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Items: 1 to 50 of 282

1.

Gel-Based Proteomics of Clinical Samples Identifies Potential Serological Biomarkers for Early Detection of Colorectal Cancer.

Thorsen SF, Gromova I, Christensen IJ, Fredriksson S, Andersen CL, Nielsen HJ, Stenvang J, Moreira JMA.

Int J Mol Sci. 2019 Dec 2;20(23). pii: E6082. doi: 10.3390/ijms20236082.

2.

Novel DNA methylation biomarkers show high sensitivity and specificity for blood-based detection of colorectal cancer-a clinical biomarker discovery and validation study.

Jensen SØ, Øgaard N, Ørntoft MW, Rasmussen MH, Bramsen JB, Kristensen H, Mouritzen P, Madsen MR, Madsen AH, Sunesen KG, Iversen LH, Laurberg S, Christensen IJ, Nielsen HJ, Andersen CL.

Clin Epigenetics. 2019 Nov 14;11(1):158. doi: 10.1186/s13148-019-0757-3.

3.

The concentration of the cleaved suPAR forms in pre- and postoperative plasma samples improves the prediction of survival in colorectal cancer: A nationwide multicenter validation and discovery study.

Rolff HC, Christensen IJ, Svendsen LB, Wilhelmsen M, Lund IK, Thurison T, Høyer-Hansen G, Illemann M, Nielsen HJ; Danish Collaborative Research Group on Colorectal Cancer.

J Surg Oncol. 2019 Dec;120(8):1404-1411. doi: 10.1002/jso.25733. Epub 2019 Oct 23.

PMID:
31646652
4.

Short-term effects of Vertical sleeve gastrectomy and Roux-en-Y gastric bypass on glucose homeostasis.

Gudbrandsen OA, Dankel SN, Skumsnes L, Flølo TN, Folkestad OH, Nielsen HJ, Våge V, Mohn AC, Nedrebø BG, Sagen JV, Fernø J, Mellgren G.

Sci Rep. 2019 Oct 15;9(1):14817. doi: 10.1038/s41598-019-51347-x.

5.

Evaluation of algorithm development approaches: Development of biomarker panels for early detection of colorectal lesions.

Gawel SH, Lucht M, Gomer H, Treado P, Christensen IJ, Nielsen HJ, Davis GJ; Danish Research Group on Early Detection of Colorectal Cancer.

Clin Chim Acta. 2019 Nov;498:108-115. doi: 10.1016/j.cca.2019.08.007. Epub 2019 Aug 13.

PMID:
31419412
6.

Genome-wide cell-free DNA fragmentation in patients with cancer.

Cristiano S, Leal A, Phallen J, Fiksel J, Adleff V, Bruhm DC, Jensen SØ, Medina JE, Hruban C, White JR, Palsgrove DN, Niknafs N, Anagnostou V, Forde P, Naidoo J, Marrone K, Brahmer J, Woodward BD, Husain H, van Rooijen KL, Ørntoft MW, Madsen AH, van de Velde CJH, Verheij M, Cats A, Punt CJA, Vink GR, van Grieken NCT, Koopman M, Fijneman RJA, Johansen JS, Nielsen HJ, Meijer GA, Andersen CL, Scharpf RB, Velculescu VE.

Nature. 2019 Jun;570(7761):385-389. doi: 10.1038/s41586-019-1272-6. Epub 2019 May 29.

7.

Increased serological, cancer-associated protein biomarker levels at diagnosis of large bowel adenoma: Risk of subsequent primary malignancy?

Piper TB, Jørgensen LN, Olsen J, Nielsen KT, Davis G, Johansen JS, Jarle Christensen I, Nielsen HJ.

Acta Oncol. 2019;58(sup1):S42-S48. doi: 10.1080/0284186X.2018.1540885. Epub 2018 Dec 7.

PMID:
30523734
8.

IRX5 regulates adipocyte amyloid precursor protein and mitochondrial respiration in obesity.

Bjune JI, Haugen C, Gudbrandsen O, Nordbø OP, Nielsen HJ, Våge V, Njølstad PR, Sagen JV, Dankel SN, Mellgren G.

Int J Obes (Lond). 2019 Nov;43(11):2151-2162. doi: 10.1038/s41366-018-0275-y. Epub 2018 Dec 11.

9.

Triage for selection to colonoscopy?

Mertz-Petersen M, Piper TB, Kleif J, Ferm L, Christensen IJ, Nielsen HJ; Danish Collaborative Group on Early Detection of Colorectal Neoplasia.

Eur J Surg Oncol. 2018 Oct;44(10):1539-1541. doi: 10.1016/j.ejso.2018.06.013. Epub 2018 Jun 23.

PMID:
30251643
10.

Genomic alterations accompanying tumour evolution in colorectal cancer: tracking the differences between primary tumours and synchronous liver metastases by whole-exome sequencing.

Mogensen MB, Rossing M, Østrup O, Larsen PN, Heiberg Engel PJ, Jørgensen LN, Hogdall EV, Eriksen J, Ibsen P, Jess P, Grauslund M, Nielsen HJ, Nielsen FC, Vainer B, Osterlind K.

BMC Cancer. 2018 Jul 20;18(1):752. doi: 10.1186/s12885-018-4639-4.

11.

Clean Colorectum at Diagnostic Colonoscopy: Subsequent Detection of Extracolonic Malignancies by Plasma Protein Biomarkers?

Wilhelmsen M, Christensen IJ, Jørgensen LN, Madsen MR, Vilandt J, Hillig T, Klærke M, Nielsen KT, Laurberg S, Gawel S, Yang X, Davis G, Heijboer AM, Martens F, Nielsen HJ.

Biomark Cancer. 2018 May 30;10:1179299X18776974. doi: 10.1177/1179299X18776974. eCollection 2018.

12.

Circulating cell-free nucleosomes as biomarkers for early detection of colorectal cancer.

Rasmussen L, Christensen IJ, Herzog M, Micallef J, Nielsen HJ; Danish Collaborative Group on Early Detection of Colorectal Cancer.

Oncotarget. 2017 Oct 20;9(12):10247-10258. doi: 10.18632/oncotarget.21908. eCollection 2018 Feb 13.

13.

Direct detection of early-stage cancers using circulating tumor DNA.

Phallen J, Sausen M, Adleff V, Leal A, Hruban C, White J, Anagnostou V, Fiksel J, Cristiano S, Papp E, Speir S, Reinert T, Orntoft MW, Woodward BD, Murphy D, Parpart-Li S, Riley D, Nesselbush M, Sengamalay N, Georgiadis A, Li QK, Madsen MR, Mortensen FV, Huiskens J, Punt C, van Grieken N, Fijneman R, Meijer G, Husain H, Scharpf RB, Diaz LA Jr, Jones S, Angiuoli S, Ørntoft T, Nielsen HJ, Andersen CL, Velculescu VE.

Sci Transl Med. 2017 Aug 16;9(403). pii: eaan2415. doi: 10.1126/scitranslmed.aan2415.

14.

Discovery and validation of a colorectal cancer classifier in a new blood test with improved performance for high-risk subjects.

Croner LJ, Dillon R, Kao A, Kairs SN, Benz R, Christensen IJ, Nielsen HJ, Blume JE, Wilcox B.

Clin Proteomics. 2017 Jul 25;14:28. doi: 10.1186/s12014-017-9163-z. eCollection 2017.

15.

Clinical Implications of Monitoring Circulating Tumor DNA in Patients with Colorectal Cancer.

Schøler LV, Reinert T, Ørntoft MW, Kassentoft CG, Árnadóttir SS, Vang S, Nordentoft I, Knudsen M, Lamy P, Andreasen D, Mortensen FV, Knudsen AR, Stribolt K, Sivesgaard K, Mouritzen P, Nielsen HJ, Laurberg S, Ørntoft TF, Andersen CL.

Clin Cancer Res. 2017 Sep 15;23(18):5437-5445. doi: 10.1158/1078-0432.CCR-17-0510. Epub 2017 Jun 9.

16.

Serological biomarkers in triage of FIT-positive subjects?

Nielsen HJ, Christensen IJ, Andersen B, Rasmussen M, Friis-Hansen LJ, Bygott T, MiCallef J; Danish–Belgian Research Group on Early Detection of Colorectal Cancer.

Scand J Gastroenterol. 2017 Jun - Jul;52(6-7):742-744. doi: 10.1080/00365521.2017.1299212. Epub 2017 Mar 8.

PMID:
28271924
17.

Detection of colorectal neoplasia: Combination of eight blood-based, cancer-associated protein biomarkers.

Wilhelmsen M, Christensen IJ, Rasmussen L, Jørgensen LN, Madsen MR, Vilandt J, Hillig T, Klaerke M, Nielsen KT, Laurberg S, Brünner N, Gawel S, Yang X, Davis G, Heijboer A, Martens F, Nielsen HJ.

Int J Cancer. 2017 Mar 15;140(6):1436-1446. doi: 10.1002/ijc.30558.

18.

Protocol Outlines for Parts 1 and 2 of the Prospective Endoscopy III Study for the Early Detection of Colorectal Cancer: Validation of a Concept Based on Blood Biomarkers.

Rasmussen L, Wilhelmsen M, Christensen IJ, Andersen J, Jørgensen LN, Rasmussen M, Hendel JW, Madsen MR, Vilandt J, Hillig T, Klærke M, Münster AM, Andersen LM, Andersen B, Hornung N, Erlandsen EJ, Khalid A, Nielsen HJ.

JMIR Res Protoc. 2016 Sep 13;5(3):e182. doi: 10.2196/resprot.6346.

19.

miRNA profiling of circulating EpCAM(+) extracellular vesicles: promising biomarkers of colorectal cancer.

Ostenfeld MS, Jensen SG, Jeppesen DK, Christensen LL, Thorsen SB, Stenvang J, Hvam ML, Thomsen A, Mouritzen P, Rasmussen MH, Nielsen HJ, Ørntoft TF, Andersen CL.

J Extracell Vesicles. 2016 Aug 29;5:31488. doi: 10.3402/jev.v5.31488. eCollection 2016.

20.

TIMP-1 is under regulation of the EGF signaling axis and promotes an aggressive phenotype in KRAS-mutated colorectal cancer cells: a potential novel approach to the treatment of metastatic colorectal cancer.

Tarpgaard LS, Ørum-Madsen MS, Christensen IJ, Nordgaard C, Noer J, Guren TK, Glimelius B, Sorbye H, Ikdahl T, Kure EH, Tveit KM, Nielsen HJ, Pfeiffer P, Brünner N, Moreira JM.

Oncotarget. 2016 Sep 13;7(37):59441-59457. doi: 10.18632/oncotarget.11118.

21.

Increased serological cancer-associated biomarkers and risk of development of primary malignancy after large bowel endoscopy.

Nielsen HJ.

Scand J Gastroenterol. 2016 Oct;51(10):1272. doi: 10.1080/00365521.2016.1195442. Epub 2016 Jun 16. No abstract available.

PMID:
27310310
22.

Pre-analytical variables of circulating cell-free nucleosomes containing 5-methylcytosine DNA or histone modification H3K9Me3.

Rasmussen L, Herzog M, Rømer E, Micallef J, Bulut O, Wilhelmsen M, Christensen IJ, Nielsen HJ.

Scand J Clin Lab Invest. 2016 Oct;76(6):448-53. doi: 10.1080/00365513.2016.1190862. Epub 2016 Jun 13.

PMID:
27291394
23.

Localization of active, dually phosphorylated extracellular signal-regulated kinase 1 and 2 in colorectal cancer with or without activating BRAF and KRAS mutations.

Holck S, Bonde J, Pedersen H, Petersen AA, Chaube A, Nielsen HJ, Larsson LI.

Hum Pathol. 2016 Aug;54:37-46. doi: 10.1016/j.humpath.2016.03.001. Epub 2016 Mar 29.

24.

Increased serological cancer-associated biomarker levels at large bowel endoscopy and risk of subsequent primary cancer (†).

Hvolris MH, Piper TB, Hammer E, Jørgensen LN, Olsen J, Rahr HB, Nielsen KT, Laurberg S, Christensen IJ, Brünner N, Johansen JS, Davis GJ, Dowell BL, Nielsen HJ.

Scand J Gastroenterol. 2016 Jul;51(7):860-5. doi: 10.3109/00365521.2016.1144783. Epub 2016 Feb 26.

PMID:
26918701
25.

The Prognostic and Predictive Value of Soluble Type IV Collagen in Colorectal Cancer: A Retrospective Multicenter Study.

Rolff HC, Christensen IJ, Vainer B, Svendsen LB, Eefsen RL, Wilhelmsen M, Lund IK, Høyer-Hansen G, Nielsen HJ, Illemann M; Danish Collaborative Research Group on Colorectal Cancer.

Clin Cancer Res. 2016 May 15;22(10):2427-34. doi: 10.1158/1078-0432.CCR-15-2342. Epub 2015 Dec 16.

26.

Blood-based Biomarkers at Large Bowel Endoscopy and Prediction of Future Malignancies.

Kring TS, Piper TB, Jørgensen LN, Olsen J, Rahr HB, Nielsen KT, Laurberg S, Davis G, Dowell B, Johansen JS, Christensen IJ, Brünner N, Nielsen HJ.

Biomark Cancer. 2015 Oct 22;7:57-61. doi: 10.4137/BIC.S31330. eCollection 2015.

27.

Performance of the colorectal cancer screening marker Sept9 is influenced by age, diabetes and arthritis: a nested case-control study.

Ørntoft MB, Nielsen HJ, Ørntoft TF, Andersen CL; Danish Study Group on Early Detection of Colorectal Cancer.

BMC Cancer. 2015 Oct 29;15:819. doi: 10.1186/s12885-015-1832-6.

28.

Plasma levels of OLFM4 in normals and patients with gastrointestinal cancer.

Clemmensen SN, Glenthøj AJ, Heebøll S, Nielsen HJ, Koch C, Borregaard N.

J Cell Mol Med. 2015 Dec;19(12):2865-73. doi: 10.1111/jcmm.12679. Epub 2015 Sep 28.

29.

Phospho-ERK1/2 levels in cancer cell nuclei predict responsiveness to radiochemotherapy of rectal adenocarcinoma.

Holck S, Nielsen HJ, Pedersen N, Larsson LI.

Oncotarget. 2015 Oct 27;6(33):34321-8. doi: 10.18632/oncotarget.5761.

30.

Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer.

Yu J, Feng Q, Wong SH, Zhang D, Liang QY, Qin Y, Tang L, Zhao H, Stenvang J, Li Y, Wang X, Xu X, Chen N, Wu WK, Al-Aama J, Nielsen HJ, Kiilerich P, Jensen BA, Yau TO, Lan Z, Jia H, Li J, Xiao L, Lam TY, Ng SC, Cheng AS, Wong VW, Chan FK, Xu X, Yang H, Madsen L, Datz C, Tilg H, Wang J, Brünner N, Kristiansen K, Arumugam M, Sung JJ, Wang J.

Gut. 2017 Jan;66(1):70-78. doi: 10.1136/gutjnl-2015-309800. Epub 2015 Sep 25.

PMID:
26408641
31.

Plasma TIMP-1 and CEA as Markers for Detection of Primary Colorectal Cancer: A Prospective Validation Study Including Symptomatic and Non-symptomatic Individuals.

Christensen IJ, Brünner N, Dowell B, Davis G, Nielsen HJ, Newstead G, King D.

Anticancer Res. 2015 Sep;35(9):4935-41.

PMID:
26254391
32.

Topoisomerase-1 and -2A gene copy numbers are elevated in mismatch repair-proficient colorectal cancers.

Sønderstrup IM, Nygård SB, Poulsen TS, Linnemann D, Stenvang J, Nielsen HJ, Bartek J, Brünner N, Nørgaard P, Riis L.

Mol Oncol. 2015 Jun;9(6):1207-17. doi: 10.1016/j.molonc.2015.02.009. Epub 2015 Mar 4.

33.

Intact and cleaved plasma soluble urokinase receptor in patients with metastatic colorectal cancer treated with oxaliplatin with or without cetuximab.

Tarpgaard LS, Christensen IJ, Høyer-Hansen G, Lund IK, Guren TK, Glimelius B, Sorbye H, Tveit KM, Nielsen HJ, Moreira JM, Pfeiffer P, Brünner N.

Int J Cancer. 2015 Nov 15;137(10):2470-7. doi: 10.1002/ijc.29476. Epub 2015 Mar 9.

34.

Analysis of circulating tumour DNA to monitor disease burden following colorectal cancer surgery.

Reinert T, Schøler LV, Thomsen R, Tobiasen H, Vang S, Nordentoft I, Lamy P, Kannerup AS, Mortensen FV, Stribolt K, Hamilton-Dutoit S, Nielsen HJ, Laurberg S, Pallisgaard N, Pedersen JS, Ørntoft TF, Andersen CL.

Gut. 2016 Apr;65(4):625-34. doi: 10.1136/gutjnl-2014-308859. Epub 2015 Feb 4.

PMID:
25654990
35.

TIMP-1 and CEA as biomarkers in third-line treatment with irinotecan and cetuximab for metastatic colorectal cancer.

Spindler KL, Christensen IJ, Nielsen HJ, Jakobsen A, Brünner N.

Tumour Biol. 2015 Jun;36(6):4301-8. doi: 10.1007/s13277-015-3069-z. Epub 2015 Jan 23.

PMID:
25608838
36.

Serum YKL-40 in risk assessment for colorectal cancer: a prospective study of 4,496 subjects at risk of colorectal cancer.

Johansen JS, Christensen IJ, Jørgensen LN, Olsen J, Rahr HB, Nielsen KT, Laurberg S, Brünner N, Nielsen HJ.

Cancer Epidemiol Biomarkers Prev. 2015 Mar;24(3):621-6. doi: 10.1158/1055-9965.EPI-13-1281. Epub 2015 Jan 18.

37.

Time course for the recovery of physical performance, blood hemoglobin, and ferritin content after blood donation.

Ziegler AK, Grand J, Stangerup I, Nielsen HJ, Dela F, Magnussen K, Helge JW.

Transfusion. 2015 Apr;55(4):898-905. doi: 10.1111/trf.12926. Epub 2014 Dec 16.

PMID:
25512178
38.

A randomized pilot study on single-port versus conventional laparoscopic rectal surgery: effects on postoperative pain and the stress response to surgery.

Bulut O, Aslak KK, Levic K, Nielsen CB, Rømer E, Sørensen S, Christensen IJ, Nielsen HJ.

Tech Coloproctol. 2015 Jan;19(1):11-22. doi: 10.1007/s10151-014-1237-6. Epub 2014 Nov 8.

PMID:
25380743
39.

Determinants of recurrence after intended curative resection for colorectal cancer.

Wilhelmsen M, Kring T, Jorgensen LN, Madsen MR, Jess P, Bulut O, Nielsen KT, Andersen CL, Nielsen HJ.

Scand J Gastroenterol. 2014 Dec;49(12):1399-408. doi: 10.3109/00365521.2014.926981. Epub 2014 Nov 5. Review.

PMID:
25370351
40.

[Screening methods for colorectal cancer can be improved].

Rasmussen L, Jørgensen LN, Madsen MR, Vilandt J, Klærke M, Andersen J, Nielsen KT, Khalid A, Laurberg S, Andersen CL, Christensen IJ, Brünner N, Nielsen HJ.

Ugeskr Laeger. 2014 Mar 10;176(11B). pii: V09130545. Review. Danish.

PMID:
25350810
41.

Circulating intact and cleaved forms of the urokinase-type plasminogen activator receptor: biological variation, reference intervals and clinical useful cut-points.

Thurison T, Christensen IJ, Lund IK, Nielsen HJ, Høyer-Hansen G.

Clin Chim Acta. 2015 Jan 15;439:84-90. doi: 10.1016/j.cca.2014.10.004. Epub 2014 Oct 13.

PMID:
25305537
42.

IQGAP1 in rectal adenocarcinomas: localization and protein expression before and after radiochemotherapy.

Holck S, Nielsen HJ, Hammer E, Christensen IJ, Larsson LI.

Cancer Lett. 2015 Jan 28;356(2 Pt B):556-60. doi: 10.1016/j.canlet.2014.10.005. Epub 2014 Oct 8.

PMID:
25305455
43.
44.

Evaluation of complement proteins as screening markers for colorectal cancer.

Storm L, Christensen IJ, Jensenius JC, Nielsen HJ, Thiel S; Danish Study Group on Early Detection of Colorectal Cancer.

Cancer Immunol Immunother. 2015 Jan;64(1):41-50. doi: 10.1007/s00262-014-1615-y. Epub 2014 Sep 27.

PMID:
25261356
45.

Mannan-binding lectin polymorphisms and serum levels in patients with endometriosis.

Kruse C, Steffensen R, Nielsen HJ, Jensenius JC.

Eur J Obstet Gynecol Reprod Biol. 2014 Oct;181:256-8. doi: 10.1016/j.ejogrb.2014.08.012. Epub 2014 Aug 17.

PMID:
25190300
46.

TIMP-1 in patients with cirrhosis: relation to liver dysfunction, portal hypertension, and hemodynamic changes.

Busk TM, Bendtsen F, Nielsen HJ, Jensen V, Brünner N, Møller S.

Scand J Gastroenterol. 2014 Sep;49(9):1103-10. doi: 10.3109/00365521.2014.934910. Epub 2014 Jul 22.

PMID:
25048331
47.

Urokinase-type plasminogen activator receptor (uPAR) on tumor-associated macrophages is a marker of poor prognosis in colorectal cancer.

Illemann M, Laerum OD, Hasselby JP, Thurison T, Høyer-Hansen G, Nielsen HJ; Danish Study Group on Early Detection of Colorectal Cancer, Christensen IJ.

Cancer Med. 2014 Aug;3(4):855-64. doi: 10.1002/cam4.242. Epub 2014 May 30.

48.

Prognostic and predictive value of cathepsin X in serum from colorectal cancer patients.

Vižin T, Christensen IJ, Wilhelmsen M, Nielsen HJ, Kos J.

BMC Cancer. 2014 Apr 13;14:259. doi: 10.1186/1471-2407-14-259.

49.

COL6A3 expression in adipocytes associates with insulin resistance and depends on PPARγ and adipocyte size.

Dankel SN, Svärd J, Matthä S, Claussnitzer M, Klöting N, Glunk V, Fandalyuk Z, Grytten E, Solsvik MH, Nielsen HJ, Busch C, Hauner H, Blüher M, Skurk T, Sagen JV, Mellgren G.

Obesity (Silver Spring). 2014 Aug;22(8):1807-13. doi: 10.1002/oby.20758. Epub 2014 Apr 10.

50.

Measuring ERCC1 protein expression in cancer specimens: validation of a novel antibody.

Smith DH, Fiehn AM, Fogh L, Christensen IJ, Hansen TP, Stenvang J, Nielsen HJ, Nielsen KV, Hasselby JP, Brünner N, Jensen SS.

Sci Rep. 2014 Mar 7;4:4313. doi: 10.1038/srep04313.

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