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Items: 1 to 50 of 82

1.

Acetaminophen Overdose as a Potential Risk Factor for Parkinson's Disease.

Bohler S, Liu X, Krauskopf J, Caiment F, Aubrecht J, Nicolaes GAF, Kleinjans JCS, Briedé JJ.

Clin Transl Sci. 2019 Jul 15. doi: 10.1111/cts.12663. [Epub ahead of print]

PMID:
31305025
2.

Rational modulator design by exploitation of protein-protein complex structures.

Wichapong K, Poelman H, Ercig B, Hrdinova J, Liu X, Lutgens E, Nicolaes GA.

Future Med Chem. 2019 May;11(9):1015-1033. doi: 10.4155/fmc-2018-0433. Epub 2019 May 29.

PMID:
31141413
3.

Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death.

Silvestre-Roig C, Braster Q, Wichapong K, Lee EY, Teulon JM, Berrebeh N, Winter J, Adrover JM, Santos GS, Froese A, Lemnitzer P, Ortega-Gómez A, Chevre R, Marschner J, Schumski A, Winter C, Perez-Olivares L, Pan C, Paulin N, Schoufour T, Hartwig H, González-Ramos S, Kamp F, Megens RTA, Mowen KA, Gunzer M, Maegdefessel L, Hackeng T, Lutgens E, Daemen M, von Blume J, Anders HJ, Nikolaev VO, Pellequer JL, Weber C, Hidalgo A, Nicolaes GAF, Wong GCL, Soehnlein O.

Nature. 2019 May;569(7755):236-240. doi: 10.1038/s41586-019-1167-6. Epub 2019 May 1.

PMID:
31043745
4.

Deficiency of the T cell regulator Casitas B-cell lymphoma-B aggravates atherosclerosis by inducing CD8+ T cell-mediated macrophage death.

Seijkens TTP, Poels K, Meiler S, van Tiel CM, Kusters PJH, Reiche M, Atzler D, Winkels H, Tjwa M, Poelman H, Slütter B, Kuiper J, Gijbels M, Kuivenhoven JA, Matic LP, Paulsson-Berne G, Hedin U, Hansson GK, Nicolaes GAF, Daemen MJAP, Weber C, Gerdes N, de Winther MPJ, Lutgens E.

Eur Heart J. 2019 Jan 21;40(4):372-382. doi: 10.1093/eurheartj/ehy714.

5.

Inhibiting Inflammation with Myeloid Cell-Specific Nanobiologics Promotes Organ Transplant Acceptance.

Braza MS, van Leent MMT, Lameijer M, Sanchez-Gaytan BL, Arts RJW, Pérez-Medina C, Conde P, Garcia MR, Gonzalez-Perez M, Brahmachary M, Fay F, Kluza E, Kossatz S, Dress RJ, Salem F, Rialdi A, Reiner T, Boros P, Strijkers GJ, Calcagno CC, Ginhoux F, Marazzi I, Lutgens E, Nicolaes GAF, Weber C, Swirski FK, Nahrendorf M, Fisher EA, Duivenvoorden R, Fayad ZA, Netea MG, Mulder WJM, Ochando J.

Immunity. 2018 Nov 20;49(5):819-828.e6. doi: 10.1016/j.immuni.2018.09.008. Epub 2018 Nov 6.

PMID:
30413362
6.

Chrono-pharmacological Targeting of the CCL2-CCR2 Axis Ameliorates Atherosclerosis.

Winter C, Silvestre-Roig C, Ortega-Gomez A, Lemnitzer P, Poelman H, Schumski A, Winter J, Drechsler M, de Jong R, Immler R, Sperandio M, Hristov M, Zeller T, Nicolaes GAF, Weber C, Viola JR, Hidalgo A, Scheiermann C, Soehnlein O.

Cell Metab. 2018 Jul 3;28(1):175-182.e5. doi: 10.1016/j.cmet.2018.05.002. Epub 2018 May 31.

7.

Child-onset thrombotic thrombocytopenic purpura caused by p.R498C and p.G259PfsX133 mutations in ADAMTS13.

Schelpe AS, Orlando C, Ercig B, Geeroms C, Pareyn I, Vandeputte N, Velásquez Pereira LC, Roose E, Fostier K, Nicolaes GAF, Deckmyn H, De Meyer SF, Vanhoorelbeke K, Jochmans K.

Eur J Haematol. 2018 May 15. doi: 10.1111/ejh.13094. [Epub ahead of print]

PMID:
29763513
8.

Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis.

Seijkens TTP, van Tiel CM, Kusters PJH, Atzler D, Soehnlein O, Zarzycka B, Aarts SABM, Lameijer M, Gijbels MJ, Beckers L, den Toom M, Slütter B, Kuiper J, Duchene J, Aslani M, Megens RTA, van 't Veer C, Kooij G, Schrijver R, Hoeksema MA, Boon L, Fay F, Tang J, Baxter S, Jongejan A, Moerland PD, Vriend G, Bleijlevens B, Fisher EA, Duivenvoorden R, Gerdes N, de Winther MPJ, Nicolaes GA, Mulder WJM, Weber C, Lutgens E.

J Am Coll Cardiol. 2018 Feb 6;71(5):527-542. doi: 10.1016/j.jacc.2017.11.055.

9.

Insights into 3D Structure of ADAMTS13: A Stepping Stone towards Novel Therapeutic Treatment of Thrombotic Thrombocytopenic Purpura.

Ercig B, Wichapong K, Reutelingsperger CPM, Vanhoorelbeke K, Voorberg J, Nicolaes GAF.

Thromb Haemost. 2018 Jan;118(1):28-41. doi: 10.1160/TH17-06-0404. Epub 2018 Jan 5.

PMID:
29304523
10.

Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation.

Aarts SABM, Seijkens TTP, Kusters PJH, van der Pol SMA, Zarzycka B, Heijnen PDAM, Beckers L, den Toom M, Gijbels MJJ, Boon L, Weber C, de Vries HE, Nicolaes GAF, Dijkstra CD, Kooij G, Lutgens E.

J Neuroinflammation. 2017 May 12;14(1):105. doi: 10.1186/s12974-017-0875-9.

11.

Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation.

von Hundelshausen P, Agten SM, Eckardt V, Blanchet X, Schmitt MM, Ippel H, Neideck C, Bidzhekov K, Leberzammer J, Wichapong K, Faussner A, Drechsler M, Grommes J, van Geffen JP, Li H, Ortega-Gomez A, Megens RT, Naumann R, Dijkgraaf I, Nicolaes GA, Döring Y, Soehnlein O, Lutgens E, Heemskerk JW, Koenen RR, Mayo KH, Hackeng TM, Weber C.

Sci Transl Med. 2017 Apr 5;9(384). pii: eaah6650. doi: 10.1126/scitranslmed.aah6650.

PMID:
28381538
12.

Presence of Cytotoxic Extracellular Histones in Machine Perfusate of Donation After Circulatory Death Kidneys.

van Smaalen TC, Beurskens DM, Hoogland ER, Winkens B, Christiaans MH, Reutelingsperger CP, van Heurn LW, Nicolaes GA.

Transplantation. 2017 Apr;101(4):e93-e101. doi: 10.1097/TP.0000000000001590.

PMID:
27906828
13.

Structure-Based Design of Peptidic Inhibitors of the Interaction between CC Chemokine Ligand 5 (CCL5) and Human Neutrophil Peptides 1 (HNP1).

Wichapong K, Alard JE, Ortega-Gomez A, Weber C, Hackeng TM, Soehnlein O, Nicolaes GA.

J Med Chem. 2016 May 12;59(9):4289-301. doi: 10.1021/acs.jmedchem.5b01952. Epub 2016 Feb 23.

PMID:
26871718
14.

Recruitment of classical monocytes can be inhibited by disturbing heteromers of neutrophil HNP1 and platelet CCL5.

Alard JE, Ortega-Gomez A, Wichapong K, Bongiovanni D, Horckmans M, Megens RT, Leoni G, Ferraro B, Rossaint J, Paulin N, Ng J, Ippel H, Suylen D, Hinkel R, Blanchet X, Gaillard F, D'Amico M, von Hundelshausen P, Zarbock A, Scheiermann C, Hackeng TM, Steffens S, Kupatt C, Nicolaes GA, Weber C, Soehnlein O.

Sci Transl Med. 2015 Dec 9;7(317):317ra196. doi: 10.1126/scitranslmed.aad5330.

PMID:
26659570
15.

Pharmacological Targeting of AMP-Activated Protein Kinase and Opportunities for Computer-Aided Drug Design.

Miglianico M, Nicolaes GA, Neumann D.

J Med Chem. 2016 Apr 14;59(7):2879-93. doi: 10.1021/acs.jmedchem.5b01201. Epub 2015 Nov 9. Review.

PMID:
26510622
16.

Stabilization of protein-protein interaction complexes through small molecules.

Zarzycka B, Kuenemann MA, Miteva MA, Nicolaes GAF, Vriend G, Sperandio O.

Drug Discov Today. 2016 Jan;21(1):48-57. doi: 10.1016/j.drudis.2015.09.011. Epub 2015 Oct 3. Review.

PMID:
26434617
17.

iPPI-DB: an online database of modulators of protein-protein interactions.

Labbé CM, Kuenemann MA, Zarzycka B, Vriend G, Nicolaes GA, Lagorce D, Miteva MA, Villoutreix BO, Sperandio O.

Nucleic Acids Res. 2016 Jan 4;44(D1):D542-7. doi: 10.1093/nar/gkv982. Epub 2015 Oct 1.

18.

Extracellular histone H3 levels are inversely correlated with antithrombin levels and platelet counts and are associated with mortality in sepsis patients.

Wildhagen KC, Wiewel MA, Schultz MJ, Horn J, Schrijver R, Reutelingsperger CP, van der Poll T, Nicolaes GA.

Thromb Res. 2015 Sep;136(3):542-7. doi: 10.1016/j.thromres.2015.06.035. Epub 2015 Jul 23.

PMID:
26232351
19.

Identification of small-molecule inhibitors against SecA by structure-based virtual ligand screening.

De Waelheyns E, Segers K, Sardis MF, Anné J, Nicolaes GA, Economou A.

J Antibiot (Tokyo). 2015 Nov;68(11):666-73. doi: 10.1038/ja.2015.53. Epub 2015 May 20.

PMID:
25990955
20.

Targeting the adaptive immune system: new strategies in the treatment of atherosclerosis.

Zarzycka B, Nicolaes GA, Lutgens E.

Expert Rev Clin Pharmacol. 2015 May;8(3):297-313. doi: 10.1586/17512433.2015.1025052. Epub 2015 Apr 4. Review.

PMID:
25843158
21.

Two Novel Mutations in the SLC25A4 Gene in a Patient with Mitochondrial Myopathy.

Körver-Keularts IM, de Visser M, Bakker HD, Wanders RJ, Vansenne F, Scholte HR, Dorland L, Nicolaes GA, Spaapen LM, Smeets HJ, Hendrickx AT, van den Bosch BJ.

JIMD Rep. 2015;22:39-45. doi: 10.1007/8904_2015_409. Epub 2015 Mar 3.

22.

Discovery of small molecule CD40-TRAF6 inhibitors.

Zarzycka B, Seijkens T, Nabuurs SB, Ritschel T, Grommes J, Soehnlein O, Schrijver R, van Tiel CM, Hackeng TM, Weber C, Giehler F, Kieser A, Lutgens E, Vriend G, Nicolaes GA.

J Chem Inf Model. 2015 Feb 23;55(2):294-307. doi: 10.1021/ci500631e. Epub 2015 Jan 27.

PMID:
25622654
23.

The structure function of the death domain of human IRAK-M.

Du J, Nicolaes GA, Kruijswijk D, Versloot M, van der Poll T, van 't Veer C.

Cell Commun Signal. 2014 Dec 7;12:77. doi: 10.1186/s12964-014-0077-3.

24.

Blocking CD40-TRAF6 interactions by small-molecule inhibitor 6860766 ameliorates the complications of diet-induced obesity in mice.

van den Berg SM, Seijkens TT, Kusters PJ, Zarzycka B, Beckers L, den Toom M, Gijbels MJ, Chatzigeorgiou A, Weber C, de Winther MP, Chavakis T, Nicolaes GA, Lutgens E.

Int J Obes (Lond). 2015 May;39(5):782-90. doi: 10.1038/ijo.2014.198. Epub 2014 Nov 13.

PMID:
25394307
25.

Molecular simulation studies of human coagulation factor VIII C domain-mediated membrane binding.

Du J, Wichapong K, Hackeng KM, Nicolaes GA.

Thromb Haemost. 2015 Feb;113(2):373-84. doi: 10.1160/TH14-02-0180. Epub 2014 Oct 30.

PMID:
25354705
26.

Understanding the functional difference between growth arrest-specific protein 6 and protein S: an evolutionary approach.

Studer RA, Opperdoes FR, Nicolaes GA, Mulder AB, Mulder R.

Open Biol. 2014 Oct;4(10). pii: 140121. doi: 10.1098/rsob.140121.

27.

Factor Va alternative conformation reconstruction using atomic force microscopy.

Chaves RC, Dahmane S, Odorico M, Nicolaes GA, Pellequer JL.

Thromb Haemost. 2014 Dec;112(6):1167-73. doi: 10.1160/TH14-06-0481. Epub 2014 Sep 4.

PMID:
25185589
28.

Effects of exogenous recombinant APC in mouse models of ischemia reperfusion injury and of atherosclerosis.

Wildhagen KC, Schrijver R, Beckers L, ten Cate H, Reutelingsperger CP, Lutgens E, Nicolaes GA.

PLoS One. 2014 Jul 17;9(7):e101446. doi: 10.1371/journal.pone.0101446. eCollection 2014.

29.

Identification of novel small molecule inhibitors of activated protein C.

Sperandio O, Wildhagen KC, Schrijver R, Wielders S, Villoutreix BO, Nicolaes GA.

Thromb Res. 2014 Jun;133(6):1105-14. doi: 10.1016/j.thromres.2014.01.026. Epub 2014 Jan 25.

PMID:
24513148
30.

Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis.

Wildhagen KC, García de Frutos P, Reutelingsperger CP, Schrijver R, Aresté C, Ortega-Gómez A, Deckers NM, Hemker HC, Soehnlein O, Nicolaes GA.

Blood. 2014 Feb 13;123(7):1098-101. doi: 10.1182/blood-2013-07-514984. Epub 2013 Nov 21.

31.

Rational design of small molecules targeting the C2 domain of coagulation factor VIII.

Nicolaes GA, Kulharia M, Voorberg J, Kaijen PH, Wroblewska A, Wielders S, Schrijver R, Sperandio O, Villoutreix BO.

Blood. 2014 Jan 2;123(1):113-20. doi: 10.1182/blood-2013-05-503227. Epub 2013 Nov 13.

32.

Optimization of compound ranking for structure-based virtual ligand screening using an established FRED-Surflex consensus approach.

Du J, Bleylevens IW, Bitorina AV, Wichapong K, Nicolaes GA.

Chem Biol Drug Des. 2014 Jan;83(1):37-51. doi: 10.1111/cbdd.12202. Epub 2013 Oct 4.

PMID:
23941463
33.

Factor Xa activation of factor V is of paramount importance in initiating the coagulation system: lessons from a tick salivary protein.

Schuijt TJ, Bakhtiari K, Daffre S, Deponte K, Wielders SJ, Marquart JA, Hovius JW, van der Poll T, Fikrig E, Bunce MW, Camire RM, Nicolaes GA, Meijers JC, van 't Veer C.

Circulation. 2013 Jul 16;128(3):254-66. doi: 10.1161/CIRCULATIONAHA.113.003191. Epub 2013 Jul 1.

34.

Two novel mutations in the prothrombin gene identified in a patient with compound heterozygous type 1/2 prothrombin deficiency.

Kuijper PH, Schellings MW, van de Kerkhof D, Nicolaes GA, Reitsma P, Halbertsma F, Dors N.

Haemophilia. 2013 Sep;19(5):e304-6. doi: 10.1111/hae.12180. Epub 2013 May 28. No abstract available.

PMID:
23711336
35.

Comparative analysis of pharmacophore screening tools.

Sanders MP, Barbosa AJ, Zarzycka B, Nicolaes GA, Klomp JP, de Vlieg J, Del Rio A.

J Chem Inf Model. 2012 Jun 25;52(6):1607-20. doi: 10.1021/ci2005274. Epub 2012 Jun 13.

PMID:
22646988
36.

Goodpasture antigen-binding protein/ceramide transporter binds to human serum amyloid P-component and is present in brain amyloid plaques.

Mencarelli C, Bode GH, Losen M, Kulharia M, Molenaar PC, Veerhuis R, Steinbusch HW, De Baets MH, Nicolaes GA, Martinez-Martinez P.

J Biol Chem. 2012 Apr 27;287(18):14897-911. doi: 10.1074/jbc.M111.299545. Epub 2012 Mar 6.

37.

The structure-function relationship of activated protein C. Lessons from natural and engineered mutations.

Wildhagen KC, Lutgens E, Loubele ST, ten Cate H, Nicolaes GA.

Thromb Haemost. 2011 Dec;106(6):1034-45. doi: 10.1160/TH11-08-0522. Epub 2011 Nov 10. Review.

PMID:
22072231
38.

Engineered annexin A5 variants have impaired cell entry for molecular imaging of apoptosis using pretargeting strategies.

Ungethüm L, Kenis H, Nicolaes GA, Autin L, Stoilova-McPhie S, Reutelingsperger CP.

J Biol Chem. 2011 Jan 21;286(3):1903-10. doi: 10.1074/jbc.M110.163527. Epub 2010 Nov 15.

39.

Riboflavin-responsive oxidative phosphorylation complex I deficiency caused by defective ACAD9: new function for an old gene.

Gerards M, van den Bosch BJ, Danhauser K, Serre V, van Weeghel M, Wanders RJ, Nicolaes GA, Sluiter W, Schoonderwoerd K, Scholte HR, Prokisch H, Rötig A, de Coo IF, Smeets HJ.

Brain. 2011 Jan;134(Pt 1):210-9. doi: 10.1093/brain/awq273. Epub 2010 Oct 7.

PMID:
20929961
40.

The D2194G mutation is responsible for increased levels of FV1 in carriers of the factor V R2 haplotype.

Yamazaki T, Okada H, Balling KW, Dahlbäck B, Nicolaes GA.

Thromb Haemost. 2010 Oct;104(4):860-1. doi: 10.1160/TH10-03-0180. Epub 2010 Aug 5. No abstract available.

PMID:
20694279
41.

Inhibition of thrombin formation by active site mutated (S360A) activated protein C.

Nicolaes GA, Bock PE, Segers K, Wildhagen KC, Dahlbäck B, Rosing J.

J Biol Chem. 2010 Jul 23;285(30):22890-900. doi: 10.1074/jbc.M110.131029. Epub 2010 May 18.

42.

Trp2313-His2315 of factor VIII C2 domain is involved in membrane binding: structure of a complex between the C2 domain and an inhibitor of membrane binding.

Liu Z, Lin L, Yuan C, Nicolaes GA, Chen L, Meehan EJ, Furie B, Furie B, Huang M.

J Biol Chem. 2010 Mar 19;285(12):8824-9. doi: 10.1074/jbc.M109.080168. Epub 2010 Jan 20.

43.

Factor VIII-eGFP fusion proteins with preserved functional activity for the analysis of the early secretory pathway of factor VIII.

Heinz S, Schüttrumpf J, Simpson JC, Pepperkok R, Nicolaes GA, Abriss D, Milanov P, Roth S, Seifried E, Tonn T.

Thromb Haemost. 2009 Nov;102(5):925-35. doi: 10.1160/TH08-12-0807.

PMID:
19888531
44.

Factor IX mutants with enhanced catalytic activity.

Hartmann R, Dockal M, Kammlander W, Panholzer E, Nicolaes GA, Fiedler C, Rosing J, Scheiflinger F.

J Thromb Haemost. 2009 Oct;7(10):1656-62. doi: 10.1111/j.1538-7836.2009.03560.x. Epub 2009 Jul 28.

45.

Multimerin 1 binds factor V and activated factor V with high affinity and inhibits thrombin generation.

Jeimy SB, Fuller N, Tasneem S, Segers K, Stafford AR, Weitz JI, Camire RM, Nicolaes GA, Hayward CP.

Thromb Haemost. 2008 Dec;100(6):1058-67.

PMID:
19132231
46.

Screening Outside the Catalytic Site: Inhibition of Macromolecular Inter-actions Through Structure-Based Virtual Ligand Screening Experiments.

Sperandio O, Miteva MA, Segers K, Nicolaes GA, Villoutreix BO.

Open Biochem J. 2008;2:29-37. doi: 10.2174/1874091X00802010029. Epub 2008 Mar 10.

47.

Identification of surface epitopes of human coagulation factor Va that are important for interaction with activated protein C and heparin.

Segers K, Dahlbäck B, Rosing J, Nicolaes GA.

J Biol Chem. 2008 Aug 15;283(33):22573-81. doi: 10.1074/jbc.M801724200. Epub 2008 Jun 2.

48.

PROS1 analysis in 87 pedigrees with hereditary protein S deficiency demonstrates striking genotype-phenotype associations.

Ten Kate MK, Platteel M, Mulder R, Terpstra P, Nicolaes GA, Reitsma PH, van der Steege G, van der Meer J.

Hum Mutat. 2008 Jul;29(7):939-47. doi: 10.1002/humu.20687.

PMID:
18435454
49.

Re-evaluation of the role of the protein S-C4b binding protein complex in activated protein C-catalyzed factor Va-inactivation.

Maurissen LF, Thomassen MC, Nicolaes GA, Dahlbäck B, Tans G, Rosing J, Hackeng TM.

Blood. 2008 Mar 15;111(6):3034-41. Epub 2007 Dec 26.

50.

Defining the structure of membrane-bound human blood coagulation factor Va.

Stoilova-McPhie S, Parmenter CD, Segers K, Villoutreix BO, Nicolaes GA.

J Thromb Haemost. 2008 Jan;6(1):76-82. Epub 2007 Oct 22.

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