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The endonuclease EEPD1 mediates synthetic lethality in RAD52-depleted BRCA1 mutant breast cancer cells.

Hromas R, Kim HS, Sidhu G, Williamson E, Jaiswal A, Totterdale TA, Nole J, Lee SH, Nickoloff JA, Kong KY.

Breast Cancer Res. 2017 Nov 16;19(1):122. doi: 10.1186/s13058-017-0912-8.


Paths from DNA damage and signaling to genome rearrangements via homologous recombination.

Nickoloff JA.

Mutat Res. 2017 Dec;806:64-74. doi: 10.1016/j.mrfmmm.2017.07.008. Epub 2017 Jul 24. Review.


Translational research in radiation-induced DNA damage signaling and repair.

Nickoloff JA, Boss MK, Allen CP, LaRue SM.

Transl Cancer Res. 2017 Jul;6(Suppl 5):S875-S891. doi: 10.21037/tcr.2017.06.02.


Low- and High-LET Ionizing Radiation Induces Delayed Homologous Recombination that Persists for Two Weeks before Resolving.

Allen CP, Hirakawa H, Nakajima NI, Moore S, Nie J, Sharma N, Sugiura M, Hoki Y, Araki R, Abe M, Okayasu R, Fujimori A, Nickoloff JA.

Radiat Res. 2017 Jul;188(1):82-93. doi: 10.1667/RR14748.1. Epub 2017 May 23.


Drugging the Cancers Addicted to DNA Repair.

Nickoloff JA, Jones D, Lee SH, Williamson EA, Hromas R.

J Natl Cancer Inst. 2017 Nov 1;109(11). doi: 10.1093/jnci/djx059. Review.


TAS-116, a Novel Hsp90 Inhibitor, Selectively Enhances Radiosensitivity of Human Cancer Cells to X-rays and Carbon Ion Radiation.

Lee Y, Sunada S, Hirakawa H, Fujimori A, Nickoloff JA, Okayasu R.

Mol Cancer Ther. 2017 Jan;16(1):16-24. doi: 10.1158/1535-7163.MCT-16-0573. Epub 2016 Nov 9.


Endonuclease EEPD1 Is a Gatekeeper for Repair of Stressed Replication Forks.

Kim HS, Nickoloff JA, Wu Y, Williamson EA, Sidhu GS, Reinert BL, Jaiswal AS, Srinivasan G, Patel B, Kong K, Burma S, Lee SH, Hromas RA.

J Biol Chem. 2017 Feb 17;292(7):2795-2804. doi: 10.1074/jbc.M116.758235. Epub 2017 Jan 3.


Metnase Mediates Loading of Exonuclease 1 onto Single Strand Overhang DNA for End Resection at Stalled Replication Forks.

Kim HS, Williamson EA, Nickoloff JA, Hromas RA, Lee SH.

J Biol Chem. 2017 Jan 27;292(4):1414-1425. doi: 10.1074/jbc.M116.745646. Epub 2016 Dec 14.


The purine scaffold Hsp90 inhibitor PU-H71 sensitizes cancer cells to heavy ion radiation by inhibiting DNA repair by homologous recombination and non-homologous end joining.

Lee Y, Li HK, Masaoka A, Sunada S, Hirakawa H, Fujimori A, Nickoloff JA, Okayasu R.

Radiother Oncol. 2016 Oct;121(1):162-168. doi: 10.1016/j.radonc.2016.08.029. Epub 2016 Sep 22.


The homologous recombination component EEPD1 is required for genome stability in response to developmental stress of vertebrate embryogenesis.

Chun C, Wu Y, Lee SH, Williamson EA, Reinert BL, Jaiswal AS, Nickoloff JA, Hromas RA.

Cell Cycle. 2016;15(7):957-62. doi: 10.1080/15384101.2016.1151585.


Photon, light ion, and heavy ion cancer radiotherapy: paths from physics and biology to clinical practice.

Nickoloff JA.

Ann Transl Med. 2015 Dec;3(21):336. doi: 10.3978/j.issn.2305-5839.2015.12.18.


DNA Damage Response Proteins and Oxygen Modulate Prostaglandin E2 Growth Factor Release in Response to Low and High LET Ionizing Radiation.

Allen CP, Tinganelli W, Sharma N, Nie J, Sicard C, Natale F, King M 3rd, Keysar SB, Jimeno A, Furusawa Y, Okayasu R, Fujimori A, Durante M, Nickoloff JA.

Front Oncol. 2015 Dec 7;5:260. doi: 10.3389/fonc.2015.00260. eCollection 2015.


EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair.

Wu Y, Lee SH, Williamson EA, Reinert BL, Cho JH, Xia F, Jaiswal AS, Srinivasan G, Patel B, Brantley A, Zhou D, Shao L, Pathak R, Hauer-Jensen M, Singh S, Kong K, Wu X, Kim HS, Beissbarth T, Gaedcke J, Burma S, Nickoloff JA, Hromas RA.

PLoS Genet. 2015 Dec 18;11(12):e1005675. doi: 10.1371/journal.pgen.1005675. eCollection 2015 Dec.


FOXF1 mediates mesenchymal stem cell fusion-induced reprogramming of lung cancer cells.

Wei HJ, Nickoloff JA, Chen WH, Liu HY, Lo WC, Chang YT, Yang PC, Wu CW, Williams DF, Gelovani JG, Deng WP.

Oncotarget. 2014 Oct 15;5(19):9514-29.


The DNA repair component Metnase regulates Chk1 stability.

Williamson EA, Wu Y, Singh S, Byrne M, Wray J, Lee SH, Nickoloff JA, Hromas R.

Cell Div. 2014 Jul 9;9:1. doi: 10.1186/1747-1028-9-1. eCollection 2014.


DNA-PK phosphorylation of RPA32 Ser4/Ser8 regulates replication stress checkpoint activation, fork restart, homologous recombination and mitotic catastrophe.

Ashley AK, Shrivastav M, Nie J, Amerin C, Troksa K, Glanzer JG, Liu S, Opiyo SO, Dimitrova DD, Le P, Sishc B, Bailey SM, Oakley GG, Nickoloff JA.

DNA Repair (Amst). 2014 Sep;21:131-9. doi: 10.1016/j.dnarep.2014.04.008. Epub 2014 May 10.


The DDN catalytic motif is required for Metnase functions in non-homologous end joining (NHEJ) repair and replication restart.

Kim HS, Chen Q, Kim SK, Nickoloff JA, Hromas R, Georgiadis MM, Lee SH.

J Biol Chem. 2014 Apr 11;289(15):10930-8. doi: 10.1074/jbc.M113.533216. Epub 2014 Feb 25.


Assaying DNA double-strand break induction and repair as fast as a speeding comet.

Nickoloff JA.

Cell Cycle. 2013 May 1;12(9):1335-6. doi: 10.4161/cc.24667. Epub 2013 Apr 15. No abstract available.


PARP1 is required for chromosomal translocations.

Wray J, Williamson EA, Singh SB, Wu Y, Cogle CR, Weinstock DM, Zhang Y, Lee SH, Zhou D, Shao L, Hauer-Jensen M, Pathak R, Klimek V, Nickoloff JA, Hromas R.

Blood. 2013 May 23;121(21):4359-65. doi: 10.1182/blood-2012-10-460527. Epub 2013 Apr 8.


Improving cancer therapy by combining cell biological, physical, and molecular targeting strategies.

Nickoloff JA.

Chin J Cancer Res. 2013 Feb;25(1):7-9. doi: 10.3978/j.issn.1000-9604.2013.01.06. No abstract available.


Targeting the transposase domain of the DNA repair component Metnase to enhance chemotherapy.

Williamson EA, Damiani L, Leitao A, Hu C, Hathaway H, Oprea T, Sklar L, Shaheen M, Bauman J, Wang W, Nickoloff JA, Lee SH, Hromas R.

Cancer Res. 2012 Dec 1;72(23):6200-8. doi: 10.1158/0008-5472.CAN-12-0313. Epub 2012 Oct 22.


Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress.

Liu S, Opiyo SO, Manthey K, Glanzer JG, Ashley AK, Amerin C, Troksa K, Shrivastav M, Nickoloff JA, Oakley GG.

Nucleic Acids Res. 2012 Nov;40(21):10780-94. doi: 10.1093/nar/gks849. Epub 2012 Sep 12.


Chk1 phosphorylation of Metnase enhances DNA repair but inhibits replication fork restart.

Hromas R, Williamson EA, Fnu S, Lee YJ, Park SJ, Beck BD, You JS, Leitao A, Nickoloff JA, Lee SH.

Oncogene. 2012 Sep 20;31(38):4245-54. doi: 10.1038/onc.2011.586. Epub 2012 Jan 9. Erratum in: Oncogene. 2014 Jan 23;33(4):536. Laitao, A [corrected to Leitao, A].


Neoamphimedine circumvents metnase-enhanced DNA topoisomerase II╬▒ activity through ATP-competitive inhibition.

Ponder J, Yoo BH, Abraham AD, Li Q, Ashley AK, Amerin CL, Zhou Q, Reid BG, Reigan P, Hromas R, Nickoloff JA, LaBarbera DV.

Mar Drugs. 2011;9(11):2397-408. doi: 10.3390/md9112397. Epub 2011 Nov 18.


Synthetic lethality: exploiting the addiction of cancer to DNA repair.

Shaheen M, Allen C, Nickoloff JA, Hromas R.

Blood. 2011 Jun 9;117(23):6074-82. doi: 10.1182/blood-2011-01-313734. Epub 2011 Mar 25. Review.


Heavy charged particle radiobiology: using enhanced biological effectiveness and improved beam focusing to advance cancer therapy.

Allen C, Borak TB, Tsujii H, Nickoloff JA.

Mutat Res. 2011 Jun 3;711(1-2):150-7. doi: 10.1016/j.mrfmmm.2011.02.012. Epub 2011 Mar 3. Review.


More forks on the road to replication stress recovery.

Allen C, Ashley AK, Hromas R, Nickoloff JA.

J Mol Cell Biol. 2011 Feb;3(1):4-12. doi: 10.1093/jmcb/mjq049. Review.


Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining.

Fnu S, Williamson EA, De Haro LP, Brenneman M, Wray J, Shaheen M, Radhakrishnan K, Lee SH, Nickoloff JA, Hromas R.

Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):540-5. doi: 10.1073/pnas.1013571108. Epub 2010 Dec 27.


The transposase domain protein Metnase/SETMAR suppresses chromosomal translocations.

Wray J, Williamson EA, Chester S, Farrington J, Sterk R, Weinstock DM, Jasin M, Lee SH, Nickoloff JA, Hromas R.

Cancer Genet Cytogenet. 2010 Jul 15;200(2):184-90. doi: 10.1016/j.cancergencyto.2010.04.011.


Metnase promotes restart and repair of stalled and collapsed replication forks.

De Haro LP, Wray J, Williamson EA, Durant ST, Corwin L, Gentry AC, Osheroff N, Lee SH, Hromas R, Nickoloff JA.

Nucleic Acids Res. 2010 Sep;38(17):5681-91. doi: 10.1093/nar/gkq339. Epub 2010 May 10.


DNA-PKcs and ATM co-regulate DNA double-strand break repair.

Shrivastav M, Miller CA, De Haro LP, Durant ST, Chen BP, Chen DJ, Nickoloff JA.

DNA Repair (Amst). 2009 Aug 6;8(8):920-9. doi: 10.1016/j.dnarep.2009.05.006. Epub 2009 Jun 16.


Metnase mediates chromosome decatenation in acute leukemia cells.

Wray J, Williamson EA, Sheema S, Lee SH, Libby E, Willman CL, Nickoloff JA, Hromas R.

Blood. 2009 Aug 27;114(9):1852-8. doi: 10.1182/blood-2008-08-175760. Epub 2009 May 20.


Metnase mediates resistance to topoisomerase II inhibitors in breast cancer cells.

Wray J, Williamson EA, Royce M, Shaheen M, Beck BD, Lee SH, Nickoloff JA, Hromas R.

PLoS One. 2009;4(4):e5323. doi: 10.1371/journal.pone.0005323. Epub 2009 Apr 24.


INO80-dependent chromatin remodeling regulates early and late stages of mitotic homologous recombination.

Tsukuda T, Lo YC, Krishna S, Sterk R, Osley MA, Nickoloff JA.

DNA Repair (Amst). 2009 Mar 1;8(3):360-9. doi: 10.1016/j.dnarep.2008.11.014. Epub 2009 Jan 3.


The SET and transposase domain protein Metnase enhances chromosome decatenation: regulation by automethylation.

Williamson EA, Rasila KK, Corwin LK, Wray J, Beck BD, Severns V, Mobarak C, Lee SH, Nickoloff JA, Hromas R.

Nucleic Acids Res. 2008 Oct;36(18):5822-31. doi: 10.1093/nar/gkn560. Epub 2008 Sep 12.


The human set and transposase domain protein Metnase interacts with DNA Ligase IV and enhances the efficiency and accuracy of non-homologous end-joining.

Hromas R, Wray J, Lee SH, Martinez L, Farrington J, Corwin LK, Ramsey H, Nickoloff JA, Williamson EA.

DNA Repair (Amst). 2008 Dec 1;7(12):1927-37. doi: 10.1016/j.dnarep.2008.08.002. Epub 2008 Sep 18.


Mechanisms of leukemia translocations.

Nickoloff JA, De Haro LP, Wray J, Hromas R.

Curr Opin Hematol. 2008 Jul;15(4):338-45. doi: 10.1097/MOH.0b013e328302f711.


Distinct RAD51 associations with RAD52 and BCCIP in response to DNA damage and replication stress.

Wray J, Liu J, Nickoloff JA, Shen Z.

Cancer Res. 2008 Apr 15;68(8):2699-707. doi: 10.1158/0008-5472.CAN-07-6505.


Regulation of DNA double-strand break repair pathway choice.

Shrivastav M, De Haro LP, Nickoloff JA.

Cell Res. 2008 Jan;18(1):134-47. Review.


A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair.

Wu S, Shi Y, Mulligan P, Gay F, Landry J, Liu H, Lu J, Qi HH, Wang W, Nickoloff JA, Wu C, Shi Y.

Nat Struct Mol Biol. 2007 Dec;14(12):1165-72. Epub 2007 Nov 18.


BCCIP regulates homologous recombination by distinct domains and suppresses spontaneous DNA damage.

Lu H, Yue J, Meng X, Nickoloff JA, Shen Z.

Nucleic Acids Res. 2007;35(21):7160-70. Epub 2007 Oct 18.


Mre11 and Ku regulation of double-strand break repair by gene conversion and break-induced replication.

Krishna S, Wagener BM, Liu HP, Lo YC, Sterk R, Petrini JH, Nickoloff JA.

DNA Repair (Amst). 2007 Jun 1;6(6):797-808. Epub 2007 Feb 26.


ATP-dependent chromatin remodeling factors and DNA damage repair.

Osley MA, Tsukuda T, Nickoloff JA.

Mutat Res. 2007 May 1;618(1-2):65-80. Epub 2007 Jan 21. Review.


Targeted and nontargeted effects of low-dose ionizing radiation on delayed genomic instability in human cells.

Huang L, Kim PM, Nickoloff JA, Morgan WF.

Cancer Res. 2007 Feb 1;67(3):1099-104.


UV radiation induces delayed hyperrecombination associated with hypermutation in human cells.

Durant ST, Paffett KS, Shrivastav M, Timmins GS, Morgan WF, Nickoloff JA.

Mol Cell Biol. 2006 Aug;26(16):6047-55.


Sgs1 regulates gene conversion tract lengths and crossovers independently of its helicase activity.

Lo YC, Paffett KS, Amit O, Clikeman JA, Sterk R, Brenneman MA, Nickoloff JA.

Mol Cell Biol. 2006 Jun;26(11):4086-94.


Transcription of a donor enhances its use during double-strand break-induced gene conversion in human cells.

Schildkraut E, Miller CA, Nickoloff JA.

Mol Cell Biol. 2006 Apr;26(8):3098-105.


The SET domain protein Metnase mediates foreign DNA integration and links integration to nonhomologous end-joining repair.

Lee SH, Oshige M, Durant ST, Rasila KK, Williamson EA, Ramsey H, Kwan L, Nickoloff JA, Hromas R.

Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18075-80. Epub 2005 Dec 6.


Chromatin remodelling at a DNA double-strand break site in Saccharomyces cerevisiae.

Tsukuda T, Fleming AB, Nickoloff JA, Osley MA.

Nature. 2005 Nov 17;438(7066):379-83.

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