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Items: 38

1.

Relationship between factor VIII activity, bleeds and individual characteristics in severe hemophilia A patients.

Abrantes JA, Solms A, Garmann D, Nielsen EI, Jönsson S, Karlsson MO.

Haematologica. 2019 Aug 1. pii: haematol.2019.217133. doi: 10.3324/haematol.2019.217133. [Epub ahead of print]

2.

Population pharmacokinetics of piperacillin in febrile children receiving cancer chemotherapy: the impact of body weight and target on an optimal dosing regimen.

Thorsted A, Kristoffersson AN, Maarbjerg SF, Schrøder H, Wang M, Brock B, Nielsen EI, Friberg LE.

J Antimicrob Chemother. 2019 Jul 4. pii: dkz270. doi: 10.1093/jac/dkz270. [Epub ahead of print]

PMID:
31273375
3.

Pharmacokinetics of Caspofungin in Critically Ill Patients in Relation to Liver Dysfunction: Differential Impact of Plasma Albumin and Bilirubin Levels.

Kurland S, Furebring M, Löwdin E, Eliasson E, Nielsen EI, Sjölin J.

Antimicrob Agents Chemother. 2019 May 24;63(6). pii: e02466-18. doi: 10.1128/AAC.02466-18. Print 2019 Jun.

PMID:
30962329
4.

A non-linear mixed effect model for innate immune response: In vivo kinetics of endotoxin and its induction of the cytokines tumor necrosis factor alpha and interleukin-6.

Thorsted A, Bouchene S, Tano E, Castegren M, Lipcsey M, Sjölin J, Karlsson MO, Friberg LE, Nielsen EI.

PLoS One. 2019 Feb 21;14(2):e0211981. doi: 10.1371/journal.pone.0211981. eCollection 2019.

5.

Handling interoccasion variability in model-based dose individualization using therapeutic drug monitoring data.

Abrantes JA, Jönsson S, Karlsson MO, Nielsen EI.

Br J Clin Pharmacol. 2019 Jun;85(6):1326-1336. doi: 10.1111/bcp.13901. Epub 2019 Apr 29.

PMID:
30767254
6.

Piperacillin pharmacokinetics and target attainment in children with cancer and fever: Can we optimize our dosing strategy?

Maarbjerg SF, Thorsted A, Kristoffersson A, Friberg LE, Nielsen EI, Wang M, Brock B, Schrøder H.

Pediatr Blood Cancer. 2019 Jun;66(6):e27654. doi: 10.1002/pbc.27654. Epub 2019 Feb 10.

PMID:
30740885
7.

Population pharmacokinetics of levodopa/carbidopa microtablets in healthy subjects and Parkinson's disease patients.

Senek M, Nyholm D, Nielsen EI.

Eur J Clin Pharmacol. 2018 Oct;74(10):1299-1307. doi: 10.1007/s00228-018-2497-2. Epub 2018 Jun 7.

8.

Real life experiences of a PK dosing study-Challenges and lessons learned.

Mangles S, Rea C, Madan B, Nielsen EI, Jönsson S, Needham J, Collins PW, Rangarajan S.

Haemophilia. 2018 May;24(3):e145-e148. doi: 10.1111/hae.13470. Epub 2018 Apr 6. No abstract available.

PMID:
29626381
9.

Semi-mechanistic pharmacokinetic-pharmacodynamic modelling of antibiotic drug combinations.

Brill MJE, Kristoffersson AN, Zhao C, Nielsen EI, Friberg LE.

Clin Microbiol Infect. 2018 Jul;24(7):697-706. doi: 10.1016/j.cmi.2017.11.023. Epub 2017 Dec 8. Review.

10.

The risk of febrile neutropenia in breast cancer patients following adjuvant chemotherapy is predicted by the time course of interleukin-6 and C-reactive protein by modelling.

Netterberg I, Karlsson MO, Nielsen EI, Quartino AL, Lindman H, Friberg LE.

Br J Clin Pharmacol. 2018 Mar;84(3):490-500. doi: 10.1111/bcp.13477. Epub 2018 Jan 18.

11.

Predicting mutant selection in competition experiments with ciprofloxacin-exposed Escherichia coli.

Khan DD, Lagerbäck P, Malmberg C, Kristoffersson AN, Wistrand-Yuen E, Sha C, Cars O, Andersson DI, Hughes D, Nielsen EI, Friberg LE.

Int J Antimicrob Agents. 2018 Mar;51(3):399-406. doi: 10.1016/j.ijantimicag.2017.10.019. Epub 2017 Nov 7.

PMID:
29127049
12.

Automated time-lapse microscopy a novel method for screening of antibiotic combination effects against multidrug-resistant Gram-negative bacteria.

Ungphakorn W, Lagerbäck P, Nielsen EI, Tängdén T.

Clin Microbiol Infect. 2018 Jul;24(7):778.e7-778.e14. doi: 10.1016/j.cmi.2017.10.029. Epub 2017 Nov 3.

13.

Can a pharmacokinetic/pharmacodynamic (PKPD) model be predictive across bacterial densities and strains? External evaluation of a PKPD model describing longitudinal in vitro data.

Nielsen EI, Khan DD, Cao S, Lustig U, Hughes D, Andersson DI, Friberg LE.

J Antimicrob Chemother. 2017 Nov 1;72(11):3108-3116. doi: 10.1093/jac/dkx269.

PMID:
28961946
14.

Medication Reviews Bridging Healthcare (MedBridge): Study protocol for a pragmatic cluster-randomised crossover trial.

Kempen TGH, Bertilsson M, Lindner KJ, Sulku J, Nielsen EI, Högberg A, Vikerfors T, Melhus H, Gillespie U.

Contemp Clin Trials. 2017 Oct;61:126-132. doi: 10.1016/j.cct.2017.07.019. Epub 2017 Jul 21.

PMID:
28739539
15.

Population Pharmacokinetic Analysis of Vaginally and Intravenously Administered Oxytocin in Postmenopausal Women.

Nielsen EI, Al-Saqi SH, Jonasson AF, Uvnäs-Moberg K.

J Clin Pharmacol. 2017 Dec;57(12):1573-1581. doi: 10.1002/jcph.961. Epub 2017 Jul 5.

PMID:
28679021
16.

Model-based prediction of myelosuppression and recovery based on frequent neutrophil monitoring.

Netterberg I, Nielsen EI, Friberg LE, Karlsson MO.

Cancer Chemother Pharmacol. 2017 Aug;80(2):343-353. doi: 10.1007/s00280-017-3366-x. Epub 2017 Jun 27.

17.

Population Pharmacokinetic Modeling as a Tool To Characterize the Decrease in Ciprofloxacin Free Interstitial Levels Caused by Pseudomonas aeruginosa Biofilm Lung Infection in Wistar Rats.

Torres BGS, Helfer VE, Bernardes PM, Macedo AJ, Nielsen EI, Friberg LE, Dalla Costa T.

Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e02553-16. doi: 10.1128/AAC.02553-16. Print 2017 Jul.

18.

Elucidation of Factor VIII Activity Pharmacokinetics: A Pooled Population Analysis in Patients With Hemophilia A Treated With Moroctocog Alfa.

Abrantes JA, Nielsen EI, Korth-Bradley J, Harnisch L, Jönsson S.

Clin Pharmacol Ther. 2017 Dec;102(6):977-988. doi: 10.1002/cpt.716. Epub 2017 May 30.

PMID:
28437834
19.

The role of infection models and PK/PD modelling for optimising care of critically ill patients with severe infections.

Tängdén T, Ramos Martín V, Felton TW, Nielsen EI, Marchand S, Brüggemann RJ, Bulitta JB, Bassetti M, Theuretzbacher U, Tsuji BT, Wareham DW, Friberg LE, De Waele JJ, Tam VH, Roberts JA; Infection Section for the European Society of Intensive Care Medicine, the Pharmacokinetics and Pharmacodynamics Study Group of the European Society of Clinical Microbiology and Infectious Diseases, the International Society of Anti-Infective Pharmacology and the Critically Ill Patients Study Group of European Society of Clinical Microbiology and Infectious Diseases.

Intensive Care Med. 2017 Jul;43(7):1021-1032. doi: 10.1007/s00134-017-4780-6. Epub 2017 Apr 13. Review.

PMID:
28409203
20.

A non-fatal intoxication and seven deaths involving the dissociative drug 3-MeO-PCP.

Johansson A, Lindstedt D, Roman M, Thelander G, Nielsen EI, Lennborn U, Sandler H, Rubertsson S, Ahlner J, Kronstrand R, Kugelberg FC.

Forensic Sci Int. 2017 Jun;275:76-82. doi: 10.1016/j.forsciint.2017.02.034. Epub 2017 Mar 7.

PMID:
28324770
21.

Levodopa-entacapone-carbidopa intestinal gel in Parkinson's disease: A randomized crossover study.

Senek M, Nielsen EI, Nyholm D.

Mov Disord. 2017 Feb;32(2):283-286. doi: 10.1002/mds.26855. Epub 2016 Dec 17.

PMID:
27987231
22.

Evaluation of automated time-lapse microscopy for assessment of in vitro activity of antibiotics.

Ungphakorn W, Malmberg C, Lagerbäck P, Cars O, Nielsen EI, Tängdén T.

J Microbiol Methods. 2017 Jan;132:69-75. doi: 10.1016/j.mimet.2016.11.001. Epub 2016 Nov 9.

PMID:
27836633
23.

A whole-body physiologically based pharmacokinetic (WB-PBPK) model of ciprofloxacin: a step towards predicting bacterial killing at sites of infection.

Sadiq MW, Nielsen EI, Khachman D, Conil JM, Georges B, Houin G, Laffont CM, Karlsson MO, Friberg LE.

J Pharmacokinet Pharmacodyn. 2017 Apr;44(2):69-79. doi: 10.1007/s10928-016-9486-9. Epub 2016 Aug 30.

24.

A pharmacokinetic-pharmacodynamic model characterizing the emergence of resistant Escherichia coli subpopulations during ertapenem exposure.

Ungphakorn W, Tängdén T, Sandegren L, Nielsen EI.

J Antimicrob Chemother. 2016 Sep;71(9):2521-33. doi: 10.1093/jac/dkw205. Epub 2016 Jun 20.

PMID:
27330073
25.

Development and Evaluation of a Gentamicin Pharmacokinetic Model That Facilitates Opportunistic Gentamicin Therapeutic Drug Monitoring in Neonates and Infants.

Germovsek E, Kent A, Metsvaht T, Lutsar I, Klein N, Turner MA, Sharland M, Nielsen EI, Heath PT, Standing JF.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4869-77. doi: 10.1128/AAC.00577-16. Print 2016 Aug.

26.

A pharmacokinetic-pharmacodynamic (PKPD) model based on in vitro time-kill data predicts the in vivo PK/PD index of colistin.

Khan DD, Friberg LE, Nielsen EI.

J Antimicrob Chemother. 2016 Jul;71(7):1881-4. doi: 10.1093/jac/dkw057. Epub 2016 Mar 16.

PMID:
26983860
27.

Dynamic interaction of colistin and meropenem on a WT and a resistant strain of Pseudomonas aeruginosa as quantified in a PK/PD model.

Mohamed AF, Kristoffersson AN, Karvanen M, Nielsen EI, Cars O, Friberg LE.

J Antimicrob Chemother. 2016 May;71(5):1279-90. doi: 10.1093/jac/dkv488. Epub 2016 Feb 4.

PMID:
26850719
28.

Population pharmacokinetics of plasma-derived factor IX: procedures for dose individualization.

Brekkan A, Berntorp E, Jensen K, Nielsen EI, Jönsson S.

J Thromb Haemost. 2016 Apr;14(4):724-32. doi: 10.1111/jth.13271. Epub 2016 Feb 23. Erratum in: J Thromb Haemost. 2016 Aug;14(8):1677.

29.

Simulation-Based Evaluation of PK/PD Indices for Meropenem Across Patient Groups and Experimental Designs.

Kristoffersson AN, David-Pierson P, Parrott NJ, Kuhlmann O, Lave T, Friberg LE, Nielsen EI.

Pharm Res. 2016 May;33(5):1115-25. doi: 10.1007/s11095-016-1856-x. Epub 2016 Jan 19.

PMID:
26786016
30.

A mechanism-based pharmacokinetic/pharmacodynamic model allows prediction of antibiotic killing from MIC values for WT and mutants.

Khan DD, Lagerbäck P, Cao S, Lustig U, Nielsen EI, Cars O, Hughes D, Andersson DI, Friberg LE.

J Antimicrob Chemother. 2015 Nov;70(11):3051-60. doi: 10.1093/jac/dkv233. Epub 2015 Sep 7.

PMID:
26349518
31.

A neonatal amikacin covariate model can be used to predict ontogeny of other drugs eliminated through glomerular filtration in neonates.

De Cock RF, Allegaert K, Sherwin CM, Nielsen EI, de Hoog M, van den Anker JN, Danhof M, Knibbe CA.

Pharm Res. 2014 Mar;31(3):754-67. doi: 10.1007/s11095-013-1197-y. Epub 2013 Sep 25.

32.

Population pharmacokinetics of daptomycin in patients affected by severe Gram-positive infections.

Di Paolo A, Tascini C, Polillo M, Gemignani G, Nielsen EI, Bocci G, Karlsson MO, Menichetti F, Danesi R.

Int J Antimicrob Agents. 2013 Sep;42(3):250-5. doi: 10.1016/j.ijantimicag.2013.06.006. Epub 2013 Jul 25.

PMID:
23891432
33.

Pharmacokinetic-pharmacodynamic modeling of antibacterial drugs.

Nielsen EI, Friberg LE.

Pharmacol Rev. 2013 Jun 26;65(3):1053-90. doi: 10.1124/pr.111.005769. Print 2013 Jul. Review.

PMID:
23803529
34.

Pharmacokinetic-pharmacodynamic model for gentamicin and its adaptive resistance with predictions of dosing schedules in newborn infants.

Mohamed AF, Nielsen EI, Cars O, Friberg LE.

Antimicrob Agents Chemother. 2012 Jan;56(1):179-88. doi: 10.1128/AAC.00694-11. Epub 2011 Oct 28.

35.

Pharmacokinetic/pharmacodynamic (PK/PD) indices of antibiotics predicted by a semimechanistic PKPD model: a step toward model-based dose optimization.

Nielsen EI, Cars O, Friberg LE.

Antimicrob Agents Chemother. 2011 Oct;55(10):4619-30. doi: 10.1128/AAC.00182-11. Epub 2011 Aug 1.

36.

Predicting in vitro antibacterial efficacy across experimental designs with a semimechanistic pharmacokinetic-pharmacodynamic model.

Nielsen EI, Cars O, Friberg LE.

Antimicrob Agents Chemother. 2011 Apr;55(4):1571-9. doi: 10.1128/AAC.01286-10. Epub 2011 Jan 31.

37.

Developmental pharmacokinetics of gentamicin in preterm and term neonates: population modelling of a prospective study.

Nielsen EI, Sandström M, Honoré PH, Ewald U, Friberg LE.

Clin Pharmacokinet. 2009;48(4):253-63. doi: 10.2165/00003088-200948040-00003.

PMID:
19492870
38.

Semimechanistic pharmacokinetic/pharmacodynamic model for assessment of activity of antibacterial agents from time-kill curve experiments.

Nielsen EI, Viberg A, Löwdin E, Cars O, Karlsson MO, Sandström M.

Antimicrob Agents Chemother. 2007 Jan;51(1):128-36. Epub 2006 Oct 23.

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