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The Hallmarks of Severe Pulmonary Arterial Hypertension: The Cancer Hypothesis - Ten years later.

Cool CD, Kuebler WM, Bogaard HJ, Spiekerkoetter E, Nicolls MR, Voelkel NF.

Am J Physiol Lung Cell Mol Physiol. 2020 Feb 5. doi: 10.1152/ajplung.00476.2019. [Epub ahead of print]


The Lymphatic System in Obesity, Insulin Resistance, and Cardiovascular Diseases.

Jiang X, Tian W, Nicolls MR, Rockson SG.

Front Physiol. 2019 Nov 14;10:1402. doi: 10.3389/fphys.2019.01402. eCollection 2019. Review.


Phenotypically Silent Bone Morphogenetic Protein Receptor 2 Mutations Predispose Rats to Inflammation-Induced Pulmonary Arterial Hypertension by Enhancing the Risk for Neointimal Transformation.

Tian W, Jiang X, Sung YK, Shuffle E, Wu TH, Kao PN, Tu AB, Dorfmüller P, Cao A, Wang L, Peng G, Kim Y, Zhang P, Chappell J, Pasupneti S, Dahms P, Maguire P, Chaib H, Zamanian R, Peters-Golden M, Snyder MP, Voelkel NF, Humbert M, Rabinovitch M, Nicolls MR.

Circulation. 2019 Oct 22;140(17):1409-1425. doi: 10.1161/CIRCULATIONAHA.119.040629. Epub 2019 Aug 29.


Airway hypoxia in lung transplantation.

Pasnupneti S, Nicolls MR.

Curr Opin Physiol. 2019 Feb;7:21-26. doi: 10.1016/j.cophys.2018.12.002. Epub 2018 Dec 13.


Inducible expression of immediate early genes is regulated through dynamic chromatin association by NF45/ILF2 and NF90/NF110/ILF3.

Wu TH, Shi L, Lowe AW, Nicolls MR, Kao PN.

PLoS One. 2019 Apr 25;14(4):e0216042. doi: 10.1371/journal.pone.0216042. eCollection 2019.


Preservation of Microvascular Integrity in Murine Orthotopic Tracheal Allografts by Clopidogrel.

Heim C, Khan MA, von Silva-Tarouca B, Kuckhahn A, Stamminger T, Ramsperger-Gleixner M, Nicolls MR, Weyand M, Ensminger SM.

Transplantation. 2019 May;103(5):899-908. doi: 10.1097/TP.0000000000002571.


Discovery of Distinct Immune Phenotypes Using Machine Learning in Pulmonary Arterial Hypertension.

Sweatt AJ, Hedlin HK, Balasubramanian V, Hsi A, Blum LK, Robinson WH, Haddad F, Hickey PM, Condliffe R, Lawrie A, Nicolls MR, Rabinovitch M, Khatri P, Zamanian RT.

Circ Res. 2019 Mar 15;124(6):904-919. doi: 10.1161/CIRCRESAHA.118.313911.


Loss of Endothelium-Derived Wnt5a Is Associated With Reduced Pericyte Recruitment and Small Vessel Loss in Pulmonary Arterial Hypertension.

Yuan K, Shamskhou EA, Orcholski ME, Nathan A, Reddy S, Honda H, Mani V, Zeng Y, Ozen MO, Wang L, Demirci U, Tian W, Nicolls MR, de Jesus Perez VA.

Circulation. 2019 Apr 2;139(14):1710-1724. doi: 10.1161/CIRCULATIONAHA.118.037642.


Endothelial Hypoxia-Inducible Factor-2α Is Required for the Maintenance of Airway Microvasculature.

Jiang X, Tian W, Tu AB, Pasupneti S, Shuffle E, Dahms P, Zhang P, Cai H, Dinh TT, Liu B, Cain C, Giaccia AJ, Butcher EC, Simon MC, Semenza GL, Nicolls MR.

Circulation. 2019 Jan 22;139(4):502-517. doi: 10.1161/CIRCULATIONAHA.118.036157.


Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives.

Humbert M, Guignabert C, Bonnet S, Dorfmüller P, Klinger JR, Nicolls MR, Olschewski AJ, Pullamsetti SS, Schermuly RT, Stenmark KR, Rabinovitch M.

Eur Respir J. 2019 Jan 24;53(1). pii: 1801887. doi: 10.1183/13993003.01887-2018. Print 2019 Jan.


Anti-hyperlipidaemic effects of synthetic analogues of nordihydroguaiaretic acid in dyslipidaemic rats.

Singh M, Bittner S, Li Y, Bittner A, Han L, Cortez Y, Inayathullah M, Arif Z, Parthasarathi R, Rajadas J, Shen WJ, Nicolls MR, Kraemer FB, Azhar S.

Br J Pharmacol. 2019 Feb;176(3):369-385. doi: 10.1111/bph.14528. Epub 2018 Dec 10.


Pilot studies demonstrate the potential benefits of antiinflammatory therapy in human lymphedema.

Rockson SG, Tian W, Jiang X, Kuznetsova T, Haddad F, Zampell J, Mehrara B, Sampson JP, Roche L, Kim J, Nicolls MR.

JCI Insight. 2018 Oct 18;3(20). pii: 123775. doi: 10.1172/jci.insight.123775.


A pro-con debate: current controversies in PAH pathogenesis at the American Thoracic Society International Conference in 2017.

Kuebler WM, Nicolls MR, Olschewski A, Abe K, Rabinovitch M, Stewart D, Chan SY, Morrell NW, Archer SL, Spiekerkoetter E.

Am J Physiol Lung Cell Mol Physiol. 2018 Oct 1;315(4):L502-L516. doi: 10.1152/ajplung.00150.2018. Epub 2018 Jun 7. Review.


Dominant Role for Regulatory T Cells in Protecting Females Against Pulmonary Hypertension.

Tamosiuniene R, Manouvakhova O, Mesange P, Saito T, Qian J, Sanyal M, Lin YC, Nguyen LP, Luria A, Tu AB, Sante JM, Rabinovitch M, Fitzgerald DJ, Graham BB, Habtezion A, Voelkel NF, Aurelian L, Nicolls MR.

Circ Res. 2018 Jun 8;122(12):1689-1702. doi: 10.1161/CIRCRESAHA.117.312058. Epub 2018 Mar 15.


Nordihydroguaiaretic Acid, a Lignan from Larrea tridentata (Creosote Bush), Protects Against American Lifestyle-Induced Obesity Syndrome Diet-Induced Metabolic Dysfunction in Mice.

Chan JKW, Bittner S, Bittner A, Atwal S, Shen WJ, Inayathullah M, Rajada J, Nicolls MR, Kraemer FB, Azhar S.

J Pharmacol Exp Ther. 2018 May;365(2):281-290. doi: 10.1124/jpet.117.243733. Epub 2018 Feb 22.


Microhemorrhage-associated tissue iron enhances the risk for Aspergillus fumigatus invasion in a mouse model of airway transplantation.

Hsu JL, Manouvakhova OV, Clemons KV, Inayathullah M, Tu AB, Sobel RA, Tian A, Nazik H, Pothineni VR, Pasupneti S, Jiang X, Dhillon GS, Bedi H, Rajadas J, Haas H, Aurelian L, Stevens DA, Nicolls MR.

Sci Transl Med. 2018 Feb 21;10(429). pii: eaag2616. doi: 10.1126/scitranslmed.aag2616.


Circulating plasmablasts are elevated and produce pathogenic anti-endothelial cell autoantibodies in idiopathic pulmonary arterial hypertension.

Blum LK, Cao RRL, Sweatt AJ, Bill M, Lahey LJ, Hsi AC, Lee CS, Kongpachith S, Ju CH, Mao R, Wong HH, Nicolls MR, Zamanian RT, Robinson WH.

Eur J Immunol. 2018 May;48(5):874-884. doi: 10.1002/eji.201747460. Epub 2018 Feb 22.


Lymphatic Dysfunction, Leukotrienes, and Lymphedema.

Jiang X, Nicolls MR, Tian W, Rockson SG.

Annu Rev Physiol. 2018 Feb 10;80:49-70. doi: 10.1146/annurev-physiol-022516-034008. Epub 2017 Oct 13. Review.


Dynamics of the human antibody repertoire after B cell depletion in systemic sclerosis.

de Bourcy CFA, Dekker CL, Davis MM, Nicolls MR, Quake SR.

Sci Immunol. 2017 Sep 29;2(15). pii: eaan8289. doi: 10.1126/sciimmunol.aan8289.


Introduction to the 59th Annual Thomas L. Petty Aspen Lung Conference. Lung Transplantation: Opportunities for Repair and Regeneration.

Zamora MR, Martinu T, Nicolls MR.

Ann Am Thorac Soc. 2017 Sep;14(Suppl_3):S209. doi: 10.1513/AnnalsATS.201705-393MG. No abstract available.


Upregulation of Human Endogenous Retrovirus-K Is Linked to Immunity and Inflammation in Pulmonary Arterial Hypertension.

Saito T, Miyagawa K, Chen SY, Tamosiuniene R, Wang L, Sharpe O, Samayoa E, Harada D, Moonen JAJ, Cao A, Chen PI, Hennigs JK, Gu M, Li CG, Leib RD, Li D, Adams CM, Del Rosario PA, Bill M, Haddad F, Montoya JG, Robinson WH, Fantl WJ, Nolan GP, Zamanian RT, Nicolls MR, Chiu CY, Ariza ME, Rabinovitch M.

Circulation. 2017 Nov 14;136(20):1920-1935. doi: 10.1161/CIRCULATIONAHA.117.027589. Epub 2017 Sep 21.


Leukotriene B4 antagonism ameliorates experimental lymphedema.

Tian W, Rockson SG, Jiang X, Kim J, Begaye A, Shuffle EM, Tu AB, Cribb M, Nepiyushchikh Z, Feroze AH, Zamanian RT, Dhillon GS, Voelkel NF, Peters-Golden M, Kitajewski J, Dixon JB, Nicolls MR.

Sci Transl Med. 2017 May 10;9(389). pii: eaal3920. doi: 10.1126/scitranslmed.aal3920.


Models of Lung Transplant Research: a consensus statement from the National Heart, Lung, and Blood Institute workshop.

Lama VN, Belperio JA, Christie JD, El-Chemaly S, Fishbein MC, Gelman AE, Hancock WW, Keshavjee S, Kreisel D, Laubach VE, Looney MR, McDyer JF, Mohanakumar T, Shilling RA, Panoskaltsis-Mortari A, Wilkes DS, Eu JP, Nicolls MR.

JCI Insight. 2017 May 4;2(9). pii: 93121. doi: 10.1172/jci.insight.93121. eCollection 2017 May 4. Review.


Enhanced Electrochemical Sensing with Carbon Nanotubes Modified with Bismuth and Magnetic Nanoparticles in a Lab-on-a-Chip.

Jothimuthu P, Hsu JL, Chen R, Inayathullah M, Pothineni VR, Jan A, Gurtner GC, Rajadas J, Nicolls MR.

ChemNanoMat. 2016 Sep;2(9):904-910. Epub 2016 Jul 25.


Aspergillus-related pulmonary diseases in lung transplantation.

Pasupneti S, Manouvakhova O, Nicolls MR, Hsu JL.

Med Mycol. 2017 Jan 1;55(1):96-102. Epub 2016 Nov 5. Review.


Simultaneously Targeting Myofibroblast Contractility and Extracellular Matrix Cross-Linking as a Therapeutic Concept in Airway Fibrosis.

Lin YC, Sung YK, Jiang X, Peters-Golden M, Nicolls MR.

Am J Transplant. 2017 May;17(5):1229-1241. doi: 10.1111/ajt.14103. Epub 2016 Dec 5.


The Roles of Immunity in the Prevention and Evolution of Pulmonary Arterial Hypertension.

Nicolls MR, Voelkel NF.

Am J Respir Crit Care Med. 2017 May 15;195(10):1292-1299. doi: 10.1164/rccm.201608-1630PP. No abstract available.


Translating Research into Improved Patient Care in Pulmonary Arterial Hypertension.

Bonnet S, Provencher S, Guignabert C, Perros F, Boucherat O, Schermuly RT, Hassoun PM, Rabinovitch M, Nicolls MR, Humbert M.

Am J Respir Crit Care Med. 2017 Mar 1;195(5):583-595. doi: 10.1164/rccm.201607-1515PP. Review. No abstract available.


Challenges and opportunities in treating inflammation associated with pulmonary hypertension.

Voelkel NF, Tamosiuniene R, Nicolls MR.

Expert Rev Cardiovasc Ther. 2016 Aug;14(8):939-51. doi: 10.1080/14779072.2016.1180976. Epub 2016 May 4. Review.


Effect of Transplant Center Volume on Cost and Readmissions in Medicare Lung Transplant Recipients.

Mooney JJ, Weill D, Boyd JH, Nicolls MR, Bhattacharya J, Dhillon GS.

Ann Am Thorac Soc. 2016 Jul;13(7):1034-41. doi: 10.1513/AnnalsATS.201601-017OC.


Microvascular injury after lung transplantation.

Nicolls MR, Hsu JL, Jiang X.

Curr Opin Organ Transplant. 2016 Jun;21(3):279-84. doi: 10.1097/MOT.0000000000000307. Review.


A Critical Role for Airway Microvessels in Lung Transplantation.

Nicolls MR, Dhillon GS, Daddi N.

Am J Respir Crit Care Med. 2016 Mar 1;193(5):479-81. doi: 10.1164/rccm.201511-2117ED. No abstract available.


Lung Quality and Utilization in Controlled Donation After Circulatory Determination of Death Within the United States.

Mooney JJ, Hedlin H, Mohabir PK, Vazquez R, Nguyen J, Ha R, Chiu P, Patel K, Zamora MR, Weill D, Nicolls MR, Dhillon GS.

Am J Transplant. 2016 Apr;16(4):1207-15. doi: 10.1111/ajt.13599. Epub 2016 Feb 4.


Leukotriene B4 Activates Pulmonary Artery Adventitial Fibroblasts in Pulmonary Hypertension.

Qian J, Tian W, Jiang X, Tamosiuniene R, Sung YK, Shuffle EM, Tu AB, Valenzuela A, Jiang S, Zamanian RT, Fiorentino DF, Voelkel NF, Peters-Golden M, Stenmark KR, Chung L, Rabinovitch M, Nicolls MR.

Hypertension. 2015 Dec;66(6):1227-1239. doi: 10.1161/HYPERTENSIONAHA.115.06370. Epub 2015 Oct 5.


Noninvasive monitoring of infection and rejection after lung transplantation.

De Vlaminck I, Martin L, Kertesz M, Patel K, Kowarsky M, Strehl C, Cohen G, Luikart H, Neff NF, Okamoto J, Nicolls MR, Cornfield D, Weill D, Valantine H, Khush KK, Quake SR.

Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):13336-41. doi: 10.1073/pnas.1517494112. Epub 2015 Oct 12.


Elafin Reverses Pulmonary Hypertension via Caveolin-1-Dependent Bone Morphogenetic Protein Signaling.

Nickel NP, Spiekerkoetter E, Gu M, Li CG, Li H, Kaschwich M, Diebold I, Hennigs JK, Kim KY, Miyagawa K, Wang L, Cao A, Sa S, Jiang X, Stockstill RW, Nicolls MR, Zamanian RT, Bland RD, Rabinovitch M.

Am J Respir Crit Care Med. 2015 Jun 1;191(11):1273-86. doi: 10.1164/rccm.201412-2291OC.


Cyclosporine Does Not Prevent Microvascular Loss in Transplantation but Can Synergize With a Neutrophil Elastase Inhibitor, Elafin, to Maintain Graft Perfusion During Acute Rejection.

Jiang X, Nguyen TT, Tian W, Sung YK, Yuan K, Qian J, Rajadas J, Sallenave JM, Nickel NP, de Jesus Perez V, Rabinovitch M, Nicolls MR.

Am J Transplant. 2015 Jul;15(7):1768-81. doi: 10.1111/ajt.13189. Epub 2015 Feb 27.


Increased resource use in lung transplant admissions in the lung allocation score era.

Maxwell BG, Mooney JJ, Lee PH, Levitt JE, Chhatwani L, Nicolls MR, Zamora MR, Valentine V, Weill D, Dhillon GS.

Am J Respir Crit Care Med. 2015 Feb 1;191(3):302-8. doi: 10.1164/rccm.201408-1562OC.


Activation of the Wnt/planar cell polarity pathway is required for pericyte recruitment during pulmonary angiogenesis.

Yuan K, Orcholski ME, Panaroni C, Shuffle EM, Huang NF, Jiang X, Tian W, Vladar EK, Wang L, Nicolls MR, Wu JY, de Jesus Perez VA.

Am J Pathol. 2015 Jan;185(1):69-84. doi: 10.1016/j.ajpath.2014.09.013. Epub 2014 Nov 6.


Impact of the lung allocation score on survival beyond 1 year.

Maxwell BG, Levitt JE, Goldstein BA, Mooney JJ, Nicolls MR, Zamora M, Valentine V, Weill D, Dhillon GS.

Am J Transplant. 2014 Oct;14(10):2288-94. doi: 10.1111/ajt.12903. Epub 2014 Sep 10.


Traumatic brain injury: lungs in a RAGE.

Nicolls MR, Laubach VE.

Sci Transl Med. 2014 Sep 3;6(252):252fs34. doi: 10.1126/scitranslmed.3010259. Review. No abstract available.


Unique predictors of mortality in patients with pulmonary arterial hypertension associated with systemic sclerosis in the REVEAL registry.

Chung L, Farber HW, Benza R, Miller DP, Parsons L, Hassoun PM, McGoon M, Nicolls MR, Zamanian RT.

Chest. 2014 Dec;146(6):1494-1504. doi: 10.1378/chest.13-3014.


Inflammation and immunity in the pathogenesis of pulmonary arterial hypertension.

Rabinovitch M, Guignabert C, Humbert M, Nicolls MR.

Circ Res. 2014 Jun 20;115(1):165-75. doi: 10.1161/CIRCRESAHA.113.301141. Review.


Graft microvascular disease in solid organ transplantation.

Jiang X, Sung YK, Tian W, Qian J, Semenza GL, Nicolls MR.

J Mol Med (Berl). 2014 Aug;92(8):797-810. doi: 10.1007/s00109-014-1173-y. Epub 2014 Jun 1. Review.


Nuclear factor κB inhibition reduces lung vascular lumen obliteration in severe pulmonary hypertension in rats.

Farkas D, Alhussaini AA, Kraskauskas D, Kraskauskiene V, Cool CD, Nicolls MR, Natarajan R, Farkas L.

Am J Respir Cell Mol Biol. 2014 Sep;51(3):413-25. doi: 10.1165/rcmb.2013-0355OC.


Macrophages in solid organ transplantation.

Jiang X, Tian W, Sung YK, Qian J, Nicolls MR.

Vasc Cell. 2014 Mar 11;6(1):5. doi: 10.1186/2045-824X-6-5.


Leukotrienes in pulmonary arterial hypertension.

Tian W, Jiang X, Sung YK, Qian J, Yuan K, Nicolls MR.

Immunol Res. 2014 May;58(2-3):387-93. doi: 10.1007/s12026-014-8492-5. Review.


Working toward immune tolerance in lung transplantation.

Jiang X, Nicolls MR.

J Clin Invest. 2014 Mar;124(3):967-70. doi: 10.1172/JCI74701. Epub 2014 Feb 24.


Complement components as potential therapeutic targets for asthma treatment.

Khan MA, Nicolls MR, Surguladze B, Saadoun I.

Respir Med. 2014 Apr;108(4):543-9. doi: 10.1016/j.rmed.2014.01.005. Epub 2014 Jan 15. Review.


Application of a non-amplification-based technology to detect invasive fungal pathogens.

Hsu JL, Binkley J, Clemons KV, Stevens DA, Nicolls MR, Holodniy M.

Diagn Microbiol Infect Dis. 2014 Feb;78(2):137-40. doi: 10.1016/j.diagmicrobio.2013.11.013. Epub 2013 Nov 21.

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