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Phase Separation-Mediated TARP/MAGUK Complex Condensation and AMPA Receptor Synaptic Transmission.

Zeng M, Díaz-Alonso J, Ye F, Chen X, Xu J, Ji Z, Nicoll RA, Zhang M.

Neuron. 2019 Nov 6;104(3):529-543.e6. doi: 10.1016/j.neuron.2019.08.001. Epub 2019 Sep 3.


Dissecting the Role of Synaptic Proteins with CRISPR.

Incontro S, Asensio CS, Nicoll RA.

In: Jaenisch R, Zhang F, Gage F, editors. Genome Editing in Neurosciences [Internet]. Cham (CH): Springer; 2017.
2017 Sep 15.


SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse.

Koopmans F, van Nierop P, Andres-Alonso M, Byrnes A, Cijsouw T, Coba MP, Cornelisse LN, Farrell RJ, Goldschmidt HL, Howrigan DP, Hussain NK, Imig C, de Jong APH, Jung H, Kohansalnodehi M, Kramarz B, Lipstein N, Lovering RC, MacGillavry H, Mariano V, Mi H, Ninov M, Osumi-Sutherland D, Pielot R, Smalla KH, Tang H, Tashman K, Toonen RFG, Verpelli C, Reig-Viader R, Watanabe K, van Weering J, Achsel T, Ashrafi G, Asi N, Brown TC, De Camilli P, Feuermann M, Foulger RE, Gaudet P, Joglekar A, Kanellopoulos A, Malenka R, Nicoll RA, Pulido C, de Juan-Sanz J, Sheng M, Südhof TC, Tilgner HU, Bagni C, Bayés À, Biederer T, Brose N, Chua JJE, Dieterich DC, Gundelfinger ED, Hoogenraad C, Huganir RL, Jahn R, Kaeser PS, Kim E, Kreutz MR, McPherson PS, Neale BM, O'Connor V, Posthuma D, Ryan TA, Sala C, Feng G, Hyman SE, Thomas PD, Smit AB, Verhage M.

Neuron. 2019 Jul 17;103(2):217-234.e4. doi: 10.1016/j.neuron.2019.05.002. Epub 2019 Jun 3.


Characterizing and Simulating the Movement of Late-Instar Gypsy Moth (Lepidoptera: Erebidae) to Evaluate the Effectiveness of Regulatory Practices.

Wittman JT, Nicoll RA, Myers SW, Chaloux PH, Aukema BH.

Environ Entomol. 2019 Jun 7;48(3):496-505. doi: 10.1093/ee/nvz025.


The STEP61 interactome reveals subunit-specific AMPA receptor binding and synaptic regulation.

Won S, Incontro S, Li Y, Nicoll RA, Roche KW.

Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):8028-8037. doi: 10.1073/pnas.1900878116. Epub 2019 Apr 1.


Mechanisms underlying the synaptic trafficking of the glutamate delta receptor GluD1.

Tao W, Ma C, Bemben MA, Li KH, Burlingame AL, Zhang M, Nicoll RA.

Mol Psychiatry. 2019 Oct;24(10):1451-1460. doi: 10.1038/s41380-019-0378-4. Epub 2019 Mar 1.


Author Correction: The CaMKII/NMDA receptor complex controls hippocampal synaptic transmission by kinase-dependent and independent mechanisms.

Incontro S, Díaz-Alonso J, Iafrati J, Vieira M, Asensio CS, Sohal VS, Roche KW, Bender KJ, Nicoll RA.

Nat Commun. 2018 Dec 3;9(1):5205. doi: 10.1038/s41467-018-07637-5.


Signal peptide represses GluK1 surface and synaptic trafficking through binding to amino-terminal domain.

Duan GF, Ye Y, Xu S, Tao W, Zhao S, Jin T, Nicoll RA, Shi YS, Sheng N.

Nat Commun. 2018 Nov 19;9(1):4879. doi: 10.1038/s41467-018-07403-7.


Isoform-specific cleavage of neuroligin-3 reduces synapse strength.

Bemben MA, Nguyen TA, Li Y, Wang T, Nicoll RA, Roche KW.

Mol Psychiatry. 2019 Jan;24(1):145-160. doi: 10.1038/s41380-018-0242-y. Epub 2018 Sep 21.


The CaMKII/NMDA receptor complex controls hippocampal synaptic transmission by kinase-dependent and independent mechanisms.

Incontro S, Díaz-Alonso J, Iafrati J, Vieira M, Asensio CS, Sohal VS, Roche KW, Bender KJ, Nicoll RA.

Nat Commun. 2018 May 25;9(1):2069. doi: 10.1038/s41467-018-04439-7. Erratum in: Nat Commun. 2018 Dec 3;9(1):5205.


Postsynaptic δ1 glutamate receptor assembles and maintains hippocampal synapses via Cbln2 and neurexin.

Tao W, Díaz-Alonso J, Sheng N, Nicoll RA.

Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):E5373-E5381. doi: 10.1073/pnas.1802737115. Epub 2018 May 21.


The GABAA Receptor β Subunit Is Required for Inhibitory Transmission.

Nguyen QA, Nicoll RA.

Neuron. 2018 May 16;98(4):718-725.e3. doi: 10.1016/j.neuron.2018.03.046. Epub 2018 Apr 26.


LTP requires postsynaptic PDZ-domain interactions with glutamate receptor/auxiliary protein complexes.

Sheng N, Bemben MA, Díaz-Alonso J, Tao W, Shi YS, Nicoll RA.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3948-3953. doi: 10.1073/pnas.1800719115. Epub 2018 Mar 26.


A mouse model of autism implicates endosome pH in the regulation of presynaptic calcium entry.

Ullman JC, Yang J, Sullivan M, Bendor J, Levy J, Pham E, Silm K, Seifikar H, Sohal VS, Nicoll RA, Edwards RH.

Nat Commun. 2018 Jan 23;9(1):330. doi: 10.1038/s41467-017-02716-5.


Somatostatin and parvalbumin inhibitory synapses onto hippocampal pyramidal neurons are regulated by distinct mechanisms.

Horn ME, Nicoll RA.

Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):589-594. doi: 10.1073/pnas.1719523115. Epub 2018 Jan 2.


Synaptic homeostasis requires the membrane-proximal carboxy tail of GluA2.

Ancona Esselmann SG, Díaz-Alonso J, Levy JM, Bemben MA, Nicoll RA.

Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):13266-13271. doi: 10.1073/pnas.1716022114. Epub 2017 Nov 27.


Phosphorylation of the kainate receptor (KAR) auxiliary subunit Neto2 at serine 409 regulates synaptic targeting of the KAR subunit GluK1.

Lomash RM, Sheng N, Li Y, Nicoll RA, Roche KW.

J Biol Chem. 2017 Sep 15;292(37):15369-15377. doi: 10.1074/jbc.M117.787903. Epub 2017 Jul 17.


Subunit-specific role for the amino-terminal domain of AMPA receptors in synaptic targeting.

Díaz-Alonso J, Sun YJ, Granger AJ, Levy JM, Blankenship SM, Nicoll RA.

Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7136-7141. doi: 10.1073/pnas.1707472114. Epub 2017 Jun 19.


MAGUKs: multifaceted synaptic organizers.

Won S, Levy JM, Nicoll RA, Roche KW.

Curr Opin Neurobiol. 2017 Apr;43:94-101. doi: 10.1016/j.conb.2017.01.006. Epub 2017 Feb 23. Review.


A Brief History of Long-Term Potentiation.

Nicoll RA.

Neuron. 2017 Jan 18;93(2):281-290. doi: 10.1016/j.neuron.2016.12.015. Review.


Amino-terminal domains of kainate receptors determine the differential dependence on Neto auxiliary subunits for trafficking.

Sheng N, Shi YS, Nicoll RA.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1159-1164. doi: 10.1073/pnas.1619253114. Epub 2017 Jan 18.


Membrane-associated guanylate kinase dynamics reveal regional and developmental specificity of synapse stability.

Levy JM, Nicoll RA.

J Physiol. 2017 Mar 1;595(5):1699-1709. doi: 10.1113/JP273147. Epub 2017 Jan 18.


Distinct roles for extracellular and intracellular domains in neuroligin function at inhibitory synapses.

Nguyen QA, Horn ME, Nicoll RA.

Elife. 2016 Nov 2;5. pii: e19236. doi: 10.7554/eLife.19236.


A slow excitatory postsynaptic current mediated by a novel metabotropic glutamate receptor in CA1 pyramidal neurons.

Sheng N, Yang J, Silm K, Edwards RH, Nicoll RA.

Neuropharmacology. 2017 Mar 15;115:4-9. doi: 10.1016/j.neuropharm.2016.08.028. Epub 2016 Aug 25.


PSD-95 stabilizes NMDA receptors by inducing the degradation of STEP61.

Won S, Incontro S, Nicoll RA, Roche KW.

Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4736-44. doi: 10.1073/pnas.1609702113. Epub 2016 Jul 25.


Long-Term Potentiation: From CaMKII to AMPA Receptor Trafficking.

Herring BE, Nicoll RA.

Annu Rev Physiol. 2016;78:351-65. doi: 10.1146/annurev-physiol-021014-071753. Review.


Kalirin and Trio proteins serve critical roles in excitatory synaptic transmission and LTP.

Herring BE, Nicoll RA.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2264-9. doi: 10.1073/pnas.1600179113. Epub 2016 Feb 8.


Neto auxiliary proteins control both the trafficking and biophysical properties of the kainate receptor GluK1.

Sheng N, Shi YS, Lomash RM, Roche KW, Nicoll RA.

Elife. 2015 Dec 31;4. pii: e11682. doi: 10.7554/eLife.11682.


PSD-95 family MAGUKs are essential for anchoring AMPA and NMDA receptor complexes at the postsynaptic density.

Chen X, Levy JM, Hou A, Winters C, Azzam R, Sousa AA, Leapman RD, Nicoll RA, Reese TS.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):E6983-92. doi: 10.1073/pnas.1517045112. Epub 2015 Nov 24.


Synaptic Consolidation Normalizes AMPAR Quantal Size following MAGUK Loss.

Levy JM, Chen X, Reese TS, Nicoll RA.

Neuron. 2015 Aug 5;87(3):534-48. doi: 10.1016/j.neuron.2015.07.015.


The cellular and molecular landscape of neuroligins.

Bemben MA, Shipman SL, Nicoll RA, Roche KW.

Trends Neurosci. 2015 Aug;38(8):496-505. doi: 10.1016/j.tins.2015.06.004. Epub 2015 Jul 21. Review.


Is Aspartate an Excitatory Neurotransmitter?

Herring BE, Silm K, Edwards RH, Nicoll RA.

J Neurosci. 2015 Jul 15;35(28):10168-71. doi: 10.1523/JNEUROSCI.0524-15.2015.


The LGI1-ADAM22 protein complex directs synapse maturation through regulation of PSD-95 function.

Lovero KL, Fukata Y, Granger AJ, Fukata M, Nicoll RA.

Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):E4129-37. doi: 10.1073/pnas.1511910112. Epub 2015 Jul 15.


Autism-associated mutation inhibits protein kinase C-mediated neuroligin-4X enhancement of excitatory synapses.

Bemben MA, Nguyen QA, Wang T, Li Y, Nicoll RA, Roche KW.

Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2551-6. doi: 10.1073/pnas.1500501112. Epub 2015 Feb 9.


Relative contribution of TARPs γ-2 and γ-7 to cerebellar excitatory synaptic transmission and motor behavior.

Yamazaki M, Le Pichon CE, Jackson AC, Cerpas M, Sakimura K, Scearce-Levie K, Nicoll RA.

Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):E371-9. doi: 10.1073/pnas.1423670112. Epub 2015 Jan 12.


Efficient, complete deletion of synaptic proteins using CRISPR.

Incontro S, Asensio CS, Edwards RH, Nicoll RA.

Neuron. 2014 Sep 3;83(5):1051-7. doi: 10.1016/j.neuron.2014.07.043. Epub 2014 Aug 21. Erratum in: Neuron. 2015 Nov 4;88(3):617.


LTD expression is independent of glutamate receptor subtype.

Granger AJ, Nicoll RA.

Front Synaptic Neurosci. 2014 Jul 8;6:15. doi: 10.3389/fnsyn.2014.00015. eCollection 2014.


Retromer mediates a discrete route of local membrane delivery to dendrites.

Choy RW, Park M, Temkin P, Herring BE, Marley A, Nicoll RA, von Zastrow M.

Neuron. 2014 Apr 2;82(1):55-62. doi: 10.1016/j.neuron.2014.02.018.


A cortical circuit for gain control by behavioral state.

Fu Y, Tucciarone JM, Espinosa JS, Sheng N, Darcy DP, Nicoll RA, Huang ZJ, Stryker MP.

Cell. 2014 Mar 13;156(6):1139-1152. doi: 10.1016/j.cell.2014.01.050.


CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses.

Bemben MA, Shipman SL, Hirai T, Herring BE, Li Y, Badger JD 2nd, Nicoll RA, Diamond JS, Roche KW.

Nat Neurosci. 2014 Jan;17(1):56-64. doi: 10.1038/nn.3601. Epub 2013 Dec 15.


Expression mechanisms underlying long-term potentiation: a postsynaptic view, 10 years on.

Granger AJ, Nicoll RA.

Philos Trans R Soc Lond B Biol Sci. 2013 Dec 2;369(1633):20130136. doi: 10.1098/rstb.2013.0136. Print 2014 Jan 5. Review.


AMPARs and synaptic plasticity: the last 25 years.

Huganir RL, Nicoll RA.

Neuron. 2013 Oct 30;80(3):704-17. doi: 10.1016/j.neuron.2013.10.025.


Distance-dependent scaling of AMPARs is cell-autonomous and GluA2 dependent.

Shipman SL, Herring BE, Suh YH, Roche KW, Nicoll RA.

J Neurosci. 2013 Aug 14;33(33):13312-9. doi: 10.1523/JNEUROSCI.0678-13.2013.


SynDIG1 promotes excitatory synaptogenesis independent of AMPA receptor trafficking and biophysical regulation.

Lovero KL, Blankenship SM, Shi Y, Nicoll RA.

PLoS One. 2013 Jun 13;8(6):e66171. doi: 10.1371/journal.pone.0066171. Print 2013.


The cell-autonomous role of excitatory synaptic transmission in the regulation of neuronal structure and function.

Lu W, Bushong EA, Shih TP, Ellisman MH, Nicoll RA.

Neuron. 2013 May 8;78(3):433-9. doi: 10.1016/j.neuron.2013.02.030.


Cornichon proteins determine the subunit composition of synaptic AMPA receptors.

Herring BE, Shi Y, Suh YH, Zheng CY, Blankenship SM, Roche KW, Nicoll RA.

Neuron. 2013 Mar 20;77(6):1083-96. doi: 10.1016/j.neuron.2013.01.017.


Activated CaMKII couples GluN2B and casein kinase 2 to control synaptic NMDA receptors.

Sanz-Clemente A, Gray JA, Ogilvie KA, Nicoll RA, Roche KW.

Cell Rep. 2013 Mar 28;3(3):607-14. doi: 10.1016/j.celrep.2013.02.011. Epub 2013 Mar 7.


Long-term potentiation: peeling the onion.

Nicoll RA, Roche KW.

Neuropharmacology. 2013 Nov;74:18-22. doi: 10.1016/j.neuropharm.2013.02.010. Epub 2013 Feb 21. Review.


LTP requires a reserve pool of glutamate receptors independent of subunit type.

Granger AJ, Shi Y, Lu W, Cerpas M, Nicoll RA.

Nature. 2013 Jan 24;493(7433):495-500. doi: 10.1038/nature11775. Epub 2012 Dec 12.


Dimerization of postsynaptic neuroligin drives synaptic assembly via transsynaptic clustering of neurexin.

Shipman SL, Nicoll RA.

Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19432-7. doi: 10.1073/pnas.1217633109. Epub 2012 Nov 5.

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