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Items: 1 to 50 of 101

1.

The tuberculosis necrotizing toxin is an NAD+ and NADP+ glycohydrolase with distinct enzymatic properties.

Tak U, Vlach J, Garza-Garcia A, William D, Danilchanka O, de Carvalho LPS, Saad JS, Niederweis M.

J Biol Chem. 2019 Mar 1;294(9):3024-3036. doi: 10.1074/jbc.RA118.005832. Epub 2018 Dec 28.

2.

A Protein Complex from Human Milk Enhances the Activity of Antibiotics and Drugs against Mycobacterium tuberculosis.

Meikle V, Mossberg AK, Mitra A, Hakansson AP, Niederweis M.

Antimicrob Agents Chemother. 2019 Jan 29;63(2). pii: e01846-18. doi: 10.1128/AAC.01846-18. Print 2019 Feb.

PMID:
30420480
3.

Cytomegalovirus promotes intestinal macrophage-mediated mucosal inflammation through induction of Smad7.

Dennis EA, Smythies LE, Grabski R, Li M, Ballestas ME, Shimamura M, Sun JJ, Grams J, Stahl R, Niederweis ME, Britt WJ, Smith PD.

Mucosal Immunol. 2018 Nov;11(6):1694-1704. doi: 10.1038/s41385-018-0041-4. Epub 2018 Aug 3.

PMID:
30076393
4.

NAD+ Depletion Triggers Macrophage Necroptosis, a Cell Death Pathway Exploited by Mycobacterium tuberculosis.

Pajuelo D, Gonzalez-Juarbe N, Tak U, Sun J, Orihuela CJ, Niederweis M.

Cell Rep. 2018 Jul 10;24(2):429-440. doi: 10.1016/j.celrep.2018.06.042.

5.

PPE Surface Proteins Are Required for Heme Utilization by Mycobacterium tuberculosis.

Mitra A, Speer A, Lin K, Ehrt S, Niederweis M.

MBio. 2017 Jan 24;8(1). pii: e01720-16. doi: 10.1128/mBio.01720-16.

6.

A Macrophage Infection Model to Predict Drug Efficacy Against Mycobacterium Tuberculosis.

Schaaf K, Hayley V, Speer A, Wolschendorf F, Niederweis M, Kutsch O, Sun J.

Assay Drug Dev Technol. 2016 Aug;14(6):345-54. doi: 10.1089/adt.2016.717. Epub 2016 Jun 21.

7.

Protein phosphatase, Mg2+/Mn2+-dependent 1A controls the innate antiviral and antibacterial response of macrophages during HIV-1 and Mycobacterium tuberculosis infection.

Sun J, Schaaf K, Duverger A, Wolschendorf F, Speer A, Wagner F, Niederweis M, Kutsch O.

Oncotarget. 2016 Mar 29;7(13):15394-409. doi: 10.18632/oncotarget.8190.

8.

Hetero-oligomeric MspA pores in Mycobacterium smegmatis.

Pavlenok M, Niederweis M.

FEMS Microbiol Lett. 2016 Apr;363(7). pii: fnw046. doi: 10.1093/femsle/fnw046. Epub 2016 Feb 23.

9.

Separable roles for Mycobacterium tuberculosis ESX-3 effectors in iron acquisition and virulence.

Tufariello JM, Chapman JR, Kerantzas CA, Wong KW, Vilchèze C, Jones CM, Cole LE, Tinaztepe E, Thompson V, Fenyö D, Niederweis M, Ueberheide B, Philips JA, Jacobs WR Jr.

Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):E348-57. doi: 10.1073/pnas.1523321113. Epub 2016 Jan 4.

10.

The tuberculosis necrotizing toxin kills macrophages by hydrolyzing NAD.

Sun J, Siroy A, Lokareddy RK, Speer A, Doornbos KS, Cingolani G, Niederweis M.

Nat Struct Mol Biol. 2015 Sep;22(9):672-8. doi: 10.1038/nsmb.3064. Epub 2015 Aug 3.

11.

Surface hydrolysis of sphingomyelin by the outer membrane protein Rv0888 supports replication of Mycobacterium tuberculosis in macrophages.

Speer A, Sun J, Danilchanka O, Meikle V, Rowland JL, Walter K, Buck BR, Pavlenok M, Hölscher C, Ehrt S, Niederweis M.

Mol Microbiol. 2015 Sep;97(5):881-97. doi: 10.1111/mmi.13073. Epub 2015 Jul 4.

12.

Disulfiram and Copper Ions Kill Mycobacterium tuberculosis in a Synergistic Manner.

Dalecki AG, Haeili M, Shah S, Speer A, Niederweis M, Kutsch O, Wolschendorf F.

Antimicrob Agents Chemother. 2015 Aug;59(8):4835-44. doi: 10.1128/AAC.00692-15. Epub 2015 Jun 1.

13.

Mycobacteria, metals, and the macrophage.

Neyrolles O, Wolschendorf F, Mitra A, Niederweis M.

Immunol Rev. 2015 Mar;264(1):249-63. doi: 10.1111/imr.12265. Review.

14.

The Mycobacterium tuberculosis outer membrane channel protein CpnT confers susceptibility to toxic molecules.

Danilchanka O, Pires D, Anes E, Niederweis M.

Antimicrob Agents Chemother. 2015 Apr;59(4):2328-36. doi: 10.1128/AAC.04222-14. Epub 2015 Feb 2.

15.

The progression of cell death affects the rejection of allogeneic tumors in immune-competent mice - implications for cancer therapy.

Chaurio RA, Muñoz LE, Maueröder C, Janko C, Harrer T, Fürnrohr BG, Niederweis M, Bilyy R, Schett G, Herrmann M, Berens C.

Front Immunol. 2014 Nov 11;5:560. doi: 10.3389/fimmu.2014.00560. eCollection 2014.

16.

An outer membrane channel protein of Mycobacterium tuberculosis with exotoxin activity.

Danilchanka O, Sun J, Pavlenok M, Maueröder C, Speer A, Siroy A, Marrero J, Trujillo C, Mayhew DL, Doornbos KS, Muñoz LE, Herrmann M, Ehrt S, Berens C, Niederweis M.

Proc Natl Acad Sci U S A. 2014 May 6;111(18):6750-5. doi: 10.1073/pnas.1400136111. Epub 2014 Apr 21.

17.

Self-poisoning of Mycobacterium tuberculosis by interrupting siderophore recycling.

Jones CM, Wells RM, Madduri AV, Renfrow MB, Ratledge C, Moody DB, Niederweis M.

Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):1945-50. doi: 10.1073/pnas.1311402111. Epub 2014 Jan 13.

18.

Role of the Mce1 transporter in the lipid homeostasis of Mycobacterium tuberculosis.

Forrellad MA, McNeil M, Santangelo Mde L, Blanco FC, García E, Klepp LI, Huff J, Niederweis M, Jackson M, Bigi F.

Tuberculosis (Edinb). 2014 Mar;94(2):170-7. doi: 10.1016/j.tube.2013.12.005. Epub 2014 Jan 2.

19.

Organ pathology in the absence of bacteria?

Jones CM, Niederweis M.

J Infect Dis. 2014 Mar;209(6):971. doi: 10.1093/infdis/jit606. Epub 2013 Nov 17. No abstract available.

20.

Porins increase copper susceptibility of Mycobacterium tuberculosis.

Speer A, Rowland JL, Haeili M, Niederweis M, Wolschendorf F.

J Bacteriol. 2013 Nov;195(22):5133-40. doi: 10.1128/JB.00763-13. Epub 2013 Sep 6.

21.

A multicopper oxidase is required for copper resistance in Mycobacterium tuberculosis.

Rowland JL, Niederweis M.

J Bacteriol. 2013 Aug;195(16):3724-33. doi: 10.1128/JB.00546-13. Epub 2013 Jun 14.

22.

Mycobacterium tuberculosis is resistant to streptolydigin.

Speer A, Rowland JL, Niederweis M.

Tuberculosis (Edinb). 2013 Jul;93(4):401-4. doi: 10.1016/j.tube.2013.03.002. Epub 2013 Apr 13.

23.

Discovery of a siderophore export system essential for virulence of Mycobacterium tuberculosis.

Wells RM, Jones CM, Xi Z, Speer A, Danilchanka O, Doornbos KS, Sun P, Wu F, Tian C, Niederweis M.

PLoS Pathog. 2013 Jan;9(1):e1003120. doi: 10.1371/journal.ppat.1003120. Epub 2013 Jan 31.

24.

Updating and curating metabolic pathways of TB.

Slayden RA, Jackson M, Zucker J, Ramirez MV, Dawson CC, Crew R, Sampson NS, Thomas ST, Jamshidi N, Sisk P, Caspi R, Crick DC, McNeil MR, Pavelka MS, Niederweis M, Siroy A, Dona V, McFadden J, Boshoff H, Lew JM.

Tuberculosis (Edinb). 2013 Jan;93(1):47-59. doi: 10.1016/j.tube.2012.11.001. Epub 2013 Feb 1. Review.

25.

Copper-boosting compounds: a novel concept for antimycobacterial drug discovery.

Speer A, Shrestha TB, Bossmann SH, Basaraba RJ, Harber GJ, Michalek SM, Niederweis M, Kutsch O, Wolschendorf F.

Antimicrob Agents Chemother. 2013 Feb;57(2):1089-91. doi: 10.1128/AAC.01781-12. Epub 2012 Dec 17.

26.

Ectoine biosynthesis in Mycobacterium smegmatis.

Ofer N, Wishkautzan M, Meijler M, Wang Y, Speer A, Niederweis M, Gur E.

Appl Environ Microbiol. 2012 Oct;78(20):7483-6. Epub 2012 Aug 10.

27.

Molecular dynamics study of MspA arginine mutants predicts slow DNA translocations and ion current blockades indicative of DNA sequence.

Bhattacharya S, Derrington IM, Pavlenok M, Niederweis M, Gundlach JH, Aksimentiev A.

ACS Nano. 2012 Aug 28;6(8):6960-8. doi: 10.1021/nn3019943. Epub 2012 Jul 13.

28.

MspA nanopores from subunit dimers.

Pavlenok M, Derrington IM, Gundlach JH, Niederweis M.

PLoS One. 2012;7(6):e38726. doi: 10.1371/journal.pone.0038726. Epub 2012 Jun 18.

29.

Cathepsin G and neutrophil elastase contribute to lung-protective immunity against mycobacterial infections in mice.

Steinwede K, Maus R, Bohling J, Voedisch S, Braun A, Ochs M, Schmiedl A, Länger F, Gauthier F, Roes J, Welte T, Bange FC, Niederweis M, Bühling F, Maus UA.

J Immunol. 2012 May 1;188(9):4476-87. doi: 10.4049/jimmunol.1103346. Epub 2012 Mar 28.

30.

Reading DNA at single-nucleotide resolution with a mutant MspA nanopore and phi29 DNA polymerase.

Manrao EA, Derrington IM, Laszlo AH, Langford KW, Hopper MK, Gillgren N, Pavlenok M, Niederweis M, Gundlach JH.

Nat Biotechnol. 2012 Mar 25;30(4):349-53. doi: 10.1038/nbt.2171.

31.

Resistance mechanisms of Mycobacterium tuberculosis against phagosomal copper overload.

Rowland JL, Niederweis M.

Tuberculosis (Edinb). 2012 May;92(3):202-10. doi: 10.1016/j.tube.2011.12.006. Epub 2012 Feb 22. Review.

32.

Molecular structure and peptidoglycan recognition of Mycobacterium tuberculosis ArfA (Rv0899).

Yao Y, Barghava N, Kim J, Niederweis M, Marassi FM.

J Mol Biol. 2012 Feb 17;416(2):208-20. doi: 10.1016/j.jmb.2011.12.030. Epub 2011 Dec 21.

33.

Elucidation and chemical modulation of sulfolipid-1 biosynthesis in Mycobacterium tuberculosis.

Seeliger JC, Holsclaw CM, Schelle MW, Botyanszki Z, Gilmore SA, Tully SE, Niederweis M, Cravatt BF, Leary JA, Bertozzi CR.

J Biol Chem. 2012 Mar 9;287(11):7990-8000. doi: 10.1074/jbc.M111.315473. Epub 2011 Dec 22.

34.

Uptake of sulfate but not phosphate by Mycobacterium tuberculosis is slower than that for Mycobacterium smegmatis.

Song H, Niederweis M.

J Bacteriol. 2012 Mar;194(5):956-64. doi: 10.1128/JB.06132-11. Epub 2011 Dec 22.

35.

Nucleotide discrimination with DNA immobilized in the MspA nanopore.

Manrao EA, Derrington IM, Pavlenok M, Niederweis M, Gundlach JH.

PLoS One. 2011;6(10):e25723. doi: 10.1371/journal.pone.0025723. Epub 2011 Oct 4.

36.

Expression of the ompATb operon accelerates ammonia secretion and adaptation of Mycobacterium tuberculosis to acidic environments.

Song H, Huff J, Janik K, Walter K, Keller C, Ehlers S, Bossmann SH, Niederweis M.

Mol Microbiol. 2011 May;80(4):900-18. doi: 10.1111/j.1365-2958.2011.07619.x. Epub 2011 Mar 16.

37.

Importance of porins for biocide efficacy against Mycobacterium smegmatis.

Frenzel E, Schmidt S, Niederweis M, Steinhauer K.

Appl Environ Microbiol. 2011 May;77(9):3068-73. doi: 10.1128/AEM.02492-10. Epub 2011 Mar 11.

38.

Mycobacterium tuberculosis can utilize heme as an iron source.

Jones CM, Niederweis M.

J Bacteriol. 2011 Apr;193(7):1767-70. doi: 10.1128/JB.01312-10. Epub 2011 Feb 4.

39.

Copper resistance is essential for virulence of Mycobacterium tuberculosis.

Wolschendorf F, Ackart D, Shrestha TB, Hascall-Dove L, Nolan S, Lamichhane G, Wang Y, Bossmann SH, Basaraba RJ, Niederweis M.

Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1621-6. doi: 10.1073/pnas.1009261108. Epub 2011 Jan 4.

40.

Role of porins in iron uptake by Mycobacterium smegmatis.

Jones CM, Niederweis M.

J Bacteriol. 2010 Dec;192(24):6411-7. doi: 10.1128/JB.00986-10. Epub 2010 Oct 15.

41.

Nanopore DNA sequencing with MspA.

Derrington IM, Butler TZ, Collins MD, Manrao E, Pavlenok M, Niederweis M, Gundlach JH.

Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16060-5. doi: 10.1073/pnas.1001831107. Epub 2010 Aug 26.

42.

Taking phage integration to the next level as a genetic tool for mycobacteria.

Huff J, Czyz A, Landick R, Niederweis M.

Gene. 2010 Nov 15;468(1-2):8-19. doi: 10.1016/j.gene.2010.07.012. Epub 2010 Aug 6.

43.

Antimycobacterial activity in vitro of pigments isolated from Antarctic bacteria.

Mojib N, Philpott R, Huang JP, Niederweis M, Bej AK.

Antonie Van Leeuwenhoek. 2010 Nov;98(4):531-40. doi: 10.1007/s10482-010-9470-0. Epub 2010 Jun 17.

PMID:
20556653
44.

Hit-and-run stimulation: a novel concept to reactivate latent HIV-1 infection without cytokine gene induction.

Wolschendorf F, Duverger A, Jones J, Wagner FH, Huff J, Benjamin WH, Saag MS, Niederweis M, Kutsch O.

J Virol. 2010 Sep;84(17):8712-20. doi: 10.1128/JVI.00523-10. Epub 2010 Jun 10.

45.

Mycobacterium tuberculosis Rv0899 adopts a mixed alpha/beta-structure and does not form a transmembrane beta-barrel.

Teriete P, Yao Y, Kolodzik A, Yu J, Song H, Niederweis M, Marassi FM.

Biochemistry. 2010 Apr 6;49(13):2768-77. doi: 10.1021/bi100158s.

46.

Poly-N-Isopropylacrylamide/acrylic Acid Copolymers for the Generation of Nanostructures at Mica Surfaces and as Hydrophobic Host Systems for the Porin MspA from Mycobacterium smegmatis.

Gamage P, Basel MT, Lovell K, Pokhrel MR, Battle D, Ito T, Pavlenok M, Niederweis M, Bossmann SH.

J Phys Chem C Nanomater Interfaces. 2009 Sep 17;113(37):16485-16494.

47.

Mycobacterial outer membranes: in search of proteins.

Niederweis M, Danilchanka O, Huff J, Hoffmann C, Engelhardt H.

Trends Microbiol. 2010 Mar;18(3):109-16. doi: 10.1016/j.tim.2009.12.005. Epub 2010 Jan 8. Review.

48.

Rapid evaluation of the mycobactericidal efficacy of disinfectants in the quantitative carrier test EN 14563 by using fluorescent Mycobacterium terrae.

Steinhauer K, Eschenbacher I, Radischat N, Detsch C, Niederweis M, Goroncy-Bermes P.

Appl Environ Microbiol. 2010 Jan;76(2):546-54. doi: 10.1128/AEM.01660-09. Epub 2009 Nov 30.

49.

Decreased outer membrane permeability protects mycobacteria from killing by ubiquitin-derived peptides.

Purdy GE, Niederweis M, Russell DG.

Mol Microbiol. 2009 Sep;73(5):844-57. doi: 10.1111/j.1365-2958.2009.06801.x. Epub 2009 Aug 6.

50.

Role of porins in the susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to aldehyde-based disinfectants and drugs.

Svetlíková Z, Skovierová H, Niederweis M, Gaillard JL, McDonnell G, Jackson M.

Antimicrob Agents Chemother. 2009 Sep;53(9):4015-8. doi: 10.1128/AAC.00590-09. Epub 2009 Jul 6.

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