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An approximate full-likelihood method for inferring selection and allele frequency trajectories from DNA sequence data.

Stern AJ, Wilton PR, Nielsen R.

PLoS Genet. 2019 Sep 13;15(9):e1008384. doi: 10.1371/journal.pgen.1008384. [Epub ahead of print]


Randomised controlled trials (RCTs) in sports injury research: authors-please report the compliance with the intervention.

Nielsen RO, Bertelsen ML, Ramskov D, Damsted C, Verhagen E, Bredeweg SW, Theisen D, Malisoux L.

Br J Sports Med. 2019 Sep 11. pii: bjsports-2019-100858. doi: 10.1136/bjsports-2019-100858. [Epub ahead of print]


A likelihood method for estimating present-day human contamination in ancient male samples using low-depth X-chromosome data.

Moreno-Mayar JV, Korneliussen TS, Dalal J, Renaud G, Albrechtsen A, Nielsen R, Malaspinas AS.

Bioinformatics. 2019 Aug 26. pii: btz660. doi: 10.1093/bioinformatics/btz660. [Epub ahead of print]


An exploration of the methods to determine the protein-specific synthesis and breakdown rates in vivo in humans.

Holm L, Dideriksen K, Nielsen RH, Doessing S, Bechshoeft RL, Højfeldt G, Moberg M, Blomstrand E, Reitelseder S, van Hall G.

Physiol Rep. 2019 Sep;7(17):e14143. doi: 10.14814/phy2.14143.


The Garmin-RUNSAFE Running Health Study on the aetiology of running-related injuries: rationale and design of an 18-month prospective cohort study including runners worldwide.

Nielsen RØ, Bertelsen ML, Ramskov D, Damsted C, Brund RK, Parner ET, Sørensen H, Rasmussen S, Kjærgaard S.

BMJ Open. 2019 Sep 6;9(9):e032627. doi: 10.1136/bmjopen-2019-032627.


Natural selection on the Arabidopsis thaliana genome in present and future climates.

Exposito-Alonso M; 500 Genomes Field Experiment Team, Burbano HA, Bossdorf O, Nielsen R, Weigel D.

Nature. 2019 Sep;573(7772):126-129. doi: 10.1038/s41586-019-1520-9. Epub 2019 Aug 28.


Duration of critically low oxygen delivery is associated with acute kidney injury after cardiac surgery.

Rasmussen SR, Kandler K, Nielsen RV, Cornelius Jakobsen P, Knudsen NN, Ranucci M, Christian Nilsson J, Ravn HB.

Acta Anaesthesiol Scand. 2019 Aug 22. doi: 10.1111/aas.13457. [Epub ahead of print]


Urokinase-type plasminogen activator contributes to amiloride-sensitive sodium retention in nephrotic range glomerular proteinuria in mice.

Hinrichs GR, Weyer K, Friis UG, Svenningsen P, Lund IK, Nielsen R, Mollet G, Antignac C, Bistrup C, Jensen BL, Birn H.

Acta Physiol (Oxf). 2019 Aug 19:e13362. doi: 10.1111/apha.13362. [Epub ahead of print]


Laboratory contamination in airway microbiome studies.

Drengenes C, Wiker HG, Kalananthan T, Nordeide E, Eagan TML, Nielsen R.

BMC Microbiol. 2019 Aug 14;19(1):187. doi: 10.1186/s12866-019-1560-1.


Myocardial strain assessed by feature tracking cardiac magnetic resonance in patients with a variety of cardiovascular diseases - A comparison with echocardiography.

Pryds K, Larsen AH, Hansen MS, Grøndal AYK, Tougaard RS, Hansson NH, Clemmensen TS, Løgstrup BB, Wiggers H, Kim WY, Bøtker HE, Nielsen RR.

Sci Rep. 2019 Aug 5;9(1):11296. doi: 10.1038/s41598-019-47775-4.


Increased mortality from somatic multimorbidity in patients with schizophrenia: a Danish nationwide cohort study.

Kugathasan P, Stubbs B, Aagaard J, Jensen SE, Munk Laursen T, Nielsen RE.

Acta Psychiatr Scand. 2019 Jul 29. doi: 10.1111/acps.13076. [Epub ahead of print]


Clinical use of lithium salts: guide for users and prescribers.

Tondo L, Alda M, Bauer M, Bergink V, Grof P, Hajek T, Lewitka U, Licht RW, Manchia M, Müller-Oerlinghausen B, Nielsen RE, Selo M, Simhandl C, Baldessarini RJ; International Group for Studies of Lithium (IGSLi).

Int J Bipolar Disord. 2019 Jul 22;7(1):16. doi: 10.1186/s40345-019-0151-2. Review.


Critical moisture point of sludge and its link to vapour sorption and dewatering.

Nielsen RV, Jensen M, Christian Duus SA, Christensen ML.

Chemosphere. 2019 Jul 8;236:124299. doi: 10.1016/j.chemosphere.2019.07.030. [Epub ahead of print]


A Child with a Swollen Nipple: A Quiz.

Nielsen RM, Bygum A.

Acta Derm Venereol. 2019 Jul 12. doi: 10.2340/00015555-3266. [Epub ahead of print] No abstract available.


[Radical prostatectomy increases the incidence of inguinal hernia].

Nielsen RA, Zetner D, Rosenberg J.

Ugeskr Laeger. 2019 Jun 17;181(25). pii: V01190068. Danish.


Reproducibility of subjective refraction before and after small incision lenticule extraction (SMILE) for myopia.

Nielsen R, Christiansen MK, Kristensen MS, Møller C, Hedegaard C, Aagaard N, Sejersen H, Hjortdal J, Ivarsen A.

Acta Ophthalmol. 2019 Jun 11. doi: 10.1111/aos.14171. [Epub ahead of print] No abstract available.


The population history of northeastern Siberia since the Pleistocene.

Sikora M, Pitulko VV, Sousa VC, Allentoft ME, Vinner L, Rasmussen S, Margaryan A, de Barros Damgaard P, de la Fuente C, Renaud G, Yang MA, Fu Q, Dupanloup I, Giampoudakis K, Nogués-Bravo D, Rahbek C, Kroonen G, Peyrot M, McColl H, Vasilyev SV, Veselovskaya E, Gerasimova M, Pavlova EY, Chasnyk VG, Nikolskiy PA, Gromov AV, Khartanovich VI, Moiseyev V, Grebenyuk PS, Fedorchenko AY, Lebedintsev AI, Slobodin SB, Malyarchuk BA, Martiniano R, Meldgaard M, Arppe L, Palo JU, Sundell T, Mannermaa K, Putkonen M, Alexandersen V, Primeau C, Baimukhanov N, Malhi RS, Sjögren KG, Kristiansen K, Wessman A, Sajantila A, Lahr MM, Durbin R, Nielsen R, Meltzer DJ, Excoffier L, Willerslev E.

Nature. 2019 Jun;570(7760):182-188. doi: 10.1038/s41586-019-1279-z. Epub 2019 Jun 5.


CCR5-∆32 is deleterious in the homozygous state in humans.

Wei X, Nielsen R.

Nat Med. 2019 Jun;25(6):909-910. doi: 10.1038/s41591-019-0459-6. Epub 2019 Jun 3.


Risk factors for lung cancer in COPD - results from the Bergen COPD cohort study.

Husebø GR, Nielsen R, Hardie J, Bakke PS, Lerner L, D'Alessandro-Gabazza C, Gyuris J, Gabazza E, Aukrust P, Eagan T.

Respir Med. 2019 Jun;152:81-88. doi: 10.1016/j.rmed.2019.04.019. Epub 2019 Apr 30.


Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions.

Wang S, Mao Y, Narimatsu Y, Ye Z, Tian W, Goth CK, Lira-Navarrete E, Pedersen NB, Benito-Vicente A, Martin C, Uribe KB, Hurtado-Guerrero R, Christoffersen C, Seidah NG, Nielsen R, Christensen EI, Hansen L, Bennett EP, Vakhrushev SY, Schjoldager KT, Clausen H.

J Biol Chem. 2019 May 24;294(21):8349. doi: 10.1074/jbc.AAC119.009121. No abstract available.


Nonionic surfactants modulate the transport activity of ATP-binding cassette (ABC) transporters and solute carriers (SLC): Relevance to oral drug absorption.

Al-Ali AAA, Nielsen RB, Steffansen B, Holm R, Nielsen CU.

Int J Pharm. 2019 Jul 20;566:410-433. doi: 10.1016/j.ijpharm.2019.05.033. Epub 2019 May 21. Review.


Joint Estimation of Pedigrees and Effective Population Size Using Markov Chain Monte Carlo.

Ko A, Nielsen R.

Genetics. 2019 Jul;212(3):855-868. doi: 10.1534/genetics.119.302280. Epub 2019 May 22.


What proportion of athletes sustained an injury during a prospective study? Censored observations matter.

Jungmalm J, Bertelsen ML, Nielsen RO.

Br J Sports Med. 2019 May 21. pii: bjsports-2018-100440. doi: 10.1136/bjsports-2018-100440. [Epub ahead of print] No abstract available.


What is the optimal serum level for lithium in the maintenance treatment of bipolar disorder? A systematic review and recommendations from the ISBD/IGSLI Task Force on treatment with lithium.

Nolen WA, Licht RW, Young AH, Malhi GS, Tohen M, Vieta E, Kupka RW, Zarate C, Nielsen RE, Baldessarini RJ, Severus E; ISBD/IGSLI Task Force on the treatment with lithium.

Bipolar Disord. 2019 Aug;21(5):394-409. doi: 10.1111/bdi.12805. Epub 2019 Jun 20. Review.



Precht H, Mørup SD, Tingberg A, Outzen CB, Kusk KW, Nielsen RM, Midtgård M, Winther MB, Waaler D, Kusk MW.

Radiat Prot Dosimetry. 2019 May 21. pii: ncz129. doi: 10.1093/rpd/ncz129. [Epub ahead of print]


Longitudinal outcomes in pediatric- and adult-onset bipolar patients compared to healthy and schizophrenia controls.

Frahm Laursen M, Valentin JB, Licht RW, Correll CU, Nielsen RE.

Bipolar Disord. 2019 May 9. doi: 10.1111/bdi.12793. [Epub ahead of print]


Motivation and response rates in bronchoscopy studies.

Martinsen EMH, Eagan TML, Leiten EO, Nordeide E, Bakke PS, Lehmann S, Nielsen R.

Multidiscip Respir Med. 2019 May 2;14:14. doi: 10.1186/s40248-019-0178-3. eCollection 2019.


Functional Traits Explain Variation in Chaparral Shrub Sensitivity to Altered Water and Nutrient Availability.

Nielsen RL, James JJ, Drenovsky RE.

Front Plant Sci. 2019 Apr 18;10:505. doi: 10.3389/fpls.2019.00505. eCollection 2019.


Why are somatic diseases in bipolar disorder insufficiently treated?

Nielsen RE, Kugathasan P, Straszek S, Jensen SE, Licht RW.

Int J Bipolar Disord. 2019 May 5;7(1):12. doi: 10.1186/s40345-019-0147-y. Review.


Temporal genomic contrasts reveal rapid evolutionary responses in an alpine mammal during recent climate change.

Bi K, Linderoth T, Singhal S, Vanderpool D, Patton JL, Nielsen R, Moritz C, Good JM.

PLoS Genet. 2019 May 3;15(5):e1008119. doi: 10.1371/journal.pgen.1008119. eCollection 2019 May.


The chemical reactions in electrosprays of water do not always correspond to those at the pristine air-water interface.

Gallo A Jr, Farinha ASF, Dinis M, Emwas AH, Santana A, Nielsen RJ, Goddard WA 3rd, Mishra H.

Chem Sci. 2018 Dec 21;10(9):2566-2577. doi: 10.1039/c8sc05538f. eCollection 2019 Mar 7.


Base-Pairing Properties of Double-Headed Nucleotides.

Hornum M, Stendevad J, Sharma PK, Kumar P, Nielsen RB, Petersen M, Nielsen P.

Chemistry. 2019 May 28;25(30):7387-7395. doi: 10.1002/chem.201901077. Epub 2019 May 7.


Music Therapy as Treatment of Negative Symptoms for Adult Patients Diagnosed with Schizophrenia-Study Protocol for a Randomized, Controlled and Blinded Study.

Pedersen IN, Bonde LO, Hannibal NJ, Nielsen J, Aagaard J, Bertelsen LR, Jensen SB, Nielsen RE.

Medicines (Basel). 2019 Apr 1;6(2). pii: E46. doi: 10.3390/medicines6020046.


Determinants of fractional exhaled nitric oxide in healthy men and women from the European Community Respiratory Health Survey III.

Nerpin E, Olivieri M, Gislason T, Olin AC, Nielsen R, Johannessen A, Ferreira DS, Marcon A, Cazzoletti L, Accordini S, Pin I, Corsico A, Demoly P, Weyler J, Nowak D, Jõgi R, Forsberg B, Zock JP, Sigsgaard T, Heinric J, Bono R, Leynaert B, Jarvis D, Janson C, Malinovschi A; European Community Respiratory Health Survey (ECRHS) study group.

Clin Exp Allergy. 2019 Jul;49(7):969-979. doi: 10.1111/cea.13394. Epub 2019 Apr 14.


Pain perception in patients with hidradenitis suppurativa.

Nielsen RM, Lindsø Andersen P, Sigsgaard V, Theut Riis P, Jemec GB.

Br J Dermatol. 2019 Mar 28. doi: 10.1111/bjd.17935. [Epub ahead of print]


Author Correction: Osteogenesis depends on commissioning of a network of stem cell transcription factors that act as repressors of adipogenesis.

Rauch A, Haakonsson AK, Madsen JGS, Larsen M, Forss I, Madsen MR, Van Hauwaert EL, Wiwie C, Jespersen NZ, Tencerova M, Nielsen R, Larsen BD, Röttger R, Baumbach J, Scheele C, Kassem M, Mandrup S.

Nat Genet. 2019 Apr;51(4):766. doi: 10.1038/s41588-019-0400-4.


Human Disease Variation in the Light of Population Genomics.

Prohaska A, Racimo F, Schork AJ, Sikora M, Stern AJ, Ilardo M, Allentoft ME, Folkersen L, Buil A, Moreno-Mayar JV, Korneliussen T, Geschwind D, Ingason A, Werge T, Nielsen R, Willerslev E.

Cell. 2019 Mar 21;177(1):115-131. doi: 10.1016/j.cell.2019.01.052. Review.


Continuous EEG Monitoring in a Consecutive Patient Cohort with Sepsis and Delirium.

Nielsen RM, Urdanibia-Centelles O, Vedel-Larsen E, Thomsen KJ, Møller K, Olsen KS, Lauritsen AØ, Eddelien HS, Lauritzen M, Benedek K.

Neurocrit Care. 2019 Mar 19. doi: 10.1007/s12028-019-00703-w. [Epub ahead of print]


Quantitative estimation of extravascular lung water volume and preload by dynamic 15O-water positron emission tomography.

Nielsen RR, Sörensen J, Tolbod L, Alstrup AKO, Iversen P, Frederiksen CA, Wiggers H, Jorsal A, Frøkier J, Harms HJ.

Eur Heart J Cardiovasc Imaging. 2019 Mar 18. pii: jez038. doi: 10.1093/ehjci/jez038. [Epub ahead of print]


Cardiovascular Effects of Treatment With the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients.

Nielsen R, Møller N, Gormsen LC, Tolbod LP, Hansson NH, Sorensen J, Harms HJ, Frøkiær J, Eiskjaer H, Jespersen NR, Mellemkjaer S, Lassen TR, Pryds K, Bøtker HE, Wiggers H.

Circulation. 2019 Apr 30;139(18):2129-2141. doi: 10.1161/CIRCULATIONAHA.118.036459.


Association between solar insolation and a history of suicide attempts in bipolar I disorder.

Bauer M, Glenn T, Alda M, Andreassen OA, Angelopoulos E, Ardau R, Ayhan Y, Baethge C, Bauer R, Baune BT, Becerra-Palars C, Bellivier F, Belmaker RH, Berk M, Bersudsky Y, Bicakci Ş, Birabwa-Oketcho H, Bjella TD, Cabrera J, Wo Cheung EY, Del Zompo M, Dodd S, Donix M, Etain B, Fagiolini A, Fountoulakis KN, Frye MA, Gonzalez-Pinto A, Gottlieb JF, Grof P, Harima H, Henry C, Isometsä ET, Janno S, Kapczinski F, Kardell M, Khaldi S, Kliwicki S, König B, Kot TL, Krogh R, Kunz M, Lafer B, Landén M, Larsen ER, Lewitzka U, Licht RW, Lopez-Jaramillo C, MacQueen G, Manchia M, Marsh W, Martinez-Cengotitabengoa M, Melle I, Meza-Urzúa F, Ming MY, Monteith S, Morken G, Mosca E, Mozzhegorov AA, Munoz R, Mythri SV, Nacef F, Nadella RK, Nery FG, Nielsen RE, O'Donovan C, Omrani A, Osher Y, Sørensen HØ, Ouali U, Ruiz YP, Pilhatsch M, Pinna M, da Ponte FDR, Quiroz D, Ramesar R, Rasgon N, Reddy MS, Reif A, Ritter P, Rybakowski JK, Sagduyu K, Raghuraman BS, Scippa ÂM, Severus E, Simhandl C, Stackhouse PW Jr, Stein DJ, Strejilevich S, Subramaniam M, Sulaiman AH, Suominen K, Tagata H, Tatebayashi Y, Tondo L, Torrent C, Vaaler AE, Vares E, Veeh J, Vieta E, Viswanath B, Yoldi-Negrete M, Zetin M, Zgueb Y, Whybrow PC.

J Psychiatr Res. 2019 Jun;113:1-9. doi: 10.1016/j.jpsychires.2019.03.001. Epub 2019 Mar 8.


Coronary Artery Calcification and Mortality Risk in Patients With Severe Mental Illness.

Kugathasan P, Johansen MB, Jensen MB, Aagaard J, Nielsen RE, Jensen SE.

Circ Cardiovasc Imaging. 2019 Mar;12(3):e008236. doi: 10.1161/CIRCIMAGING.118.008236.


Osteogenesis depends on commissioning of a network of stem cell transcription factors that act as repressors of adipogenesis.

Rauch A, Haakonsson AK, Madsen JGS, Larsen M, Forss I, Madsen MR, Van Hauwaert EL, Wiwie C, Jespersen NZ, Tencerova M, Nielsen R, Larsen BD, Röttger R, Baumbach J, Scheele C, Kassem M, Mandrup S.

Nat Genet. 2019 Apr;51(4):716-727. doi: 10.1038/s41588-019-0359-1. Epub 2019 Mar 4. Erratum in: Nat Genet. 2019 Mar 25;:.


Mortality rate trends in patients diagnosed with schizophrenia or bipolar disorder: a nationwide study with 20 years of follow-up.

Lomholt LH, Andersen DV, Sejrsgaard-Jacobsen C, Øzdemir CM, Graff C, Schjerning O, Jensen SE, Straszek SPV, Licht RW, Grøntved S, Nielsen RE.

Int J Bipolar Disord. 2019 Mar 1;7(1):6. doi: 10.1186/s40345-018-0140-x.


Parallel adaptation of rabbit populations to myxoma virus.

Alves JM, Carneiro M, Cheng JY, Lemos de Matos A, Rahman MM, Loog L, Campos PF, Wales N, Eriksson A, Manica A, Strive T, Graham SC, Afonso S, Bell DJ, Belmont L, Day JP, Fuller SJ, Marchandeau S, Palmer WJ, Queney G, Surridge AK, Vieira FG, McFadden G, Nielsen R, Gilbert MTP, Esteves PJ, Ferrand N, Jiggins FM.

Science. 2019 Mar 22;363(6433):1319-1326. doi: 10.1126/science.aau7285. Epub 2019 Feb 14.


Elucidating the Mechanism of Absorption of Fast-Acting Insulin Aspart: The Role of Niacinamide.

Kildegaard J, Buckley ST, Nielsen RH, Povlsen GK, Seested T, Ribel U, Olsen HB, Ludvigsen S, Jeppesen CB, Refsgaard HHF, Bendtsen KM, Kristensen NR, Hostrup S, Sturis J.

Pharm Res. 2019 Feb 11;36(3):49. doi: 10.1007/s11095-019-2578-7.


Effects of Lewis Acidic Metal Ions (M) on Oxygen-Atom Transfer Reactivity of Heterometallic Mn3MO4 Cubane and Fe3MO(OH) and Mn3MO(OH) Clusters.

Lionetti D, Suseno S, Tsui EY, Lu L, Stich TA, Carsch KM, Nielsen RJ, Goddard WA 3rd, Britt RD, Agapie T.

Inorg Chem. 2019 Feb 18;58(4):2336-2345. doi: 10.1021/acs.inorgchem.8b02701. Epub 2019 Feb 7.


Pharmacological treatment of asthma in a cohort of adults during a 20-year period: results from the European Community Respiratory Health Survey I, II and III.

Janson C, Accordini S, Cazzoletti L, Cerveri I, Chanoine S, Corsico A, Ferreira DS, Garcia-Aymerich J, Gislason D, Nielsen R, Johannessen A, Jogi R, Malinovschi A, Martinez-Moratalla Rovira J, Marcon A, Pin I, Quint J, Siroux V, Almar E, Bellisario V, Franklin KA, Gullón JA, Holm M, Heinrich J, Nowak D, Sánchez-Ramos JL, Weyler JJ, Jarvis D.

ERJ Open Res. 2019 Feb 1;5(1). pii: 00073-2018. doi: 10.1183/23120541.00073-2018. eCollection 2019 Feb.


The efficacy of adjunctive N-acetylcysteine in acute bipolar depression: A randomized placebo-controlled study.

Ellegaard PK, Licht RW, Nielsen RE, Dean OM, Berk M, Poulsen HE, Mohebbi M, Nielsen CT.

J Affect Disord. 2019 Feb 15;245:1043-1051. doi: 10.1016/j.jad.2018.10.083. Epub 2018 Oct 6.


Selective Ablation of Megalin in the Retinal Pigment Epithelium Results in Megaophthalmos, Macromelanosome Formation and Severe Retina Degeneration.

Storm T, Burgoyne T, Dunaief JL, Christensen EI, Futter C, Nielsen R.

Invest Ophthalmol Vis Sci. 2019 Jan 2;60(1):322-330. doi: 10.1167/iovs.18-25667.

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