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Shock Index and Pulse Pressure as Triggers for Massive Transfusion.

Zhu CS, Cobb D, Jonas RB, Pokorny D, Rani M, Cotner-Pouncy T, Oliver J, Cap A, Cestero R, Nicholson SE, Eastridge BJ, Jenkins DH.

J Trauma Acute Care Surg. 2019 Apr 25. doi: 10.1097/TA.0000000000002333. [Epub ahead of print]


Give the trauma patient what they bleed, when and where they need it: establishing a comprehensive regional system of resuscitation based on patient need utilizing cold-stored, low-titer O+ whole blood.

Zhu CS, Pokorny DM, Eastridge BJ, Nicholson SE, Epley E, Forcum J, Long T, Miramontes D, Schaefer R, Shiels M, Stewart RM, Stringfellow M, Summers R, Winckler CJ, Jenkins DH.

Transfusion. 2019 Apr;59(S2):1429-1438. doi: 10.1111/trf.15264.


Burn injury is associated with an infiltration of the wound site with myeloid-derived suppressor cells.

Schwacha MG, Scroggins SR, Montgomery RK, Nicholson SE, Cap AP.

Cell Immunol. 2019 Apr;338:21-26. doi: 10.1016/j.cellimm.2019.03.001. Epub 2019 Mar 13.


Spinal cord injury and the human microbiome: beyond the brain-gut axis.

Wallace DJ, Sayre NL, Patterson TT, Nicholson SE, Hilton D, Grandhi R.

Neurosurg Focus. 2019 Mar 1;46(3):E11. doi: 10.3171/2018.12.FOCUS18206.


A prospective study in severely injured patients reveals an altered gut microbiome is associated with transfusion volume.

Nicholson SE, Burmeister DM, Johnson TR, Zou Y, Lai Z, Scroggins S, DeRosa M, Jonas RB, Merrill DR, Zhu C, Newton LM, Stewart RM, Schwacha MG, Jenkins DH, Eastridge BJ.

J Trauma Acute Care Surg. 2019 Apr;86(4):573-582. doi: 10.1097/TA.0000000000002201.


Understanding SOCS protein specificity.

Linossi EM, Calleja DJ, Nicholson SE.

Growth Factors. 2018 Aug;36(3-4):104-117. doi: 10.1080/08977194.2018.1518324. Epub 2018 Oct 15.


Introduction to the Special Issue: The tumor microenvironment and molecular regulation of innate immune cells.

Nicholson SE, Watowich SS.

Mol Immunol. 2019 Jun;110:1-2. doi: 10.1016/j.molimm.2018.10.009. Epub 2018 Oct 11. No abstract available.


A Cyclic Peptide Inhibitor of the iNOS-SPSB Protein-Protein Interaction as a Potential Anti-Infective Agent.

Sadek MM, Barlow N, Leung EWW, Williams-Noonan BJ, Yap BK, Shariff FM, Caradoc-Davies TT, Nicholson SE, Chalmers DK, Thompson PE, Law RHP, Norton RS.

ACS Chem Biol. 2018 Oct 19;13(10):2930-2938. doi: 10.1021/acschembio.8b00561. Epub 2018 Sep 18.


The Cutaneous Microbiome and Wounds: New Molecular Targets to Promote Wound Healing.

Johnson TR, Gómez BI, McIntyre MK, Dubick MA, Christy RJ, Nicholson SE, Burmeister DM.

Int J Mol Sci. 2018 Sep 11;19(9). pii: E2699. doi: 10.3390/ijms19092699. Review.


Polytrauma independent of therapeutic intervention alters the gastrointestinal microbiome.

Nicholson SE, Merrill D, Zhu C, Burmeister DM, Zou Y, Lai Z, Darlington DN, Lewis AM, Newton L, Scroggins S, Eastridge BJ, Schwacha MG.

Am J Surg. 2018 Oct;216(4):699-705. doi: 10.1016/j.amjsurg.2018.07.026. Epub 2018 Jul 26.


Corrigendum: The Centennial Trends Greater Horn of Africa precipitation dataset.

Funk C, Nicholson SE, Landsfeld M, Klotter D, Peterson P, Harrison L.

Sci Data. 2018 Jul 3;5:180121. doi: 10.1038/sdata.2018.121.


Moderate Traumatic Brain Injury Alters the Gastrointestinal Microbiome in a Time-Dependent Manner.

Nicholson SE, Watts LT, Burmeister DM, Merrill D, Scroggins S, Zou Y, Lai Z, Grandhi R, Lewis AM, Newton LM, Eastridge BJ, Schwacha MG.

Shock. 2018 Jun 26. doi: 10.1097/SHK.0000000000001211. [Epub ahead of print]


A Review of Traumatic Brain Injury and the Gut Microbiome: Insights into Novel Mechanisms of Secondary Brain Injury and Promising Targets for Neuroprotection.

Zhu CS, Grandhi R, Patterson TT, Nicholson SE.

Brain Sci. 2018 Jun 19;8(6). pii: E113. doi: 10.3390/brainsci8060113. Review.


SOCS-mediated immunomodulation of natural killer cells.

Keating N, Nicholson SE.

Cytokine. 2018 Mar 30. pii: S1043-4666(18)30119-4. doi: 10.1016/j.cyto.2018.03.033. [Epub ahead of print] Review.


Prehospital low-titer cold-stored whole blood: Philosophy for ubiquitous utilization of O-positive product for emergency use in hemorrhage due to injury.

McGinity AC, Zhu CS, Greebon L, Xenakis E, Waltman E, Epley E, Cobb D, Jonas R, Nicholson SE, Eastridge BJ, Stewart RM, Jenkins DH.

J Trauma Acute Care Surg. 2018 Jun;84(6S Suppl 1):S115-S119. doi: 10.1097/TA.0000000000001905.


Identification of a second binding site on the TRIM25 B30.2 domain.

D'Cruz AA, Kershaw NJ, Hayman TJ, Linossi EM, Chiang JJ, Wang MK, Dagley LF, Kolesnik TB, Zhang JG, Masters SL, Griffin MDW, Gack MU, Murphy JM, Nicola NA, Babon JJ, Nicholson SE.

Biochem J. 2018 Jan 23;475(2):429-440. doi: 10.1042/BCJ20170427.


Natural killer cells and anti-tumor immunity.

Nicholson SE, Keating N, Belz GT.

Mol Immunol. 2019 Jun;110:40-47. doi: 10.1016/j.molimm.2017.12.002. Epub 2017 Dec 9.


Long-term variations of aerosol optical depth and aerosol radiative forcing over Iran based on satellite and AERONET data.

Arkian F, Nicholson SE.

Environ Monit Assess. 2017 Dec 1;190(1):1. doi: 10.1007/s10661-017-6336-1.


Characterisation of a novel coumarin-based fluorescent probe for monitoring nitric oxide production in macrophages.

Sadek MM, Barzegar Amiri Olia M, Nowell CJ, Barlow Ν, Schiesser CH, Nicholson SE, Norton RS.

Bioorg Med Chem. 2017 Oct 15;25(20):5743-5748. doi: 10.1016/j.bmc.2017.08.054. Epub 2017 Sep 5.


Targeting cytokine signaling checkpoint CIS activates NK cells to protect from tumor initiation and metastasis.

Putz EM, Guillerey C, Kos K, Stannard K, Miles K, Delconte RB, Takeda K, Nicholson SE, Huntington ND, Smyth MJ.

Oncoimmunology. 2017 Feb 7;6(2):e1267892. doi: 10.1080/2162402X.2016.1267892. eCollection 2017.


Damage-associated molecular patterns (DAMPs) released after burn are associated with inflammation and monocyte activation.

Rani M, Nicholson SE, Zhang Q, Schwacha MG.

Burns. 2017 Mar;43(2):297-303. doi: 10.1016/j.burns.2016.10.001. Epub 2016 Oct 27.


Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling.

Kedzierski L, Tate MD, Hsu AC, Kolesnik TB, Linossi EM, Dagley L, Dong Z, Freeman S, Infusini G, Starkey MR, Bird NL, Chatfield SM, Babon JJ, Huntington N, Belz G, Webb A, Wark PA, Nicola NA, Xu J, Kedzierska K, Hansbro PM, Nicholson SE.

Elife. 2017 Feb 14;6. pii: e20444. doi: 10.7554/eLife.20444.


Toll-like receptor responses are suppressed in trauma ICU patients.

Holloway TL, Nicholson SE, Rani M, Cap AP, Schwacha MG.

J Surg Res. 2016 Nov;206(1):139-145. doi: 10.1016/j.jss.2016.06.056. Epub 2016 Jun 25.


Dermal γδ T-Cells Can Be Activated by Mitochondrial Damage-Associated Molecular Patterns.

Schwacha MG, Rani M, Nicholson SE, Lewis AM, Holloway TL, Sordo S, Cap AP.

PLoS One. 2016 Jul 12;11(7):e0158993. doi: 10.1371/journal.pone.0158993. eCollection 2016.


Design, Synthesis, and Characterization of Cyclic Peptidomimetics of the Inducible Nitric Oxide Synthase Binding Epitope That Disrupt the Protein-Protein Interaction Involving SPRY Domain-Containing Suppressor of Cytokine Signaling Box Protein (SPSB) 2 and Inducible Nitric Oxide Synthase.

Harjani JR, Yap BK, Leung EW, Lucke A, Nicholson SE, Scanlon MJ, Chalmers DK, Thompson PE, Norton RS, Baell JB.

J Med Chem. 2016 Jun 23;59(12):5799-809. doi: 10.1021/acs.jmedchem.6b00386. Epub 2016 Jun 8.


CIS is a potent checkpoint in NK cell-mediated tumor immunity.

Delconte RB, Kolesnik TB, Dagley LF, Rautela J, Shi W, Putz EM, Stannard K, Zhang JG, Teh C, Firth M, Ushiki T, Andoniou CE, Degli-Esposti MA, Sharp PP, Sanvitale CE, Infusini G, Liau NP, Linossi EM, Burns CJ, Carotta S, Gray DH, Seillet C, Hutchinson DS, Belz GT, Webb AI, Alexander WS, Li SS, Bullock AN, Babon JJ, Smyth MJ, Nicholson SE, Huntington ND.

Nat Immunol. 2016 Jul;17(7):816-24. doi: 10.1038/ni.3470. Epub 2016 May 23.


Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation.

Masters SL, Lagou V, Jéru I, Baker PJ, Van Eyck L, Parry DA, Lawless D, De Nardo D, Garcia-Perez JE, Dagley LF, Holley CL, Dooley J, Moghaddas F, Pasciuto E, Jeandel PY, Sciot R, Lyras D, Webb AI, Nicholson SE, De Somer L, van Nieuwenhove E, Ruuth-Praz J, Copin B, Cochet E, Medlej-Hashim M, Megarbane A, Schroder K, Savic S, Goris A, Amselem S, Wouters C, Liston A.

Sci Transl Med. 2016 Mar 30;8(332):332ra45. doi: 10.1126/scitranslmed.aaf1471.


Redox-stable cyclic peptide inhibitors of the SPSB2-iNOS interaction.

Yap BK, Harjani JR, Leung EW, Nicholson SE, Scanlon MJ, Chalmers DK, Thompson PE, Baell JB, Norton RS.

FEBS Lett. 2016 Mar;590(6):696-704. doi: 10.1002/1873-3468.12115. Epub 2016 Mar 6.


The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15.

Delconte RB, Shi W, Sathe P, Ushiki T, Seillet C, Minnich M, Kolesnik TB, Rankin LC, Mielke LA, Zhang JG, Busslinger M, Smyth MJ, Hutchinson DS, Nutt SL, Nicholson SE, Alexander WS, Corcoran LM, Vivier E, Belz GT, Carotta S, Huntington ND.

Immunity. 2016 Jan 19;44(1):103-115. doi: 10.1016/j.immuni.2015.12.007. Epub 2016 Jan 12.


Cortical Layer Inversion and Deregulation of Reelin Signaling in the Absence of SOCS6 and SOCS7.

Lawrenson ID, Krebs DL, Linossi EM, Zhang JG, McLennan TJ, Collin C, McRae HM, Kolesnik TB, Koh K, Britto JM, Kueh AJ, Sheikh BN, El-Saafin F, Nicola NA, Tan SS, Babon JJ, Nicholson SE, Alexander WS, Thomas T, Voss AK.

Cereb Cortex. 2017 Jan 1;27(1):576-588. doi: 10.1093/cercor/bhv253.


The Centennial Trends Greater Horn of Africa precipitation dataset.

Funk C, Nicholson SE, Landsfeld M, Klotter D, Peterson P, Harrison L.

Sci Data. 2015 Sep 29;2:150050. doi: 10.1038/sdata.2015.50. eCollection 2015. Erratum in: Sci Data. 2018 Jul 03;5:180121.


Structure and Functional Characterization of the Conserved JAK Interaction Region in the Intrinsically Disordered N-Terminus of SOCS5.

Chandrashekaran IR, Mohanty B, Linossi EM, Dagley LF, Leung EW, Murphy JM, Babon JJ, Nicholson SE, Norton RS.

Biochemistry. 2015 Aug 4;54(30):4672-82. doi: 10.1021/acs.biochem.5b00619. Epub 2015 Jul 27.


SOCS4 is dispensable for an efficient recall response to influenza despite being required for primary immunity.

Kedzierski L, Clemens EB, Bird NL, Kile BT, Belz GT, Nicola NA, Kedzierska K, Nicholson SE.

Immunol Cell Biol. 2015 Nov;93(10):909-13. doi: 10.1038/icb.2015.55. Epub 2015 Jun 16.


SPSB1, a Novel Negative Regulator of the Transforming Growth Factor-β Signaling Pathway Targeting the Type II Receptor.

Liu S, Nheu T, Luwor R, Nicholson SE, Zhu HJ.

J Biol Chem. 2015 Jul 17;290(29):17894-908. doi: 10.1074/jbc.M114.607184. Epub 2015 Jun 1.


Correction for Zhang et al., The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation.

Zhang JG, Farley A, Nicholson SE, Willson TA, Zugaro LM, Simpson RJ, Moritz RL, Cary D, Richardson R, Hausmann G, Kile BT, Kent SB, Alexander WS, Metcalf D, Hilton DJ, Nicola NA, Baca M.

Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):E2979. doi: 10.1073/pnas.1507812112. Epub 2015 May 8. No abstract available.


DNAM-1 expression marks an alternative program of NK cell maturation.

Martinet L, Ferrari De Andrade L, Guillerey C, Lee JS, Liu J, Souza-Fonseca-Guimaraes F, Hutchinson DS, Kolesnik TB, Nicholson SE, Huntington ND, Smyth MJ.

Cell Rep. 2015 Apr 7;11(1):85-97. doi: 10.1016/j.celrep.2015.03.006. Epub 2015 Mar 26.


Increased nuclear suppressor of cytokine signaling 1 in asthmatic bronchial epithelium suppresses rhinovirus induction of innate interferons.

Gielen V, Sykes A, Zhu J, Chan B, Macintyre J, Regamey N, Kieninger E, Gupta A, Shoemark A, Bossley C, Davies J, Saglani S, Walker P, Nicholson SE, Dalpke AH, Kon OM, Bush A, Johnston SL, Edwards MR.

J Allergy Clin Immunol. 2015 Jul;136(1):177-188.e11. doi: 10.1016/j.jaci.2014.11.039. Epub 2015 Jan 25.


Coherent changes of southeastern equatorial and northern African rainfall during the last deglaciation.

Otto-Bliesner BL, Russell JM, Clark PU, Liu Z, Overpeck JT, Konecky B, deMenocal P, Nicholson SE, He F, Lu Z.

Science. 2014 Dec 5;346(6214):1223-7. doi: 10.1126/science.1259531.


Innate immunodeficiency following genetic ablation of Mcl1 in natural killer cells.

Sathe P, Delconte RB, Souza-Fonseca-Guimaraes F, Seillet C, Chopin M, Vandenberg CJ, Rankin LC, Mielke LA, Vikstrom I, Kolesnik TB, Nicholson SE, Vivier E, Smyth MJ, Nutt SL, Glaser SP, Strasser A, Belz GT, Carotta S, Huntington ND.

Nat Commun. 2014 Aug 14;5:4539. doi: 10.1038/ncomms5539.


A potent cyclic peptide targeting SPSB2 protein as a potential anti-infective agent.

Yap BK, Leung EW, Yagi H, Galea CA, Chhabra S, Chalmers DK, Nicholson SE, Thompson PE, Norton RS.

J Med Chem. 2014 Aug 28;57(16):7006-15. doi: 10.1021/jm500596j. Epub 2014 Aug 6.


Key role of suppressor of cytokine signaling 3 in regulating gp130 cytokine-induced signaling and limiting chondrocyte responses during murine inflammatory arthritis.

Liu X, Croker BA, Campbell IK, Gauci SJ, Alexander WS, Tonkin BA, Walsh NC, Linossi EM, Nicholson SE, Lawlor KE, Wicks IP.

Arthritis Rheumatol. 2014 Sep;66(9):2391-402. doi: 10.1002/art.38701.


Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection.

Kedzierski L, Linossi EM, Kolesnik TB, Day EB, Bird NL, Kile BT, Belz GT, Metcalf D, Nicola NA, Kedzierska K, Nicholson SE.

PLoS Pathog. 2014 May 8;10(5):e1004134. doi: 10.1371/journal.ppat.1004134. eCollection 2014 May.


Crystal structure of the TRIM25 B30.2 (PRYSPRY) domain: a key component of antiviral signalling.

D'Cruz AA, Kershaw NJ, Chiang JJ, Wang MK, Nicola NA, Babon JJ, Gack MU, Nicholson SE.

Biochem J. 2013 Dec 1;456(2):231-40. doi: 10.1042/BJ20121425.


Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1.

Linossi EM, Chandrashekaran IR, Kolesnik TB, Murphy JM, Webb AI, Willson TA, Kedzierski L, Bullock AN, Babon JJ, Norton RS, Nicola NA, Nicholson SE.

PLoS One. 2013 Aug 21;8(8):e70536. doi: 10.1371/journal.pone.0070536. eCollection 2013.


Suppression of cytokine signaling: the SOCS perspective.

Linossi EM, Babon JJ, Hilton DJ, Nicholson SE.

Cytokine Growth Factor Rev. 2013 Jun;24(3):241-8. doi: 10.1016/j.cytogfr.2013.03.005. Epub 2013 Mar 30. Review.


Detection of endogenous SOCS1 and SOCS3 proteins by immunoprecipitation and Western blot analysis.

Zhang JG, Nicholson SE.

Methods Mol Biol. 2013;967:249-59. doi: 10.1007/978-1-62703-242-1_18.


Analysis of Suppressor of Cytokine Signalling (SOCS) gene expression by real-time quantitative PCR.

Kolesnik TB, Nicholson SE.

Methods Mol Biol. 2013;967:235-48. doi: 10.1007/978-1-62703-242-1_17.


Structure and function of the SPRY/B30.2 domain proteins involved in innate immunity.

D'Cruz AA, Babon JJ, Norton RS, Nicola NA, Nicholson SE.

Protein Sci. 2013 Jan;22(1):1-10. doi: 10.1002/pro.2185. Review.


The anti-inflammatory actions of IL-4 in human monocytes are not mediated by IL-10, RP105 or the kinase activity of RIPK2.

Woodward EA, Kolesnik TB, Nicholson SE, Prêle CM, Hart PH.

Cytokine. 2012 Jun;58(3):415-23. doi: 10.1016/j.cyto.2012.03.009. Epub 2012 Apr 7.


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