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Assessment and Clinical Relevance of Serum IL-19 Levels in Psoriasis and Atopic Dermatitis Using a Sensitive and Specific Novel Immunoassay.

Konrad RJ, Higgs RE, Rodgers GH, Ming W, Qian YW, Bivi N, Mack JK, Siegel RW, Nickoloff BJ.

Sci Rep. 2019 Mar 26;9(1):5211. doi: 10.1038/s41598-019-41609-z.


Loss of miR-204 expression is a key event in melanoma.

Galasso M, Morrison C, Minotti L, Corrà F, Zerbinati C, Agnoletto C, Baldassari F, Fassan M, Bartolazzi A, Vecchione A, Nuovo GJ, Di Leva G, D'Atri S, Alvino E, Previati M, Nickoloff BJ, Croce CM, Volinia S.

Mol Cancer. 2018 Mar 9;17(1):71. doi: 10.1186/s12943-018-0819-8.


Baricitinib in adult patients with moderate-to-severe atopic dermatitis: A phase 2 parallel, double-blinded, randomized placebo-controlled multiple-dose study.

Guttman-Yassky E, Silverberg JI, Nemoto O, Forman SB, Wilke A, Prescilla R, de la Peña A, Nunes FP, Janes J, Gamalo M, Donley D, Paik J, DeLozier AM, Nickoloff BJ, Simpson EL.

J Am Acad Dermatol. 2019 Apr;80(4):913-921.e9. doi: 10.1016/j.jaad.2018.01.018. Epub 2018 Feb 2.


Molecular Insights into Fully Human and Humanized Monoclonal Antibodies: What are the Differences and Should Dermatologists Care?

Mallbris L, Davies J, Glasebrook A, Tang Y, Glaesner W, Nickoloff BJ.

J Clin Aesthet Dermatol. 2016 Jul;9(7):13-5. Epub 2016 Jul 1.


Phase 3 Trials of Ixekizumab in Moderate-to-Severe Plaque Psoriasis.

Gordon KB, Blauvelt A, Papp KA, Langley RG, Luger T, Ohtsuki M, Reich K, Amato D, Ball SG, Braun DK, Cameron GS, Erickson J, Konrad RJ, Muram TM, Nickoloff BJ, Osuntokun OO, Secrest RJ, Zhao F, Mallbris L, Leonardi CL; UNCOVER-1 Study Group; UNCOVER-2 Study Group; UNCOVER-3 Study Group.

N Engl J Med. 2016 Jul 28;375(4):345-56. doi: 10.1056/NEJMoa1512711. Epub 2016 Jun 8.


Ixekizumab for psoriasis--Authors' reply.

Griffiths CE, Papp KA, Ball SG, Nickoloff BJ.

Lancet. 2016 Jan 16;387(10015):226-7. doi: 10.1016/S0140-6736(16)00048-9. Epub 2016 Jan 15. No abstract available.


Psoriasis: The Poster Child for Bench-to-bedside Translational Medicine.

Mallbris L, Nickoloff BJ.

J Clin Aesthet Dermatol. 2015 Jul;8(7):14-6.


Melanoma patient derived xenografts acquire distinct Vemurafenib resistance mechanisms.

Monsma DJ, Cherba DM, Eugster EE, Dylewski DL, Davidson PT, Peterson CA, Borgman AS, Winn ME, Dykema KJ, Webb CP, MacKeigan JP, Duesbery NS, Nickoloff BJ, Monks NR.

Am J Cancer Res. 2015 Mar 15;5(4):1507-18. eCollection 2015.


Comparison of ixekizumab with etanercept or placebo in moderate-to-severe psoriasis (UNCOVER-2 and UNCOVER-3): results from two phase 3 randomised trials.

Griffiths CE, Reich K, Lebwohl M, van de Kerkhof P, Paul C, Menter A, Cameron GS, Erickson J, Zhang L, Secrest RJ, Ball S, Braun DK, Osuntokun OO, Heffernan MP, Nickoloff BJ, Papp K; UNCOVER-2 and UNCOVER-3 investigators.

Lancet. 2015 Aug 8;386(9993):541-51. doi: 10.1016/S0140-6736(15)60125-8. Epub 2015 Jun 10.


Melanoma genotypes and phenotypes get personal.

Pimiento JM, Larkin EM, Smalley KS, Wiersma GL, Monks NR, Fedorenko IV, Peterson CA, Nickoloff BJ.

Lab Invest. 2013 Aug;93(8):858-67. doi: 10.1038/labinvest.2013.84. Epub 2013 Jul 1. Review.


Pharmacologic inhibition of MEK signaling prevents growth of canine hemangiosarcoma.

Andersen NJ, Nickoloff BJ, Dykema KJ, Boguslawski EA, Krivochenitser RI, Froman RE, Dawes MJ, Baker LH, Thomas DG, Kamstock DA, Kitchell BE, Furge KA, Duesbery NS.

Mol Cancer Ther. 2013 Sep;12(9):1701-14. doi: 10.1158/1535-7163.MCT-12-0893. Epub 2013 Jun 26.


Hepatocyte growth factor in the neighborhood reverses resistance to BRAF inhibitor in melanoma.

Nickoloff BJ, Vande Woude G.

Pigment Cell Melanoma Res. 2012 Nov;25(6):758-61. doi: 10.1111/pcmr.12020. No abstract available.


Genomic characterization of explant tumorgraft models derived from fresh patient tumor tissue.

Monsma DJ, Monks NR, Cherba DM, Dylewski D, Eugster E, Jahn H, Srikanth S, Scott SB, Richardson PJ, Everts RE, Ishkin A, Nikolsky Y, Resau JH, Sigler R, Nickoloff BJ, Webb CP.

J Transl Med. 2012 Jun 18;10:125. doi: 10.1186/1479-5876-10-125.


Specifically targeting ERK1 or ERK2 kills melanoma cells.

Qin J, Xin H, Nickoloff BJ.

J Transl Med. 2012 Jan 25;10:15. doi: 10.1186/1479-5876-10-15.


Identification of a novel proinflammatory human skin-homing Vγ9Vδ2 T cell subset with a potential role in psoriasis.

Laggner U, Di Meglio P, Perera GK, Hundhausen C, Lacy KE, Ali N, Smith CH, Hayday AC, Nickoloff BJ, Nestle FO.

J Immunol. 2011 Sep 1;187(5):2783-93. doi: 10.4049/jimmunol.1100804. Epub 2011 Aug 3.


Notch signaling regulates mouse and human Th17 differentiation.

Keerthivasan S, Suleiman R, Lawlor R, Roderick J, Bates T, Minter L, Anguita J, Juncadella I, Nickoloff BJ, Le Poole IC, Miele L, Osborne BA.

J Immunol. 2011 Jul 15;187(2):692-701. doi: 10.4049/jimmunol.1003658. Epub 2011 Jun 17.


Cutting edge: A critical functional role for IL-23 in psoriasis.

Tonel G, Conrad C, Laggner U, Di Meglio P, Grys K, McClanahan TK, Blumenschein WM, Qin JZ, Xin H, Oldham E, Kastelein R, Nickoloff BJ, Nestle FO.

J Immunol. 2010 Nov 15;185(10):5688-91. doi: 10.4049/jimmunol.1001538. Epub 2010 Oct 18.


Loss of inositol polyphosphate 5-phosphatase is an early event in development of cutaneous squamous cell carcinoma.

Sekulic A, Kim SY, Hostetter G, Savage S, Einspahr JG, Prasad A, Sagerman P, Curiel-Lewandrowski C, Krouse R, Bowden GT, Warneke J, Alberts DS, Pittelkow MR, DiCaudo D, Nickoloff BJ, Trent JM, Bittner M.

Cancer Prev Res (Phila). 2010 Oct;3(10):1277-83. doi: 10.1158/1940-6207.CAPR-10-0058. Epub 2010 Sep 28.


2-deoxyglucose sensitizes melanoma cells to TRAIL-induced apoptosis which is reduced by mannose.

Qin JZ, Xin H, Nickoloff BJ.

Biochem Biophys Res Commun. 2010 Oct 15;401(2):293-9. doi: 10.1016/j.bbrc.2010.09.054. Epub 2010 Sep 17.


Targeting glutamine metabolism sensitizes melanoma cells to TRAIL-induced death.

Qin JZ, Xin H, Nickoloff BJ.

Biochem Biophys Res Commun. 2010 Jul 16;398(1):146-52. doi: 10.1016/j.bbrc.2010.06.057. Epub 2010 Jun 19.


3-Bromopyruvate induces necrotic cell death in sensitive melanoma cell lines.

Qin JZ, Xin H, Nickoloff BJ.

Biochem Biophys Res Commun. 2010 May 28;396(2):495-500. doi: 10.1016/j.bbrc.2010.04.126. Epub 2010 Apr 27.


A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer.

Stratton SP, Alberts DS, Einspahr JG, Sagerman PM, Warneke JA, Curiel-Lewandrowski C, Myrdal PB, Karlage KL, Nickoloff BJ, Brooks C, Saboda K, Yozwiak ML, Krutzsch MF, Hu C, Lluria-Prevatt M, Dong Z, Bowden GT, Bartels PH.

Cancer Prev Res (Phila). 2010 Feb;3(2):160-9. doi: 10.1158/1940-6207.CAPR-09-0183. Epub 2010 Jan 26.


Random DNA fragmentation allows detection of single-copy, single-exon alterations of copy number by oligonucleotide array CGH in clinical FFPE samples.

Hostetter G, Kim SY, Savage S, Gooden GC, Barrett M, Zhang J, Alla L, Watanabe A, Einspahr J, Prasad A, Nickoloff BJ, Carpten J, Trent J, Alberts D, Bittner M.

Nucleic Acids Res. 2010 Jan;38(2):e9. doi: 10.1093/nar/gkp881. Epub 2009 Oct 29.


Sweet's syndrome with neurologic manifestations in a patient with esophageal adenocarcinoma: case report and review of the literature.

Sobol UA, Sherman KL, Smith J, Nagda SN, Micetich K, Nickoloff BJ, Shoup MC.

Int J Dermatol. 2009 Oct;48(10):1062-5. Review.


Skin immune sentinels in health and disease.

Nestle FO, Di Meglio P, Qin JZ, Nickoloff BJ.

Nat Rev Immunol. 2009 Oct;9(10):679-91. doi: 10.1038/nri2622. Epub 2009 Sep 18. Review.


Active Notch1 confers a transformed phenotype to primary human melanocytes.

Pinnix CC, Lee JT, Liu ZJ, McDaid R, Balint K, Beverly LJ, Brafford PA, Xiao M, Himes B, Zabierowski SE, Yashiro-Ohtani Y, Nathanson KL, Bengston A, Pollock PM, Weeraratna AT, Nickoloff BJ, Pear WS, Capobianco AJ, Herlyn M.

Cancer Res. 2009 Jul 1;69(13):5312-20. doi: 10.1158/0008-5472.CAN-08-3767. Epub 2009 Jun 23.


Wnt5A regulates expression of tumor-associated antigens in melanoma via changes in signal transducers and activators of transcription 3 phosphorylation.

Dissanayake SK, Olkhanud PB, O'Connell MP, Carter A, French AD, Camilli TC, Emeche CD, Hewitt KJ, Rosenthal DT, Leotlela PD, Wade MS, Yang SW, Brant L, Nickoloff BJ, Messina JL, Biragyn A, Hoek KS, Taub DD, Longo DL, Sondak VK, Hewitt SM, Weeraratna AT.

Cancer Res. 2008 Dec 15;68(24):10205-14. doi: 10.1158/0008-5472.CAN-08-2149.


Saving the skin from drug-induced detachment.

Nickoloff BJ.

Nat Med. 2008 Dec;14(12):1311-3. doi: 10.1038/nm1208-1311. No abstract available.


Inhibition of PAX3 by TGF-beta modulates melanocyte viability.

Yang G, Li Y, Nishimura EK, Xin H, Zhou A, Guo Y, Dong L, Denning MF, Nickoloff BJ, Cui R.

Mol Cell. 2008 Nov 21;32(4):554-63. doi: 10.1016/j.molcel.2008.11.002.


Notch1 is an effector of Akt and hypoxia in melanoma development.

Bedogni B, Warneke JA, Nickoloff BJ, Giaccia AJ, Powell MB.

J Clin Invest. 2008 Nov;118(11):3660-70. doi: 10.1172/JCI36157. Epub 2008 Oct 16.


Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches.

Rizzo P, Miao H, D'Souza G, Osipo C, Song LL, Yun J, Zhao H, Mascarenhas J, Wyatt D, Antico G, Hao L, Yao K, Rajan P, Hicks C, Siziopikou K, Selvaggi S, Bashir A, Bhandari D, Marchese A, Lendahl U, Qin JZ, Tonetti DA, Albain K, Nickoloff BJ, Miele L.

Cancer Res. 2008 Jul 1;68(13):5226-35. doi: 10.1158/0008-5472.CAN-07-5744. Erratum in: Cancer Res. 2008 Sep 1;68(17):7246. Song, Lynda L [added].


Notch-1 associates with IKKalpha and regulates IKK activity in cervical cancer cells.

Song LL, Peng Y, Yun J, Rizzo P, Chaturvedi V, Weijzen S, Kast WM, Stone PJ, Santos L, Loredo A, Lendahl U, Sonenshein G, Osborne B, Qin JZ, Pannuti A, Nickoloff BJ, Miele L.

Oncogene. 2008 Oct 2;27(44):5833-44. doi: 10.1038/onc.2008.190. Epub 2008 Jun 16.


56th annual Montagna Symposium on the Biology of Skin: Epidermal T-cell interactions--clinicopathological and basic mechanisms.

Cooper KD, Sontheimer RD, Dutz J, Hwang ST, Nickoloff BJ, Shimada S, Kulesz-Martin M, Bickenbach JR.

J Invest Dermatol. 2008 Jun;128(6):1351-3. doi: 10.1038/jid.2008.99. No abstract available.


Immunobiology of acute cytotoxic drug reactions.

Nickoloff BJ.

Curr Dir Autoimmun. 2008;10:53-64. doi: 10.1159/000131413. Review.


Ecthyma gangrenosum following toxic epidermal necrolysis syndrome in a 3-year-old boy-a survivable series of events.

Gresik CM, Brewster LP, Abood G, Supple KG, Silver GM, Gamelli RL, Nickoloff BJ.

J Burn Care Res. 2008 May-Jun;29(3):555-8. doi: 10.1097/BCR.0b013e318171136a.


Cross-validation of murine UV signal transduction pathways in human skin.

Einspahr JG, Bowden GT, Alberts DS, McKenzie N, Saboda K, Warneke J, Salasche S, Ranger-Moore J, Curiel-Lewandrowski C, Nagle RB, Nickoloff BJ, Brooks C, Dong Z, Stratton SP.

Photochem Photobiol. 2008 Mar-Apr;84(2):463-76. doi: 10.1111/j.1751-1097.2007.00287.x. Epub 2008 Jan 29.


Treatment strategies in toxic epidermal necrolysis syndrome: where are we at?

Abood GJ, Nickoloff BJ, Gamelli RL.

J Burn Care Res. 2008 Jan-Feb;29(1):269-76. doi: 10.1097/BCR.0b013e31815f3658. Review.


Conservation of genetic alterations in recurrent melanoma supports the melanoma stem cell hypothesis.

Sabatino M, Zhao Y, Voiculescu S, Monaco A, Robbins P, Karai L, Nickoloff BJ, Maio M, Selleri S, Marincola FM, Wang E.

Cancer Res. 2008 Jan 1;68(1):122-31. doi: 10.1158/0008-5472.CAN-07-1939.


Maintenance of hair follicle immune privilege is linked to prevention of NK cell attack.

Ito T, Ito N, Saatoff M, Hashizume H, Fukamizu H, Nickoloff BJ, Takigawa M, Paus R.

J Invest Dermatol. 2008 May;128(5):1196-206. Epub 2007 Dec 27.


Immunopathogenesis of psoriasis.

Nickoloff BJ, Qin JZ, Nestle FO.

Clin Rev Allergy Immunol. 2007 Oct;33(1-2):45-56. Review.


Occurrence of a basal cell carcinoma and dermatofibroma in a smallpox vaccination scar.

Curry JL, Goulder SJ, Nickoloff BJ.

Dermatol Surg. 2008 Jan;34(1):132-3; discussion 133-4. Epub 2007 Dec 5. No abstract available.


The cytokine and chemokine network in psoriasis.

Nickoloff BJ, Xin H, Nestle FO, Qin JZ.

Clin Dermatol. 2007 Nov-Dec;25(6):568-73. Review.


Deepening our understanding of immune sentinels in the skin.

Nestle FO, Nickoloff BJ.

J Clin Invest. 2007 Sep;117(9):2382-5.


The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition.

Dissanayake SK, Wade M, Johnson CE, O'Connell MP, Leotlela PD, French AD, Shah KV, Hewitt KJ, Rosenthal DT, Indig FE, Jiang Y, Nickoloff BJ, Taub DD, Trent JM, Moon RT, Bittner M, Weeraratna AT.

J Biol Chem. 2007 Jun 8;282(23):17259-71. Epub 2007 Apr 10.


Alefacept in corticosteroid refractory graft versus host disease: early results indicate promising activity.

Toor AA, Stiff PJ, Nickoloff BJ, Rodriguez T, Klein JL, Gordon KB.

J Dermatolog Treat. 2007;18(1):13-8.


Cracking the cytokine code in psoriasis.

Nickoloff BJ.

Nat Med. 2007 Mar;13(3):242-4. No abstract available.


Overexpression of Akt converts radial growth melanoma to vertical growth melanoma.

Govindarajan B, Sligh JE, Vincent BJ, Li M, Canter JA, Nickoloff BJ, Rodenburg RJ, Smeitink JA, Oberley L, Zhang Y, Slingerland J, Arnold RS, Lambeth JD, Cohen C, Hilenski L, Griendling K, Martínez-Diez M, Cuezva JM, Arbiser JL.

J Clin Invest. 2007 Mar;117(3):719-29. Epub 2007 Feb 22.


Claudin-1 overexpression in melanoma is regulated by PKC and contributes to melanoma cell motility.

Leotlela PD, Wade MS, Duray PH, Rhode MJ, Brown HF, Rosenthal DT, Dissanayake SK, Earley R, Indig FE, Nickoloff BJ, Taub DD, Kallioniemi OP, Meltzer P, Morin PJ, Weeraratna AT.

Oncogene. 2007 May 31;26(26):3846-56. Epub 2006 Dec 11.


Lessons learned from psoriatic plaques concerning mechanisms of tissue repair, remodeling, and inflammation.

Nickoloff BJ, Bonish BK, Marble DJ, Schriedel KA, DiPietro LA, Gordon KB, Lingen MW.

J Investig Dermatol Symp Proc. 2006 Sep;11(1):16-29. Review.

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