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Items: 11

1.

Pptc7 is an essential phosphatase for promoting mammalian mitochondrial metabolism and biogenesis.

Niemi NM, Wilson GM, Overmyer KA, Vögtle FN, Myketin L, Lohman DC, Schueler KL, Attie AD, Meisinger C, Coon JJ, Pagliarini DJ.

Nat Commun. 2019 Jul 19;10(1):3197. doi: 10.1038/s41467-019-11047-6.

2.

Integrative proteomics and biochemical analyses define Ptc6p as the Saccharomyces cerevisiae pyruvate dehydrogenase phosphatase.

Guo X, Niemi NM, Coon JJ, Pagliarini DJ.

J Biol Chem. 2017 Jul 14;292(28):11751-11759. doi: 10.1074/jbc.M117.787341. Epub 2017 May 24.

3.

Ptc7p Dephosphorylates Select Mitochondrial Proteins to Enhance Metabolic Function.

Guo X, Niemi NM, Hutchins PD, Condon SGF, Jochem A, Ulbrich A, Higbee AJ, Russell JD, Senes A, Coon JJ, Pagliarini DJ.

Cell Rep. 2017 Jan 10;18(2):307-313. doi: 10.1016/j.celrep.2016.12.049.

4.

A mitochondrial RNAi screen defines cellular bioenergetic determinants and identifies an adenylate kinase as a key regulator of ATP levels.

Lanning NJ, Looyenga BD, Kauffman AL, Niemi NM, Sudderth J, DeBerardinis RJ, MacKeigan JP.

Cell Rep. 2014 May 8;7(3):907-17. doi: 10.1016/j.celrep.2014.03.065. Epub 2014 Apr 24.

5.

The pseudophosphatase MK-STYX physically and genetically interacts with the mitochondrial phosphatase PTPMT1.

Niemi NM, Sacoman JL, Westrate LM, Gaither LA, Lanning NJ, Martin KR, MacKeigan JP.

PLoS One. 2014 Apr 7;9(4):e93896. doi: 10.1371/journal.pone.0093896. eCollection 2014.

6.

Downregulation of the mitochondrial phosphatase PTPMT1 is sufficient to promote cancer cell death.

Niemi NM, Lanning NJ, Westrate LM, MacKeigan JP.

PLoS One. 2013;8(1):e53803. doi: 10.1371/journal.pone.0053803. Epub 2013 Jan 10.

7.

A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis.

Grimsrud PA, Carson JJ, Hebert AS, Hubler SL, Niemi NM, Bailey DJ, Jochem A, Stapleton DS, Keller MP, Westphall MS, Yandell BS, Attie AD, Coon JJ, Pagliarini DJ.

Cell Metab. 2012 Nov 7;16(5):672-83. doi: 10.1016/j.cmet.2012.10.004.

8.

Mitochondrial phosphorylation in apoptosis: flipping the death switch.

Niemi NM, MacKeigan JP.

Antioxid Redox Signal. 2013 Aug 20;19(6):572-82. doi: 10.1089/ars.2012.4982. Epub 2012 Dec 7. Review.

9.

Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing.

Stark MS, Woods SL, Gartside MG, Bonazzi VF, Dutton-Regester K, Aoude LG, Chow D, Sereduk C, Niemi NM, Tang N, Ellis JJ, Reid J, Zismann V, Tyagi S, Muzny D, Newsham I, Wu Y, Palmer JM, Pollak T, Youngkin D, Brooks BR, Lanagan C, Schmidt CW, Kobe B, MacKeigan JP, Yin H, Brown KM, Gibbs R, Trent J, Hayward NK.

Nat Genet. 2011 Dec 25;44(2):165-9. doi: 10.1038/ng.1041.

10.

MK-STYX, a catalytically inactive phosphatase regulating mitochondrially dependent apoptosis.

Niemi NM, Lanning NJ, Klomp JA, Tait SW, Xu Y, Dykema KJ, Murphy LO, Gaither LA, Xu HE, Furge KA, Green DR, MacKeigan JP.

Mol Cell Biol. 2011 Apr;31(7):1357-68. doi: 10.1128/MCB.00788-10. Epub 2011 Jan 24.

11.

Birt-Hogg-Dubé renal tumors are genetically distinct from other renal neoplasias and are associated with up-regulation of mitochondrial gene expression.

Klomp JA, Petillo D, Niemi NM, Dykema KJ, Chen J, Yang XJ, Sääf A, Zickert P, Aly M, Bergerheim U, Nordenskjöld M, Gad S, Giraud S, Denoux Y, Yonneau L, Méjean A, Vasiliu V, Richard S, MacKeigan JP, Teh BT, Furge KA.

BMC Med Genomics. 2010 Dec 16;3:59. doi: 10.1186/1755-8794-3-59.

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