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Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation.

Mooser C, Symeonidou IE, Leimbacher PA, Ribeiro A, Shorrocks AK, Jungmichel S, Larsen SC, Knechtle K, Jasrotia A, Zurbriggen D, Jeanrenaud A, Leikauf C, Fink D, Nielsen ML, Blackford AN, Stucki M.

Nat Commun. 2020 Jan 8;11(1):123. doi: 10.1038/s41467-019-13981-x.


Shift work and use of psychotropic medicine: a follow-up study with register linkage.

Albertsen K, Hannerz H, Nielsen ML, Garde AH.

Scand J Work Environ Health. 2019 Dec 12. pii: 3872. doi: 10.5271/sjweh.3872. [Epub ahead of print]


Chances of live birth after exposure to vitamin D-fortified margarine in women with fertility problems: results from a Danish population-based cohort study.

Jensen A, Nielsen ML, Guleria S, Kjaer SK, Heitmann BL, Kesmodel US.

Fertil Steril. 2019 Nov 20. pii: S0015-0282(19)32371-4. doi: 10.1016/j.fertnstert.2019.09.017. [Epub ahead of print]


Analytical performance of canine acylated and unacylated ghrelin enzyme-linked immunosorbent assays.

Lass J, Nielsen ML, Bjørnvad CR, Vitger AD, Cremer SE.

Vet Clin Pathol. 2019 Dec;48(4):748-753. doi: 10.1111/vcp.12801. Epub 2019 Nov 7.


Acoustic crypsis in southern right whale mother-calf pairs: infrequent, low-output calls to avoid predation?

Nielsen MLK, Bejder L, Videsen SKA, Christiansen F, Madsen PT.

J Exp Biol. 2019 Jul 11;222(Pt 13). pii: jeb190728. doi: 10.1242/jeb.190728.


Regulation of GLI1 by cis DNA elements and epigenetic marks.

Taylor R, Long J, Yoon JW, Childs R, Sylvestersen KB, Nielsen ML, Leong KF, Iannaccone S, Walterhouse DO, Robbins DJ, Iannaccone P.

DNA Repair (Amst). 2019 Jul;79:10-21. doi: 10.1016/j.dnarep.2019.04.011. Epub 2019 May 2.


Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells.

Samudyata, Amaral PP, Engström PG, Robson SC, Nielsen ML, Kouzarides T, Castelo-Branco G.

Exp Cell Res. 2019 Aug 1;381(1):129-138. doi: 10.1016/j.yexcr.2019.05.006. Epub 2019 May 9.


Family Medicine Patients Have Shorter Length of Stay When Cared for on a Family Medicine Inpatient Service.

Garrison GM, Keuseman RL, Boswell CL, Horn JL, Nielsen NT, Nielsen ML.

J Prim Care Community Health. 2019 Jan-Dec;10:2150132719840517. doi: 10.1177/2150132719840517.


PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination.

Falcão AM, Meijer M, Scaglione A, Rinwa P, Agirre E, Liang J, Larsen SC, Heskol A, Frawley R, Klingener M, Varas-Godoy M, Raposo AASF, Ernfors P, Castro DS, Nielsen ML, Casaccia P, Castelo-Branco G.

Cell Rep. 2019 Apr 23;27(4):1090-1102.e10. doi: 10.1016/j.celrep.2019.03.108.


Citrullination of HP1γ chromodomain affects association with chromatin.

Wiese M, Bannister AJ, Basu S, Boucher W, Wohlfahrt K, Christophorou MA, Nielsen ML, Klenerman D, Laue ED, Kouzarides T.

Epigenetics Chromatin. 2019 Apr 2;12(1):21. doi: 10.1186/s13072-019-0265-x.


SUMOylation promotes protective responses to DNA-protein crosslinks.

Borgermann N, Ackermann L, Schwertman P, Hendriks IA, Thijssen K, Liu JC, Lans H, Nielsen ML, Mailand N.

EMBO J. 2019 Apr 15;38(8). pii: e101496. doi: 10.15252/embj.2019101496. Epub 2019 Mar 26.


Cascading trend of Early Paleozoic marine radiations paused by Late Ordovician extinctions.

Rasmussen CMØ, Kröger B, Nielsen ML, Colmenar J.

Proc Natl Acad Sci U S A. 2019 Apr 9;116(15):7207-7213. doi: 10.1073/pnas.1821123116. Epub 2019 Mar 25.


An Advanced Strategy for Comprehensive Profiling of ADP-ribosylation Sites Using Mass Spectrometry-based Proteomics.

Hendriks IA, Larsen SC, Nielsen ML.

Mol Cell Proteomics. 2019 May;18(5):1010-1026. doi: 10.1074/mcp.TIR119.001315. Epub 2019 Feb 23.


Systems-wide Analysis of Serine ADP-Ribosylation Reveals Widespread Occurrence and Site-Specific Overlap with Phosphorylation.

Larsen SC, Hendriks IA, Lyon D, Jensen LJ, Nielsen ML.

Cell Rep. 2018 Aug 28;24(9):2493-2505.e4. doi: 10.1016/j.celrep.2018.07.083.


Site-specific characterization of endogenous SUMOylation across species and organs.

Hendriks IA, Lyon D, Su D, Skotte NH, Daniel JA, Jensen LJ, Nielsen ML.

Nat Commun. 2018 Jun 25;9(1):2456. doi: 10.1038/s41467-018-04957-4.


Integrative Characterization of the R6/2 Mouse Model of Huntington's Disease Reveals Dysfunctional Astrocyte Metabolism.

Skotte NH, Andersen JV, Santos A, Aldana BI, Willert CW, Nørremølle A, Waagepetersen HS, Nielsen ML.

Cell Rep. 2018 May 15;23(7):2211-2224. doi: 10.1016/j.celrep.2018.04.052.


Arginine Methylation by PRMT2 Controls the Functions of the Actin Nucleator Cobl.

Hou W, Nemitz S, Schopper S, Nielsen ML, Kessels MM, Qualmann B.

Dev Cell. 2018 Apr 23;45(2):262-275.e8. doi: 10.1016/j.devcel.2018.03.007.


[Novel antidiabetic drugs and cardiovascular complications].

Pareek M, Mortensen MB, Løfgren B, Nielsen ML, Olsen MH, Andersen NH.

Ugeskr Laeger. 2018 Feb 5;180(6). pii: V07170551. Review. Danish.


Long working hours and depressive symptoms: systematic review and meta-analysis of published studies and unpublished individual participant data.

Virtanen M, Jokela M, Madsen IE, Magnusson Hanson LL, Lallukka T, Nyberg ST, Alfredsson L, Batty GD, Bjorner JB, Borritz M, Burr H, Dragano N, Erbel R, Ferrie JE, Heikkilä K, Knutsson A, Koskenvuo M, Lahelma E, Nielsen ML, Oksanen T, Pejtersen JH, Pentti J, Rahkonen O, Rugulies R, Salo P, Schupp J, Shipley MJ, Siegrist J, Singh-Manoux A, Suominen SB, Theorell T, Vahtera J, Wagner GG, Wang JL, Yiengprugsawan V, Westerlund H, Kivimäki M.

Scand J Work Environ Health. 2018 May 1;44(3):239-250. doi: 10.5271/sjweh.3712. Epub 2018 Feb 8.


Effect of an In-Hospital Multifaceted Clinical Pharmacist Intervention on the Risk of Readmission: A Randomized Clinical Trial.

Ravn-Nielsen LV, Duckert ML, Lund ML, Henriksen JP, Nielsen ML, Eriksen CS, Buck TC, Pottegård A, Hansen MR, Hallas J.

JAMA Intern Med. 2018 Mar 1;178(3):375-382. doi: 10.1001/jamainternmed.2017.8274.


One-hour glucose value as a long-term predictor of cardiovascular morbidity and mortality: the Malmö Preventive Project.

Nielsen ML, Pareek M, Leósdóttir M, Eriksson KF, Nilsson PM, Olsen MH.

Eur J Endocrinol. 2018 Mar;178(3):225-236. doi: 10.1530/EJE-17-0824. Epub 2017 Dec 19.


Long working hours and stroke among employees in the general workforce of Denmark.

Hannerz H, Albertsen K, Burr H, Nielsen ML, Garde AH, Larsen AD, Pejtersen JH.

Scand J Public Health. 2018 May;46(3):368-374. doi: 10.1177/1403494817748264. Epub 2017 Dec 17.


Targeted gene sequencing and whole-exome sequencing in autopsied fetuses with prenatally diagnosed kidney anomalies.

Rasmussen M, Sunde L, Nielsen ML, Ramsing M, Petersen A, Hjortshøj TD, Olsen TE, Tabor A, Hertz JM, Johnsen I, Sperling L, Petersen OB, Jensen UB, Møller FG, Petersen MB, Lildballe DL.

Clin Genet. 2018 Apr;93(4):860-869. doi: 10.1111/cge.13185. Epub 2018 Feb 23.


Changes in Allostatic Load during workplace reorganization.

Carlsson RH, Hansen ÅM, Nielsen ML, Blønd M, Netterstrøm B.

J Psychosom Res. 2017 Dec;103:34-41. doi: 10.1016/j.jpsychores.2017.09.015. Epub 2017 Sep 30.


Enhanced Predictive Capability of a 1-Hour Oral Glucose Tolerance Test: A Prospective Population-Based Cohort Study.

Pareek M, Bhatt DL, Nielsen ML, Jagannathan R, Eriksson KF, Nilsson PM, Bergman M, Olsen MH.

Diabetes Care. 2018 Jan;41(1):171-177. doi: 10.2337/dc17-1351. Epub 2017 Nov 14.


Long working hours as a risk factor for atrial fibrillation: a multi-cohort study.

Kivimäki M, Nyberg ST, Batty GD, Kawachi I, Jokela M, Alfredsson L, Bjorner JB, Borritz M, Burr H, Dragano N, Fransson EI, Heikkilä K, Knutsson A, Koskenvuo M, Kumari M, Madsen IEH, Nielsen ML, Nordin M, Oksanen T, Pejtersen JH, Pentti J, Rugulies R, Salo P, Shipley MJ, Suominen S, Theorell T, Vahtera J, Westerholm P, Westerlund H, Steptoe A, Singh-Manoux A, Hamer M, Ferrie JE, Virtanen M, Tabak AG; IPD-Work consortium.

Eur Heart J. 2017 Sep 7;38(34):2621-2628. doi: 10.1093/eurheartj/ehx324.


Proteome-Wide Identification of In Vivo ADP-Ribose Acceptor Sites by Liquid Chromatography-Tandem Mass Spectrometry.

Larsen SC, Leutert M, Bilan V, Martello R, Jungmichel S, Young C, Hottiger MO, Nielsen ML.

Methods Mol Biol. 2017;1608:149-162. doi: 10.1007/978-1-4939-6993-7_11.


Specifying RNA-Binding Regions in Proteins by Peptide Cross-Linking and Affinity Purification.

Mullari M, Lyon D, Jensen LJ, Nielsen ML.

J Proteome Res. 2017 Aug 4;16(8):2762-2772. doi: 10.1021/acs.jproteome.7b00042. Epub 2017 Jul 7.


Bub1 positions Mad1 close to KNL1 MELT repeats to promote checkpoint signalling.

Zhang G, Kruse T, López-Méndez B, Sylvestersen KB, Garvanska DH, Schopper S, Nielsen ML, Nilsson J.

Nat Commun. 2017 Jun 12;8:15822. doi: 10.1038/ncomms15822.


An Optimized Shotgun Strategy for the Rapid Generation of Comprehensive Human Proteomes.

Bekker-Jensen DB, Kelstrup CD, Batth TS, Larsen SC, Haldrup C, Bramsen JB, Sørensen KD, Høyer S, Ørntoft TF, Andersen CL, Nielsen ML, Olsen JV.

Cell Syst. 2017 Jun 28;4(6):587-599.e4. doi: 10.1016/j.cels.2017.05.009. Epub 2017 Jun 7.


Effort-Reward Imbalance at Work and Incident Coronary Heart Disease: A Multicohort Study of 90,164 Individuals.

Dragano N, Siegrist J, Nyberg ST, Lunau T, Fransson EI, Alfredsson L, Bjorner JB, Borritz M, Burr H, Erbel R, Fahlén G, Goldberg M, Hamer M, Heikkilä K, Jöckel KH, Knutsson A, Madsen IEH, Nielsen ML, Nordin M, Oksanen T, Pejtersen JH, Pentti J, Rugulies R, Salo P, Schupp J, Singh-Manoux A, Steptoe A, Theorell T, Vahtera J, Westerholm PJM, Westerlund H, Virtanen M, Zins M, Batty GD, Kivimäki M; IPD-Work consortium.

Epidemiology. 2017 Jul;28(4):619-626. doi: 10.1097/EDE.0000000000000666. Review.


Improved Reversed Phase Chromatography of Hydrophilic Peptides from Spatial and Temporal Changes in Column Temperature.

Young C, Podtelejnikov AV, Nielsen ML.

J Proteome Res. 2017 Jun 2;16(6):2307-2317. doi: 10.1021/acs.jproteome.6b01055. Epub 2017 Apr 7.


Job strain as a risk factor for clinical depression: systematic review and meta-analysis with additional individual participant data.

Madsen IEH, Nyberg ST, Magnusson Hanson LL, Ferrie JE, Ahola K, Alfredsson L, Batty GD, Bjorner JB, Borritz M, Burr H, Chastang JF, de Graaf R, Dragano N, Hamer M, Jokela M, Knutsson A, Koskenvuo M, Koskinen A, Leineweber C, Niedhammer I, Nielsen ML, Nordin M, Oksanen T, Pejtersen JH, Pentti J, Plaisier I, Salo P, Singh-Manoux A, Suominen S, Ten Have M, Theorell T, Toppinen-Tanner S, Vahtera J, Väänänen A, Westerholm PJM, Westerlund H, Fransson EI, Heikkilä K, Virtanen M, Rugulies R, Kivimäki M; IPD-Work Consortium.

Psychol Med. 2017 Jun;47(8):1342-1356. doi: 10.1017/S003329171600355X. Epub 2017 Jan 26. Review.


Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

Hendriks IA, Lyon D, Young C, Jensen LJ, Vertegaal AC, Nielsen ML.

Nat Struct Mol Biol. 2017 Mar;24(3):325-336. doi: 10.1038/nsmb.3366. Epub 2017 Jan 23.


Genes Linked to Production of Secondary Metabolites in Talaromyces atroroseus Revealed Using CRISPR-Cas9.

Nielsen ML, Isbrandt T, Rasmussen KB, Thrane U, Hoof JB, Larsen TO, Mortensen UH.

PLoS One. 2017 Jan 5;12(1):e0169712. doi: 10.1371/journal.pone.0169712. eCollection 2017.


Evaluation of a membrane bioreactor system as post-treatment in waste water treatment for better removal of micropollutants.

Arriaga S, de Jonge N, Nielsen ML, Andersen HR, Borregaard V, Jewel K, Ternes TA, Nielsen JL.

Water Res. 2016 Dec 15;107:37-46. doi: 10.1016/j.watres.2016.10.046. Epub 2016 Oct 19.


Job insecurity and risk of diabetes: a meta-analysis of individual participant data.

Ferrie JE, Virtanen M, Jokela M, Madsen IEH, Heikkilä K, Alfredsson L, Batty GD, Bjorner JB, Borritz M, Burr H, Dragano N, Elovainio M, Fransson EI, Knutsson A, Koskenvuo M, Koskinen A, Kouvonen A, Kumari M, Nielsen ML, Nordin M, Oksanen T, Pahkin K, Pejtersen JH, Pentti J, Salo P, Shipley MJ, Suominen SB, Tabák A, Theorell T, Väänänen A, Vahtera J, Westerholm PJM, Westerlund H, Rugulies R, Nyberg ST, Kivimäki M; IPD-Work Consortium.

CMAJ. 2016 Dec 6;188(17-18):E447-E455. doi: 10.1503/cmaj.150942. Epub 2016 Oct 3.


Proteome-wide identification of the endogenous ADP-ribosylome of mammalian cells and tissue.

Martello R, Leutert M, Jungmichel S, Bilan V, Larsen SC, Young C, Hottiger MO, Nielsen ML.

Nat Commun. 2016 Sep 30;7:12917. doi: 10.1038/ncomms12917.


Factors associated with diagnostic discrepancy for left ventricular hypertrophy between electrocardiography and echocardiography.

Petersen SS, Pedersen LR, Pareek M, Nielsen ML, Diederichsen SZ, Leósdóttir M, Nilsson PM, Diederichsen AC, Olsen MH.

Blood Press. 2017 Feb;26(1):54-63. doi: 10.1080/08037051.2016.1235959. Epub 2016 Sep 23. Erratum in: Blood Press. 2017 Feb;26(1):i.


Proteome-wide analysis of arginine monomethylation reveals widespread occurrence in human cells.

Larsen SC, Sylvestersen KB, Mund A, Lyon D, Mullari M, Madsen MV, Daniel JA, Jensen LJ, Nielsen ML.

Sci Signal. 2016 Aug 30;9(443):rs9. doi: 10.1126/scisignal.aaf7329.


Linker Flexibility Facilitates Module Exchange in Fungal Hybrid PKS-NRPS Engineering.

Nielsen ML, Isbrandt T, Petersen LM, Mortensen UH, Andersen MR, Hoof JB, Larsen TO.

PLoS One. 2016 Aug 23;11(8):e0161199. doi: 10.1371/journal.pone.0161199. eCollection 2016.


Long working hours and cancer risk: a multi-cohort study.

Heikkila K, Nyberg ST, Madsen IE, de Vroome E, Alfredsson L, Bjorner JJ, Borritz M, Burr H, Erbel R, Ferrie JE, Fransson EI, Geuskens GA, Hooftman WE, Houtman IL, Jöckel KH, Knutsson A, Koskenvuo M, Lunau T, Nielsen ML, Nordin M, Oksanen T, Pejtersen JH, Pentti J, Shipley MJ, Steptoe A, Suominen SB, Theorell T, Vahtera J, Westerholm PJ, Westerlund H, Dragano N, Rugulies R, Kawachi I, Batty GD, Singh-Manoux A, Virtanen M, Kivimäki M; IPD-Work Consortium.

Br J Cancer. 2016 Mar 29;114(7):813-8. doi: 10.1038/bjc.2016.9. Epub 2016 Feb 18.


Follow-up duration influences the relative importance of OGTT and optimal timing of glucose measurements for predicting future type 2 diabetes.

Nielsen ML, Pareek M, Leósdóttir M, Højlund K, Eriksson KF, Nilsson PM, Olsen MH.

Eur J Endocrinol. 2016 May;174(5):591-600. doi: 10.1530/EJE-15-1221. Epub 2016 Feb 12.


Diagnostic accuracy of imaging methods for the diagnosis of skeletal malignancies: A retrospective analysis against a pathology-proven reference.

Lange MB, Nielsen ML, Andersen JD, Lilholt HJ, Vyberg M, Petersen LJ.

Eur J Radiol. 2016 Jan;85(1):61-67. doi: 10.1016/j.ejrad.2015.10.012. Epub 2015 Oct 23.


Greater body mass index is a better predictor of subclinical cardiac damage at long-term follow-up in men than is insulin sensitivity: a prospective, population-based cohort study.

Nielsen ML, Pareek M, Gerke O, Leósdóttir M, Nilsson PM, Olsen MH.

BMC Cardiovasc Disord. 2015 Dec 10;15:168. doi: 10.1186/s12872-015-0165-3.


Large-Scale Identification of the Arginine Methylome by Mass Spectrometry.

Sylvestersen KB, Nielsen ML.

Curr Protoc Protein Sci. 2015 Nov 2;82:24.7.1-24.7.17. doi: 10.1002/0471140864.ps2407s82.


Long working hours and risk of coronary heart disease and stroke: a systematic review and meta-analysis of published and unpublished data for 603,838 individuals.

Kivimäki M, Jokela M, Nyberg ST, Singh-Manoux A, Fransson EI, Alfredsson L, Bjorner JB, Borritz M, Burr H, Casini A, Clays E, De Bacquer D, Dragano N, Erbel R, Geuskens GA, Hamer M, Hooftman WE, Houtman IL, Jöckel KH, Kittel F, Knutsson A, Koskenvuo M, Lunau T, Madsen IE, Nielsen ML, Nordin M, Oksanen T, Pejtersen JH, Pentti J, Rugulies R, Salo P, Shipley MJ, Siegrist J, Steptoe A, Suominen SB, Theorell T, Vahtera J, Westerholm PJ, Westerlund H, O'Reilly D, Kumari M, Batty GD, Ferrie JE, Virtanen M; IPD-Work Consortium.

Lancet. 2015 Oct 31;386(10005):1739-46. doi: 10.1016/S0140-6736(15)60295-1. Epub 2015 Aug 19. Review.


Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose).

Altmeyer M, Neelsen KJ, Teloni F, Pozdnyakova I, Pellegrino S, Grøfte M, Rask MD, Streicher W, Jungmichel S, Nielsen ML, Lukas J.

Nat Commun. 2015 Aug 19;6:8088. doi: 10.1038/ncomms9088.


Biotin starvation causes mitochondrial protein hyperacetylation and partial rescue by the SIRT3-like deacetylase Hst4p.

Madsen CT, Sylvestersen KB, Young C, Larsen SC, Poulsen JW, Andersen MA, Palmqvist EA, Hey-Mogensen M, Jensen PB, Treebak JT, Lisby M, Nielsen ML.

Nat Commun. 2015 Jul 9;6:7726. doi: 10.1038/ncomms8726.


A Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission Yeast.

Mathiassen SG, Larsen IB, Poulsen EG, Madsen CT, Papaleo E, Lindorff-Larsen K, Kragelund BB, Nielsen ML, Kriegenburg F, Hartmann-Petersen R.

J Biol Chem. 2015 Aug 21;290(34):21141-53. doi: 10.1074/jbc.M115.662312. Epub 2015 Jul 7.

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