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Items: 1 to 50 of 69

1.

Homeostasis of the sebaceous gland and mechanisms of acne pathogenesis.

Clayton RW, Göbel K, Niessen CM, Paus R, van Steensel MAM, Lim X.

Br J Dermatol. 2019 Oct;181(4):677-690. doi: 10.1111/bjd.17981. Epub 2019 May 6. Review.

PMID:
31056753
2.

Epithelial polarity limits EMT.

Persa OD, Niessen CM.

Nat Cell Biol. 2019 Mar;21(3):299-300. doi: 10.1038/s41556-019-0284-7. No abstract available.

PMID:
30824839
3.

Hepatitis B virus promotes β-catenin-signalling and disassembly of adherens junctions in a Src kinase dependent fashion.

von Olshausen G, Quasdorff M, Bester R, Arzberger S, Ko C, van de Klundert M, Zhang K, Odenthal M, Ringelhan M, Niessen CM, Protzer U.

Oncotarget. 2018 Sep 21;9(74):33947-33960. doi: 10.18632/oncotarget.26103. eCollection 2018 Sep 21.

4.

Transition of responsive mechanosensitive elements from focal adhesions to adherens junctions on epithelial differentiation.

Noethel B, Ramms L, Dreissen G, Hoffmann M, Springer R, Rübsam M, Ziegler WH, Niessen CM, Merkel R, Hoffmann B.

Mol Biol Cell. 2018 Sep 15;29(19):2317-2325. doi: 10.1091/mbc.E17-06-0387. Epub 2018 Jul 25.

5.

E-cadherin binds to desmoglein to facilitate desmosome assembly.

Shafraz O, Rübsam M, Stahley SN, Caldara AL, Kowalczyk AP, Niessen CM, Sivasankar S.

Elife. 2018 Jul 12;7. pii: e37629. doi: 10.7554/eLife.37629.

6.

Cell adhesion and mechanics as drivers of tissue organization and differentiation: local cues for large scale organization.

Wickström SA, Niessen CM.

Curr Opin Cell Biol. 2018 Oct;54:89-97. doi: 10.1016/j.ceb.2018.05.003. Epub 2018 Jun 1. Review.

PMID:
29864721
7.

Shared and independent functions of aPKCλ and Par3 in skin tumorigenesis.

Vorhagen S, Kleefisch D, Persa OD, Graband A, Schwickert A, Saynisch M, Leitges M, Niessen CM, Iden S.

Oncogene. 2018 Sep;37(37):5136-5146. doi: 10.1038/s41388-018-0313-1. Epub 2018 May 23.

8.

AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer.

Welcker D, Jain M, Khurshid S, Jokić M, Höhne M, Schmitt A, Frommolt P, Niessen CM, Spiro J, Persigehl T, Wittersheim M, Büttner R, Fanciulli M, Schermer B, Reinhardt HC, Benzing T, Höpker K.

Oncogene. 2018 Mar;37(11):1503-1518. doi: 10.1038/s41388-017-0054-6. Epub 2018 Jan 11.

PMID:
29321668
9.

Adhesion forces and cortical tension couple cell proliferation and differentiation to drive epidermal stratification.

Miroshnikova YA, Le HQ, Schneider D, Thalheim T, Rübsam M, Bremicker N, Polleux J, Kamprad N, Tarantola M, Wang I, Balland M, Niessen CM, Galle J, Wickström SA.

Nat Cell Biol. 2018 Jan;20(1):69-80. doi: 10.1038/s41556-017-0005-z. Epub 2017 Dec 11.

PMID:
29230016
10.

E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning.

Rübsam M, Mertz AF, Kubo A, Marg S, Jüngst C, Goranci-Buzhala G, Schauss AC, Horsley V, Dufresne ER, Moser M, Ziegler W, Amagai M, Wickström SA, Niessen CM.

Nat Commun. 2017 Nov 1;8(1):1250. doi: 10.1038/s41467-017-01170-7.

11.

Adherens Junctions and Desmosomes Coordinate Mechanics and Signaling to Orchestrate Tissue Morphogenesis and Function: An Evolutionary Perspective.

Rübsam M, Broussard JA, Wickström SA, Nekrasova O, Green KJ, Niessen CM.

Cold Spring Harb Perspect Biol. 2018 Nov 1;10(11). pii: a029207. doi: 10.1101/cshperspect.a029207. Review.

PMID:
28893859
12.

Imbalance of Mitochondrial Respiratory Chain Complexes in the Epidermis Induces Severe Skin Inflammation.

Weiland D, Brachvogel B, Hornig-Do HT, Neuhaus JFG, Holzer T, Tobin DJ, Niessen CM, Wiesner RJ, Baris OR.

J Invest Dermatol. 2018 Jan;138(1):132-140. doi: 10.1016/j.jid.2017.08.019. Epub 2017 Sep 1.

13.

The epidermal polarity protein Par3 is a non-cell autonomous suppressor of malignant melanoma.

Mescher M, Jeong P, Knapp SK, Rübsam M, Saynisch M, Kranen M, Landsberg J, Schlaak M, Mauch C, Tüting T, Niessen CM, Iden S.

J Exp Med. 2017 Feb;214(2):339-358. doi: 10.1084/jem.20160596. Epub 2017 Jan 17.

14.

Epithelial Barriers in Murine Skin during Herpes Simplex Virus 1 Infection: The Role of Tight Junction Formation.

Rahn E, Thier K, Petermann P, Rübsam M, Staeheli P, Iden S, Niessen CM, Knebel-Mörsdorf D.

J Invest Dermatol. 2017 Apr;137(4):884-893. doi: 10.1016/j.jid.2016.11.027. Epub 2016 Dec 6.

15.

The Mitochondrial m-AAA Protease Prevents Demyelination and Hair Greying.

Wang S, Jacquemyn J, Murru S, Martinelli P, Barth E, Langer T, Niessen CM, Rugarli EI.

PLoS Genet. 2016 Dec 2;12(12):e1006463. doi: 10.1371/journal.pgen.1006463. eCollection 2016 Dec.

16.

Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment.

Le HQ, Ghatak S, Yeung CY, Tellkamp F, Günschmann C, Dieterich C, Yeroslaviz A, Habermann B, Pombo A, Niessen CM, Wickström SA.

Nat Cell Biol. 2016 Aug;18(8):864-75. doi: 10.1038/ncb3387. Epub 2016 Jul 11.

PMID:
27398909
17.

Degrees of Freedom: Your Future in Biomedical Research.

Green KJ, Niessen CM.

J Invest Dermatol. 2016 Jun;136(6):1073-1076. doi: 10.1016/j.jid.2016.03.025. No abstract available.

18.

Par3A is dispensable for the function of the glomerular filtration barrier of the kidney.

Koehler S, Tellkamp F, Niessen CM, Bloch W, Kerjaschki D, Schermer B, Benzing T, Brinkkoetter PT.

Am J Physiol Renal Physiol. 2016 Jul 1;311(1):F112-9. doi: 10.1152/ajprenal.00171.2016. Epub 2016 Apr 27.

19.

Growth Retardation, Loss of Desmosomal Adhesion, and Impaired Tight Junction Function Identify a Unique Role of Plakophilin 1 In Vivo.

Rietscher K, Wolf A, Hause G, Rother A, Keil R, Magin TM, Glass M, Niessen CM, Hatzfeld M.

J Invest Dermatol. 2016 Jul;136(7):1471-1478. doi: 10.1016/j.jid.2016.03.021. Epub 2016 Mar 28.

20.

Myeloid Cell-Restricted Insulin/IGF-1 Receptor Deficiency Protects against Skin Inflammation.

Knuever J, Willenborg S, Ding X, Akyüz MD, Partridge L, Niessen CM, Brüning JC, Eming SA.

J Immunol. 2015 Dec 1;195(11):5296-5308. doi: 10.4049/jimmunol.1501237. Epub 2015 Oct 30.

21.

Ceramide synthase 4 regulates stem cell homeostasis and hair follicle cycling.

Peters F, Vorhagen S, Brodesser S, Jakobshagen K, Brüning JC, Niessen CM, Krönke M.

J Invest Dermatol. 2015 Jun;135(6):1501-1509. doi: 10.1038/jid.2015.60. Epub 2015 Feb 23.

22.

Epidermal polarity genes in health and disease.

Tellkamp F, Vorhagen S, Niessen CM.

Cold Spring Harb Perspect Med. 2014 Dec 1;4(12):a015255. doi: 10.1101/cshperspect.a015255. Review.

23.

Mammalian aPKC/Par polarity complex mediated regulation of epithelial division orientation and cell fate.

Vorhagen S, Niessen CM.

Exp Cell Res. 2014 Nov 1;328(2):296-302. doi: 10.1016/j.yexcr.2014.08.008. Epub 2014 Aug 13. Review.

PMID:
25128813
24.

Tropism-modified AAV vectors overcome barriers to successful cutaneous therapy.

Sallach J, Di Pasquale G, Larcher F, Niehoff N, Rübsam M, Huber A, Chiorini J, Almarza D, Eming SA, Ulus H, Nishimura S, Hacker UT, Hallek M, Niessen CM, Büning H.

Mol Ther. 2014 May;22(5):929-39. doi: 10.1038/mt.2014.14. Epub 2014 Jan 28.

25.

Clinician scientists and PhDs: the need to connect basic research to translational medicine-a personal experience.

Niessen CM, Krieg T.

J Invest Dermatol. 2014 Feb;134(2):295-298. doi: 10.1038/jid.2013.466. No abstract available.

26.

aPKCλ controls epidermal homeostasis and stem cell fate through regulation of division orientation.

Niessen MT, Scott J, Zielinski JG, Vorhagen S, Sotiropoulou PA, Blanpain C, Leitges M, Niessen CM.

J Cell Biol. 2013 Sep 16;202(6):887-900. doi: 10.1083/jcb.201307001. Epub 2013 Sep 9.

27.

Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition.

Günschmann C, Stachelscheid H, Akyüz MD, Schmitz A, Missero C, Brüning JC, Niessen CM.

Dev Cell. 2013 Jul 29;26(2):176-87. doi: 10.1016/j.devcel.2013.05.017.

28.

Montagna Symposium 2012: Keeping it all together--adhesion, the cytoskeleton, and signaling in morphogenesis and tissue function.

Green KJ, Niessen CM, Godsel LM, Kulesz-Martin MF.

J Invest Dermatol. 2013 May;133(5):1124-8. doi: 10.1038/jid.2013.59. No abstract available.

29.

Analysis of bulge stem cells from the epidermis using flow cytometry.

Villani RM, Akyuz MD, Niessen MT, Niessen CM.

Methods Mol Biol. 2013;989:33-43. doi: 10.1007/978-1-62703-330-5_4.

PMID:
23483385
30.

Cadherin-based intercellular adhesions organize epithelial cell-matrix traction forces.

Mertz AF, Che Y, Banerjee S, Goldstein JM, Rosowski KA, Revilla SF, Niessen CM, Marchetti MC, Dufresne ER, Horsley V.

Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):842-7. doi: 10.1073/pnas.1217279110. Epub 2012 Dec 31.

31.

The in vivo function of mammalian cell and tissue polarity regulators--how to shape and maintain the epidermal barrier.

Niessen MT, Iden S, Niessen CM.

J Cell Sci. 2012 Aug 1;125(Pt 15):3501-10. Epub 2012 Aug 30. Review.

32.

Experimental analysis of risk factors for ulcerative dermatitis in mice.

Neuhaus B, Niessen CM, Mesaros A, Withers DJ, Krieg T, Partridge L.

Exp Dermatol. 2012 Sep;21(9):712-3. doi: 10.1111/j.1600-0625.2012.01558.x.

PMID:
22897579
33.

Classical and desmosomal cadherins at a glance.

Saito M, Tucker DK, Kohlhorst D, Niessen CM, Kowalczyk AP.

J Cell Sci. 2012 Jun 1;125(Pt 11):2547-52. doi: 10.1242/jcs.066654. Review. No abstract available.

34.

Adherens junctions in mammalian development, homeostasis and disease: lessons from mice.

Boggetti B, Niessen CM.

Subcell Biochem. 2012;60:321-55. doi: 10.1007/978-94-007-4186-7_14. Review.

PMID:
22674078
35.

Vascular endothelial insulin/IGF-1 signaling controls skin wound vascularization.

Aghdam SY, Eming SA, Willenborg S, Neuhaus B, Niessen CM, Partridge L, Krieg T, Bruning JC.

Biochem Biophys Res Commun. 2012 May 4;421(2):197-202. doi: 10.1016/j.bbrc.2012.03.134. Epub 2012 Apr 4.

PMID:
22503682
36.

Cadherin-dependent differential cell adhesion in Xenopus causes cell sorting in vitro but not in the embryo.

Ninomiya H, David R, Damm EW, Fagotto F, Niessen CM, Winklbauer R.

J Cell Sci. 2012 Apr 15;125(Pt 8):1877-83. doi: 10.1242/jcs.095315. Epub 2012 Feb 10.

37.

TCF/Lef1-mediated control of lipid metabolism regulates skin barrier function.

Fehrenschild D, Galli U, Breiden B, Bloch W, Schettina P, Brodesser S, Michels C, Günschmann C, Sandhoff K, Niessen CM, Niemann C.

J Invest Dermatol. 2012 Feb;132(2):337-45. doi: 10.1038/jid.2011.301. Epub 2011 Sep 22.

38.

Impaired keratinocyte proliferative and clonogenic potential in transgenic mice overexpressing 14-3-3σ in the epidermis.

Cianfarani F, Bernardini S, De Luca N, Dellambra E, Tatangelo L, Tiveron C, Niessen CM, Zambruno G, Castiglia D, Odorisio T.

J Invest Dermatol. 2011 Sep;131(9):1821-9. doi: 10.1038/jid.2011.137. Epub 2011 Jun 9.

39.

Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulation.

Niessen CM, Leckband D, Yap AS.

Physiol Rev. 2011 Apr;91(2):691-731. doi: 10.1152/physrev.00004.2010. Review.

40.

The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling.

Weber S, Niessen MT, Prox J, Lüllmann-Rauch R, Schmitz A, Schwanbeck R, Blobel CP, Jorissen E, de Strooper B, Niessen CM, Saftig P.

Development. 2011 Feb;138(3):495-505. doi: 10.1242/dev.055210.

41.

CD44 regulates tight-junction assembly and barrier function.

Kirschner N, Haftek M, Niessen CM, Behne MJ, Furuse M, Moll I, Brandner JM.

J Invest Dermatol. 2011 Apr;131(4):932-43. doi: 10.1038/jid.2010.390. Epub 2010 Dec 30.

42.

An adhesion-independent, aPKC-dependent function for cadherins in morphogenetic movements.

Seifert K, Ibrahim H, Stodtmeister T, Winklbauer R, Niessen CM.

J Cell Sci. 2009 Jul 15;122(Pt 14):2514-23. doi: 10.1242/jcs.042796. Epub 2009 Jun 23.

43.

Cadherin-mediated regulation of tight junctions in stratifying epithelia.

Michels C, Aghdam SY, Niessen CM.

Ann N Y Acad Sci. 2009 May;1165:163-8. doi: 10.1111/j.1749-6632.2009.04443.x.

PMID:
19538302
44.

Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity.

Garinis GA, Uittenboogaard LM, Stachelscheid H, Fousteri M, van Ijcken W, Breit TM, van Steeg H, Mullenders LH, van der Horst GT, Brüning JC, Niessen CM, Hoeijmakers JH, Schumacher B.

Nat Cell Biol. 2009 May;11(5):604-15. doi: 10.1038/ncb1866. Epub 2009 Apr 12.

45.

Classical cadherins regulate desmosome formation.

Michels C, Buchta T, Bloch W, Krieg T, Niessen CM.

J Invest Dermatol. 2009 Aug;129(8):2072-5. doi: 10.1038/jid.2009.17. Epub 2009 Mar 5. No abstract available.

46.

Epidermal insulin/IGF-1 signalling control interfollicular morphogenesis and proliferative potential through Rac activation.

Stachelscheid H, Ibrahim H, Koch L, Schmitz A, Tscharntke M, Wunderlich FT, Scott J, Michels C, Wickenhauser C, Haase I, Brüning JC, Niessen CM.

EMBO J. 2008 Aug 6;27(15):2091-101. doi: 10.1038/emboj.2008.141. Epub 2008 Jul 24.

47.

Molecular components of the adherens junction.

Niessen CM, Gottardi CJ.

Biochim Biophys Acta. 2008 Mar;1778(3):562-71. doi: 10.1016/j.bbamem.2007.12.015. Epub 2008 Jan 14. Review.

48.

Tight junctions/adherens junctions: basic structure and function.

Niessen CM.

J Invest Dermatol. 2007 Nov;127(11):2525-32. Review.

49.

Another job for the talented p120-catenin.

Niessen CM, Yap AS.

Cell. 2006 Dec 1;127(5):875-7.

50.

Role of aPKC isoforms and their binding partners Par3 and Par6 in epidermal barrier formation.

Helfrich I, Schmitz A, Zigrino P, Michels C, Haase I, le Bivic A, Leitges M, Niessen CM.

J Invest Dermatol. 2007 Apr;127(4):782-91. Epub 2006 Nov 16.

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