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Improved production of 76Br, 77Br and 80mBr via CoSe cyclotron targets and vertical dry distillation.

Ellison PA, Olson AP, Barnhart TE, Hoffman SLV, Reilly SW, Makvandi M, Bartels JL, Murali D, DeJesus OT, Lapi SE, Bednarz B, Nickles RJ, Mach RH, Engle JW.

Nucl Med Biol. 2019 Sep 5. pii: S0969-8051(19)30162-3. doi: 10.1016/j.nucmedbio.2019.09.001. [Epub ahead of print]


PET Measures of D1, D2, and DAT Binding Are Associated With Heightened Tactile Responsivity in Rhesus Macaques: Implications for Sensory Processing Disorder.

Schneider ML, Moore CF, Ahlers EO, Barnhart TE, Christian BT, DeJesus OT, Engle JW, Holden JE, Larson JA, Moirano JM, Murali D, Nickles RJ, Resch LM, Converse AK.

Front Integr Neurosci. 2019 Jul 17;13:29. doi: 10.3389/fnint.2019.00029. eCollection 2019.


Radiochemical isolation method for the production of 52gMn from natCr for accelerator targets.

Barrett KE, Aluicio-Sarduy E, Olson AP, Kutyreff CJ, Ellison PA, Barnhart TE, Nickles RJ, Engle JW.

Appl Radiat Isot. 2019 Apr;146:99-103. doi: 10.1016/j.apradiso.2019.01.025. Epub 2019 Feb 1.


Simplified and automatable radiochemical separation strategy for the production of radiopharmaceutical quality 86Y using single column extraction chromatography.

Aluicio-Sarduy E, Hernandez R, Valdovinos HF, Kutyreff CJ, Ellison PA, Barnhart TE, Nickles RJ, Engle JW.

Appl Radiat Isot. 2018 Dec;142:28-31. doi: 10.1016/j.apradiso.2018.09.016. Epub 2018 Sep 14.


In vivo imaging of inflammation and oxidative stress in a nonhuman primate model of cardiac sympathetic neurodegeneration.

Metzger JM, Moore CF, Boettcher CA, Brunner KG, Fleddermann RA, Matsoff HN, Resnikoff HA, Bondarenko V, Kamp TJ, Hacker TA, Barnhart TE, Lao PJ, Christian BT, Nickles RJ, Gallagher CL, Holden JE, Emborg ME.

NPJ Parkinsons Dis. 2018 Jul 13;4:22. doi: 10.1038/s41531-018-0057-1. eCollection 2018.


Evaluation of a chloride-based 89Zr isolation strategy using a tributyl phosphate (TBP)-functionalized extraction resin.

Graves SA, Kutyreff C, Barrett KE, Hernandez R, Ellison PA, Happel S, Aluicio-Sarduy E, Barnhart TE, Nickles RJ, Engle JW.

Nucl Med Biol. 2018 Sep - Oct;64-65:1-7. doi: 10.1016/j.nucmedbio.2018.06.003. Epub 2018 Jun 18.


PET radiometals for antibody labeling.

Aluicio-Sarduy E, Ellison PA, Barnhart TE, Cai W, Nickles RJ, Engle JW.

J Labelled Comp Radiopharm. 2018 Jul;61(9):636-651. doi: 10.1002/jlcr.3607. Epub 2018 Mar 12. Review.


Characterization of the radiosynthesis and purification of [18F]THK-5351, a PET ligand for neurofibrillary tau.

Betthauser TJ, Ellison PA, Murali D, Lao PJ, Barnhart TE, Furumoto S, Okamura N, Johnson SC, Engle JW, Nickles RJ, Christian BT.

Appl Radiat Isot. 2017 Dec;130:230-237. doi: 10.1016/j.apradiso.2017.10.002. Epub 2017 Oct 4.


Cyclotron production and radiochemical separation of 55Co and 58mCo from 54Fe, 58Ni and 57Fe targets.

Valdovinos HF, Hernandez R, Graves S, Ellison PA, Barnhart TE, Theuer CP, Engle JW, Cai W, Nickles RJ.

Appl Radiat Isot. 2017 Dec;130:90-101. doi: 10.1016/j.apradiso.2017.09.005. Epub 2017 Sep 6.


Preparation and in vivo characterization of 51MnCl2 as PET tracer of Ca2+ channel-mediated transport.

Graves SA, Hernandez R, Valdovinos HF, Ellison PA, Engle JW, Barnhart TE, Cai W, Nickles RJ.

Sci Rep. 2017 Jun 8;7(1):3033. doi: 10.1038/s41598-017-03202-0.


Radiomanganese PET Detects Changes in Functional β-Cell Mass in Mouse Models of Diabetes.

Hernandez R, Graves SA, Gregg T, VanDeusen HR, Fenske RJ, Wienkes HN, England CG, Valdovinos HF, Jeffery JJ, Barnhart TE, Severin GW, Nickles RJ, Kimple ME, Merrins MJ, Cai W.

Diabetes. 2017 Aug;66(8):2163-2174. doi: 10.2337/db16-1285. Epub 2017 May 17.


ImmunoPET Imaging of CTLA-4 Expression in Mouse Models of Non-small Cell Lung Cancer.

Ehlerding EB, England CG, Majewski RL, Valdovinos HF, Jiang D, Liu G, McNeel DG, Nickles RJ, Cai W.

Mol Pharm. 2017 May 1;14(5):1782-1789. doi: 10.1021/acs.molpharmaceut.7b00056. Epub 2017 Apr 12.


ImmunoPET and Near-Infrared Fluorescence Imaging of Pancreatic Cancer with a Dual-Labeled Bispecific Antibody Fragment.

Luo H, England CG, Goel S, Graves SA, Ai F, Liu B, Theuer CP, Wong HC, Nickles RJ, Cai W.

Mol Pharm. 2017 May 1;14(5):1646-1655. doi: 10.1021/acs.molpharmaceut.6b01123. Epub 2017 Mar 24.


Radiolabeled pertuzumab for imaging of human epidermal growth factor receptor 2 expression in ovarian cancer.

Jiang D, Im HJ, Sun H, Valdovinos HF, England CG, Ehlerding EB, Nickles RJ, Lee DS, Cho SY, Huang P, Cai W.

Eur J Nucl Med Mol Imaging. 2017 Aug;44(8):1296-1305. doi: 10.1007/s00259-017-3663-y. Epub 2017 Mar 6.


Surfactant-stripped naphthalocyanines for multimodal tumor theranostics with upconversion guidance cream.

Zhang Y, Hong H, Sun B, Carter K, Qin Y, Wei W, Wang D, Jeon M, Geng J, Nickles RJ, Chen G, Prasad PN, Kim C, Xia J, Cai W, Lovell JF.

Nanoscale. 2017 Mar 9;9(10):3391-3398. doi: 10.1039/c6nr09321c.


Nuclear excitation functions of proton-induced reactions (Ep = 35 - 90 MeV) from Fe, Cu, and Al.

Graves SA, Ellison PA, Barnhart TE, Valdovinos HF, Birnbaum ER, Nortier FM, Nickles RJ, Engle JW.

Nucl Instrum Methods Phys Res B. 2016 Nov 1;386:44-53. doi: 10.1016/j.nimb.2016.09.018. Epub 2016 Sep 28.


Chelator-Free Radiolabeling of Nanographene: Breaking the Stereotype of Chelation.

Shi S, Xu C, Yang K, Goel S, Valdovinos HF, Luo H, Ehlerding EB, England CG, Cheng L, Chen F, Nickles RJ, Liu Z, Cai W.

Angew Chem Int Ed Engl. 2017 Mar 6;56(11):2889-2892. doi: 10.1002/anie.201610649. Epub 2017 Feb 7.


Intrinsic and Stable Conjugation of Thiolated Mesoporous Silica Nanoparticles with Radioarsenic.

Ellison PA, Chen F, Goel S, Barnhart TE, Nickles RJ, DeJesus OT, Cai W.

ACS Appl Mater Interfaces. 2017 Mar 1;9(8):6772-6781. doi: 10.1021/acsami.6b14049. Epub 2017 Feb 16.


Spot-welding solid targets for high current cyclotron irradiation.

Ellison PA, Valdovinos HF, Graves SA, Barnhart TE, Nickles RJ.

Appl Radiat Isot. 2016 Dec;118:350-353. doi: 10.1016/j.apradiso.2016.10.010. Epub 2016 Oct 13.


Uptake and retention of manganese contrast agents for PET and MRI in the rodent brain.

Brunnquell CL, Hernandez R, Graves SA, Smit-Oistad I, Nickles RJ, Cai W, Meyerand ME, Suzuki M.

Contrast Media Mol Imaging. 2016 Sep;11(5):371-380. doi: 10.1002/cmmi.1701. Epub 2016 Jul 11.


Development of a novel linearly-filled Derenzo microPET phantom.

Cox BL, Graves SA, Farhoud M, Barnhart TE, Jeffery JJ, Eliceiri KW, Nickles RJ.

Am J Nucl Med Mol Imaging. 2016 Jul 6;6(3):199-204. eCollection 2016.


Accelerated Blood Clearance Phenomenon Reduces the Passive Targeting of PEGylated Nanoparticles in Peripheral Arterial Disease.

Im HJ, England CG, Feng L, Graves SA, Hernandez R, Nickles RJ, Liu Z, Lee DS, Cho SY, Cai W.

ACS Appl Mater Interfaces. 2016 Jul 20;8(28):17955-63. doi: 10.1021/acsami.6b05840. Epub 2016 Jul 7.


Re-assessing the enhanced permeability and retention effect in peripheral arterial disease using radiolabeled long circulating nanoparticles.

England CG, Im HJ, Feng L, Chen F, Graves SA, Hernandez R, Orbay H, Xu C, Cho SY, Nickles RJ, Liu Z, Lee DS, Cai W.

Biomaterials. 2016 Sep;100:101-9. doi: 10.1016/j.biomaterials.2016.05.018. Epub 2016 May 21.


Long circulating reduced graphene oxide-iron oxide nanoparticles for efficient tumor targeting and multimodality imaging.

Xu C, Shi S, Feng L, Chen F, Graves SA, Ehlerding EB, Goel S, Sun H, England CG, Nickles RJ, Liu Z, Wang T, Cai W.

Nanoscale. 2016 Jul 7;8(25):12683-92. doi: 10.1039/c5nr09193d. Epub 2016 Apr 25.


Dynamic Positron Emission Tomography Imaging of Renal Clearable Gold Nanoparticles.

Chen F, Goel S, Hernandez R, Graves SA, Shi S, Nickles RJ, Cai W.

Small. 2016 May;12(20):2775-82. doi: 10.1002/smll.201600194. Epub 2016 Apr 9.


Dual Targeting of Tissue Factor and CD105 for Preclinical PET Imaging of Pancreatic Cancer.

Luo H, England CG, Shi S, Graves SA, Hernandez R, Liu B, Theuer CP, Wong HC, Nickles RJ, Cai W.

Clin Cancer Res. 2016 Aug 1;22(15):3821-30. doi: 10.1158/1078-0432.CCR-15-2054. Epub 2016 Mar 29.


High Yield Production and Radiochemical Isolation of Isotopically Pure Arsenic-72 and Novel Radioarsenic Labeling Strategies for the Development of Theranostic Radiopharmaceuticals.

Ellison PA, Barnhart TE, Chen F, Hong H, Zhang Y, Theuer CP, Cai W, Nickles RJ, DeJesus OT.

Bioconjug Chem. 2016 Jan 20;27(1):179-88. doi: 10.1021/acs.bioconjchem.5b00592. Epub 2015 Dec 22.


Chelator-Free Labeling of Layered Double Hydroxide Nanoparticles for in Vivo PET Imaging.

Shi S, Fliss BC, Gu Z, Zhu Y, Hong H, Valdovinos HF, Hernandez R, Goel S, Luo H, Chen F, Barnhart TE, Nickles RJ, Xu ZP, Cai W.

Sci Rep. 2015 Nov 20;5:16930. doi: 10.1038/srep16930.


Targeting CD146 with a 64Cu-labeled antibody enables in vivo immunoPET imaging of high-grade gliomas.

Yang Y, Hernandez R, Rao J, Yin L, Qu Y, Wu J, England CG, Graves SA, Lewis CM, Wang P, Meyerand ME, Nickles RJ, Bian XW, Cai W.

Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):E6525-34. doi: 10.1073/pnas.1502648112. Epub 2015 Nov 9.


PET Imaging of VEGFR-2 Expression in Lung Cancer with 64Cu-Labeled Ramucirumab.

Luo H, England CG, Graves SA, Sun H, Liu G, Nickles RJ, Cai W.

J Nucl Med. 2016 Feb;57(2):285-90. doi: 10.2967/jnumed.115.166462. Epub 2015 Nov 5.


A porphyrin-PEG polymer with rapid renal clearance.

Huang H, Hernandez R, Geng J, Sun H, Song W, Chen F, Graves SA, Nickles RJ, Cheng C, Cai W, Lovell JF.

Biomaterials. 2016 Jan;76:25-32. doi: 10.1016/j.biomaterials.2015.10.049. Epub 2015 Oct 21.


Noninvasive brain cancer imaging with a bispecific antibody fragment, generated via click chemistry.

Luo H, Hernandez R, Hong H, Graves SA, Yang Y, England CG, Theuer CP, Nickles RJ, Cai W.

Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12806-11. doi: 10.1073/pnas.1509667112. Epub 2015 Sep 28.


Novel Preparation Methods of (52)Mn for ImmunoPET Imaging.

Graves SA, Hernandez R, Fonslet J, England CG, Valdovinos HF, Ellison PA, Barnhart TE, Elema DR, Theuer CP, Cai W, Nickles RJ, Severin GW.

Bioconjug Chem. 2015 Oct 21;26(10):2118-24. doi: 10.1021/acs.bioconjchem.5b00414. Epub 2015 Sep 10.


Evaluation of two novel ⁶⁴Cu-labeled RGD peptide radiotracers for enhanced PET imaging of tumor integrin αvβ₃.

Hernandez R, Czerwinski A, Chakravarty R, Graves SA, Yang Y, England CG, Nickles RJ, Valenzuela F, Cai W.

Eur J Nucl Med Mol Imaging. 2015 Nov;42(12):1859-68. doi: 10.1007/s00259-015-3085-7. Epub 2015 May 28.


PET Imaging of Abdominal Aortic Aneurysm with 64Cu-Labeled Anti-CD105 Antibody Fab Fragment.

Shi S, Orbay H, Yang Y, Graves SA, Nayak TR, Hong H, Hernandez R, Luo H, Goel S, Theuer CP, Nickles RJ, Cai W.

J Nucl Med. 2015 Jun;56(6):927-32. doi: 10.2967/jnumed.114.153098. Epub 2015 Apr 16.


In Vivo Tumor Vasculature Targeting of CuS@MSN Based Theranostic Nanomedicine.

Chen F, Hong H, Goel S, Graves SA, Orbay H, Ehlerding EB, Shi S, Theuer CP, Nickles RJ, Cai W.

ACS Nano. 2015;9(4):3926-34. doi: 10.1021/nn507241v. Epub 2015 Apr 8.


PET of c-Met in Cancer with ⁶⁴Cu-Labeled Hepatocyte Growth Factor.

Luo H, Hong H, Slater MR, Graves SA, Shi S, Yang Y, Nickles RJ, Fan F, Cai W.

J Nucl Med. 2015 May;56(5):758-63. doi: 10.2967/jnumed.115.154690. Epub 2015 Apr 3.


ImmunoPET of tissue factor expression in triple-negative breast cancer with a radiolabeled antibody Fab fragment.

Shi S, Hong H, Orbay H, Graves SA, Yang Y, Ohman JD, Liu B, Nickles RJ, Wong HC, Cai W.

Eur J Nucl Med Mol Imaging. 2015 Jul;42(8):1295-303. doi: 10.1007/s00259-015-3038-1. Epub 2015 Mar 24.


Mathematical modeling of positron emission tomography (PET) data to assess radiofluoride transport in living plants following petiolar administration.

Converse AK, Ahlers EO, Bryan TW, Hetue JD, Lake KA, Ellison PA, Engle JW, Barnhart TE, Nickles RJ, Williams PH, DeJesus OT.

Plant Methods. 2015 Mar 13;11:18. doi: 10.1186/s13007-015-0061-y. eCollection 2015.


Hexamodal imaging with porphyrin-phospholipid-coated upconversion nanoparticles.

Rieffel J, Chen F, Kim J, Chen G, Shao W, Shao S, Chitgupi U, Hernandez R, Graves SA, Nickles RJ, Prasad PN, Kim C, Cai W, Lovell JF.

Adv Mater. 2015 Mar 11;27(10):1785-90. doi: 10.1002/adma.201404739. Epub 2015 Jan 14.


Red fluorescent zinc oxide nanoparticle: a novel platform for cancer targeting.

Hong H, Wang F, Zhang Y, Graves SA, Eddine SB, Yang Y, Theuer CP, Nickles RJ, Wang X, Cai W.

ACS Appl Mater Interfaces. 2015 Feb 11;7(5):3373-81. doi: 10.1021/am508440j. Epub 2015 Jan 29.


Moderate-level prenatal alcohol exposure induces sex differences in dopamine d1 receptor binding in adult rhesus monkeys.

Converse AK, Moore CF, Holden JE, Ahlers EO, Moirano JM, Larson JA, Resch LM, DeJesus OT, Barnhart TE, Nickles RJ, Murali D, Christian BT, Schneider ML.

Alcohol Clin Exp Res. 2014 Dec;38(12):2934-43. doi: 10.1111/acer.12575.


PET of follicle-stimulating hormone receptor: broad applicability to cancer imaging.

Hong H, Yan Y, Shi S, Graves SA, Krasteva LK, Nickles RJ, Yang M, Cai W.

Mol Pharm. 2015 Feb 2;12(2):403-10. doi: 10.1021/mp500766x. Epub 2015 Jan 20.


⁵²Mn production for PET/MRI tracking of human stem cells expressing divalent metal transporter 1 (DMT1).

Lewis CM, Graves SA, Hernandez R, Valdovinos HF, Barnhart TE, Cai W, Meyerand ME, Nickles RJ, Suzuki M.

Theranostics. 2015 Jan 1;5(3):227-39. doi: 10.7150/thno.10185. eCollection 2015.


Anterior cingulate dopamine turnover and behavior change in Parkinson's disease.

Gallagher CL, Bell B, Palotti M, Oh J, Christian BT, Okonkwo O, Sojkova J, Buyan-Dent L, Nickles RJ, Harding SJ, Stone CK, Johnson SC, Holden JE.

Brain Imaging Behav. 2015 Dec;9(4):821-7. doi: 10.1007/s11682-014-9338-4.


Separation of cyclotron-produced 44Sc from a natural calcium target using a dipentyl pentylphosphonate functionalized extraction resin.

Valdovinos HF, Hernandez R, Barnhart TE, Graves S, Cai W, Nickles RJ.

Appl Radiat Isot. 2015 Jan;95:23-29. doi: 10.1016/j.apradiso.2014.09.020. Epub 2014 Oct 8.


Matching the decay half-life with the biological half-life: ImmunoPET imaging with (44)Sc-labeled cetuximab Fab fragment.

Chakravarty R, Goel S, Valdovinos HF, Hernandez R, Hong H, Nickles RJ, Cai W.

Bioconjug Chem. 2014 Dec 17;25(12):2197-204. doi: 10.1021/bc500415x. Epub 2014 Nov 24.


Intrinsically germanium-69-labeled iron oxide nanoparticles: synthesis and in-vivo dual-modality PET/MR imaging.

Chakravarty R, Valdovinos HF, Chen F, Lewis CM, Ellison PA, Luo H, Meyerand ME, Nickles RJ, Cai W.

Adv Mater. 2014 Aug 13;26(30):5119-23. doi: 10.1002/adma.201401372. Epub 2014 Jun 18.


A dual-tracer study of extrastriatal 6-[18F]fluoro-m-tyrosine and 6-[18F]-fluoro-L-dopa uptake in Parkinson's disease.

Li CT, Palotti M, Holden JE, Oh J, Okonkwo O, Christian BT, Bendlin BB, Buyan-Dent L, Harding SJ, Stone CK, DeJesus OT, Nickles RJ, Gallagher CL.

Synapse. 2014 Aug;68(8):325-31. doi: 10.1002/syn.21745. Epub 2014 Apr 22.


Positron emission tomography imaging of CD105 expression in a rat myocardial infarction model with (64)Cu-NOTA-TRC105.

Orbay H, Zhang Y, Valdovinos HF, Song G, Hernandez R, Theuer CP, Hacker TA, Nickles RJ, Cai W.

Am J Nucl Med Mol Imaging. 2013 Dec 15;4(1):1-9. eCollection 2013.

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