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Items: 20


Basic research opportunities focused on bio-based and bio-inspired materials and potential applications.

Nick McElhinny SA, Becker JJ.

Front Chem. 2014 May 13;2:24. doi: 10.3389/fchem.2014.00024. eCollection 2014. No abstract available.


Ribonucleotide incorporation by yeast DNA polymerase ζ.

Makarova AV, Nick McElhinny SA, Watts BE, Kunkel TA, Burgers PM.

DNA Repair (Amst). 2014 Jun;18:63-7. doi: 10.1016/j.dnarep.2014.02.017. Epub 2014 Mar 24.


Mismatch repair balances leading and lagging strand DNA replication fidelity.

Lujan SA, Williams JS, Pursell ZF, Abdulovic-Cui AA, Clark AB, Nick McElhinny SA, Kunkel TA.

PLoS Genet. 2012;8(10):e1003016. doi: 10.1371/journal.pgen.1003016. Epub 2012 Oct 11.


Proofreading of ribonucleotides inserted into DNA by yeast DNA polymerase ɛ.

Williams JS, Clausen AR, Nick McElhinny SA, Watts BE, Johansson E, Kunkel TA.

DNA Repair (Amst). 2012 Aug 1;11(8):649-56. doi: 10.1016/j.dnarep.2012.05.004. Epub 2012 Jun 8.


Differential correction of lagging-strand replication errors made by DNA polymerases {alpha} and {delta}.

Nick McElhinny SA, Kissling GE, Kunkel TA.

Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21070-5. doi: 10.1073/pnas.1013048107. Epub 2010 Nov 1.


Genome-wide model for the normal eukaryotic DNA replication fork.

Larrea AA, Lujan SA, Nick McElhinny SA, Mieczkowski PA, Resnick MA, Gordenin DA, Kunkel TA.

Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17674-9. doi: 10.1073/pnas.1010178107. Epub 2010 Sep 27.


Genome instability due to ribonucleotide incorporation into DNA.

Nick McElhinny SA, Kumar D, Clark AB, Watt DL, Watts BE, Lundström EB, Johansson E, Chabes A, Kunkel TA.

Nat Chem Biol. 2010 Oct;6(10):774-81. doi: 10.1038/nchembio.424. Epub 2010 Aug 22.


Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases.

Nick McElhinny SA, Watts BE, Kumar D, Watt DL, Lundström EB, Burgers PM, Johansson E, Chabes A, Kunkel TA.

Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4949-54. doi: 10.1073/pnas.0914857107. Epub 2010 Mar 1.


Division of labor at the eukaryotic replication fork.

Nick McElhinny SA, Gordenin DA, Stith CM, Burgers PM, Kunkel TA.

Mol Cell. 2008 Apr 25;30(2):137-44. doi: 10.1016/j.molcel.2008.02.022.


Inefficient proofreading and biased error rates during inaccurate DNA synthesis by a mutant derivative of Saccharomyces cerevisiae DNA polymerase delta.

Nick McElhinny SA, Stith CM, Burgers PM, Kunkel TA.

J Biol Chem. 2007 Jan 26;282(4):2324-32. Epub 2006 Nov 22.


The fidelity of DNA synthesis by yeast DNA polymerase zeta alone and with accessory proteins.

Zhong X, Garg P, Stith CM, Nick McElhinny SA, Kissling GE, Burgers PM, Kunkel TA.

Nucleic Acids Res. 2006;34(17):4731-42. Epub 2006 Sep 13.


A specific loop in human DNA polymerase mu allows switching between creative and DNA-instructed synthesis.

Juárez R, Ruiz JF, Nick McElhinny SA, Ramsden D, Blanco L.

Nucleic Acids Res. 2006;34(16):4572-82. Epub 2006 Sep 8.


Evidence for extrinsic exonucleolytic proofreading.

Nick McElhinny SA, Pavlov YI, Kunkel TA.

Cell Cycle. 2006 May;5(9):958-62. Epub 2006 May 1.


Evidence that errors made by DNA polymerase alpha are corrected by DNA polymerase delta.

Pavlov YI, Frahm C, Nick McElhinny SA, Niimi A, Suzuki M, Kunkel TA.

Curr Biol. 2006 Jan 24;16(2):202-7.


A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining.

Nick McElhinny SA, Havener JM, Garcia-Diaz M, Juárez R, Bebenek K, Kee BL, Blanco L, Kunkel TA, Ramsden DA.

Mol Cell. 2005 Aug 5;19(3):357-66.


Polymerase mu is a DNA-directed DNA/RNA polymerase.

Nick McElhinny SA, Ramsden DA.

Mol Cell Biol. 2003 Apr;23(7):2309-15.


Translesion synthesis past platinum DNA adducts by human DNA polymerase mu.

Havener JM, Nick McElhinny SA, Bassett E, Gauger M, Ramsden DA, Chaney SG.

Biochemistry. 2003 Feb 18;42(6):1777-88.


Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair.

Mahajan KN, Nick McElhinny SA, Mitchell BS, Ramsden DA.

Mol Cell Biol. 2002 Jul;22(14):5194-202.


Ku recruits the XRCC4-ligase IV complex to DNA ends.

Nick McElhinny SA, Snowden CM, McCarville J, Ramsden DA.

Mol Cell Biol. 2000 May;20(9):2996-3003.

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