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Items: 1 to 50 of 271

1.

The Eye Sees Eye to Eye With the Immune System: The 2019 Proctor Lecture.

Niederkorn JY.

Invest Ophthalmol Vis Sci. 2019 Oct 1;60(13):4489-4495. doi: 10.1167/iovs.19-28632. No abstract available.

2.

Defective FasL expression is associated with increased resistance to melanoma liver metastases and enhanced natural killer cell activity.

Neelam S, Mellon J, Wilkerson A, Niederkorn JY.

Melanoma Res. 2019 Aug;29(4):401-412. doi: 10.1097/CMR.0000000000000614.

PMID:
30932943
3.

Induction of Contrasuppressor Cells and Loss of Immune Privilege Produced by Corneal Nerve Ablation.

Neelam S, Mellon J, Wilkerson A, Niederkorn JY.

Invest Ophthalmol Vis Sci. 2018 Sep 4;59(11):4738-4747. doi: 10.1167/iovs.18-24894.

4.

Pathobiology and Immunobiology of Acanthamoeba Keratitis: Insights from Animal Models
.

Neelam S, Niederkorn JY.

Yale J Biol Med. 2017 Jun 23;90(2):261-268. eCollection 2017 Jun. Review.

5.

Effect of Corneal Nerve Ablation on Immune Tolerance Induced by Corneal Allografts, Oral Immunization, or Anterior Chamber Injection of Antigens.

Mo J, Neelam S, Mellon J, Brown JR, Niederkorn JY.

Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):137-148. doi: 10.1167/iovs.16-20601.

6.

Growth and Metastasis of Intraocular Tumors in Aged Mice.

Han Z, Brown JR, Niederkorn JY.

Invest Ophthalmol Vis Sci. 2016 May 1;57(6):2366-76. doi: 10.1167/iovs.16-19156.

7.

Natural Killer T Cells Contribute to Neutrophil Recruitment and Ocular Tissue Damage in a Model of Intraocular Tumor Rejection.

Ligocki AJ, Niederkorn JY.

Invest Ophthalmol Vis Sci. 2016 Mar;57(3):813-23. doi: 10.1167/iovs.15-18786.

8.

Role of interferon-γ and cytotoxic T lymphocytes in intraocular tumor rejection.

Ligocki AJ, Brown JR, Niederkorn JY.

J Leukoc Biol. 2016 May;99(5):735-47. doi: 10.1189/jlb.3A0315-093RRR. Epub 2015 Nov 17.

9.

Immunology of Corneal Allografts: Insights from Animal Models.

Niederkorn JY.

J Clin Exp Ophthalmol. 2015 Jun;6(3). pii: 429.

10.

Advances on Non-CD4 + Foxp3+ T Regulatory Cells: CD8+, Type 1, and Double Negative T Regulatory Cells in Organ Transplantation.

Ligocki AJ, Niederkorn JY.

Transplantation. 2015 Aug;99(8):1553-9. doi: 10.1097/TP.0000000000000813. Review.

11.

Severing corneal nerves in one eye induces sympathetic loss of immune privilege and promotes rejection of future corneal allografts placed in either eye.

Paunicka KJ, Mellon J, Robertson D, Petroll M, Brown JR, Niederkorn JY.

Am J Transplant. 2015 Jun;15(6):1490-501. doi: 10.1111/ajt.13240. Epub 2015 Apr 14.

12.

NKT cells act through third party bone marrow-derived cells to suppress NK cell activity in the liver and exacerbate hepatic melanoma metastases.

Sadegh L, Chen PW, Brown JR, Han Z, Niederkorn JY.

Int J Cancer. 2015 Sep 1;137(5):1085-94. doi: 10.1002/ijc.29480. Epub 2015 Feb 27.

13.

Development, alteration and real time dynamics of conjunctiva-associated lymphoid tissue.

Siebelmann S, Gehlsen U, Hüttmann G, Koop N, Bölke T, Gebert A, Stern ME, Niederkorn JY, Steven P.

PLoS One. 2013 Dec 20;8(12):e82355. doi: 10.1371/journal.pone.0082355. eCollection 2013.

14.

IFN-γ blocks CD4+CD25+ Tregs and abolishes immune privilege of minor histocompatibility mismatched corneal allografts.

Cunnusamy K, Niederkorn JY.

Am J Transplant. 2013 Dec;13(12):3076-84. doi: 10.1111/ajt.12466. Epub 2013 Oct 1.

15.

CD8⁺ cells regulate the T helper-17 response in an experimental murine model of Sjögren syndrome.

Zhang X, Schaumburg CS, Coursey TG, Siemasko KF, Volpe EA, Gandhi NB, Li DQ, Niederkorn JY, Stern ME, Pflugfelder SC, de Paiva CS.

Mucosal Immunol. 2014 Mar;7(2):417-27. doi: 10.1038/mi.2013.61. Epub 2013 Sep 11.

16.

Allergic conjunctivitis renders CD4(+) T cells resistant to t regulatory cells and exacerbates corneal allograft rejection.

Reyes NJ, Chen PW, Niederkorn JY.

Am J Transplant. 2013 May;13(5):1181-92. doi: 10.1111/ajt.12198. Epub 2013 Mar 13.

17.

Corneal transplantation and immune privilege.

Niederkorn JY.

Int Rev Immunol. 2013 Feb;32(1):57-67. doi: 10.3109/08830185.2012.737877. Review.

18.

New twists to an old story: novel concepts in the pathogenesis of allergic eye disease.

Saban DR, Calder V, Kuo CH, Reyes NJ, Dartt DA, Ono SJ, Niederkorn JY.

Curr Eye Res. 2013 Mar;38(3):317-30. doi: 10.3109/02713683.2012.747617. Epub 2013 Jan 2. Review.

19.

Epigenetic regulation of CXCR4 expression by the ocular microenvironment.

Li H, Niederkorn JY, Sadegh L, Mellon J, Chen PW.

Invest Ophthalmol Vis Sci. 2013 Jan 9;54(1):234-43. doi: 10.1167/iovs.12-10643.

20.

Ocular immune privilege and ocular melanoma: parallel universes or immunological plagiarism?

Niederkorn JY.

Front Immunol. 2012 Jun 13;3:148. doi: 10.3389/fimmu.2012.00148. eCollection 2012.

21.

IFN-γ-independent intraocular tumor rejection is mediated by a macrophage-dependent process that leaves the eye intact.

Coursey TG, Chen PW, Niederkorn JY.

J Leukoc Biol. 2012 Nov;92(5):939-50. doi: 10.1189/jlb.0312122. Epub 2012 Jun 12.

22.

NK cells promote Th-17 mediated corneal barrier disruption in dry eye.

Zhang X, Volpe EA, Gandhi NB, Schaumburg CS, Siemasko KF, Pangelinan SB, Kelly SD, Hayday AC, Li DQ, Stern ME, Niederkorn JY, Pflugfelder SC, De Paiva CS.

PLoS One. 2012;7(5):e36822. doi: 10.1371/journal.pone.0036822. Epub 2012 May 8.

23.

Autoantibodies contribute to the immunopathogenesis of experimental dry eye disease.

Stern ME, Schaumburg CS, Siemasko KF, Gao J, Wheeler LA, Grupe DA, De Paiva CS, Calder VL, Calonge M, Niederkorn JY, Pflugfelder SC.

Invest Ophthalmol Vis Sci. 2012 Apr 24;53(4):2062-75. doi: 10.1167/iovs.11-9299.

24.

Disruption of TGF-β signaling improves ocular surface epithelial disease in experimental autoimmune keratoconjunctivitis sicca.

De Paiva CS, Volpe EA, Gandhi NB, Zhang X, Zheng X, Pitcher JD 3rd, Farley WJ, Stern ME, Niederkorn JY, Li DQ, Flavell RA, Pflugfelder SC.

PLoS One. 2011;6(12):e29017. doi: 10.1371/journal.pone.0029017. Epub 2011 Dec 14.

25.

Role of IFN-γ in the establishment of anterior chamber-associated immune deviation (ACAID)-induced CD8+ T regulatory cells.

Paunicka K, Chen PW, Niederkorn JY.

J Leukoc Biol. 2012 Mar;91(3):475-83. doi: 10.1189/jlb.0311173. Epub 2011 Dec 16.

26.

IL-17-dependent, IFN-gamma-independent tumor rejection is mediated by cytotoxic T lymphocytes and occurs at extraocular sites, but is excluded from the eye.

Coursey TG, Chen PW, Niederkorn JY.

J Immunol. 2011 Oct 15;187(8):4219-28. doi: 10.4049/jimmunol.1100826. Epub 2011 Sep 14.

27.

Ocular surface APCs are necessary for autoreactive T cell-mediated experimental autoimmune lacrimal keratoconjunctivitis.

Schaumburg CS, Siemasko KF, De Paiva CS, Wheeler LA, Niederkorn JY, Pflugfelder SC, Stern ME.

J Immunol. 2011 Oct 1;187(7):3653-62. doi: 10.4049/jimmunol.1101442. Epub 2011 Aug 31.

28.

Desiccating stress induces CD4+ T-cell-mediated Sjögren's syndrome-like corneal epithelial apoptosis via activation of the extrinsic apoptotic pathway by interferon-γ.

Zhang X, Chen W, De Paiva CS, Volpe EA, Gandhi NB, Farley WJ, Li DQ, Niederkorn JY, Stern ME, Pflugfelder SC.

Am J Pathol. 2011 Oct;179(4):1807-14. doi: 10.1016/j.ajpath.2011.06.030. Epub 2011 Aug 16.

29.

Cornea: Window to Ocular Immunology.

Niederkorn JY.

Curr Immunol Rev. 2011 Aug;7(3):328-335.

30.

IL-17A-dependent CD4+CD25+ regulatory T cells promote immune privilege of corneal allografts.

Cunnusamy K, Chen PW, Niederkorn JY.

J Immunol. 2011 Jun 15;186(12):6737-45. doi: 10.4049/jimmunol.1100101. Epub 2011 May 6.

31.

NKT cell exacerbation of liver metastases arising from melanomas transplanted into either the eyes or spleens of mice.

Yang W, Li H, Mayhew E, Mellon J, Chen PW, Niederkorn JY.

Invest Ophthalmol Vis Sci. 2011 May 11;52(6):3094-102. doi: 10.1167/iovs.10-7067.

32.

Abrogating TNF-α expression prevents bystander destruction of normal tissues during iNOS-mediated elimination of intraocular tumors.

Coursey TG, Chen PW, Niederkorn JY.

Cancer Res. 2011 Apr 1;71(7):2445-54. doi: 10.1158/0008-5472.CAN-10-2628. Epub 2011 Feb 9.

33.

γδ T cells are required for maximal expression of allergic conjunctivitis.

Reyes NJ, Mayhew E, Chen PW, Niederkorn JY.

Invest Ophthalmol Vis Sci. 2011 Apr 6;52(5):2211-6. doi: 10.1167/iovs.10-5959.

34.

Paradigm shifts in the role of CD4+ T cells in keratoplasty.

Cunnusamy K, Chen PW, Niederkorn JY.

Discov Med. 2010 Nov;10(54):452-61.

35.

IL-17 promotes immune privilege of corneal allografts.

Cunnusamy K, Chen PW, Niederkorn JY.

J Immunol. 2010 Oct 15;185(8):4651-8. doi: 10.4049/jimmunol.1001576. Epub 2010 Sep 15.

36.

Two different regulatory T cell populations that promote corneal allograft survival.

Cunnusamy K, Paunicka K, Reyes N, Yang W, Chen PW, Niederkorn JY.

Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6566-74. doi: 10.1167/iovs.10-6161. Epub 2010 Aug 11.

37.

High-risk corneal allografts and why they lose their immune privilege.

Niederkorn JY.

Curr Opin Allergy Clin Immunol. 2010 Oct;10(5):493-7. doi: 10.1097/ACI.0b013e32833dfa11. Review.

38.

Spontaneous autoimmune dacryoadenitis in aged CD25KO mice.

Rahimy E, Pitcher JD 3rd, Pangelinan SB, Chen W, Farley WJ, Niederkorn JY, Stern ME, Li DQ, Pflugfelder SC, De Paiva CS.

Am J Pathol. 2010 Aug;177(2):744-53. doi: 10.2353/ajpath.2010.091116. Epub 2010 Jun 21.

39.

Transgenic mice expressing variants of complement factor H develop AMD-like retinal findings.

Ufret-Vincenty RL, Aredo B, Liu X, McMahon A, Chen PW, Sun H, Niederkorn JY, Kedzierski W.

Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5878-87. doi: 10.1167/iovs.09-4457. Epub 2010 Jun 10.

PMID:
20538999
40.

NKT cells are necessary for maximal expression of allergic conjunctivitis.

Reyes NJ, Mayhew E, Chen PW, Niederkorn JY.

Int Immunol. 2010 Aug;22(8):627-36. doi: 10.1093/intimm/dxq046. Epub 2010 May 26.

41.

Autoimmunity at the ocular surface: pathogenesis and regulation.

Stern ME, Schaumburg CS, Dana R, Calonge M, Niederkorn JY, Pflugfelder SC.

Mucosal Immunol. 2010 Sep;3(5):425-42. doi: 10.1038/mi.2010.26. Epub 2010 May 19. Review.

42.

Immune privilege of corneal allografts.

Niederkorn JY, Larkin DF.

Ocul Immunol Inflamm. 2010 Jun;18(3):162-71. doi: 10.3109/09273948.2010.486100. Review.

43.

Allergic conjunctivitis exacerbates corneal allograft rejection by activating Th1 and th2 alloimmune responses.

Niederkorn JY, Chen PW, Mellon J, Stevens C, Mayhew E.

J Immunol. 2010 Jun 1;184(11):6076-83. doi: 10.4049/jimmunol.0902300. Epub 2010 Apr 21.

44.

History and physiology of immune privilege.

Niederkorn JY, Stein-Streilein J.

Ocul Immunol Inflamm. 2010 Jan;18(1):19-23. doi: 10.3109/09273940903564766.

PMID:
20128645
45.

Role of NKT cells in anterior chamber-associated immune deviation.

Niederkorn JY.

Expert Rev Clin Immunol. 2009 Mar;5(2):137-144.

46.

Age-related T-cell cytokine profile parallels corneal disease severity in Sjogren's syndrome-like keratoconjunctivitis sicca in CD25KO mice.

De Paiva CS, Hwang CS, Pitcher JD 3rd, Pangelinan SB, Rahimy E, Chen W, Yoon KC, Farley WJ, Niederkorn JY, Stern ME, Li DQ, Pflugfelder SC.

Rheumatology (Oxford). 2010 Feb;49(2):246-58. doi: 10.1093/rheumatology/kep357. Epub 2009 Dec 9.

47.

Immune escape mechanisms of intraocular tumors.

Niederkorn JY.

Prog Retin Eye Res. 2009 Sep;28(5):329-47. doi: 10.1016/j.preteyeres.2009.06.002. Epub 2009 Jun 27. Review.

48.

Inhibition of chemokine receptor expression on uveal melanomas by CXCR4 siRNA and its effect on uveal melanoma liver metastases.

Li H, Yang W, Chen PW, Alizadeh H, Niederkorn JY.

Invest Ophthalmol Vis Sci. 2009 Dec;50(12):5522-8. doi: 10.1167/iovs.09-3804. Epub 2009 Jun 24.

49.

Allergic airway hyperreactivity increases the risk for corneal allograft rejection.

Niederkorn JY, Chen PW, Mellon J, Stevens C, Mayhew E.

Am J Transplant. 2009 May;9(5):1017-26. doi: 10.1111/j.1600-6143.2009.02603.x.

50.

IL-17 disrupts corneal barrier following desiccating stress.

De Paiva CS, Chotikavanich S, Pangelinan SB, Pitcher JD 3rd, Fang B, Zheng X, Ma P, Farley WJ, Siemasko KF, Niederkorn JY, Stern ME, Li DQ, Pflugfelder SC.

Mucosal Immunol. 2009 May;2(3):243-53. doi: 10.1038/mi.2009.5. Epub 2009 Feb 25.

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