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Monitoring CD8a+ T Cell Responses to Radiotherapy and CTLA-4 Blockade Using [64Cu]NOTA-CD8a PET Imaging.

Kristensen LK, Christensen C, Alfsen MZ, Cold S, Nielsen CH, Kjaer A.

Mol Imaging Biol. 2020 Feb 21. doi: 10.1007/s11307-020-01481-0. [Epub ahead of print]


Nutrient Restriction has Limited Short-Term Effects on Gut, Immunity, and Brain Development in Preterm Pigs.

Ahnfeldt AM, Bæk O, Hui Y, Nielsen CH, Obelitz-Ryom K, Busk-Anderson T, Ruge A, Holst JJ, Rudloff S, Burrin D, Nguyen DN, Nielsen DS, Zachariassen G, Bering SB, Thymann T, Sangild PT.

J Nutr. 2020 Feb 18. pii: nxaa030. doi: 10.1093/jn/nxaa030. [Epub ahead of print]


Alpha-Lactalbumin Enriched Whey Protein Concentrate to Improve Gut, Immunity and Brain Development in Preterm Pigs.

Nielsen CH, Hui Y, Nguyen DN, Ahnfeldt AM, Burrin DG, Hartmann B, Heckmann AB, Sangild PT, Thymann T, Bering SB.

Nutrients. 2020 Jan 17;12(1). pii: E245. doi: 10.3390/nu12010245.


Quantitative PET imaging of PD-L1 expression in xenograft and syngeneic tumour models using a site-specifically labelled PD-L1 antibody.

Christensen C, Kristensen LK, Alfsen MZ, Nielsen CH, Kjaer A.

Eur J Nucl Med Mol Imaging. 2020 May;47(5):1302-1313. doi: 10.1007/s00259-019-04646-4. Epub 2019 Dec 27.


Ruxolitinib and interferon-α2 combination therapy for patients with polycythemia vera or myelofibrosis: a phase II study.

Sørensen AL, Mikkelsen SU, Knudsen TA, Bjørn ME, Andersen CL, Bjerrum OW, Brochmann N, Patel DA, Gjerdrum LMR, El Fassi D, Kruse TA, Larsen TS, Mourits-Andersen HT, Nielsen CH, Ellervik C, Pallisgaard N, Thomassen M, Kjær L, Skov V, Hasselbalch HC.

Haematologica. 2019 Dec 26. pii: haematol.2019.235648. doi: 10.3324/haematol.2019.235648. [Epub ahead of print]


CD4+ and CD8a+ PET imaging predicts response to novel PD-1 checkpoint inhibitor: studies of Sym021 in syngeneic mouse cancer models.

Kristensen LK, Fröhlich C, Christensen C, Melander MC, Poulsen TT, Galler GR, Lantto J, Horak ID, Kragh M, Nielsen CH, Kjaer A.

Theranostics. 2019 Oct 18;9(26):8221-8238. doi: 10.7150/thno.37513. eCollection 2019.


Citrullination of fibrinogen by peptidylarginine deiminase 2 impairs fibrin clot structure.

Damiana T, Damgaard D, Sidelmann JJ, Nielsen CH, de Maat MPM, Münster AB, Palarasah Y.

Clin Chim Acta. 2020 Feb;501:6-11. doi: 10.1016/j.cca.2019.10.033. Epub 2019 Nov 12.


Proteomics-Based Comparative Mapping of the Secretomes of Human Brown and White Adipocytes Reveals EPDR1 as a Novel Batokine.

Deshmukh AS, Peijs L, Beaudry JL, Jespersen NZ, Nielsen CH, Ma T, Brunner AD, Larsen TJ, Bayarri-Olmos R, Prabhakar BS, Helgstrand C, Severinsen MCK, Holst B, Kjaer A, Tang-Christensen M, Sanfridson A, Garred P, Privé GG, Pedersen BK, Gerhart-Hines Z, Nielsen S, Drucker DJ, Mann M, Scheele C.

Cell Metab. 2019 Nov 5;30(5):963-975.e7. doi: 10.1016/j.cmet.2019.10.001. Epub 2019 Oct 24.


Porphyromonas gingivalis in saliva associates with chronic and aggressive periodontitis.

Damgaard C, Danielsen AK, Enevold C, Massarenti L, Nielsen CH, Holmstrup P, Belstrøm D.

J Oral Microbiol. 2019 Aug 9;11(1):1653123. doi: 10.1080/20002297.2019.1653123. eCollection 2019.


Expanding the citrullinome of synovial fibrinogen from rheumatoid arthritis patients.

Sharma M, Damgaard D, Senolt L, Svensson B, Bay-Jensen AC, Nielsen CH, Hägglund P.

J Proteomics. 2019 Sep 30;208:103484. doi: 10.1016/j.jprot.2019.103484. Epub 2019 Aug 10.


Thyroid Peroxidase Antibodies and Prospective Live Birth Rate: A Cohort Study of Women with Recurrent Pregnancy Loss.

Bliddal S, Feldt-Rasmussen U, Rasmussen ÅK, Kolte AM, Hilsted LM, Christiansen OB, Nielsen CH, Nielsen HS.

Thyroid. 2019 Oct;29(10):1465-1474. doi: 10.1089/thy.2019.0077. Epub 2019 Sep 24.


B-cell frequencies and immunoregulatory phenotypes in myeloproliferative neoplasms: Influence of ruxolitinib, interferon-α2, or combination treatment.

Sørensen AL, Bjørn ME, Riley CH, Holmstrøm M, Andersen MH, Svane IM, Mikkelsen SU, Skov V, Kjaer L, Hasselbalch HC, Nielsen CH.

Eur J Haematol. 2019 Oct;103(4):351-361. doi: 10.1111/ejh.13292. Epub 2019 Aug 18.


Site-specifically labeled 89Zr-DFO-trastuzumab improves immuno-reactivity and tumor uptake for immuno-PET in a subcutaneous HER2-positive xenograft mouse model.

Kristensen LK, Christensen C, Jensen MM, Agnew BJ, Schjöth-Frydendahl C, Kjaer A, Nielsen CH.

Theranostics. 2019 Jun 9;9(15):4409-4420. doi: 10.7150/thno.32883. eCollection 2019.


Associations between serum and plasma brain-derived neurotrophic factor and influence of storage time and centrifugation strategy.

Gejl AK, Enevold C, Bugge A, Andersen MS, Nielsen CH, Andersen LB.

Sci Rep. 2019 Jul 4;9(1):9655. doi: 10.1038/s41598-019-45976-5.


Release of active peptidylarginine deiminase into the circulation during acute inflammation induced by coronary artery bypass surgery.

Vejlstrup A, Møller AM, Nielsen CH, Damgaard D.

J Inflamm Res. 2019 May 29;12:137-144. doi: 10.2147/JIR.S198611. eCollection 2019.


Erythrocytes restrict microvesicle-induced production of reactive oxygen species by polymorphonuclear leukocytes.

Winberg LK, Rasmussen NS, Nielsen CH, Jacobsen S.

APMIS. 2019 Jul;127(7):538-542. doi: 10.1111/apm.12954. Epub 2019 May 24.


Lewis and AB0 blood group-phenotypes in periodontitis, cardiovascular disease, obesity and stroke.

Enevold C, Nielsen CH, Molbo D, Lund R, Bendtzen K, Fiehn NE, Holmstrup P.

Sci Rep. 2019 Apr 18;9(1):6283. doi: 10.1038/s41598-019-42594-z.


Affinity-Guided Conjugation to Antibodies for Use in Positron Emission Tomography.

Skovsgaard MB, Jeppesen TE, Mortensen MR, Nielsen CH, Madsen J, Kjaer A, Gothelf KV.

Bioconjug Chem. 2019 Mar 20;30(3):881-887. doi: 10.1021/acs.bioconjchem.9b00013. Epub 2019 Mar 12.


Ruxolitinib treatment reduces monocytic superoxide radical formation without affecting hydrogen peroxide formation or systemic oxidative nucleoside damage in myelofibrosis.

Bjørn ME, Brimnes MK, Gudbrandsdottir S, Andersen CL, Poulsen HE, Henriksen T, Hasselbalch HC, Nielsen CH.

Leuk Lymphoma. 2019 Oct;60(10):2549-2557. doi: 10.1080/10428194.2019.1579323. Epub 2019 Feb 20.


Oxime Coupling of Active Site Inhibited Factor Seven with a Nonvolatile, Water-Soluble Fluorine-18 Labeled Aldehyde.

Jeppesen TE, Kristensen LK, Nielsen CH, Petersen LC, Kristensen JB, Behrens C, Madsen J, Kjaer A.

Bioconjug Chem. 2019 Mar 20;30(3):775-784. doi: 10.1021/acs.bioconjchem.8b00900. Epub 2019 Feb 6.


Prognostic role of genetic polymorphisms of the interleukin-6 signaling pathway in patients with severe heart failure.

Hansen PR, Nelveg-Kristensen KE, Rasmussen HB, Torp-Pedersen C, Køber L, Nielsen CH, Enevold C.

Pharmacogenomics J. 2019 Oct;19(5):428-437. doi: 10.1038/s41397-019-0068-2. Epub 2019 Jan 17.


Surfactant Protein D Deficiency Aggravates Cigarette Smoke-Induced Lung Inflammation by Upregulation of Ceramide Synthesis.

Pilecki B, Wulf-Johansson H, Støttrup C, Jørgensen PT, Djiadeu P, Nexøe AB, Schlosser A, Hansen SWK, Madsen J, Clark HW, Nielsen CH, Vestbo J, Palaniyar N, Holmskov U, Sorensen GL.

Front Immunol. 2018 Dec 18;9:3013. doi: 10.3389/fimmu.2018.03013. eCollection 2018.


Statin treatment, oxidative stress and inflammation in a Danish population.

Sørensen AL, Hasselbalch HC, Nielsen CH, Poulsen HE, Ellervik C.

Redox Biol. 2019 Feb;21:101088. doi: 10.1016/j.redox.2018.101088. Epub 2018 Dec 21.


Assessment of Peptidylarginine Deiminase Activity by ELISA Using Human Fibrinogen as Substrate.

Damgaard D, Nielsen CH.

Methods Mol Biol. 2019;1901:239-242. doi: 10.1007/978-1-4939-8949-2_20.


Inflammatory functional iron deficiency common in myelofibrosis, contributes to anaemia and impairs quality of life. From the Nordic MPN study Group.

Birgegard G, Samuelsson J, Ahlstrand E, Ejerblad E, Enevold C, Ghanima W, Hasselbalch H, Nielsen CH, Knutsen H, Pedersen OB, Sørensen A, Andreasson B.

Eur J Haematol. 2019 Mar;102(3):235-240. doi: 10.1111/ejh.13198. Epub 2019 Jan 1.


Peptidylarginine deiminase-4 gene polymorphisms are associated with systemic lupus erythematosus and lupus nephritis.

Massarenti L, Enevold C, Damgaard D, Ødum N, Nielsen CH, Jacobsen S.

Scand J Rheumatol. 2019 Mar;48(2):133-140. doi: 10.1080/03009742.2018.1488273. Epub 2018 Sep 30.


Relative efficiencies of peptidylarginine deiminase 2 and 4 in generating target sites for anti-citrullinated protein antibodies in fibrinogen, alpha-enolase and histone H3.

Damgaard D, Bawadekar M, Senolt L, Stensballe A, Shelef MA, Nielsen CH.

PLoS One. 2018 Aug 30;13(8):e0203214. doi: 10.1371/journal.pone.0203214. eCollection 2018.


Safety and efficacy of combination therapy of interferon-α2 and ruxolitinib in polycythemia vera and myelofibrosis.

Mikkelsen SU, Kjaer L, Bjørn ME, Knudsen TA, Sørensen AL, Andersen CBL, Bjerrum OW, Brochmann N, Fassi DE, Kruse TA, Larsen TS, Mourits-Andersen HT, Nielsen CH, Pallisgaard N, Thomassen M, Skov V, Hasselbalch HC.

Cancer Med. 2018 Aug;7(8):3571-3581. doi: 10.1002/cam4.1619. Epub 2018 Jun 22.


Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis.

Sustarsic EG, Ma T, Lynes MD, Larsen M, Karavaeva I, Havelund JF, Nielsen CH, Jedrychowski MP, Moreno-Torres M, Lundh M, Plucinska K, Jespersen NZ, Grevengoed TJ, Kramar B, Peics J, Hansen JB, Shamsi F, Forss I, Neess D, Keipert S, Wang J, Stohlmann K, Brandslund I, Christensen C, Jørgensen ME, Linneberg A, Pedersen O, Kiebish MA, Qvortrup K, Han X, Pedersen BK, Jastroch M, Mandrup S, Kjær A, Gygi SP, Hansen T, Gillum MP, Grarup N, Emanuelli B, Nielsen S, Scheele C, Tseng YH, Færgeman NJ, Gerhart-Hines Z.

Cell Metab. 2018 Jul 3;28(1):159-174.e11. doi: 10.1016/j.cmet.2018.05.003. Epub 2018 May 31.


Development of anti-drug antibodies is associated with shortened survival in patients with metastatic melanoma treated with ipilimumab.

Kverneland AH, Enevold C, Donia M, Bastholt L, Svane IM, Nielsen CH.

Oncoimmunology. 2018 Feb 1;7(5):e1424674. doi: 10.1080/2162402X.2018.1424674. eCollection 2018.


A blood biomarker for monitoring response to anti-EGFR therapy.

Hughes NP, Xu L, Nielsen CH, Chang E, Hori SS, Natarajan A, Lee S, Kjær A, Kani K, Wang SX, Mallick P, Gambhir SS.

Cancer Biomark. 2018;22(2):333-344. doi: 10.3233/CBM-171149.


Drug concentrations and anti-drug antibodies during treatment with biosimilar infliximab (CT-P13) in routine care.

Glintborg B, Kringelbach T, Bolstad N, Warren DJ, Eng G, Sørensen IJ, Loft AG, Hendricks O, Hansen I, Linauskas A, Nordin H, Kristensen S, Lindegaard H, Jensen DV, Goll GL, Høgdall E, Gehin J, Enevold C, Nielsen CH, Krogh NS, Johansen JS, Hetland ML.

Scand J Rheumatol. 2018 Sep;47(5):418-421. doi: 10.1080/03009742.2017.1376110. Epub 2018 Jan 9. No abstract available.


The Apolipoprotein M/S1P Axis Controls Triglyceride Metabolism and Brown Fat Activity.

Christoffersen C, Federspiel CK, Borup A, Christensen PM, Madsen AN, Heine M, Nielsen CH, Kjaer A, Holst B, Heeren J, Nielsen LB.

Cell Rep. 2018 Jan 2;22(1):175-188. doi: 10.1016/j.celrep.2017.12.029.


Increased proportions of B cells with spontaneous production of interleukin-10 in HIV-infected individuals are normalized during combination antiretroviral therapy: a longitudinal study.

Sambleben C, Knudsen AD, Hartling HJ, Nielsen CH, Nielsen SD.

APMIS. 2018 Feb;126(2):143-151. doi: 10.1111/apm.12795. Epub 2017 Dec 21.


Site-Specific 64Cu Labeling of the Serine Protease, Active Site Inhibited Factor Seven Azide (FVIIai-N3), Using Copper Free Click Chemistry.

Jeppesen TE, Kristensen LK, Nielsen CH, Petersen LC, Kristensen JB, Behrens C, Madsen J, Kjaer A.

Bioconjug Chem. 2018 Jan 17;29(1):117-125. doi: 10.1021/acs.bioconjchem.7b00649. Epub 2017 Dec 21.


Immunoglobulin G antibodies against Porphyromonas gingivalis or Aggregatibacter actinomycetemcomitans in cardiovascular disease and periodontitis.

Damgaard C, Reinholdt J, Enevold C, Fiehn NE, Nielsen CH, Holmstrup P.

J Oral Microbiol. 2017 Sep 10;9(1):1374154. doi: 10.1080/20002297.2017.1374154. eCollection 2017.


Recent advances in understanding autoimmune thyroid disease: the tallest tree in the forest of polyautoimmunity.

Bliddal S, Nielsen CH, Feldt-Rasmussen U.

F1000Res. 2017 Sep 28;6:1776. doi: 10.12688/f1000research.11535.1. eCollection 2017. Review.


Reconstitution of Th17, Tc17 and Treg cells after paediatric haematopoietic stem cell transplantation: Impact of interleukin-7.

Kielsen K, Ryder LP, Lennox-Hvenekilde D, Gad M, Nielsen CH, Heilmann C, Ifversen M, Pedersen AE, Müller K.

Immunobiology. 2018 Feb;223(2):220-226. doi: 10.1016/j.imbio.2017.10.023. Epub 2017 Oct 9.


Effects of rituximab and dexamethasone on regulatory and proinflammatory B-cell subsets in patients with primary immune thrombocytopenia.

Gudbrandsdottir S, Brimnes M, Køllgaard T, Hasselbalch HC, Nielsen CH.

Eur J Haematol. 2018 Jan;100(1):45-52. doi: 10.1111/ejh.12978. Epub 2017 Oct 18.


Reactive oxygen species inhibit catalytic activity of peptidylarginine deiminase.

Damgaard D, Bjørn ME, Jensen PØ, Nielsen CH.

J Enzyme Inhib Med Chem. 2017 Dec;32(1):1203-1208. doi: 10.1080/14756366.2017.1368505.


Neodymium-140 DOTA-LM3: Evaluation of an In Vivo Generator for PET with a Non-Internalizing Vector.

Severin GW, Kristensen LK, Nielsen CH, Fonslet J, Jensen AI, Frellsen AF, Jensen KM, Elema DR, Maecke H, Kjær A, Johnston K, Köster U.

Front Med (Lausanne). 2017 Jul 12;4:98. doi: 10.3389/fmed.2017.00098. eCollection 2017.


Comorbidity of periodontal disease: two sides of the same coin? An introduction for the clinician.

Holmstrup P, Damgaard C, Olsen I, Klinge B, Flyvbjerg A, Nielsen CH, Hansen PR.

J Oral Microbiol. 2017 Jun 14;9(1):1332710. doi: 10.1080/20002297.2017.1332710. eCollection 2017. Review.


Uremia does not affect neointima formation in mice.

Aarup A, Nielsen CH, Bisgaard LS, Bot I, El-Ali HH, Kjaer A, Nielsen LB, Pedersen TX.

Sci Rep. 2017 Jul 26;7(1):6496. doi: 10.1038/s41598-017-06816-6.


The flame retardant DE-71 (a mixture of polybrominated diphenyl ethers) inhibits human differentiated thyroid cell function in vitro.

Kronborg TM, Hansen JF, Rasmussen ÅK, Vorkamp K, Nielsen CH, Frederiksen M, Hofman-Bang J, Hahn CH, Ramhøj L, Feldt-Rasmussen U.

PLoS One. 2017 Jun 23;12(6):e0179858. doi: 10.1371/journal.pone.0179858. eCollection 2017.


Calgizzarin (S100A11): a novel inflammatory mediator associated with disease activity of rheumatoid arthritis.

Andrés Cerezo L, Šumová B, Prajzlerová K, Veigl D, Damgaard D, Nielsen CH, Pavelka K, Vencovský J, Šenolt L.

Arthritis Res Ther. 2017 Apr 26;19(1):79. doi: 10.1186/s13075-017-1288-y.


Associations between levels of insulin-like growth factor 1 and sinusoidal obstruction syndrome after allogeneic haematopoietic stem cell transplantation.

Weischendorff S, Kielsen K, Sengeløv H, Jordan K, Nielsen CH, Pedersen AE, Ryder LP, Juul A, Müller KG.

Bone Marrow Transplant. 2017 Jun;52(6):863-869. doi: 10.1038/bmt.2017.43. Epub 2017 Apr 24.


Surface complement C3 fragments and cellular binding of microparticles in patients with SLE.

Winberg LK, Nielsen CH, Jacobsen S.

Lupus Sci Med. 2017 Mar 31;4(1):e000193. doi: 10.1136/lupus-2016-000193. eCollection 2017.


Pericyte modulation by a functional antibody obtained by a novel single-cell selection strategy.

Just J, Lykkemark S, Nielsen CH, Roshenas AR, Drasbek KR, Petersen SV, Bek T, Kristensen P.

Microcirculation. 2017 Aug;24(6). doi: 10.1111/micc.12365.


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