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Items: 1 to 50 of 67

1.

Cellular Uptake of the Atypical Antipsychotic Clozapine Is a Carrier-Mediated Process.

Dickens D, Rädisch S, Chiduza GN, Giannoudis A, Cross MJ, Malik H, Schaeffeler E, Sison-Young RL, Wilkinson EL, Goldring CE, Schwab M, Pirmohamed M, Nies AT.

Mol Pharm. 2018 Jul 10. doi: 10.1021/acs.molpharmaceut.8b00547. [Epub ahead of print]

PMID:
29944835
2.

The fruit fly Drosophila melanogaster as an innovative preclinical ADME model for solute carrier membrane transporters, with consequences for pharmacology and drug therapy.

Wang Y, Moussian B, Schaeffeler E, Schwab M, Nies AT.

Drug Discov Today. 2018 Jun 8. pii: S1359-6446(18)30080-1. doi: 10.1016/j.drudis.2018.06.002. [Epub ahead of print] Review.

PMID:
29890226
3.

Systemic regulation of bilirubin homeostasis: Potential benefits of hyperbilirubinemia.

Fujiwara R, Haag M, Schaeffeler E, Nies AT, Zanger UM, Schwab M.

Hepatology. 2018 Apr;67(4):1609-1619. doi: 10.1002/hep.29599. Epub 2018 Mar 2. Review.

PMID:
29059457
4.

Comment on "Epigenetic activation of the drug transporter OCT2 sensitizes renal cell carcinoma to oxaliplatin".

Winter S, Fisel P, Büttner F, Nies AT, Stenzl A, Bedke J, Schwab M, Schaeffeler E.

Sci Transl Med. 2017 May 24;9(391). pii: eaal2439. doi: 10.1126/scitranslmed.aal2439. No abstract available.

PMID:
28539468
5.

OCTN1 Is a High-Affinity Carrier of Nucleoside Analogues.

Drenberg CD, Gibson AA, Pounds SB, Shi L, Rhinehart DP, Li L, Hu S, Du G, Nies AT, Schwab M, Pabla N, Blum W, Gruber TA, Baker SD, Sparreboom A.

Cancer Res. 2017 Apr 15;77(8):2102-2111. doi: 10.1158/0008-5472.CAN-16-2548. Epub 2017 Feb 16.

6.

The importance of drug transporter characterization to precision medicine.

Fisel P, Nies AT, Schaeffeler E, Schwab M.

Expert Opin Drug Metab Toxicol. 2017 Apr;13(4):361-365. doi: 10.1080/17425255.2017.1290083. Epub 2017 Feb 9. No abstract available.

PMID:
28140687
7.

Impact of Membrane Drug Transporters on Resistance to Small-Molecule Tyrosine Kinase Inhibitors.

Neul C, Schaeffeler E, Sparreboom A, Laufer S, Schwab M, Nies AT.

Trends Pharmacol Sci. 2016 Nov;37(11):904-932. doi: 10.1016/j.tips.2016.08.003. Epub 2016 Sep 19. Review.

PMID:
27659854
8.

Methylomes of renal cell lines and tumors or metastases differ significantly with impact on pharmacogenes.

Winter S, Fisel P, Büttner F, Rausch S, D'Amico D, Hennenlotter J, Kruck S, Nies AT, Stenzl A, Junker K, Scharpf M, Hofmann U, van der Kuip H, Fend F, Ott G, Agaimy A, Hartmann A, Bedke J, Schwab M, Schaeffeler E.

Sci Rep. 2016 Jul 20;6:29930. doi: 10.1038/srep29930.

9.

Structure and function of multidrug and toxin extrusion proteins (MATEs) and their relevance to drug therapy and personalized medicine.

Nies AT, Damme K, Kruck S, Schaeffeler E, Schwab M.

Arch Toxicol. 2016 Jul;90(7):1555-84. doi: 10.1007/s00204-016-1728-5. Epub 2016 May 10. Review.

PMID:
27165417
10.

A phosphotyrosine switch regulates organic cation transporters.

Sprowl JA, Ong SS, Gibson AA, Hu S, Du G, Lin W, Li L, Bharill S, Ness RA, Stecula A, Offer SM, Diasio RB, Nies AT, Schwab M, Cavaletti G, Schlatter E, Ciarimboli G, Schellens JH, Isacoff EY, Sali A, Chen T, Baker SD, Sparreboom A, Pabla N.

Nat Commun. 2016 Mar 16;7:10880. doi: 10.1038/ncomms10880.

11.

Development of Human Membrane Transporters: Drug Disposition and Pharmacogenetics.

Mooij MG, Nies AT, Knibbe CA, Schaeffeler E, Tibboel D, Schwab M, de Wildt SN.

Clin Pharmacokinet. 2016 May;55(5):507-24. doi: 10.1007/s40262-015-0328-5. Review.

12.

MCT4 surpasses the prognostic relevance of the ancillary protein CD147 in clear cell renal cell carcinoma.

Fisel P, Stühler V, Bedke J, Winter S, Rausch S, Hennenlotter J, Nies AT, Stenzl A, Scharpf M, Fend F, Kruck S, Schwab M, Schaeffeler E.

Oncotarget. 2015 Oct 13;6(31):30615-27. doi: 10.18632/oncotarget.5593.

13.

Variability in hepatic expression of organic anion transporter 7/SLC22A9, a novel pravastatin uptake transporter: impact of genetic and regulatory factors.

Emami Riedmaier A, Burk O, van Eijck BA, Schaeffeler E, Klein K, Fehr S, Biskup S, Müller S, Winter S, Zanger UM, Schwab M, Nies AT.

Pharmacogenomics J. 2016 Aug;16(4):341-51. doi: 10.1038/tpj.2015.55. Epub 2015 Aug 4.

PMID:
26239079
14.

Functional characterization of common protein variants in the efflux transporter ABCC11 and identification of T546M as functionally damaging variant.

Arlanov R, Lang T, Jedlitschky G, Schaeffeler E, Ishikawa T, Schwab M, Nies AT.

Pharmacogenomics J. 2016 Apr;16(2):193-201. doi: 10.1038/tpj.2015.27. Epub 2015 Apr 21.

PMID:
25896536
15.

Impact of Genetic Polymorphisms of ABCB1 (MDR1, P-Glycoprotein) on Drug Disposition and Potential Clinical Implications: Update of the Literature.

Wolking S, Schaeffeler E, Lerche H, Schwab M, Nies AT.

Clin Pharmacokinet. 2015 Jul;54(7):709-35. doi: 10.1007/s40262-015-0267-1. Review.

PMID:
25860377
16.

Role of ABC transporters in fluoropyrimidine-based chemotherapy response.

Nies AT, Magdy T, Schwab M, Zanger UM.

Adv Cancer Res. 2015;125:217-43. doi: 10.1016/bs.acr.2014.10.007. Epub 2015 Jan 8. Review.

PMID:
25640272
17.

Stratified medicine for the use of antidiabetic medication in treatment of type II diabetes and cancer: where do we go from here?

Emami-Riedmaier A, Schaeffeler E, Nies AT, Mörike K, Schwab M.

J Intern Med. 2015 Feb;277(2):235-247. doi: 10.1111/joim.12330. Review.

18.

Differential expression of drug uptake and efflux transporters in Japanese patients with hepatocellular carcinoma.

Namisaki T, Schaeffeler E, Fukui H, Yoshiji H, Nakajima Y, Fritz P, Schwab M, Nies AT.

Drug Metab Dispos. 2014 Dec;42(12):2033-40. doi: 10.1124/dmd.114.059832. Epub 2014 Sep 17.

19.

Genetic biomarkers in epilepsy.

Weber YG, Nies AT, Schwab M, Lerche H.

Neurotherapeutics. 2014 Apr;11(2):324-33. doi: 10.1007/s13311-014-0262-5. Review.

20.

Solute carrier transporter and drug-related nephrotoxicity: the impact of proximal tubule cell models for preclinical research.

Fisel P, Renner O, Nies AT, Schwab M, Schaeffeler E.

Expert Opin Drug Metab Toxicol. 2014 Mar;10(3):395-408. doi: 10.1517/17425255.2014.876990. Epub 2014 Jan 8. Review.

PMID:
24397389
21.

Cellular uptake of imatinib into leukemic cells is independent of human organic cation transporter 1 (OCT1).

Nies AT, Schaeffeler E, van der Kuip H, Cascorbi I, Bruhn O, Kneba M, Pott C, Hofmann U, Volk C, Hu S, Baker SD, Sparreboom A, Ruth P, Koepsell H, Schwab M.

Clin Cancer Res. 2014 Feb 15;20(4):985-94. doi: 10.1158/1078-0432.CCR-13-1999. Epub 2013 Dec 18.

22.

DNA methylation of the SLC16A3 promoter regulates expression of the human lactate transporter MCT4 in renal cancer with consequences for clinical outcome.

Fisel P, Kruck S, Winter S, Bedke J, Hennenlotter J, Nies AT, Scharpf M, Fend F, Stenzl A, Schwab M, Schaeffeler E.

Clin Cancer Res. 2013 Sep 15;19(18):5170-81. doi: 10.1158/1078-0432.CCR-13-1180. Epub 2013 Jul 23.

23.

Histamine transport and metabolism are deranged in salivary glands in Sjogren's syndrome.

Stegaev V, Nies AT, Porola P, Mieliauskaite D, Sánchez-Jiménez F, Urdiales JL, Sillat T, Schwelberger HG, Chazot PL, Katebe M, Mackiewicz Z, Konttinen YT, Nordström DC.

Rheumatology (Oxford). 2013 Sep;52(9):1599-608. doi: 10.1093/rheumatology/ket188. Epub 2013 May 24.

PMID:
23709238
24.

Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1.

Nies AT, Niemi M, Burk O, Winter S, Zanger UM, Stieger B, Schwab M, Schaeffeler E.

Genome Med. 2013 Jan 11;5(1):1. doi: 10.1186/gm405. eCollection 2013.

25.

Metformin and cancer: from the old medicine cabinet to pharmacological pitfalls and prospects.

Emami Riedmaier A, Fisel P, Nies AT, Schaeffeler E, Schwab M.

Trends Pharmacol Sci. 2013 Feb;34(2):126-35. doi: 10.1016/j.tips.2012.11.005. Epub 2012 Dec 29. Review.

PMID:
23277337
26.

Multidrug and toxin extrusion proteins as transporters of antimicrobial drugs.

Nies AT, Damme K, Schaeffeler E, Schwab M.

Expert Opin Drug Metab Toxicol. 2012 Dec;8(12):1565-77. doi: 10.1517/17425255.2012.722996. Epub 2012 Sep 13. Review.

PMID:
22970772
27.

Retigabine/Ezogabine, a KCNQ/K(V)7 channel opener: pharmacological and clinical data.

Orhan G, Wuttke TV, Nies AT, Schwab M, Lerche H.

Expert Opin Pharmacother. 2012 Aug;13(12):1807-16. doi: 10.1517/14656566.2012.706278. Epub 2012 Jul 12. Review.

PMID:
22783830
28.

Organic anion transporters and their implications in pharmacotherapy.

Emami Riedmaier A, Nies AT, Schaeffeler E, Schwab M.

Pharmacol Rev. 2012 Jul;64(3):421-49. doi: 10.1124/pr.111.004614. Epub 2012 Mar 28. Review.

29.

Human pregnane X receptor genotype of the donor but not of the recipient is a risk factor for delayed graft function after renal transplantation.

Hauser IA, Kruck S, Gauer S, Nies AT, Winter S, Bedke J, Geiger H, Hoefeld H, Kleemann J, Asbe-Vollkopf A, Engel J, Burk O, Schwab M, Schaeffeler E.

Clin Pharmacol Ther. 2012 May;91(5):905-16. doi: 10.1038/clpt.2011.346. Epub 2012 Mar 28.

PMID:
22453193
30.

DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma.

Schaeffeler E, Hellerbrand C, Nies AT, Winter S, Kruck S, Hofmann U, van der Kuip H, Zanger UM, Koepsell H, Schwab M.

Genome Med. 2011 Dec 23;3(12):82. doi: 10.1186/gm298.

31.

Organic cation transporter pharmacogenomics and drug-drug interaction.

Nies AT, Schwab M.

Expert Rev Clin Pharmacol. 2010 Nov;3(6):707-11. doi: 10.1586/ecp.10.60. No abstract available.

PMID:
22111772
32.

Mammalian MATE (SLC47A) transport proteins: impact on efflux of endogenous substrates and xenobiotics.

Damme K, Nies AT, Schaeffeler E, Schwab M.

Drug Metab Rev. 2011 Nov;43(4):499-523. doi: 10.3109/03602532.2011.602687. Epub 2011 Sep 17. Review.

PMID:
21923552
33.

Proton pump inhibitors inhibit metformin uptake by organic cation transporters (OCTs).

Nies AT, Hofmann U, Resch C, Schaeffeler E, Rius M, Schwab M.

PLoS One. 2011;6(7):e22163. doi: 10.1371/journal.pone.0022163. Epub 2011 Jul 14.

34.

Organic cation transporters (OCTs, MATEs), in vitro and in vivo evidence for the importance in drug therapy.

Nies AT, Koepsell H, Damme K, Schwab M.

Handb Exp Pharmacol. 2011;(201):105-67. doi: 10.1007/978-3-642-14541-4_3. Review.

PMID:
21103969
35.

Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver.

Nies AT, Koepsell H, Winter S, Burk O, Klein K, Kerb R, Zanger UM, Keppler D, Schwab M, Schaeffeler E.

Hepatology. 2009 Oct;50(4):1227-40. doi: 10.1002/hep.23103.

PMID:
19591196
36.

Interplay of conjugating enzymes with OATP uptake transporters and ABCC/MRP efflux pumps in the elimination of drugs.

Nies AT, Schwab M, Keppler D.

Expert Opin Drug Metab Toxicol. 2008 May;4(5):545-68. doi: 10.1517/17425255.4.5.545 . Review.

PMID:
18484914
37.
38.

The role of membrane transporters in drug delivery to brain tumors.

Nies AT.

Cancer Lett. 2007 Aug 28;254(1):11-29. Epub 2007 Jan 31. Review.

PMID:
17275180
39.

The apical conjugate efflux pump ABCC2 (MRP2).

Nies AT, Keppler D.

Pflugers Arch. 2007 Feb;453(5):643-59. Epub 2006 Jul 18. Review.

PMID:
16847695
40.

Human multidrug resistance protein 8 (MRP8/ABCC11), an apical efflux pump for steroid sulfates, is an axonal protein of the CNS and peripheral nervous system.

Bortfeld M, Rius M, König J, Herold-Mende C, Nies AT, Keppler D.

Neuroscience. 2006;137(4):1247-57. Epub 2005 Dec 15.

PMID:
16359813
41.

ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier.

Bronger H, König J, Kopplow K, Steiner HH, Ahmadi R, Herold-Mende C, Keppler D, Nies AT.

Cancer Res. 2005 Dec 15;65(24):11419-28.

42.
43.

Expression and localization of human multidrug resistance protein (ABCC) family members in pancreatic carcinoma.

König J, Hartel M, Nies AT, Martignoni ME, Guo J, Büchler MW, Friess H, Keppler D.

Int J Cancer. 2005 Jun 20;115(3):359-67.

44.

Expression and immunolocalization of the multidrug resistance proteins, MRP1-MRP6 (ABCC1-ABCC6), in human brain.

Nies AT, Jedlitschky G, König J, Herold-Mende C, Steiner HH, Schmitt HP, Keppler D.

Neuroscience. 2004;129(2):349-60.

PMID:
15501592
45.

Increased protein kinase A regulatory subunit content and cGMP binding in erythrocyte membranes in liver cirrhosis.

Montoliu C, Kosenko E, Calvete JJ, Nies AT, Del Olmo JA, Serra MA, Rodrigo JM, Felipo V.

J Hepatol. 2004 May;40(5):766-73.

PMID:
15094223
46.

Identification and functional characterization of the natural variant MRP3-Arg1297His of human multidrug resistance protein 3 (MRP3/ABCC3).

Lee YM, Cui Y, König J, Risch A, Jäger B, Drings P, Bartsch H, Keppler D, Nies AT.

Pharmacogenetics. 2004 Apr;14(4):213-23.

PMID:
15083066
47.

Changes in the expression and localization of hepatocellular transporters and radixin in primary biliary cirrhosis.

Kojima H, Nies AT, König J, Hagmann W, Spring H, Uemura M, Fukui H, Keppler D.

J Hepatol. 2003 Nov;39(5):693-702.

PMID:
14568249
48.

Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane.

Rius M, Nies AT, Hummel-Eisenbeiss J, Jedlitschky G, Keppler D.

Hepatology. 2003 Aug;38(2):374-84.

PMID:
12883481
49.

Detection of the human organic anion transporters SLC21A6 (OATP2) and SLC21A8 (OATP8) in liver and hepatocellular carcinoma.

Cui Y, König J, Nies AT, Pfannschmidt M, Hergt M, Franke WW, Alt W, Moll R, Keppler D.

Lab Invest. 2003 Apr;83(4):527-38.

PMID:
12695556
50.

A common Dubin-Johnson syndrome mutation impairs protein maturation and transport activity of MRP2 (ABCC2).

Keitel V, Nies AT, Brom M, Hummel-Eisenbeiss J, Spring H, Keppler D.

Am J Physiol Gastrointest Liver Physiol. 2003 Jan;284(1):G165-74. Epub 2002 Oct 2.

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