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Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans.

Itkonen MK, Tornio A, Neuvonen M, Neuvonen PJ, Niemi M, Backman JT.

Drug Metab Dispos. 2019 Jan 10. pii: dmd.118.084665. doi: 10.1124/dmd.118.084665. [Epub ahead of print]


Winter behavior of Saimaa ringed seals: Non-overlapping core areas as indicators of avoidance in breeding females.

Niemi M, Liukkonen L, Koivuniemi M, Auttila M, Rautio A, Kunnasranta M.

PLoS One. 2019 Jan 4;14(1):e0210266. doi: 10.1371/journal.pone.0210266. eCollection 2019.


What is learned from Mindfulness Based Childbirth and Parenting Education? - Participants' experiences.

Lönnberg G, Nissen E, Niemi M.

BMC Pregnancy Childbirth. 2018 Dec 3;18(1):466. doi: 10.1186/s12884-018-2098-1.


Quantifying the contribution of recessive coding variation to developmental disorders.

Martin HC, Jones WD, McIntyre R, Sanchez-Andrade G, Sanderson M, Stephenson JD, Jones CP, Handsaker J, Gallone G, Bruntraeger M, McRae JF, Prigmore E, Short P, Niemi M, Kaplanis J, Radford EJ, Akawi N, Balasubramanian M, Dean J, Horton R, Hulbert A, Johnson DS, Johnson K, Kumar D, Lynch SA, Mehta SG, Morton J, Parker MJ, Splitt M, Turnpenny PD, Vasudevan PC, Wright M, Bassett A, Gerety SS, Wright CF, FitzPatrick DR, Firth HV, Hurles ME, Barrett JC; Deciphering Developmental Disorders Study.

Science. 2018 Dec 7;362(6419):1161-1164. doi: 10.1126/science.aar6731. Epub 2018 Nov 8.


Reflux aspiration in lungs of dogs with respiratory disease and in healthy West Highland White Terriers.

Määttä OLM, Laurila HP, Holopainen S, Lilja-Maula L, Melamies M, Viitanen SJ, Johnson LR, Koho N, Neuvonen M, Niemi M, Rajamäki MM.

J Vet Intern Med. 2018 Nov;32(6):2074-2081. doi: 10.1111/jvim.15321. Epub 2018 Oct 12.


Common genetic variants contribute to risk of rare severe neurodevelopmental disorders.

Niemi MEK, Martin HC, Rice DL, Gallone G, Gordon S, Kelemen M, McAloney K, McRae J, Radford EJ, Yu S, Gecz J, Martin NG, Wright CF, Fitzpatrick DR, Firth HV, Hurles ME, Barrett JC.

Nature. 2018 Oct;562(7726):268-271. doi: 10.1038/s41586-018-0566-4. Epub 2018 Sep 26.


Response to "Interaction of Dasabuvir With Clopidogrel: Did Predictions by Physiologically Based Pharmacokinetics Modeling Pass the Test?"

Itkonen MK, Tornio A, Lapatto-Reiniluoto O, Neuvonen M, Neuvonen PJ, Niemi M, Backman JT.

Clin Pharmacol Ther. 2018 Sep 17. doi: 10.1002/cpt.1195. [Epub ahead of print] No abstract available.


Completed suicides of citalopram users-the role of CYP genotypes and adverse drug interactions.

Rahikainen AL, Vauhkonen P, Pett H, Palo JU, Haukka J, Ojanperä I, Niemi M, Sajantila A.

Int J Legal Med. 2018 Sep 1. doi: 10.1007/s00414-018-1927-0. [Epub ahead of print]


CYP3A4*22 Impairs the Elimination of Ticagrelor, But Has No Significant Effect on the Bioactivation of Clopidogrel or Prasugrel.

Holmberg MT, Tornio A, Paile-Hyvärinen M, Tarkiainen EK, Neuvonen M, Neuvonen PJ, Backman JT, Niemi M.

Clin Pharmacol Ther. 2018 Jul 11. doi: 10.1002/cpt.1177. [Epub ahead of print]


Clopidogrel Increases Dasabuvir Exposure With or Without Ritonavir, and Ritonavir Inhibits the Bioactivation of Clopidogrel.

Itkonen MK, Tornio A, Lapatto-Reiniluoto O, Neuvonen M, Neuvonen PJ, Niemi M, Backman JT.

Clin Pharmacol Ther. 2019 Jan;105(1):219-228. doi: 10.1002/cpt.1099. Epub 2018 Aug 9.


Ketamine and norketamine attenuate oxycodone tolerance markedly less than that of morphine: from behaviour to drug availability.

Lilius T, Kangas E, Niemi M, Rauhala P, Kalso E.

Br J Anaesth. 2018 Apr;120(4):818-826. doi: 10.1016/j.bja.2017.11.081. Epub 2017 Dec 2.


Safety of Single-Dose Primaquine in G6PD-Deficient and G6PD-Normal Males in Mali Without Malaria: An Open-Label, Phase 1, Dose-Adjustment Trial.

Chen I, Diawara H, Mahamar A, Sanogo K, Keita S, Kone D, Diarra K, Djimde M, Keita M, Brown J, Roh ME, Hwang J, Pett H, Murphy M, Niemi M, Greenhouse B, Bousema T, Gosling R, Dicko A.

J Infect Dis. 2018 Mar 28;217(8):1298-1308. doi: 10.1093/infdis/jiy014.


Safety of single low-dose primaquine in glucose-6-phosphate dehydrogenase deficient falciparum-infected African males: Two open-label, randomized, safety trials.

Bastiaens GJH, Tiono AB, Okebe J, Pett HE, Coulibaly SA, Gonçalves BP, Affara M, Ouédraogo A, Bougouma EC, Sanou GS, Nébié I, Bradley J, Lanke KHW, Niemi M, Sirima SB, d'Alessandro U, Bousema T, Drakeley C.

PLoS One. 2018 Jan 11;13(1):e0190272. doi: 10.1371/journal.pone.0190272. eCollection 2018.


Transporter-Mediated Alterations in Patients With NASH Increase Systemic and Hepatic Exposure to an OATP and MRP2 Substrate.

Ali I, Slizgi JR, Kaullen JD, Ivanovic M, Niemi M, Stewart PW, Barritt AS 4th, Brouwer KLR.

Clin Pharmacol Ther. 2017 Dec 22. doi: 10.1002/cpt.997. [Epub ahead of print]


Novel copy-number variations in pharmacogenes contribute to interindividual differences in drug pharmacokinetics.

Santos M, Niemi M, Hiratsuka M, Kumondai M, Ingelman-Sundberg M, Lauschke VM, Rodríguez-Antona C.

Genet Med. 2018 Jun;20(6):622-629. doi: 10.1038/gim.2017.156. Epub 2017 Oct 26.


Applications of genomic medicine in the treatment of diseases.

Porkka K, Niemi M, Leppä E, Västrik I, Partanen J, Ihalainen J, Jokiranta S, Pöllänen P.

Duodecim. 2017;133(8):782-90. Review.


Interactions of (2S,6S;2R,6R)-Hydroxynorketamine, a Secondary Metabolite of (R,S)-Ketamine, with Morphine.

Lilius TO, Viisanen H, Jokinen V, Niemi M, Kalso EA, Rauhala PV.

Basic Clin Pharmacol Toxicol. 2018 May;122(5):481-488. doi: 10.1111/bcpt.12941. Epub 2017 Dec 27.


Clopidogrel but Not Prasugrel Significantly Inhibits the CYP2C8-Mediated Metabolism of Montelukast in Humans.

Itkonen MK, Tornio A, Filppula AM, Neuvonen M, Neuvonen PJ, Niemi M, Backman JT.

Clin Pharmacol Ther. 2018 Sep;104(3):495-504. doi: 10.1002/cpt.947. Epub 2017 Dec 23.


Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17: Implications for Pharmacogenetics and Drug-Drug Interactions.

Kahma H, Filppula AM, Neuvonen M, Tarkiainen EK, Tornio A, Holmberg MT, Itkonen MK, Finel M, Neuvonen PJ, Niemi M, Backman JT.

Drug Metab Dispos. 2018 Feb;46(2):141-150. doi: 10.1124/dmd.117.078162. Epub 2017 Nov 14.


A systematic review and meta-analysis of tertiary interventions in clinical burnout.

Perski O, Grossi G, Perski A, Niemi M.

Scand J Psychol. 2017 Dec;58(6):551-561. doi: 10.1111/sjop.12398. Review.


Effects of Genetic Variants on Carboxylesterase 1 Gene Expression, and Clopidogrel Pharmacokinetics and Antiplatelet Effects.

Neuvonen M, Tarkiainen EK, Tornio A, Hirvensalo P, Tapaninen T, Paile-Hyvärinen M, Itkonen MK, Holmberg MT, Kärjä V, Männistö VT, Neuvonen PJ, Pihlajamäki J, Backman JT, Niemi M.

Basic Clin Pharmacol Toxicol. 2018 Mar;122(3):341-345. doi: 10.1111/bcpt.12916. Epub 2017 Nov 17.


Comprehensive Pharmacogenomic Study Reveals an Important Role of UGT1A3 in Montelukast Pharmacokinetics.

Hirvensalo P, Tornio A, Neuvonen M, Tapaninen T, Paile-Hyvärinen M, Kärjä V, Männistö VT, Pihlajamäki J, Backman JT, Niemi M.

Clin Pharmacol Ther. 2018 Jul;104(1):158-168. doi: 10.1002/cpt.891. Epub 2017 Nov 6.


Rebuttal From Drs Niemi and Stoff.

Niemi MA, Stoff JS.

Chest. 2017 Dec;152(6):1115-1116. doi: 10.1016/j.chest.2017.08.1161. Epub 2017 Sep 11. No abstract available.


COUNTERPOINT: Should Continuous Venovenous Hemofiltration Always Be the Preferred Mode of Renal Replacement Therapy for the Patient With Acute Brain Injury? No.

Niemi MA, Stoff JS.

Chest. 2017 Dec;152(6):1111-1114. doi: 10.1016/j.chest.2017.08.1158. Epub 2017 Sep 11. No abstract available.


The effect of a cannula milk sampling technique on the microbiological diagnosis of bovine mastitis.

Friman M, Hiitiö H, Niemi M, Holopainen J, Pyörälä S, Simojoki H.

Vet J. 2017 Aug;226:57-61. doi: 10.1016/j.tvjl.2017.07.003. Epub 2017 Jul 21.


Analgesic Plasma Concentrations of Oxycodone After Surgery for Breast Cancer-Which Factors Matter?

Cajanus K, Neuvonen M, Koskela O, Kaunisto MA, Neuvonen PJ, Niemi M, Kalso E.

Clin Pharmacol Ther. 2018 Apr;103(4):653-662. doi: 10.1002/cpt.771. Epub 2017 Aug 24.


Age, Weight, and CYP2D6 Genotype Are Major Determinants of Primaquine Pharmacokinetics in African Children.

Gonçalves BP, Pett H, Tiono AB, Murry D, Sirima SB, Niemi M, Bousema T, Drakeley C, Ter Heine R.

Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02590-16. doi: 10.1128/AAC.02590-16. Print 2017 May.


Temporal patterns of moose-vehicle collisions with and without personal injuries.

Niemi M, Rolandsen CM, Neumann W, Kukko T, Tiilikainen R, Pusenius J, Solberg EJ, Ericsson G.

Accid Anal Prev. 2017 Jan;98:167-173. doi: 10.1016/j.aap.2016.09.024. Epub 2016 Oct 8.


Role of gemfibrozil as an inhibitor of CYP2C8 and membrane transporters.

Tornio A, Neuvonen PJ, Niemi M, Backman JT.

Expert Opin Drug Metab Toxicol. 2017 Jan;13(1):83-95. Epub 2016 Aug 31. Review.


Do Diuretics have Antinociceptive Actions: Studies of Spironolactone, Eplerenone, Furosemide and Chlorothiazide, Individually and with Oxycodone and Morphine.

Jokinen V, Lilius T, Laitila J, Niemi M, Kambur O, Kalso E, Rauhala P.

Basic Clin Pharmacol Toxicol. 2017 Jan;120(1):38-45. doi: 10.1111/bcpt.12634. Epub 2016 Jul 21.


Temporal variation in coat colour (genotypes) supports major changes in the Nordic cattle population after Iron Age.

Niemi M, Sajantila A, Vilkki J.

Anim Genet. 2016 Aug;47(4):495-8. doi: 10.1111/age.12445. Epub 2016 Jun 14.


Clopidogrel Markedly Increases Plasma Concentrations of CYP2C8 Substrate Pioglitazone.

Itkonen MK, Tornio A, Neuvonen M, Neuvonen PJ, Niemi M, Backman JT.

Drug Metab Dispos. 2016 Aug;44(8):1364-71. doi: 10.1124/dmd.116.070375. Epub 2016 Jun 3.


High Frequency of CYP2D6 Ultrarapid Metabolizer Genotype in the Finnish Population.

Pietarinen P, Tornio A, Niemi M.

Basic Clin Pharmacol Toxicol. 2016 Sep;119(3):291-6. doi: 10.1111/bcpt.12590. Epub 2016 May 14.


Prevalence and correlates of vitamin D deficiency in adults after traumatic brain injury.

Jamall OA, Feeney C, Zaw-Linn J, Malik A, Niemi ME, Tenorio-Jimenez C, Ham TE, Jilka SR, Jenkins PO, Scott G, Li LM, Gorgoraptis N, Baxter D, Sharp DJ, Goldstone AP.

Clin Endocrinol (Oxf). 2016 Oct;85(4):636-44. doi: 10.1111/cen.13045. Epub 2016 Mar 28.


Primaquine to reduce transmission of Plasmodium falciparum malaria in Mali: a single-blind, dose-ranging, adaptive randomised phase 2 trial.

Dicko A, Brown JM, Diawara H, Baber I, Mahamar A, Soumare HM, Sanogo K, Koita F, Keita S, Traore SF, Chen I, Poirot E, Hwang J, McCulloch C, Lanke K, Pett H, Niemi M, Nosten F, Bousema T, Gosling R.

Lancet Infect Dis. 2016 Jun;16(6):674-684. doi: 10.1016/S1473-3099(15)00479-X. Epub 2016 Feb 20. Erratum in: Lancet Infect Dis. 2017 Jan;17(1):17.


The use of ayurvedic medicine in the context of health promotion--a mixed methods case study of an ayurvedic centre in Sweden.

Niemi M, Ståhle G.

BMC Complement Altern Med. 2016 Feb 17;16:62. doi: 10.1186/s12906-016-1042-z.


Community-based intervention for depression management at the primary care level in Ha Nam Province, Vietnam: a cluster-randomised controlled trial.

Niemi M, Kiel S, Allebeck P, Hoan le T.

Trop Med Int Health. 2016 May;21(5):654-61. doi: 10.1111/tmi.12674. Epub 2016 Mar 7.


Maternal and paternal genetic diversity of ancient sheep in Estonia from the Late Bronze Age to the post-medieval period and comparison with other regions in Eurasia.

Rannamäe E, Lõugas L, Niemi M, Kantanen J, Maldre L, Kadõrova N, Saarma U.

Anim Genet. 2016 Apr;47(2):208-18. doi: 10.1111/age.12407. Epub 2016 Jan 25.


Charge separation and charge recombination photophysical studies in a series of perylene-C60 linear and cyclic dyads.

Pla S, Niemi M, Martín-Gomis L, Fernández-Lázaro F, Lemmetyinen H, Tkachenko NV, Sastre-Santos Á.

Phys Chem Chem Phys. 2016 Feb 7;18(5):3598-605. doi: 10.1039/c5cp06340j.


Gendered use of experts in the media: Analysis of the gender gap in Finnish news journalism.

Niemi MK, Pitkänen V.

Public Underst Sci. 2017 Apr;26(3):355-368. doi: 10.1177/0963662515621470. Epub 2016 Jan 6.


Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions.

Backman JT, Filppula AM, Niemi M, Neuvonen PJ.

Pharmacol Rev. 2016 Jan;68(1):168-241. doi: 10.1124/pr.115.011411. Review.


Identifying foraging habitats of Baltic ringed seals using movement data.

Oksanen SM, Niemi M, Ahola MP, Kunnasranta M.

Mov Ecol. 2015 Sep 23;3(1):33. doi: 10.1186/s40462-015-0058-1. eCollection 2015.


Dimerization of lipocalin allergens.

Niemi MH, Rytkönen-Nissinen M, Miettinen I, Jänis J, Virtanen T, Rouvinen J.

Sci Rep. 2015 Sep 8;5:13841. doi: 10.1038/srep13841.


Clopidogrel Has No Clinically Meaningful Effect on the Pharmacokinetics of the Organic Anion Transporting Polypeptide 1B1 and Cytochrome P450 3A4 Substrate Simvastatin.

Itkonen MK, Tornio A, Neuvonen M, Neuvonen PJ, Niemi M, Backman JT.

Drug Metab Dispos. 2015 Nov;43(11):1655-60. doi: 10.1124/dmd.115.065938. Epub 2015 Sep 1.


Drug-Related Inadvertent Deaths in a University Hospital--A Declining Trend.

Lapatto-Reiniluoto O, Patinen L, Niemi M, Backman JT, Neuvonen PJ.

Basic Clin Pharmacol Toxicol. 2015 Dec;117(6):421-6. doi: 10.1111/bcpt.12435. Epub 2015 Jul 21.


Evaluation of microscopic hematuria: a critical review and proposed algorithm.

Niemi MA, Cohen RA.

Adv Chronic Kidney Dis. 2015 Jul;22(4):289-96. doi: 10.1053/j.ackd.2015.04.006. Review.


Pregabalin enhances the antinociceptive effect of oxycodone and morphine in thermal models of nociception in the rat without any pharmacokinetic interactions.

Jokinen V, Lilius TO, Laitila J, Niemi M, Rauhala PV, Kalso EA.

Eur J Pain. 2016 Feb;20(2):297-306. doi: 10.1002/ejp.728. Epub 2015 May 29.


SLCO1B1 polymorphism markedly affects the pharmacokinetics of lovastatin acid.

Tornio A, Vakkilainen J, Neuvonen M, Backman JT, Neuvonen PJ, Niemi M.

Pharmacogenet Genomics. 2015 Aug;25(8):382-7. doi: 10.1097/FPC.0000000000000148.


Isolation of Mal d 1 and Api g 1 - specific recombinant antibodies from mouse IgG Fab fragment libraries - Mal d 1-specific antibody exhibits cross-reactivity against Bet v 1.

Haka J, Niemi MH, Iljin K, Reddy VS, Takkinen K, Laukkanen ML.

BMC Biotechnol. 2015 May 27;15:34. doi: 10.1186/s12896-015-0157-5.


Temporal fluctuation in North East Baltic Sea region cattle population revealed by mitochondrial and Y-chromosomal DNA analyses.

Niemi M, Bläuer A, Iso-Touru T, Harjula J, Nyström Edmark V, Rannamäe E, Lõugas L, Sajantila A, Lidén K, Taavitsainen JP.

PLoS One. 2015 May 20;10(5):e0123821. doi: 10.1371/journal.pone.0123821. eCollection 2015.

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