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Items: 17


Polyphosphate nanoparticles on the platelet surface trigger contact system activation.

Verhoef JJ, Barendrecht AD, Nickel KF, Dijkxhoorn K, Kenne E, Labberton L, McCarty OJ, Schiffelers R, Heijnen HF, Hendrickx AP, Schellekens H, Fens MH, de Maat S, Renné T, Maas C.

Blood. 2017 Mar 23;129(12):1707-1717. doi: 10.1182/blood-2016-08-734988. Epub 2017 Jan 3.


Factor XII as a Therapeutic Target in Thromboembolic and Inflammatory Diseases.

Nickel KF, Long AT, Fuchs TA, Butler LM, Renné T.

Arterioscler Thromb Vasc Biol. 2017 Jan;37(1):13-20. doi: 10.1161/ATVBAHA.116.308595. Epub 2016 Nov 10. Review.


A Flow Cytometry-Based Assay for Procoagulant Platelet Polyphosphate.

Labberton L, Long AT, Gendler SJ, Snozek CL, Stavrou EX, Nickel KF, Maas C, Blankenberg S, Hernandez JS, Renné T.

Cytometry B Clin Cytom. 2018 Mar;94(2):369-373. doi: 10.1002/cyto.b.21492. Epub 2016 Nov 28.


Neutralizing blood-borne polyphosphate in vivo provides safe thromboprotection.

Labberton L, Kenne E, Long AT, Nickel KF, Di Gennaro A, Rigg RA, Hernandez JS, Butler L, Maas C, Stavrou EX, Renné T.

Nat Commun. 2016 Sep 6;7:12616. doi: 10.1038/ncomms12616.


The polyphosphate/factor XII pathway in cancer-associated thrombosis: novel perspectives for safe anticoagulation in patients with malignancies.

Nickel KF, Labberton L, Long AT, Langer F, Fuchs TA, Stavrou EX, Butler LM, Renné T.

Thromb Res. 2016 May;141 Suppl 2:S4-7. doi: 10.1016/S0049-3848(16)30353-X. Review.


The factor XIIa blocking antibody 3F7: a safe anticoagulant with anti-inflammatory activities.

Worm M, Köhler EC, Panda R, Long A, Butler LM, Stavrou EX, Nickel KF, Fuchs TA, Renné T.

Ann Transl Med. 2015 Oct;3(17):247. doi: 10.3978/j.issn.2305-5839.2015.09.07. Review.


Factor XII: a novel target for safe prevention of thrombosis and inflammation.

Kenne E, Nickel KF, Long AT, Fuchs TA, Stavrou EX, Stahl FR, Renné T.

J Intern Med. 2015 Dec;278(6):571-85. doi: 10.1111/joim.12430. Epub 2015 Sep 16. Review.


The polyphosphate-factor XII pathway drives coagulation in prostate cancer-associated thrombosis.

Nickel KF, Ronquist G, Langer F, Labberton L, Fuchs TA, Bokemeyer C, Sauter G, Graefen M, Mackman N, Stavrou EX, Ronquist G, Renné T.

Blood. 2015 Sep 10;126(11):1379-89. doi: 10.1182/blood-2015-01-622811. Epub 2015 Jul 7.


Plasma contact system activation drives anaphylaxis in severe mast cell-mediated allergic reactions.

Sala-Cunill A, Björkqvist J, Senter R, Guilarte M, Cardona V, Labrador M, Nickel KF, Butler L, Luengo O, Kumar P, Labberton L, Long A, Di Gennaro A, Kenne E, Jämsä A, Krieger T, Schlüter H, Fuchs T, Flohr S, Hassiepen U, Cumin F, McCrae K, Maas C, Stavrou E, Renné T.

J Allergy Clin Immunol. 2015 Apr;135(4):1031-43.e6. doi: 10.1016/j.jaci.2014.07.057. Epub 2014 Sep 18.


In vivo activation and functions of the protease factor XII.

Björkqvist J, Nickel KF, Stavrou E, Renné T.

Thromb Haemost. 2014 Nov;112(5):868-75. doi: 10.1160/TH14-04-0311. Epub 2014 Sep 4. Review.


A factor XIIa inhibitory antibody provides thromboprotection in extracorporeal circulation without increasing bleeding risk.

Larsson M, Rayzman V, Nolte MW, Nickel KF, Björkqvist J, Jämsä A, Hardy MP, Fries M, Schmidbauer S, Hedenqvist P, Broomé M, Pragst I, Dickneite G, Wilson MJ, Nash AD, Panousis C, Renné T.

Sci Transl Med. 2014 Feb 5;6(222):222ra17. doi: 10.1126/scitranslmed.3006804.


Time-dependent degradation and tissue factor addition mask the ability of platelet polyphosphates in activating factor XII-mediated coagulation.

Nickel KF, Spronk HM, Mutch NJ, Renné T.

Blood. 2013 Nov 28;122(23):3847-9. doi: 10.1182/blood-2013-09-525840. No abstract available.


Thrombin has biphasic effects on the nitric oxide-cGMP pathway in endothelial cells and contributes to experimental pulmonary hypertension.

Nickel KF, Laux V, Heumann R, von Degenfeld G.

PLoS One. 2013 Jun 13;8(6):e63504. doi: 10.1371/journal.pone.0063504. Print 2013.


Crosstalk of the plasma contact system with bacteria.

Nickel KF, Renné T.

Thromb Res. 2012 Oct;130 Suppl 1:S78-83. doi: 10.1016/j.thromres.2012.08.284. Review.


In vivo roles of factor XII.

Renné T, Schmaier AH, Nickel KF, Blombäck M, Maas C.

Blood. 2012 Nov 22;120(22):4296-303. doi: 10.1182/blood-2012-07-292094. Epub 2012 Sep 19. Review.


A role for coagulation factor Xa in experimental pulmonary arterial hypertension.

Delbeck M, Nickel KF, Perzborn E, Ellinghaus P, Strassburger J, Kast R, Laux V, Schäfer S, Schermuly RT, von Degenfeld G.

Cardiovasc Res. 2011 Oct 1;92(1):159-68. doi: 10.1093/cvr/cvr168. Epub 2011 Jun 15.


A novel cardiotropic murine adenovirus representing a distinct species of mastadenoviruses.

Klempa B, Krüger DH, Auste B, Stanko M, Krawczyk A, Nickel KF, Uberla K, Stang A.

J Virol. 2009 Jun;83(11):5749-59. doi: 10.1128/JVI.02281-08. Epub 2009 Mar 18.

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