasculature.

Larrivée B, Niessen K, Pollet I, Corbel SY, Long M, Rossi FM, Olive PL, Karsan A.

J Immunol. 2005 Sep 1;175(5):2890-9.

39.

Notch-dependent cell cycle arrest is associated with downregulation of minichromosome maintenance proteins.

Noseda M, Niessen K, McLean G, Chang L, Karsan A.

Circ Res. 2005 Jul 22;97(2):102-4. Epub 2005 Jun 23.

PMID:
15976316
40.

Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation.

Noseda M, McLean G, Niessen K, Chang L, Pollet I, Montpetit R, Shahidi R, Dorovini-Zis K, Li L, Beckstead B, Durand RE, Hoodless PA, Karsan A.

Circ Res. 2004 Apr 16;94(7):910-7. Epub 2004 Feb 26.

PMID:
14988227
41.

[Congenital pulmonary fibrosarcoma. Differential diagnosis of infantile pulmonary spindle cell tumors].

Kuhnen C, Harms D, Niessen KH, Diehm T, Müller KM.

Pathologe. 2001 Mar;22(2):151-6. German.

PMID:
11321732
42.

Is there a correlation between organochlorine compounds and undescended testes?

Hosie S, Loff S, Witt K, Niessen K, Waag KL.

Eur J Pediatr Surg. 2000 Oct;10(5):304-9.

PMID:
11194541
43.

Polyvinylchloride infusion lines expose infants to large amounts of toxic plasticizers.

Loff S, Kabs F, Witt K, Sartoris J, Mandl B, Niessen KH, Waag KL.

J Pediatr Surg. 2000 Dec;35(12):1775-81.

PMID:
11101735
44.

Toxaphenes and chlorinated naphthalenes in adipose tissue of children.

Witt K, Niessen KH.

J Pediatr Gastroenterol Nutr. 2000 Feb;30(2):164-9.

PMID:
10697135
45.
46.

[Chlorinated carbohydrate content of fetal and pediatric organs and tissues].

Bosse U, Bannert N, Niessen KH, Teufel M, Röse I.

Zentralbl Hyg Umweltmed. 1996 Mar;198(4):331-9. German.

PMID:
9376058
47.

Chlorinated hydrocarbons in human bone marrow of healthy individuals and leukemia patients.

Scheele J, Teufel M, Niessen KH.

Arch Environ Health. 1996 Jan-Feb;51(1):22-5.

PMID:
8629858
49.

[Simultaneous determination of inorganic anions in body fluids. A new method in pediatric laboratory diagnosis--results of a pilot study].

Böhn I, Niessen KH, Reineke F, Teufel M.

Klin Padiatr. 1994 Mar-Apr;206(2):95-9. German.

PMID:
8196314
50.

A pilot study on polychlorinated biphenyl levels in the bone marrow of healthy individuals and leukemia patients.

Scheele J, Teufel M, Niessen KH.

J Environ Pathol Toxicol Oncol. 1994;13(3):181-5.

PMID:
7722885

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