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Items: 27

1.

RNA-ALIS: Methodology for screening soluble RNAs as small molecule targets using ALIS affinity-selection mass spectrometry.

Rizvi NF, Nickbarg EB.

Methods. 2019 May 3. pii: S1046-2023(18)30386-4. doi: 10.1016/j.ymeth.2019.04.024. [Epub ahead of print]

PMID:
31059829
2.

Identification of G-Quadruplex-Binding Inhibitors of Myc Expression through Affinity Selection-Mass Spectrometry.

Flusberg DA, Rizvi NF, Kutilek V, Andrews C, Saradjian P, Chamberlin C, Curran P, Swalm B, Kattar S, Smith GF, Dandliker P, Nickbarg EB, O'Neil J.

SLAS Discov. 2019 Feb;24(2):142-157. doi: 10.1177/2472555218796656. Epub 2018 Sep 11.

PMID:
30204533
3.

Discovery of Selective RNA-Binding Small Molecules by Affinity-Selection Mass Spectrometry.

Rizvi NF, Howe JA, Nahvi A, Klein DJ, Fischmann TO, Kim HY, McCoy MA, Walker SS, Hruza A, Richards MP, Chamberlin C, Saradjian P, Butko MT, Mercado G, Burchard J, Strickland C, Dandliker PJ, Smith GF, Nickbarg EB.

ACS Chem Biol. 2018 Mar 16;13(3):820-831. doi: 10.1021/acschembio.7b01013. Epub 2018 Feb 14.

PMID:
29412640
4.

Linking High-Throughput Screens to Identify MoAs and Novel Inhibitors of Mycobacterium tuberculosis Dihydrofolate Reductase.

Santa Maria JP Jr, Park Y, Yang L, Murgolo N, Altman MD, Zuck P, Adam G, Chamberlin C, Saradjian P, Dandliker P, Boshoff HIM, Barry CE 3rd, Garlisi C, Olsen DB, Young K, Glick M, Nickbarg E, Kutchukian PS.

ACS Chem Biol. 2017 Sep 15;12(9):2448-2456. doi: 10.1021/acschembio.7b00468. Epub 2017 Aug 29.

5.

Affinity Selection-Mass Spectrometry Identifies a Novel Antibacterial RNA Polymerase Inhibitor.

Walker SS, Degen D, Nickbarg E, Carr D, Soriano A, Mandal M, Painter RE, Sheth P, Xiao L, Sher X, Murgolo N, Su J, Olsen DB, Ebright RH, Young K.

ACS Chem Biol. 2017 May 19;12(5):1346-1352. doi: 10.1021/acschembio.6b01133. Epub 2017 Mar 31.

6.

Structural characterization of nonactive site, TrkA-selective kinase inhibitors.

Su HP, Rickert K, Burlein C, Narayan K, Bukhtiyarova M, Hurzy DM, Stump CA, Zhang X, Reid J, Krasowska-Zoladek A, Tummala S, Shipman JM, Kornienko M, Lemaire PA, Krosky D, Heller A, Achab A, Chamberlin C, Saradjian P, Sauvagnat B, Yang X, Ziebell MR, Nickbarg E, Sanders JM, Bilodeau MT, Carroll SS, Lumb KJ, Soisson SM, Henze DA, Cooke AJ.

Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):E297-E306. doi: 10.1073/pnas.1611577114. Epub 2016 Dec 30.

7.

Integration of Affinity Selection-Mass Spectrometry and Functional Cell-Based Assays to Rapidly Triage Druggable Target Space within the NF-κB Pathway.

Kutilek VD, Andrews CL, Richards MP, Xu Z, Sun T, Chen Y, Hashke A, Smotrov N, Fernandez R, Nickbarg EB, Chamberlin C, Sauvagnat B, Curran PJ, Boinay R, Saradjian P, Allen SJ, Byrne N, Elsen NL, Ford RE, Hall DL, Kornienko M, Rickert KW, Sharma S, Shipman JM, Lumb KJ, Coleman K, Dandliker PJ, Kariv I, Beutel B.

J Biomol Screen. 2016 Jul;21(6):608-19. doi: 10.1177/1087057116637353. Epub 2016 Mar 11.

PMID:
26969322
8.

Application of affinity selection-mass spectrometry assays to purification and affinity-based screening of the chemokine receptor CXCR4.

Whitehurst CE, Yao Z, Murphy D, Zhang M, Taremi S, Wojcik L, Strizki JM, Bracken JD, Cheng CC, Yang X, Shipps GW Jr, Ziebell M, Nickbarg E.

Comb Chem High Throughput Screen. 2012 Jul;15(6):473-85.

PMID:
22651846
9.

Multidimensional profiling of CSF1R screening hits and inhibitors: assessing cellular activity, target residence time, and selectivity in a higher throughput way.

Uitdehaag JC, Sünnen CM, van Doornmalen AM, de Rouw N, Oubrie A, Azevedo R, Ziebell M, Nickbarg E, Karstens WJ, Ruygrok S.

J Biomol Screen. 2011 Oct;16(9):1007-17. doi: 10.1177/1087057111418113. Epub 2011 Aug 26.

PMID:
21873591
10.

Evaluation of in vitro PXR-based assays and in silico modeling approaches for understanding the binding of a structurally diverse set of drugs to PXR.

Xiao L, Nickbarg E, Wang W, Thomas A, Ziebell M, Prosise WW, Lesburg CA, Taremi SS, Gerlach VL, Le HV, Cheng KC.

Biochem Pharmacol. 2011 Mar 1;81(5):669-79. doi: 10.1016/j.bcp.2010.12.003. Epub 2010 Dec 9.

PMID:
21145880
11.

Novel benzimidazole inhibitors bind to a unique site in the kinesin spindle protein motor domain.

Sheth PR, Shipps GW Jr, Seghezzi W, Smith CK, Chuang CC, Sanden D, Basso AD, Vilenchik L, Gray K, Annis DA, Nickbarg E, Ma Y, Lahue B, Herbst R, Le HV.

Biochemistry. 2010 Sep 28;49(38):8350-8. doi: 10.1021/bi1005283.

PMID:
20718440
12.

Retraction for Wong et al., "Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade".

Wong CW, McNally C, Nickbarg E, Komm BS, Cheskis BJ.

Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14180. doi: 10.1073/pnas.0907607106. Epub 2009 Jul 28. No abstract available.

13.

Affinity selection-mass spectrometry screening techniques for small molecule drug discovery.

Annis DA, Nickbarg E, Yang X, Ziebell MR, Whitehurst CE.

Curr Opin Chem Biol. 2007 Oct;11(5):518-26. Epub 2007 Oct 10. Review.

PMID:
17931956
14.

Proteomic analysis and identification of Streptococcus pyogenes surface-associated proteins.

Severin A, Nickbarg E, Wooters J, Quazi SA, Matsuka YV, Murphy E, Moutsatsos IK, Zagursky RJ, Olmsted SB.

J Bacteriol. 2007 Mar;189(5):1514-22. Epub 2006 Dec 1.

15.

NAK is recruited to the TNFR1 complex in a TNFalpha-dependent manner and mediates the production of RANTES: identification of endogenous TNFR-interacting proteins by a proteomic approach.

Kuai J, Wooters J, Hall JP, Rao VR, Nickbarg E, Li B, Chatterjee-Kishore M, Qiu Y, Lin LL.

J Biol Chem. 2004 Dec 17;279(51):53266-71. Epub 2004 Oct 13.

16.

Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis.

Kuai J, Nickbarg E, Wooters J, Qiu Y, Wang J, Lin LL.

J Biol Chem. 2003 Apr 18;278(16):14363-9. Epub 2003 Feb 5.

17.
18.

Characterization of murine Flt4 ligand/VEGF-C.

Fitz LJ, Morris JC, Towler P, Long A, Burgess P, Greco R, Wang J, Gassaway R, Nickbarg E, Kovacic S, Ciarletta A, Giannotti J, Finnerty H, Zollner R, Beier DR, Leak LV, Turner KJ, Wood CR.

Oncogene. 1997 Jul 31;15(5):613-8.

19.

Structural identification of the hematopoietic progenitor antigen ER-MP12 as the vascular endothelial adhesion molecule PECAM-1 (CD31).

Ling V, Luxenberg D, Wang J, Nickbarg E, Leenen PJ, Neben S, Kobayashi M.

Eur J Immunol. 1997 Feb;27(2):509-14.

PMID:
9045924
20.

Synergistic interaction between interleukin-12 and steel factor in support of proliferation of murine lymphohematopoietic progenitors in culture.

Hirayama F, Katayama N, Neben S, Donaldson D, Nickbarg EB, Clark SC, Ogawa M.

Blood. 1994 Jan 1;83(1):92-8.

21.

Antichymotrypsin interaction with chymotrypsin. Partitioning of the complex.

Cooperman BS, Stavridi E, Nickbarg E, Rescorla E, Schechter NM, Rubin H.

J Biol Chem. 1993 Nov 5;268(31):23616-25.

22.

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells.

D'Andrea A, Rengaraju M, Valiante NM, Chehimi J, Kubin M, Aste M, Chan SH, Kobayashi M, Young D, Nickbarg E, et al.

J Exp Med. 1992 Nov 1;176(5):1387-98.

23.

Natural killer (NK) cell stimulatory factor increases the cytotoxic activity of NK cells from both healthy donors and human immunodeficiency virus-infected patients.

Chehimi J, Starr SE, Frank I, Rengaraju M, Jackson SJ, Llanes C, Kobayashi M, Perussia B, Young D, Nickbarg E, et al.

J Exp Med. 1992 Mar 1;175(3):789-96.

24.

Inhibition of human neutrophil superoxide generation by alpha 1-antichymotrypsin.

Kilpatrick L, Johnson JL, Nickbarg EB, Wang ZM, Clifford TF, Banach M, Cooperman BS, Douglas SD, Rubin H.

J Immunol. 1991 Apr 1;146(7):2388-93.

PMID:
1848582
25.

Cloning, expression, purification, and biological activity of recombinant native and variant human alpha 1-antichymotrypsins.

Rubin H, Wang ZM, Nickbarg EB, McLarney S, Naidoo N, Schoenberger OL, Johnson JL, Cooperman BS.

J Biol Chem. 1990 Jan 15;265(2):1199-207.

26.
27.

Triosephosphate isomerase: removal of a putatively electrophilic histidine residue results in a subtle change in catalytic mechanism.

Nickbarg EB, Davenport RC, Petsko GA, Knowles JR.

Biochemistry. 1988 Aug 9;27(16):5948-60.

PMID:
2847777

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