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Items: 1 to 50 of 78

1.

Peptide-Directed DNA-Templated Protein Labelling for The Assembly of a Pseudo-IgM.

Nielsen TB, Thomsen RP, Mortensen MR, Kjems J, Nielsen PF, Nielsen TE, Kodal ALB, Cló E, Gothelf KV.

Angew Chem Int Ed Engl. 2019 Apr 17. doi: 10.1002/anie.201903134. [Epub ahead of print]

PMID:
30995340
2.

Itaconimides as Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa.

Fong J, Mortensen KT, Nørskov A, Qvortrup K, Yang L, Tan CH, Nielsen TE, Givskov M.

Front Cell Infect Microbiol. 2019 Jan 7;8:443. doi: 10.3389/fcimb.2018.00443. eCollection 2018.

3.

Repurposing the anticancer drug cisplatin with the aim of developing novel Pseudomonas aeruginosa infection control agents.

Yuan M, Chua SL, Liu Y, Drautz-Moses DI, Yam JKH, Aung TT, Beuerman RW, Salido MMS, Schuster SC, Tan CH, Givskov M, Yang L, Nielsen TE.

Beilstein J Org Chem. 2018 Dec 14;14:3059-3069. doi: 10.3762/bjoc.14.284. eCollection 2018.

4.

Petasis three-component reactions for the synthesis of diverse heterocyclic scaffolds.

Wu P, Nielsen TE.

Drug Discov Today Technol. 2018 Nov;29:27-33. doi: 10.1016/j.ddtec.2018.06.010. Epub 2018 Jul 17. Review.

PMID:
30471670
5.

Bead-based screening in chemical biology and drug discovery.

Komnatnyy VV, Nielsen TE, Qvortrup K.

Chem Commun (Camb). 2018 Jun 19;54(50):6759-6771. doi: 10.1039/c8cc02486c. Review.

PMID:
29888365
6.

Photolabile Linkers for Solid-Phase Synthesis.

Mikkelsen RJT, Grier KE, Mortensen KT, Nielsen TE, Qvortrup K.

ACS Comb Sci. 2018 Jul 9;20(7):377-399. doi: 10.1021/acscombsci.8b00028. Epub 2018 Jun 22.

PMID:
29863839
7.

Oxidative Modification of Tryptophan-Containing Peptides.

Petersen J, Christensen KE, Nielsen MT, Mortensen KT, Komnatnyy VV, Nielsen TE, Qvortrup K.

ACS Comb Sci. 2018 Jun 11;20(6):344-349. doi: 10.1021/acscombsci.8b00014. Epub 2018 May 11.

PMID:
29719155
8.

Combination Therapy Strategy of Quorum Quenching Enzyme and Quorum Sensing Inhibitor in Suppressing Multiple Quorum Sensing Pathways of P. aeruginosa.

Fong J, Zhang C, Yang R, Boo ZZ, Tan SK, Nielsen TE, Givskov M, Liu XW, Bin W, Su H, Yang L.

Sci Rep. 2018 Jan 18;8(1):1155. doi: 10.1038/s41598-018-19504-w.

9.

Click-Chemistry-Mediated Synthesis of Selective Melanocortin Receptor 4 Agonists.

Palmer D, Gonçalves JPL, V Hansen L, Wu B, Hald H, Schoffelen S, Diness F, Le Quement ST, Nielsen TE, Meldal M.

J Med Chem. 2017 Nov 9;60(21):8716-8730. doi: 10.1021/acs.jmedchem.7b00353. Epub 2017 Oct 24.

PMID:
28972753
10.

A broad range quorum sensing inhibitor working through sRNA inhibition.

Jakobsen TH, Warming AN, Vejborg RM, Moscoso JA, Stegger M, Lorenzen F, Rybtke M, Andersen JB, Petersen R, Andersen PS, Nielsen TE, Tolker-Nielsen T, Filloux A, Ingmer H, Givskov M.

Sci Rep. 2017 Aug 29;7(1):9857. doi: 10.1038/s41598-017-09886-8.

11.

A Linker for the Solid-Phase Synthesis of Hydroxamic Acids and Identification of HDAC6 Inhibitors.

Bang CG, Jensen JF, O'Hanlon Cohrt E, Olsen LB, Siyum SG, Mortensen KT, Skovgaard T, Berthelsen J, Yang L, Givskov M, Qvortrup K, Nielsen TE.

ACS Comb Sci. 2017 Oct 9;19(10):657-669. doi: 10.1021/acscombsci.7b00068. Epub 2017 Sep 6.

PMID:
28746804
12.

Diastereoselective synthesis of novel heterocyclic scaffolds through tandem Petasis 3-component/intramolecular Diels-Alder and ROM-RCM reactions.

Ishoey M, Petersen RG, Petersen MÅ, Wu P, Clausen MH, Nielsen TE.

Chem Commun (Camb). 2017 Aug 22;53(68):9410-9413. doi: 10.1039/c7cc02948a.

PMID:
28714998
13.

Solvent-Controlled Chemoselectivity in the Photolytic Release of Hydroxamic Acids and Carboxamides from Solid Support.

Qvortrup K, Petersen RG, Dohn AO, Møller KB, Nielsen TE.

Org Lett. 2017 Jun 16;19(12):3263-3266. doi: 10.1021/acs.orglett.7b01386. Epub 2017 Jun 1.

PMID:
28570068
14.

Scaffold Diversity from N-Acyliminium Ions.

Wu P, Nielsen TE.

Chem Rev. 2017 Jun 28;117(12):7811-7856. doi: 10.1021/acs.chemrev.6b00806. Epub 2017 May 11.

PMID:
28493667
15.

Synthesis and biological evaluation of dihydropyrano-[2,3-c]pyrazoles as a new class of PPARγ partial agonists.

Qvortrup K, Jensen JF, Sørensen MS, Kouskoumvekaki I, Petersen RK, Taboureau O, Kristiansen K, Nielsen TE.

PLoS One. 2017 Feb 28;12(2):e0162642. doi: 10.1371/journal.pone.0162642. eCollection 2017.

16.

Disulfide Bond-Containing Ajoene Analogues As Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa.

Fong J, Yuan M, Jakobsen TH, Mortensen KT, Delos Santos MM, Chua SL, Yang L, Tan CH, Nielsen TE, Givskov M.

J Med Chem. 2017 Jan 12;60(1):215-227. doi: 10.1021/acs.jmedchem.6b01025. Epub 2016 Dec 28.

PMID:
27977197
17.

Catalytic Enantioselective Synthesis of Tetrahydocarbazoles and Exocyclic Pictet-Spengler-Type Reactions.

Hansen CL, Ohm RG, Olsen LB, Ascic E, Tanner D, Nielsen TE.

Org Lett. 2016 Dec 2;18(23):5990-5993. Epub 2016 Nov 16.

PMID:
27934390
18.

The anti-cancerous drug doxorubicin decreases the c-di-GMP content in Pseudomonas aeruginosa but promotes biofilm formation.

Groizeleau J, Rybtke M, Andersen JB, Berthelsen J, Liu Y, Yang L, Nielsen TE, Kaever V, Givskov M, Tolker-Nielsen T.

Microbiology. 2016 Oct;162(10):1797-1807. doi: 10.1099/mic.0.000354. Epub 2016 Aug 15.

PMID:
27526691
19.

A metal-catalyzed enyne-cyclization step for the synthesis of bi- and tricyclic scaffolds amenable to molecular library production.

Wu P, Petersen MÅ, Cohrt AE, Petersen R, Morgentin R, Lemoine H, Roche C, Willaume A, Clausen MH, Nielsen TE.

Org Biomol Chem. 2016 Aug 7;14(29):6947-50. doi: 10.1039/c6ob01148a. Epub 2016 Jun 30.

PMID:
27356738
20.

Synthesis of sp(3)-rich scaffolds for molecular libraries through complexity-generating cascade reactions.

Flagstad T, Min G, Bonnet K, Morgentin R, Roche D, Clausen MH, Nielsen TE.

Org Biomol Chem. 2016 Jun 7;14(21):4943-6. doi: 10.1039/c6ob00961a. Epub 2016 May 12.

PMID:
27171614
21.

In-Bead Screening of Hydroxamic Acids for the Identification of HDAC Inhibitors.

Qvortrup K, Nielsen TE.

Angew Chem Int Ed Engl. 2016 Mar 24;55(14):4472-5. doi: 10.1002/anie.201511308. Epub 2016 Mar 4.

PMID:
26945672
22.

Allosteric small-molecule kinase inhibitors.

Wu P, Clausen MH, Nielsen TE.

Pharmacol Ther. 2015 Dec;156:59-68. doi: 10.1016/j.pharmthera.2015.10.002. Epub 2015 Oct 24. Review.

PMID:
26478442
23.

Small-molecule kinase inhibitors: an analysis of FDA-approved drugs.

Wu P, Nielsen TE, Clausen MH.

Drug Discov Today. 2016 Jan;21(1):5-10. doi: 10.1016/j.drudis.2015.07.008. Epub 2015 Jul 23.

PMID:
26210956
24.

In vitro and in vivo generation and characterization of Pseudomonas aeruginosa biofilm-dispersed cells via c-di-GMP manipulation.

Chua SL, Hultqvist LD, Yuan M, Rybtke M, Nielsen TE, Givskov M, Tolker-Nielsen T, Yang L.

Nat Protoc. 2015 Aug;10(8):1165-80. doi: 10.1038/nprot.2015.067. Epub 2015 Jul 9.

PMID:
26158442
25.

A Four-Component Reaction for the Synthesis of Dioxadiazaborocines.

Flagstad T, Petersen MT, Nielsen TE.

Angew Chem Int Ed Engl. 2015 Jul 13;54(29):8395-7. doi: 10.1002/anie.201502989. Epub 2015 Jun 9.

PMID:
26068978
26.

C-di-GMP regulates Pseudomonas aeruginosa stress response to tellurite during both planktonic and biofilm modes of growth.

Chua SL, Sivakumar K, Rybtke M, Yuan M, Andersen JB, Nielsen TE, Givskov M, Tolker-Nielsen T, Cao B, Kjelleberg S, Yang L.

Sci Rep. 2015 May 20;5:10052. doi: 10.1038/srep10052.

27.

FDA-approved small-molecule kinase inhibitors.

Wu P, Nielsen TE, Clausen MH.

Trends Pharmacol Sci. 2015 Jul;36(7):422-39. doi: 10.1016/j.tips.2015.04.005. Epub 2015 May 12. Review.

PMID:
25975227
28.

Triazole-containing N-acyl homoserine lactones targeting the quorum sensing system in Pseudomonas aeruginosa.

Hansen MR, Jakobsen TH, Bang CG, Cohrt AE, Hansen CL, Clausen JW, Le Quement ST, Tolker-Nielsen T, Givskov M, Nielsen TE.

Bioorg Med Chem. 2015 Apr 1;23(7):1638-50. doi: 10.1016/j.bmc.2015.01.038. Epub 2015 Jan 31.

PMID:
25716005
29.

Synthesis of hexahydropyrrolo[2,1-a]isoquinoline compound libraries through a Pictet-Spengler cyclization/metal-catalyzed cross coupling/amidation sequence.

Petersen R, Cohrt AE, Petersen MÅ, Wu P, Clausen MH, Nielsen TE.

Bioorg Med Chem. 2015 Jun 1;23(11):2646-9. doi: 10.1016/j.bmc.2015.01.039. Epub 2015 Jan 31.

PMID:
25703308
30.

Synthesis of 1,4,5 trisubstituted γ-lactams via a 3-component cascade reaction.

Petersen MÅ, Mortensen MA, Cohrt AE, Petersen R, Wu P, Fleury-Brégeot N, Morgentin R, Lardy C, Nielsen TE, Clausen MH.

Bioorg Med Chem. 2015 Jun 1;23(11):2695-8. doi: 10.1016/j.bmc.2015.01.041. Epub 2015 Jan 31.

PMID:
25684425
31.

Multiple diguanylate cyclase-coordinated regulation of pyoverdine synthesis in Pseudomonas aeruginosa.

Chen Y, Yuan M, Mohanty A, Yam JK, Liu Y, Chua SL, Nielsen TE, Tolker-Nielsen T, Givskov M, Cao B, Yang L.

Environ Microbiol Rep. 2015 Jun;7(3):498-507. doi: 10.1111/1758-2229.12278. Epub 2015 Apr 8.

PMID:
25683454
32.

Combining the Petasis 3-component reaction with multiple modes of cyclization: a build/couple/pair strategy for the synthesis of densely functionalized small molecules.

Flagstad T, Hansen MR, Le Quement ST, Givskov M, Nielsen TE.

ACS Comb Sci. 2015 Jan 12;17(1):19-23. doi: 10.1021/co500091f. Epub 2014 Dec 17.

PMID:
25469710
33.

Synthesis of a natural product-like compound collection through oxidative cleavage and cyclization of linear peptides.

Petersen R, Le Quement ST, Nielsen TE.

Angew Chem Int Ed Engl. 2014 Oct 27;53(44):11778-82. doi: 10.1002/anie.201405747. Epub 2014 Sep 11.

PMID:
25214457
34.

A photolabile linker for the solid-phase synthesis of peptide hydrazides and heterocycles.

Qvortrup K, Komnatnyy VV, Nielsen TE.

Org Lett. 2014 Sep 19;16(18):4782-5. doi: 10.1021/ol502219s. Epub 2014 Aug 28.

PMID:
25166929
35.

Comparative systems biology analysis to study the mode of action of the isothiocyanate compound Iberin on Pseudomonas aeruginosa.

Tan SY, Liu Y, Chua SL, Vejborg RM, Jakobsen TH, Chew SC, Li Y, Nielsen TE, Tolker-Nielsen T, Yang L, Givskov M.

Antimicrob Agents Chemother. 2014 Nov;58(11):6648-59. doi: 10.1128/AAC.02620-13. Epub 2014 Aug 25.

36.

Synthesis of heterocycles through transition-metal-catalyzed isomerization reactions.

Ishoey M, Nielsen TE.

Chemistry. 2014 Jul 14;20(29):8832-40. doi: 10.1002/chem.201400216. Epub 2014 Jun 12.

PMID:
24924616
37.

Synthesis of oxacyclic scaffolds via dual ruthenium hydride/Brønsted acid-catalyzed isomerization/cyclization of allylic ethers.

Ascic E, Ohm RG, Petersen R, Hansen MR, Hansen CL, Madsen D, Tanner D, Nielsen TE.

Chemistry. 2014 Mar 17;20(12):3297-300. doi: 10.1002/chem.201304270. Epub 2014 Feb 24.

PMID:
24616060
38.

Solid-phase synthesis and biological evaluation of N-dipeptido L-homoserine lactones as quorum sensing activators.

Hansen MR, Le Quement ST, Jakobsen TH, Skovstrup S, Taboureau O, Tolker-Nielsen T, Givskov M, Nielsen TE.

Chembiochem. 2014 Feb 10;15(3):460-5. doi: 10.1002/cbic.201300533. Epub 2014 Jan 16.

PMID:
24436223
39.

Solid-phase synthesis of peptide thioureas and thiazole-containing macrocycles through Ru-catalyzed ring-closing metathesis.

Cohrt AE, Nielsen TE.

ACS Comb Sci. 2014 Feb 10;16(2):71-7. doi: 10.1021/co400102v. Epub 2014 Jan 17.

PMID:
24377264
40.

Bacteria-triggered release of antimicrobial agents.

Komnatnyy VV, Chiang WC, Tolker-Nielsen T, Givskov M, Nielsen TE.

Angew Chem Int Ed Engl. 2014 Jan 7;53(2):439-41. doi: 10.1002/anie.201307975. Epub 2013 Nov 29.

PMID:
24288347
41.

Ruthenium hydride/Brønsted acid-catalyzed tandem isomerization/N-acyliminium cyclization sequence for the synthesis of tetrahydro-β-carbolines.

Hansen CL, Clausen JW, Ohm RG, Ascic E, Le Quement ST, Tanner D, Nielsen TE.

J Org Chem. 2013 Dec 20;78(24):12545-65. doi: 10.1021/jo402192s. Epub 2013 Nov 18.

PMID:
24180610
42.

Identification of five structurally unrelated quorum-sensing inhibitors of Pseudomonas aeruginosa from a natural-derivative database.

Tan SY, Chua SL, Chen Y, Rice SA, Kjelleberg S, Nielsen TE, Yang L, Givskov M.

Antimicrob Agents Chemother. 2013 Nov;57(11):5629-41. doi: 10.1128/AAC.00955-13. Epub 2013 Sep 3.

43.

Clearance of Pseudomonas aeruginosa foreign-body biofilm infections through reduction of the cyclic Di-GMP level in the bacteria.

Christensen LD, van Gennip M, Rybtke MT, Wu H, Chiang WC, Alhede M, Høiby N, Nielsen TE, Givskov M, Tolker-Nielsen T.

Infect Immun. 2013 Aug;81(8):2705-13. doi: 10.1128/IAI.00332-13. Epub 2013 May 20.

44.

Tandem ring-closing metathesis/isomerization reactions for the total synthesis of violacein.

Petersen MT, Nielsen TE.

Org Lett. 2013 Apr 19;15(8):1986-9. doi: 10.1021/ol400654r. Epub 2013 Apr 3.

PMID:
23550830
45.

Extracellular DNA shields against aminoglycosides in Pseudomonas aeruginosa biofilms.

Chiang WC, Nilsson M, Jensen PØ, Høiby N, Nielsen TE, Givskov M, Tolker-Nielsen T.

Antimicrob Agents Chemother. 2013 May;57(5):2352-61. doi: 10.1128/AAC.00001-13. Epub 2013 Mar 11.

46.

Discovery of a novel selective PPARγ ligand with partial agonist binding properties by integrated in silico/in vitro work flow.

Kouskoumvekaki I, Petersen RK, Fratev F, Taboureau O, Nielsen TE, Oprea TI, Sonne SB, Flindt EN, Jónsdóttir SÓ, Kristiansen K.

J Chem Inf Model. 2013 Apr 22;53(4):923-37. doi: 10.1021/ci3006148. Epub 2013 Mar 19.

PMID:
23432662
47.

Synthesis and biological evaluation of triazole-containing N-acyl homoserine lactones as quorum sensing modulators.

Stacy DM, Le Quement ST, Hansen CL, Clausen JW, Tolker-Nielsen T, Brummond JW, Givskov M, Nielsen TE, Blackwell HE.

Org Biomol Chem. 2013 Feb 14;11(6):938-54. doi: 10.1039/c2ob27155a. Epub 2012 Dec 20.

48.

Identification of LasR ligands through a virtual screening approach.

Skovstrup S, Le Quement ST, Hansen T, Jakobsen TH, Harmsen M, Tolker-Nielsen T, Nielsen TE, Givskov M, Taboureau O.

ChemMedChem. 2013 Jan;8(1):157-63. doi: 10.1002/cmdc.201200434. Epub 2012 Nov 30.

PMID:
23203920
49.

Solid-phase synthesis of structurally diverse heterocycles by an amide-ketone condensation/N-acyliminium pictet-spengler sequence.

Komnatnyy VV, Givskov M, Nielsen TE.

Chemistry. 2012 Dec 21;18(52):16793-800. doi: 10.1002/chem.201202745. Epub 2012 Nov 6.

PMID:
23132763
50.

Fluorescence-based reporter for gauging cyclic di-GMP levels in Pseudomonas aeruginosa.

Rybtke MT, Borlee BR, Murakami K, Irie Y, Hentzer M, Nielsen TE, Givskov M, Parsek MR, Tolker-Nielsen T.

Appl Environ Microbiol. 2012 Aug;78(15):5060-9. doi: 10.1128/AEM.00414-12. Epub 2012 May 11.

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